Genome-wide RNAi screening implicates the E3 ubiquitin ligase Sherpa in mediating innate immune signaling by Toll in Drosophila adults

Science Signaling

Volumn 8, Issue 400, 2015, Pages

  Kanoh, Hirotaka ^a,c   Tong, Li Li ^a   Kuraishi, Takayuki ^a,b,d   Suda, Yamato ^a   Momiuchi, Yoshiki ^a   Shishido, Fumi ^a   Kurata, Shoichiro ^a  

^a TOHOKU UNIVERSITY   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^c TOHOKU PHARMACEUTICAL UNIVERSITY   (Japan)

^d KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CACTUS PROTEIN; CASEIN KINASE IALPHA; DEFORMED EPIDERMAL AUTOREGULATORY FACTOR 1; DIF PROTEIN; DROSOMYCIN; E3 UBIQUITIN LIGASE SHERPA; IMD PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MESSENGER RNA; MYELOID DIFFERENTIATION FACTOR 88; NUCLEAR PROTEIN; PELLE PROTEIN; PHOSPHOTRANSFERASE; PROTEIN; PROTEIN KINASE; RENILLA LUCIFERIN 2 MONOOXYGENASE; RNA; SUMO PROTEIN; TOLL LIKE RECEPTOR; TRANSCRIPTION FACTOR GATA; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG; ZINC FINGER PROTEIN; DROSOPHILA PROTEIN; PLL PROTEIN, DROSOPHILA; PROTEIN SERINE THREONINE KINASE; SMALL INTERFERING RNA; SUMO 1 PROTEIN; TL PROTEIN, DROSOPHILA; UBIQUITIN PROTEIN LIGASE;

5' UNTRANSLATED REGION; ADULT; ANIMAL CELL; ARTICLE; BACTERIAL INFECTION; CANDIDA ALBICANS; CELL ACTIVATION; CELL CULTURE; CELL MEMBRANE; CELL STIMULATION; CELL VIABILITY; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOSKELETON; DROSOPHILA; ENTEROCOCCUS FAECALIS; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; ENZYME REGULATION; EPISTASIS; EX VIVO STUDY; GENE OVEREXPRESSION; GENE SILENCING; GENETIC ASSOCIATION; GENETIC SCREENING; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; HOST RESISTANCE; IMMUNOREGULATION; INFECTION SENSITIVITY; INNATE IMMUNITY; INTRACELLULAR SIGNALING; LOSS OF FUNCTION MUTATION; MOLECULAR WEIGHT; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROCESSING; RNA INTERFERENCE; STAPHYLOCOCCUS SAPROPHYTICUS; SUMOYLATION; SURFACE PROPERTY; TRANSCRIPTION REGULATION; UBIQUITINATION; ANIMAL; DROSOPHILA MELANOGASTER; GENETICS; GENOME-WIDE ASSOCIATION STUDY; GRAM POSITIVE BACTERIUM; GRAM POSITIVE INFECTION; IMMUNOLOGY;

ANIMALS; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; GENOME-WIDE ASSOCIATION STUDY; GRAM-POSITIVE BACTERIA; GRAM-POSITIVE BACTERIAL INFECTIONS; PROTEIN-SERINE-THREONINE KINASES; RNA, SMALL INTERFERING; SUMO-1 PROTEIN; TOLL-LIKE RECEPTORS; UBIQUITIN-PROTEIN LIGASES;

EID: 84945578601     PISSN: 19450877     EISSN: 19379145     Source Type: Journal    
DOI: 10.1126/scisignal.2005971     Document Type: Article

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