Synbiotics in surgery for chronic pancreatitis: Are they truly effective?: A single-blind prospective randomized control trial

Annals of Surgery

Volumn 262, Issue 1, 2015, Pages 31-37

  Rammohan, Ashwin ^a   Sathyanesan, Jeswanth ^a   Rajendran, Kamalakannan ^a   Pitchaimuthu, Anbalagan ^a   Perumal, Senthil Kumar ^a   Balaraman, Kesavan ^a   Ramasamy, Ravi ^a   Palaniappan, Ravichandran ^a   Govindan, Manoharan ^a  

^a Division of HPB Diseases   (India)

Author keywords

Chronic pancreatitis; Infectious complications; Morbidity; Pancreatic surgery; Synbiotics

Indexed keywords

CEFUROXIME; PLACEBO; SYNBIOTIC AGENT;

ABDOMINAL CRAMP; ABDOMINAL DISTENSION; ACINETOBACTER CALCOACETICUS; ACINETOBACTER CALCOACETICUS INFECTION; ACINETOBACTER INFECTION; ADULT; AGED; ANTIBIOTIC THERAPY; ARTICLE; CHRONIC PANCREATITIS; COAGULASE NEGATIVE STAPHYLOCOCCUS; COAGULASE NEGATIVE STAPHYLOCOCCUS AUREUS INFECTION; CONSTIPATION; CONTROLLED STUDY; DIARRHEA; DRUG EFFICACY; DRUG TOLERABILITY; ESCHERICHIA COLI INFECTION; FEMALE; FREY PROCEDURE; HUMAN; INTENSIVE CARE; KLEBSIELLA PNEUMONIAE INFECTION; LENGTH OF STAY; MAJOR CLINICAL STUDY; MALE; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS INFECTION; OUTCOME ASSESSMENT; PANCREAS SURGERY; POSTOPERATIVE CARE; POSTOPERATIVE INFECTION; PREOPERATIVE TREATMENT; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; RESPIRATORY TRACT INFECTION; SEPSIS; SINGLE BLIND PROCEDURE; SINGLE DRUG DOSE; STAPHYLOCOCCUS INFECTION; SURGICAL INFECTION; SURGICAL MORTALITY; TREATMENT DURATION; UNSPECIFIED SIDE EFFECT; URINARY TRACT INFECTION; VOMITING; ADVERSE EFFECTS; BACTERIAL INFECTIONS; MIDDLE AGED; PANCREATICOJEJUNOSTOMY; PANCREATITIS, CHRONIC; PROCEDURES;

ADULT; BACTERIAL INFECTIONS; FEMALE; HUMANS; MALE; MIDDLE AGED; PANCREATICOJEJUNOSTOMY; PANCREATITIS, CHRONIC; PROSPECTIVE STUDIES; SINGLE-BLIND METHOD; SYNBIOTICS;

EID: 84939441787     PISSN: 00034932     EISSN: 15281140     Source Type: Journal    
DOI: 10.1097/SLA.0000000000001077     Document Type: Article

References (46)

1. Martin GS, Mannino DM, Eaton S, Moss M. The epidemiology of sepsis in the United States from 1979 through 2000. N Engl J Med. 2003;348:1546-1554.
2. Pisters PWT, Hudec WA, Hess KR, et al. Effect of preoperative biliary decompression on pancreaticoduodenectomy-associated morbidity in 300 consecutive cases. Ann Surg. 2001;234:47-55.
3. Jagannath P, Dhir V, Shrikande S, et al. Effect of preoperative biliary stenting on immediate outcome after pancreatoduodenectomy. Br J Surg. 2005;92:356-361.
4. Wilson SE, Faulkner K. Impact of anatomical site on bacteriological and clinical outcome in the management of intraabdominal infections. Am Surg. 1998;64:402-407.
5. Bäckhed F, Ley RE, Sonnenburg JL, et al. Host-bacterial mutualism in the human intestine. Science. 2005;307:1915-1919.
6. Hooper LV, Gordon JL. Commensal host-bacterial relationships in the gut. Science. 2001;292:1115-1118.
7. Guarner F, Malagelada JR. Gut flora in health and disease. Lancet. 2003;361:512-519.
8. MacFie J, Reddy BS, Gatt M, et al. Bacterial translocation studied in 927 patients over 13 years. Br J Surg. 2006;93:87-93.
9. Nieuwenhuijs VB, Verheem A, Duijvenbode-Beumer H, et al. The role of interdigestive small bowel motility in the regulation of gut microflora, bacterial overgrowth, and bacterial translocation in rats. Ann Surg. 1998;228:188-193.
10. Deitch EA, Dazhong X, Naruhn MB, et al. Elemental diet and IV-TPN-induced bacterial translocation is associated with loss of intestinal mucosal barrier function against bacteria. Ann Surg. 1995;221:299-307.
11. Naaber P, Smidt I, Tamme K, et al. Translocation of indigenous microflora in an experimental model of sepsis. J Med Microbiol. 2000;49:431-439.
12. Runkel NSF, Moody FG, Smith GS, et al. The role of the gut in the development of sepsis in acute pancreatitis. J Surg Res. 1991;51:18-23.
13. Schrezemeier J, de Vrese M. Probiotics, prebiotics and synbiotics-approaching a definition. Am J Clin Nutr. 2001;73:361-364.
14. Lin HC, Su BH, Chen AC, et al. Oral probiotics reduce the incidence and severity of necrotizing enterocolitis in very low birth weight infants. Outcome and cost of intensive care for very low birth weight infants. Pediatrics. 2005;115:1-4.
15. McCarthy J, O'Mahony L, Dunne C, et al. An open trial of a novel probiotic as an alternative to steroids in mild/moderately active Crohn's disease. Gut. 2001;49(suppl 3):A2447.
16. Liu Q, Duan ZP, Ha da K, et al. Synbiotic modulation of gut flora: effect on minimal hepatic encephalopathy in patients with cirrhosis. Hepatology. 2004;39:1441-1449.
17. Marco ML, Pavan S, Kleerezebem M. Towards understanding molecular modes of probiotic action. Curr Opin Biotechnol. 2006;17:204-210.
18. D'Souza AL, Raj Cumar C, Cooke J, et al. Probiotics in prevention of antibiotic associated diarrhoea: meta-analysis. BMJ. 2002;324:1361.
19. Mack DR, Michail S, Wel S, et al. Probiotics inhibit enteropathogenic E. coli adherence in vitro by inducing intestinal mucin gene expression. Am J Physiol. 1999;276:G941-G950.
20. Bengmark S. Bioecological control of the gastrointestinal tract: the role of flora and supplemented probiotics and synbiotics. Gastroenterol Clin North Am. 2005;34:413-436.
21. Otte JM, Podolsky DK. Functional modulation of enterocytes by gram-positive and gram-negative microorganisms. Am J Physiol Gastrointest Liver Physiol. 2004;286:613-626.
22. Hart AL, Lammers K, Brigidi P, et al. Modulation of human dendritic cell phenotype and function by probiotic bacteria. Gut. 2004;53:1602-1609.
23. Niers LE, Timmermann HM, Rijkers GT, et al. Identification of strong interleukin-10 inducing lactic acid bacteria which down-regulate T helper type 2 cytokines. Clin Exp Allergy. 2005;35:1481-1489.
24. Kaila M, Isolauri E, Soppi E, et al. Enhancement of the circulating antibody secreting cell response in human diarrhoea by a human Lactobacillus strain. Pediatr Res. 1992;32:141-144.
25. Wang X, Andersson R, Soltesz V, et al. Effect of portal hypertension on bacterial translocation induced by major liver resection in rats. Eur J Surg. 1993;159:343-350.
26. Kotzampassi K, Giamarellos-Bourboulis EJ, Voudouris A, et al. Benefits of a synbiotic formula (Synbiotic 2000 Forte) in critically ill trauma patients: early results of a randomized controlled trial. World J Surg. 2006;30:1848-1855.
27. Spindler-Vesel A, Bengmark S, Vovk I, et al. Synbiotics, prebiotics, glutamine, or peptide in early enteral nutrition: a randomized study in trauma patients. J Parent Enteral Nutr. 2007;31:119-126.
28. Isolauri E, Salminen S. Probiotics, gut inflammation and barrier function. Gastroenterol Clin N Am. 2005;34:437-450.
29. Usami M, Miyoshi M, Kanbara Y, et al. Effects of perioperative synbiotic treatment on infectious complications, intestinal integrity, and fecal flora and organic acids in hepatic surgery with or without cirrhosis. J Parenter Enteral Nutr. 2011;35:317-328.
30. Seehofer D, Rayes N, Schiller RA, et al. Probiotics partly reverse increased bacterial translocation after simultaneous liver resection and colonic anastomosis in the rat. J Surg Res. 2004;117:262-271.
31. Rammohan A, Sathyanesan J, Rajendran K, et al. Impact of perioperative enteral synbiotics in hepatic & pancreatic surgery: design and rationale of a single blind placebo controlled prospective randomized control trial. Frontline Gastroenterol. 2014;5:118-122.
32. McNaught CE, Woodcock NP, MacFie J, et al. A prospective randomised study of the probiotic Lactobacillus plantarum 299v on indices of gut barrier function in elective surgical patients. Gut. 2002;51:827-831.
33. Anderson ADG, McNaught CE, Jain PK, et al. Randomised clinical trial of synbiotic therapy in elective surgical patients. Gut. 2004;53:241-245.
34. Reddy BS, MacFie J, Gatt M, et al. Randomized clinical trial of effect of synbiotics, neomycin and mechanical bowel preparation on intestinal barrier function in patients undergoing colectomy. Br J Surg. 2007;94: 546-554.
35. Rayes N, Hansen S, Seehofer D, et al. Early enteral supply of fiber and lacto-bacilli versus conventional nutrition: a controlled trial in patients with major abdominal surgery. Nutrition. 2002;18:609-615.
36. Nomura T, Tsuchiya Y, Nashimoto A, et al. Probiotics reduce infectious complications after pancreaticoduodenectomy. Hepatogastroenterology. 2007;54:661-663.
37. Rayes N, Seehofer D, Theruvath T, et al. Effect of enteral nutrition and synbi-otics on bacterial infection rates after pylorus preserving pancreatoduodenec-tomy. Ann Surg. 2007;246:36-41.
38. Besselink MGH, van Santvoort HC, Buskens E, et al. for the Dutch Acute Pancreatitis Study Group. Probiotic prophylaxis in predicted severe acute pancreatitis: a randomised, double-blind, placebo-controlled trial. Lancet. 2008;371:651-659.
39. Olah A, Belagyi T, Issekutz A, et al. Randomized clinical trial of specific Lactobacillus and fibre supplement to early enteral nutrition in patients with acute pancreatitis. Br J Surg. 2002;89:1103-1107.
40. Olah A, Belagyi T, Poto L, et al. Synbiotic control of inflammation and infection in severe acute pancreatitis: a prospective, randomized, double-blind study. Hepatogastroenterology. 2007;54:590-594.
41. Rayes N, Seehofer D, Neuhaus P. Prebiotics, probiotics, synbiotics in surgery-are they only trendy, truly effective or even dangerous? Langenbecks Arch Surg. 2009;394:547-555.
42. Shigata H, Nagino M, Kamiya J, et al. Bacteremia after hepatectomy: an analysis of a single-center, 10-year experience with 407 patients. Langenbecks Arch Surg. 2002;387:117-124.
43. Sugawara G, Nagino M, Nishio H, et al. Perioperative synbiotic treatment to prevent postoperative infectious complications in biliary cancer surgery: a randomized controlled trial. Ann Surg. 2006;244:706-714.
44. Togo S, Matsuo K, Tanaka K, et al. Perioperative infection control and its effectiveness in hepatectomy patients. J Gastroenterol Hepatol. 2007;22:1942-1948.
45. Betancourt JR. Cultural competency: providing quality care to diverse populations. Consult Pharm. 2006;21:988-995.
46. Fenn CG, Wong E, Zambrano D. The contemporary situation for the conduct of clinical trials in Asia. Int J Pharmaceut Med. 2001;15:169-173.