Genome Mining and Assembly-Line Biosynthesis of the UCS1025A Pyrrolizidinone Family of Fungal Alkaloids

Journal of the American Chemical Society

Volumn 140, Issue 6, 2018, Pages 2067-2071

  Li, Li ^a,b   Tang, Man Cheng ^b   Tang, Shoubin ^c   Gao, Shushan ^b   Soliman, Sameh ^b,e   Hang, Leibniz ^b   Xu, Wei ^b   Ye, Tao ^c   Watanabe, Kenji ^d   Tang, Yi ^b  

^a FUJIAN NORMAL UNIVERSITY   (China)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c PEKING UNIVERSITY   (China)

^d UNIVERSITY OF SHIZUOKA   (Japan)

^e UNIVERSITY OF SHARJAH   (United Arab Emirates)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALOIDS; AMINO ACIDS; ASSEMBLY; BIOCHEMISTRY; CARBOXYLATION; GENES; KETONES; METABOLITES; ORGANIC SOLVENTS;

ASSEMBLY LINE; BIOCHEMICAL ANALYSIS; GENE CLUSTERS; GENOME MINING; KNOEVENAGEL CONDENSATION; NATURAL PRODUCTS; PYRROLIZIDINONE; THERMOPHILIC FUNGUS;

ASSEMBLY MACHINES;

2,3 METHYLPROLINE; ACYL CARRIER PROTEIN; ALKALOID DERIVATIVE; FUNGAL ALKALOID; FUROPYRROLIZIDINE; HETEROCYCLIC COMPOUND; ISOLEUCINE; KETOREDUCTASE; KETOSYNTHASE; MALONYL COENZYME A TRANSFERASE; NONRIBOSOMAL PEPTIDE SYNTHETASE; OXIDOREDUCTASE; POLYKETIDE SYNTHASE; PROLINE DERIVATIVE; PYRROLIZIDINE DERIVATIVE; SYNTHETASE; TRANSFERASE; UNCLASSIFIED DRUG; PEPTIDE SYNTHASE; PYRROLIZIDINE ALKALOID; UCS 1025A;

ADENYLATION; ARTICLE; BIOCHEMICAL ANALYSIS; BIOSYNTHESIS; CARBOXYLATION; CHEMICAL ANALYSIS; CHEMICAL STRUCTURE; CHROMATOGRAPHY; CONTROLLED STUDY; CYCLIZATION; FUNGAL GENETICS; FUNGAL STRAIN; GENE CLUSTER; GENE OVEREXPRESSION; GENETIC ANALYSIS; GENOMICS; KNOEVENAGEL CONDENSATION; MICHAEL ADDITION; MYCELIOPHTHORA THERMOPHILA; NONHUMAN; OXIDATION; THERMOPHILE; THERMOPHILIC FUNGUS; ENZYMOLOGY; FUNGAL GENE; GENETICS; METABOLISM; MULTIGENE FAMILY; SORDARIALES;

BIOSYNTHETIC PATHWAYS; CYCLIZATION; GENES, FUNGAL; MULTIGENE FAMILY; PEPTIDE SYNTHASES; POLYKETIDE SYNTHASES; PYRROLIZIDINE ALKALOIDS; SORDARIALES;

EID: 85042058614     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/jacs.8b00056     Document Type: Article

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