Target Identification of Yaku'amide B and Its Two Distinct Activities against Mitochondrial FoF1-ATP Synthase

Journal of the American Chemical Society

Volumn 140, Issue 38, 2018, Pages 12189-12199

  Kitamura, Kai ^a   Itoh, Hiroaki ^a   Sakurai, Kaori ^b   Dan, Shingo ^c   Inoue, Masayuki ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b TOKYO UNIVERSITY OF AGRICULTURE AND TECHNOLOGY   (Japan)

^c CANCER CHEMOTHERAPY CENTER   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AMIDES; CELL CULTURE; DISEASES; FLUORESCENCE; HYDROLYSIS; PROBES;

BIOCHEMICAL ACTIVITY; DESIGN AND DEVELOPMENT; HYDROLYTIC ACTIVITIES; MCF-7 HUMAN BREAST CANCER CELLS; MULTI MODAL FUNCTION; SUBCELLULAR LOCALIZATIONS; TARGET IDENTIFICATION; UNSATURATED AMINO ACIDS;

MITOCHONDRIA;

AMIDE; OLIGOMYCIN; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE; UNCLASSIFIED DRUG; YAKU AMIDE B; BIOTIN; BORON DERIVATIVE; ENZYME INHIBITOR; FLUORESCENT DYE; MITOCHONDRIAL PROTEIN; OLIGOPEPTIDE; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATASE; YAKU'AMIDE B;

ARTICLE; BIOACCUMULATION; CELL GROWTH; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOTOXICITY; DRUG DESIGN; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME SYNTHESIS; FLOW CYTOMETRY; FLUORESCENCE; HUMAN; HUMAN CELL; HYDROLYSIS; LC50; MITOCHONDRION; PROTEIN TARGETING; STEREOCHEMISTRY; ANALOGS AND DERIVATIVES; ANIMAL; ANTAGONISTS AND INHIBITORS; CHEMISTRY; DRUG EFFECT; ENZYME ASSAY; METABOLISM; PIG; PROCEDURES; STEREOISOMERISM; SYNTHESIS; TUMOR CELL LINE;

ANIMALS; BIOTIN; BORON COMPOUNDS; CELL LINE, TUMOR; ENZYME ASSAYS; ENZYME INHIBITORS; FLUORESCENT DYES; HUMANS; HYDROLYSIS; MITOCHONDRIA; MITOCHONDRIAL PROTEINS; OLIGOPEPTIDES; PROTON-TRANSLOCATING ATPASES; STEREOISOMERISM; SWINE;

EID: 85053491845     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/jacs.8b07339     Document Type: Article

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