Synthetic biology based construction of biological activity-related library of fungal decalin-containing diterpenoid pyrones

Nature Communications

Volumn 11, Issue 1, 2020, Pages

  Tsukada, Kento ^a   Shinki, Shono ^a   Kaneko, Akiho ^a   Murakami, Kazuma ^b   Irie, Kazuhiro ^b   Murai, Masatoshi ^b   Miyoshi, Hideto ^b   Dan, Shingo ^c   Kawaji, Kumi ^d   Hayashi, Hironori ^e   Kodama, Eiichi N ^d,e   Hori, Aki ^f   Salim, Emil ^f   Kuraishi, Takayuki ^f   Hirata, Naoya ^g   Kanda, Yasunari ^g   Asai, Teigo ^a,d  

^a UNIVERSITY OF TOKYO   (Japan)

^b KYOTO UNIVERSITY   (Japan)

^c CANCER CHEMOTHERAPY CENTER   (Japan)

^d TOHOKU UNIVERSITY   (Japan)

^e TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^f KANAZAWA UNIVERSITY   (Japan)

^g NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL PRODUCT; DECALIN; DITERPENOID; GENOMIC DNA; PYRONE DERIVATIVE; AMYLOID BETA PROTEIN; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; NAPHTHALENE DERIVATIVE; PROTEIN AGGREGATE;

DESIGN; FUNGUS; GENE; GENETIC ANALYSIS; GENOME; PROBE; SPECIES DIVERSITY; TERPENE;

ANTIPROLIFERATIVE ACTIVITY; ARTICLE; ASPERGILLUS ORYZAE; BIOENGINEERING; BIOLOGICAL ACTIVITY; BIOSYNTHESIS; CANCER STEM CELL; CATALYSIS; CELL PROLIFERATION; COLUMN CHROMATOGRAPHY; CONTROLLED STUDY; CYTOTOXICITY; DNA ENGINEERING; ENZYME ACTIVITY; ESCHERICHIA COLI; FOURIER TRANSFORM INFRARED SPECTROSCOPY; FUNGAL STRAIN; GENE CLUSTER; GENE SEQUENCE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; IC50; LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PEPTIDE LIBRARY; POLYMERASE CHAIN REACTION; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; STEREOCHEMISTRY; SYNTHETIC BIOLOGY; ANIMAL; ASPERGILLUS; CHEMISTRY; DROSOPHILA; DRUG EFFECT; FUNGAL GENOME; FUNGUS; GENETICS; MCF-7 CELL LINE; METABOLISM; MULTICELLULAR SPHEROID; PATHOLOGY; STEREOISOMERISM;

ASPERGILLUS ORYZAE;

AMYLOID BETA-PEPTIDES; ANIMALS; ANTI-HIV AGENTS; ASPERGILLUS; BIOSYNTHETIC PATHWAYS; CELL PROLIFERATION; DITERPENES; DROSOPHILA; FUNGI; GENOME, FUNGAL; HIV-1; HUMANS; MCF-7 CELLS; NAPHTHALENES; NEOPLASTIC STEM CELLS; PROTEIN AGGREGATES; PYRONES; SPHEROIDS, CELLULAR; STEREOISOMERISM; SYNTHETIC BIOLOGY;

EID: 85083503179     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/s41467-020-15664-4     Document Type: Article

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