Preventing respiratory tract infections by synbiotic interventions: A systematic review and meta-analysis of randomized controlled trials

Advances in Nutrition

Volumn 11, Issue 4, 2021, Pages 979-988

  Chan, Carty K Y ^a   Tao, Jun ^a   Chan, Olivia S ^a   Li, Hua Bin ^b   Pang, Herbert ^a  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

^b SUN YAT SEN UNIVERSITY   (China)

Author keywords

Meta analysis; Prebiotics; Probiotics; RCT; Respiratory tract infections; Synbiotics

Indexed keywords

PREBIOTIC AGENT; PROBIOTIC AGENT; SYNBIOTIC AGENT;

ADULT; CHILD; HUMAN; INFANT; META ANALYSIS; RANDOMIZED CONTROLLED TRIAL (TOPIC); RESPIRATORY TRACT INFECTION;

ADULT; CHILD; HUMANS; INFANT; PREBIOTICS; PROBIOTICS; RANDOMIZED CONTROLLED TRIALS AS TOPIC; RESPIRATORY TRACT INFECTIONS; SYNBIOTICS;

EID: 85085194241     PISSN: 21618313     EISSN: 21565376     Source Type: Journal    
DOI: 10.1093/ADVANCES/NMAA003     Document Type: Review

References (45)

1. Helmink BA, Khan MAW, Hermann A, Gopalakrishnan V, Wargo JA. The microbiome, cancer, and cancer therapy. Nat Med 2019;25: 377-88.
2. Flint HJ, Scott KP, Louis P, Duncan SH. The role of the gut microbiota in nutrition and health. Nat Rev Gastroenterol Hepatol 2012;9:577.
3. Suez J, Zmora N, Zilberman-Schapira G, Mor U, Dori-Bachash M, Bashiardes S, Zur M, Regev-Lehavi D, Brik RB-Z, Federici S. Post-antibiotic gut mucosal microbiome reconstitution is impaired by probiotics and improved by autologous FMT. Cell 2018;174:1406-23, e16.
4. Tao J, Li S, Gan RY, Zhao CN, Meng X, Li HB. Targeting gut microbiota with dietary components on cancer: effects and potential mechanisms of action. Crit Rev Food Sci Nutr, 2019, 1-13.
5. Hill C, Guarner F, Reid G, Gibson GR, Merenstein DJ, Pot B, Morelli L, Canani RB, Flint HJ, Salminen S. Expert consensus document: the International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic. Nat Rev Gastroenterol Hepatol 2014;11(8):506.
6. de Vrese M, Schrezenmeir J. Probiotics, prebiotics, and synbiotics. In: Stahl U, Donalies U, Nevoigt E. (editors) Food biotechnology. Adv Biochem Eng Biot 2008;111:1-66.Berlin (Germany): Springer.
7. Gibson GR, Hutkins R, Sanders ME, Prescott SL, Reimer RA, Salminen SJ, Scott K, Stanton C, Swanson KS, Cani PD. Expert consensus document: the International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of prebiotics. Nat Rev Gastroenterol Hepatol 2017;14:491.
8. Rondanelli M, Faliva MA, Perna S, Giacosa A, Peroni G, Castellazzi AM. Using probiotics in clinical practice: where are we now? A review of existing meta-analyses. Gut Microbes 2017;8:521-43.
9. World Health Organization. Diseases of the respiratory system. In: International Classification of Diseases, 11th revision. Geneva (Switzerland): World Health Organization. 2018; chapter 12.
10. Fleming-Dutra KE, Hersh AL, Shapiro DJ, Bartoces M, Enns EA, File TM, Jr, Finkelstein JA, Gerber JS, Hyun DY, Linder JA, et al. Prevalence of inappropriate antibiotic prescriptions among US ambulatory care visits, 2010-2011. JAMA 2016;315:1864-73.
11. World Health Organization. Medicines used in primary care in developing and transitional countries: fact book summarizing results from studies reported between 1990 and 2006. Geneva (Switzerland): World Health Organization; 2009.
12. Wang Y, Li X, Ge T, Xiao Y, Liao Y, Cui Y, Zhang Y, Ho W, Yu G, Zhang T. Probiotics for prevention and treatment of respiratory tract infections in children: a systematic review and meta-analysis of randomized controlled trials. Medicine 2016;95:e4509.
13. Hao Q, Dong BR, Wu T. Probiotics for preventing acute upper respiratory tract infections. Cochrane Database Syst Rev 2015;2:CD006895.
14. The Cochrane Collaboration; Higgins JPT, Green S, editors. Cochrane handbook for systematic reviews of interventions, version 5.1.0. Chichester (UK): Wiley; 2011.
15. Kukkonen K, Savilahti E, Haahtela T, Juntunen-Backman K, Korpela R, Poussa T, Tuure T, Kuitunen M. Long-term safety and impact on infection rates of postnatal probiotic and prebiotic (synbiotic) treatment: randomized, double-blind, placebo-controlled trial. Pediatrics 2008;122:8-12.
16. Higgins J, Churchill R, Chandler J, Cumpston M. Analysing data and undertaking meta-analyses. In: Deeks JJ, Higgins JP, Altman DG, editors. Cochrane handbook for systematic reviews of interventions, version 5.2.0. Chichester (UK): Wiley; 2017.
17. Sedgwick P. Meta-analyses: what is heterogeneity? BMJ 2015;350:h1435.
18. Sedgwick P, Marston L. How to read a funnel plot in a meta-analysis. BMJ 2015;351:h4718.
19. Thompson SG, Higgins JPT. How should meta-regression analyses be undertaken and interpreted? Stat Med 2002;21:1559-73.
20. Willis BH, Riley RD. Measuring the statistical validity of summary meta-analysis and meta-regression results for use in clinical practice. Stat Med 2017;36:3283-301.
21. Pregliasco F, Anselmi G, Fonte L, Giussani F, Schieppati S, Soletti L. A new chance of preventing winter diseases by the administration of synbiotic formulations. Clin Gastroenterol Hepatol 2008;42(Suppl 3, Pt 2):S224-33.
22. Vlieger AM, Robroch A, van Buuren S, Kiers J, Rijkers G, Benninga MA, te Biesebeke R. Tolerance and safety of Lactobacillus paracasei ssp. paracasei in combination with Bifidobacterium animalis ssp. lactis in a prebiotic-containing infant formula: a randomised controlled trial. Br J Nutr 2009;102:869-7.
23. Gerasimov SV, Ivantsiv VA, Bobryk LM, Tsitsura OO, Dedyshin LP, Guta NV, Yandyo BV. Role of short-term use of L. acidophilus DDS-1 and B. lactis UABLA-12 in acute respiratory infections in children: a randomized controlled trial. Eur J Clin Nutr 2016;70(4): 463-9.
24. Auinger A, Riede L, Bothe G, Busch R, Gruenwald J. Yeast (1,3)-(1,6)-beta-glucan helps to maintain the body's defence against pathogens: a double-blind, randomized, placebo-controlled, multicentric study in healthy subjects. Eur J Nutr 2013;52:1913-8.
25. Cazzola M, Pham-Thi N, Kerihuel JC, Durand H, Bohbot S. Efficacy of a synbiotic supplementation in the prevention of common winter diseases in children: a randomized, double-blind, placebo-controlled pilot study. Ther Adv Respir Dis 2010;4:271-8.
26. Cohen R, Martin E, de La Rocque F, Thollot F, Pecquet S, Werner A, Boucherat M, Varon E, Bingen E, Levy C. Probiotics and prebiotics in preventing episodes of acute otitis media in high-risk children: a randomized, double-blind, placebo-controlled study. Pediatr Infect Dis J 2013;32:810-4.
27. Panigrahi P, Parida S, Nanda NC, Satpathy R, Pradhan L, Chandel DS, Baccaglini L, Mohapatra A, Mohapatra SS, Misra PR, et al. A randomized synbiotic trial to prevent sepsis among infants in rural India. Nature 2017;548:407-12.
28. Sazawal S, Dhingra U, Hiremath G, Sarkar A, Dhingra P, Dutta A, Verma P, Menon VP, Black RE. Prebiotic and probiotic fortified milk in prevention of morbidities among children: community-based, randomized, double-blind, controlled trial. PLoS One 2010;5: e12164
29. Picaud JC, Chapalain V, Paineau D, Zourabichvili O, Bornet FR, Duhamel JF. Incidence of infectious diseases in infants fed follow-on formula containing synbiotics: an observational study. Acta Paediatrica 2010;99:1695-700.
30. Puccio G, Cajozzo C, Meli F, Rochat F, Grathwohl D, Steenhout P. Clinical evaluation of a new starter formula for infants containing live Bifidobacterium longum BL999 and prebiotics. Nutrition 2007;23: 1-8.
31. Xuan NN, Wang D, Grathwohl D, Lan PNT, Kim HVT, Goyer A, Benyacoub J. Effect of a growing-up milk containing synbiotics on immune function and growth in children: a cluster randomized, multicenter, double-blind, placebo controlled study. Clin Med Insights Pediatr 2013;7:49-56.
32. Bocquet A, Lachambre E, Kempf C, Beck L. Effect of infant and follow-on formulas containing B lactis and galacto- and fructo-oligosaccharides on infection in healthy term infants. J Pediatr Gastroenterol Nutr 2013;57:180-7.
33. Gil-Campos M, Lopez MA, Rodriguez-Benitez MV, Romero J, Roncero I, Linares MD, Maldonado J, Lopez-Huertas E, Berwind R, Ritzenthaler KL, et al. Lactobacillus fermentum CECT 5716 is safe and well tolerated in infants of 1-6 months of age: a randomized controlled trial. Pharmacol Res 2012;65:231-8.
34. Maldonado J, Lara-Villoslada F, Sierra S, Sempere L, Gomez M, Rodriguez JM, Boza J, Xaus J, Olivares M. Safety and tolerance of the human milk probiotic strain Lactobacillus salivarius CECT5713 in 6-month-old children. Nutrition 2010;26:1082-7.
35. Szajewska H, Ruszczynski M, Szymanski H, Sadowska-Krawczenko I, Piwowarczyk A, Rasmussen PB, Kristensen MB, West CE, Hernell O. Effects of infant formula supplemented with prebiotics compared with synbiotics on growth up to the age of 12 mo: a randomized controlled trial. Pediatr Res 2017;81:752-8.
36. Johnson-Henry KC, Abrahamsson TR, Wu RY, Sherman PM. Probiotics, prebiotics, and synbiotics for the prevention of necrotizing enterocolitis. Adv Nutr 2016;7:928-37
37. Kuo SM. The interplay between fiber and the intestinal microbiome in the inflammatory response. Adv Nutr 2013;4:16-28
38. Voreades N, Kozil A, Weir TL. Diet and the development of the human intestinal microbiome. Front Microbiol 2014;5:494.
39. Markowiak P, Slizewska K. Effects of probiotics, prebiotics, and synbiotics on human health. Nutrients 2017;9(9):1021.
40. Zmora N, Zilberman-Schapira G, Suez J, Mor U, Dori-Bachash M, Bashiardes S, Kotler E, Zur M, Regev-Lehavi D, Brik RB, et al. Personalized gut mucosal colonization resistance to empiric probiotics is associated with unique host and microbiome features. Cell 2018;174(6):1388-405.
41. Zhang C, Derrien M, Levenez F, Brazeilles R, Ballal SA, Kim J, Degivry MC, Quéré G, Garault P, van Hylckama Vlieg JE, et al. Ecological robustness of the gut microbiota in response to ingestion of transient food-borne microbes. ISME J 2016;10:2235.
42. Suez J, Zmora N, Segal E, Elinav E. The pros, cons, and many unknowns of probiotics. Nature Med 2019;25:716-29.
43. Chouraqui JP, Grathwohl D, Labaune JM, Hascoet JM, de Montgolfier I, Leclaire M, Giarre M, Steenhout P. Assessment of the safety, tolerance, and protective effect against diarrhea of infant formulas containing mixtures of probiotics or probiotics and prebiotics in a randomized controlled trial. Am J Clin Nutr 2008;87: 1365-73.
44. Krumbeck JA, Walter J, Hutkins RW. Synbiotics for improved human health: recent developments, challenges, and opportunities. Annu Rev Food Sci T 2018;9:451-79.
45. Crittenden R, Playne J. Prebiotics. In: Lee YK, Salminen S, editors. Handbook of probiotics and prebiotics, Hoboken, New Jersey (USA): John Wiley and Sons, 2009:533-81.