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Volumn 69, Issue , 2018, Pages 152-163

Cancer stem cell in breast cancer therapeutic resistance

Author keywords

Breast cancer; Cancer stem cell; Pathway; Recurrence; Resistance

Indexed keywords

ALDEHYDE DEHYDROGENASE ISOENZYME 1; ANTHRAX TOXIN; BETA CATENIN; CD133 ANTIGEN; CHEMOKINE RECEPTOR CXCR4; EPITHELIAL CELL ADHESION MOLECULE; HERMES ANTIGEN; PACLITAXEL; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN C; SONIC HEDGEHOG PROTEIN; STAT3 PROTEIN; TESTIS DETERMINING FACTOR; TRANSCRIPTION FACTOR SOX2; WNT PROTEIN;

EID: 85049872624     PISSN: 03057372     EISSN: 15321967     Source Type: Journal    
DOI: 10.1016/j.ctrv.2018.07.004     Document Type: Review
Times cited : (231)

References (100)
  • 2
    • 29144475553 scopus 로고    scopus 로고
    • Effects of radiotherapy and of differences in the extent of surgery for early breast cancer on local recurrence and 15-year survival: an overview of the randomised trials
    • Clarke, M., Collins, R., Darby, S., Davies, C., Elphinstone, P., Evans, V., et al. Effects of radiotherapy and of differences in the extent of surgery for early breast cancer on local recurrence and 15-year survival: an overview of the randomised trials. Lancet 366 (2005), 2087–2106.
    • (2005) Lancet , vol.366 , pp. 2087-2106
    • Clarke, M.1    Collins, R.2    Darby, S.3    Davies, C.4    Elphinstone, P.5    Evans, V.6
  • 3
    • 33845904383 scopus 로고    scopus 로고
    • The response of CD24(-/low)/CD44+ breast cancer-initiating cells to radiation
    • Phillips, T.M., McBride, W.H., Pajonk, F., The response of CD24(-/low)/CD44+ breast cancer-initiating cells to radiation. J Natl Cancer Inst 98 (2006), 1777–1785.
    • (2006) J Natl Cancer Inst , vol.98 , pp. 1777-1785
    • Phillips, T.M.1    McBride, W.H.2    Pajonk, F.3
  • 4
    • 84963718904 scopus 로고    scopus 로고
    • Aspirin suppresses the acquisition of chemoresistance in breast cancer by disrupting an NFkappaB-IL6 signaling axis responsible for the generation of cancer stem cells
    • Saha, S., Mukherjee, S., Khan, P., Kajal, K., Mazumdar, M., Manna, A., et al. Aspirin suppresses the acquisition of chemoresistance in breast cancer by disrupting an NFkappaB-IL6 signaling axis responsible for the generation of cancer stem cells. Cancer Res 76 (2016), 2000–2012.
    • (2016) Cancer Res , vol.76 , pp. 2000-2012
    • Saha, S.1    Mukherjee, S.2    Khan, P.3    Kajal, K.4    Mazumdar, M.5    Manna, A.6
  • 5
    • 0030789242 scopus 로고    scopus 로고
    • Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell
    • Bonnet, D., Dick, J.E., Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nat Med 3 (1997), 730–737.
    • (1997) Nat Med , vol.3 , pp. 730-737
    • Bonnet, D.1    Dick, J.E.2
  • 6
    • 33750313208 scopus 로고    scopus 로고
    • Cancer stem cells–perspectives on current status and future directions: AACR workshop on cancer stem cells
    • Clarke, M.F., Dick, J.E., Dirks, P.B., Eaves, C.J., Jamieson, C.H., Jones, D.L., et al. Cancer stem cells–perspectives on current status and future directions: AACR workshop on cancer stem cells. Cancer Res 66 (2006), 9339–9344.
    • (2006) Cancer Res , vol.66 , pp. 9339-9344
    • Clarke, M.F.1    Dick, J.E.2    Dirks, P.B.3    Eaves, C.J.4    Jamieson, C.H.5    Jones, D.L.6
  • 7
    • 73149110562 scopus 로고    scopus 로고
    • Biological and molecular heterogeneity of breast cancers correlates with their cancer stem cell content
    • Pece, S., Tosoni, D., Confalonieri, S., Mazzarol, G., Vecchi, M., Ronzoni, S., et al. Biological and molecular heterogeneity of breast cancers correlates with their cancer stem cell content. Cell 140 (2010), 62–73.
    • (2010) Cell , vol.140 , pp. 62-73
    • Pece, S.1    Tosoni, D.2    Confalonieri, S.3    Mazzarol, G.4    Vecchi, M.5    Ronzoni, S.6
  • 8
    • 84858608410 scopus 로고    scopus 로고
    • Cancer stem cells: impact, heterogeneity, and uncertainty
    • Magee, J.A., Piskounova, E., Morrison, S.J., Cancer stem cells: impact, heterogeneity, and uncertainty. Cancer Cell 21 (2012), 283–296.
    • (2012) Cancer Cell , vol.21 , pp. 283-296
    • Magee, J.A.1    Piskounova, E.2    Morrison, S.J.3
  • 9
    • 70349123829 scopus 로고    scopus 로고
    • The tumor suppressor p53 regulates polarity of self-renewing divisions in mammary stem cells
    • Cicalese, A., Bonizzi, G., Pasi, C.E., Faretta, M., Ronzoni, S., Giulini, B., et al. The tumor suppressor p53 regulates polarity of self-renewing divisions in mammary stem cells. Cell 138 (2009), 1083–1095.
    • (2009) Cell , vol.138 , pp. 1083-1095
    • Cicalese, A.1    Bonizzi, G.2    Pasi, C.E.3    Faretta, M.4    Ronzoni, S.5    Giulini, B.6
  • 10
    • 46149089421 scopus 로고    scopus 로고
    • Growth-inhibitory and tumor- suppressive functions of p53 depend on its repression of CD44 expression
    • Godar, S., Ince, T.A., Bell, G.W., Feldser, D., Donaher, J.L., Bergh, J., et al. Growth-inhibitory and tumor- suppressive functions of p53 depend on its repression of CD44 expression. Cell 134 (2008), 62–73.
    • (2008) Cell , vol.134 , pp. 62-73
    • Godar, S.1    Ince, T.A.2    Bell, G.W.3    Feldser, D.4    Donaher, J.L.5    Bergh, J.6
  • 11
    • 68349130357 scopus 로고    scopus 로고
    • Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers
    • Lim, E., Vaillant, F., Wu, D., Forrest, N.C., Pal, B., Hart, A.H., et al. Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers. Nat Med 15 (2009), 907–913.
    • (2009) Nat Med , vol.15 , pp. 907-913
    • Lim, E.1    Vaillant, F.2    Wu, D.3    Forrest, N.C.4    Pal, B.5    Hart, A.H.6
  • 12
    • 54249086214 scopus 로고    scopus 로고
    • The mammary progenitor marker CD61/beta3 integrin identifies cancer stem cells in mouse models of mammary tumorigenesis
    • Vaillant, F., Asselin-Labat, M.L., Shackleton, M., Forrest, N.C., Lindeman, G.J., Visvader, J.E., The mammary progenitor marker CD61/beta3 integrin identifies cancer stem cells in mouse models of mammary tumorigenesis. Cancer Res 68 (2008), 7711–7717.
    • (2008) Cancer Res , vol.68 , pp. 7711-7717
    • Vaillant, F.1    Asselin-Labat, M.L.2    Shackleton, M.3    Forrest, N.C.4    Lindeman, G.J.5    Visvader, J.E.6
  • 13
    • 0037351887 scopus 로고    scopus 로고
    • The patched polymorphism Pro1315Leu (C3944T) may modulate the association between use of oral contraceptives and breast cancer risk
    • Chang-Claude, J., Dunning, A., Schnitzbauer, U., Galmbacher, P., Tee, L., Wjst, M., et al. The patched polymorphism Pro1315Leu (C3944T) may modulate the association between use of oral contraceptives and breast cancer risk. Int J Cancer 103 (2003), 779–783.
    • (2003) Int J Cancer , vol.103 , pp. 779-783
    • Chang-Claude, J.1    Dunning, A.2    Schnitzbauer, U.3    Galmbacher, P.4    Tee, L.5    Wjst, M.6
  • 14
    • 1642570244 scopus 로고    scopus 로고
    • The transforming activity of Wnt effectors correlates with their ability to induce the accumulation of mammary progenitor cells
    • Liu, B.Y., McDermott, S.P., Khwaja, S.S., Alexander, C.M., The transforming activity of Wnt effectors correlates with their ability to induce the accumulation of mammary progenitor cells. Proc Natl Acad Sci USA 101 (2004), 4158–4163.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 4158-4163
    • Liu, B.Y.1    McDermott, S.P.2    Khwaja, S.S.3    Alexander, C.M.4
  • 15
    • 84991107767 scopus 로고    scopus 로고
    • Emerging role of NRF2 in chemoresistance by regulating drug-metabolizing enzymes and efflux transporters
    • Bai, X., Chen, Y., Hou, X., Huang, M., Jin, J., Emerging role of NRF2 in chemoresistance by regulating drug-metabolizing enzymes and efflux transporters. Drug Metab Rev 48 (2016), 541–567.
    • (2016) Drug Metab Rev , vol.48 , pp. 541-567
    • Bai, X.1    Chen, Y.2    Hou, X.3    Huang, M.4    Jin, J.5
  • 16
    • 63049123066 scopus 로고    scopus 로고
    • Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits
    • Polyak, K., Weinberg, R.A., Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits. Nat Rev Cancer 9 (2009), 265–273.
    • (2009) Nat Rev Cancer , vol.9 , pp. 265-273
    • Polyak, K.1    Weinberg, R.A.2
  • 17
    • 9244219598 scopus 로고    scopus 로고
    • Breast cancer-loss of PTEN predicts resistance to treatment
    • Pandolfi, P.P., Breast cancer-loss of PTEN predicts resistance to treatment. N Engl J Med 351 (2004), 2337–2338.
    • (2004) N Engl J Med , vol.351 , pp. 2337-2338
    • Pandolfi, P.P.1
  • 20
    • 84880270290 scopus 로고    scopus 로고
    • Identification of a population of blood circulating tumor cells from breast cancer patients that initiates metastasis in a xenograft assay
    • Baccelli, I., Schneeweiss, A., Riethdorf, S., Stenzinger, A., Schillert, A., Vogel, V., et al. Identification of a population of blood circulating tumor cells from breast cancer patients that initiates metastasis in a xenograft assay. Nat Biotechnol 31 (2013), 539–544.
    • (2013) Nat Biotechnol , vol.31 , pp. 539-544
    • Baccelli, I.1    Schneeweiss, A.2    Riethdorf, S.3    Stenzinger, A.4    Schillert, A.5    Vogel, V.6
  • 21
    • 84863201206 scopus 로고    scopus 로고
    • CD44+/CD24- phenotype contributes to malignant relapse following surgical resection and chemotherapy in patients with invasive ductal carcinoma
    • Lin, Y., Zhong, Y., Guan, H., Zhang, X., Sun, Q., CD44+/CD24- phenotype contributes to malignant relapse following surgical resection and chemotherapy in patients with invasive ductal carcinoma. J Exp Clin Cancer Res, 31, 2012, 59.
    • (2012) J Exp Clin Cancer Res , vol.31 , pp. 59
    • Lin, Y.1    Zhong, Y.2    Guan, H.3    Zhang, X.4    Sun, Q.5
  • 22
    • 77954064420 scopus 로고    scopus 로고
    • Multiple lineages of human breast cancer stem/progenitor cells identified by profiling with stem cell markers
    • Hwang-Verslues, W.W., Kuo, W.H., Chang, P.H., Pan, C.C., Wang, H.H., Tsai, S.T., et al. Multiple lineages of human breast cancer stem/progenitor cells identified by profiling with stem cell markers. PLoS One, 4, 2009, e8377.
    • (2009) PLoS One , vol.4
    • Hwang-Verslues, W.W.1    Kuo, W.H.2    Chang, P.H.3    Pan, C.C.4    Wang, H.H.5    Tsai, S.T.6
  • 23
    • 84999287149 scopus 로고    scopus 로고
    • Breast cancer stem cells expressing different stem cell markers exhibit distinct biological characteristics
    • Shao, J., Fan, W., Ma, B., Wu, Y., Breast cancer stem cells expressing different stem cell markers exhibit distinct biological characteristics. Mol Med Rep 14 (2016), 4991–4998.
    • (2016) Mol Med Rep , vol.14 , pp. 4991-4998
    • Shao, J.1    Fan, W.2    Ma, B.3    Wu, Y.4
  • 24
    • 80054879984 scopus 로고    scopus 로고
    • Breast cancer stem cell markers CD44, CD24 and ALDH1: expression distribution within intrinsic molecular subtype
    • Ricardo, S., Vieira, A.F., Gerhard, R., Leitao, D., Pinto, R., Cameselle-Teijeiro, J.F., et al. Breast cancer stem cell markers CD44, CD24 and ALDH1: expression distribution within intrinsic molecular subtype. J Clin Pathol 64 (2011), 937–946.
    • (2011) J Clin Pathol , vol.64 , pp. 937-946
    • Ricardo, S.1    Vieira, A.F.2    Gerhard, R.3    Leitao, D.4    Pinto, R.5    Cameselle-Teijeiro, J.F.6
  • 25
    • 84908105767 scopus 로고    scopus 로고
    • ABCG2, a novel antigen to sort luminal progenitors of BRCA1- breast cancer cells
    • Leccia, F., Del Vecchio, L., Mariotti, E., Di Noto, R., Morel, A.P., Puisieux, A., et al. ABCG2, a novel antigen to sort luminal progenitors of BRCA1- breast cancer cells. Mol Cancer 13 (2014), 213–226.
    • (2014) Mol Cancer , vol.13 , pp. 213-226
    • Leccia, F.1    Del Vecchio, L.2    Mariotti, E.3    Di Noto, R.4    Morel, A.P.5    Puisieux, A.6
  • 26
    • 84884769367 scopus 로고    scopus 로고
    • ANTXR1, a stem cell-enriched functional biomarker, connects collagen signaling to cancer stem-like cells and metastasis in breast cancer
    • Chen, D., Bhat-Nakshatri, P., Goswami, C., Badve, S., Nakshatri, H., ANTXR1, a stem cell-enriched functional biomarker, connects collagen signaling to cancer stem-like cells and metastasis in breast cancer. Cancer Res 73 (2013), 5821–5833.
    • (2013) Cancer Res , vol.73 , pp. 5821-5833
    • Chen, D.1    Bhat-Nakshatri, P.2    Goswami, C.3    Badve, S.4    Nakshatri, H.5
  • 27
    • 36849013105 scopus 로고    scopus 로고
    • Alpha-6 integrin is necessary for the tumourigenicity of a stem cell-like subpopulation within the MCF7 breast cancer cell line
    • Cariati, M., Naderi, A., Brown, J.P., Smalley, M.J., Pinder, S.E., Caldas, C., et al. Alpha-6 integrin is necessary for the tumourigenicity of a stem cell-like subpopulation within the MCF7 breast cancer cell line. Int J Cancer 122 (2008), 298–304.
    • (2008) Int J Cancer , vol.122 , pp. 298-304
    • Cariati, M.1    Naderi, A.2    Brown, J.P.3    Smalley, M.J.4    Pinder, S.E.5    Caldas, C.6
  • 29
    • 84873409223 scopus 로고    scopus 로고
    • CD133+ cells with cancer stem cell characteristics associates with vasculogenic mimicry in triple-negative breast cancer
    • Liu, T.J., Sun, B.C., Zhao, X.L., Zhao, X.M., Sun, T., Gu, Q., et al. CD133+ cells with cancer stem cell characteristics associates with vasculogenic mimicry in triple-negative breast cancer. Oncogene 32 (2013), 544–553.
    • (2013) Oncogene , vol.32 , pp. 544-553
    • Liu, T.J.1    Sun, B.C.2    Zhao, X.L.3    Zhao, X.M.4    Sun, T.5    Gu, Q.6
  • 30
    • 84957921760 scopus 로고    scopus 로고
    • Self-renewal of CD133(hi) cells by IL6/Notch3 signalling regulates endocrine resistance in metastatic breast cancer
    • Sansone, P., Ceccarelli, C., Berishaj, M., Chang, Q., Rajasekhar, V.K., Perna, F., et al. Self-renewal of CD133(hi) cells by IL6/Notch3 signalling regulates endocrine resistance in metastatic breast cancer. Nat Commun, 7, 2016, 10442.
    • (2016) Nat Commun , vol.7 , pp. 10442
    • Sansone, P.1    Ceccarelli, C.2    Berishaj, M.3    Chang, Q.4    Rajasekhar, V.K.5    Perna, F.6
  • 31
    • 84959230422 scopus 로고    scopus 로고
    • Non-migratory tumorigenic intrinsic cancer stem cells ensure breast cancer metastasis by generation of CXCR4(+) migrating cancer stem cells
    • Mukherjee, S., Manna, A., Bhattacharjee, P., Mazumdar, M., Saha, S., Chakraborty, S., et al. Non-migratory tumorigenic intrinsic cancer stem cells ensure breast cancer metastasis by generation of CXCR4(+) migrating cancer stem cells. Oncogene 35 (2016), 4937–4948.
    • (2016) Oncogene , vol.35 , pp. 4937-4948
    • Mukherjee, S.1    Manna, A.2    Bhattacharjee, P.3    Mazumdar, M.4    Saha, S.5    Chakraborty, S.6
  • 33
    • 44449115111 scopus 로고    scopus 로고
    • Identification and characterization of cancer initiating cells from BRCA1 related mammary tumors using markers for normal mammary stem cells
    • Vassilopoulos, A., Wang, R.H., Petrovas, C., Ambrozak, D., Koup, R., Deng, C.X., Identification and characterization of cancer initiating cells from BRCA1 related mammary tumors using markers for normal mammary stem cells. Int J Biol Sci 4 (2008), 133–142.
    • (2008) Int J Biol Sci , vol.4 , pp. 133-142
    • Vassilopoulos, A.1    Wang, R.H.2    Petrovas, C.3    Ambrozak, D.4    Koup, R.5    Deng, C.X.6
  • 34
    • 84883650392 scopus 로고    scopus 로고
    • Dietary suppression of the mammary CD29(hi)CD24(+) epithelial subpopulation and its cytokine/chemokine transcriptional signatures modifies mammary tumor risk in MMTV-Wnt1 transgenic mice
    • Rahal, O.M., Machado, H.L., Montales, M.T., Pabona, J.M., Heard, M.E., Nagarajan, S., et al. Dietary suppression of the mammary CD29(hi)CD24(+) epithelial subpopulation and its cytokine/chemokine transcriptional signatures modifies mammary tumor risk in MMTV-Wnt1 transgenic mice. Stem Cell Res 11 (2013), 1149–1162.
    • (2013) Stem Cell Res , vol.11 , pp. 1149-1162
    • Rahal, O.M.1    Machado, H.L.2    Montales, M.T.3    Pabona, J.M.4    Heard, M.E.5    Nagarajan, S.6
  • 35
    • 84861514155 scopus 로고    scopus 로고
    • CD49f and CD61 identify Her2/neu-induced mammary tumor-initiating cells that are potentially derived from luminal progenitors and maintained by the integrin-TGFbeta signaling
    • Lo, P.K., Kanojia, D., Liu, X., Singh, U.P., Berger, F.G., Wang, Q., et al. CD49f and CD61 identify Her2/neu-induced mammary tumor-initiating cells that are potentially derived from luminal progenitors and maintained by the integrin-TGFbeta signaling. Oncogene 31 (2012), 2614–2626.
    • (2012) Oncogene , vol.31 , pp. 2614-2626
    • Lo, P.K.1    Kanojia, D.2    Liu, X.3    Singh, U.P.4    Berger, F.G.5    Wang, Q.6
  • 36
    • 84958042581 scopus 로고    scopus 로고
    • Association between ALDH1+/CD133+ stem-like cells and tumor angiogenesis in invasive ductal breast carcinoma
    • Lv, X., Wang, Y., Song, Y., Pang, X., Li, H., Association between ALDH1+/CD133+ stem-like cells and tumor angiogenesis in invasive ductal breast carcinoma. Oncol Lett 11 (2016), 1750–1756.
    • (2016) Oncol Lett , vol.11 , pp. 1750-1756
    • Lv, X.1    Wang, Y.2    Song, Y.3    Pang, X.4    Li, H.5
  • 37
    • 84947489548 scopus 로고    scopus 로고
    • Enhanced efficacy of chemotherapy for breast cancer stem cells by simultaneous suppression of multidrug resistance and antiapoptotic cellular defense
    • Sun, M., Yang, C., Zheng, J., Wang, M., Chen, M., Le, D.Q.S., et al. Enhanced efficacy of chemotherapy for breast cancer stem cells by simultaneous suppression of multidrug resistance and antiapoptotic cellular defense. Acta Biomater 28 (2015), 171–182.
    • (2015) Acta Biomater , vol.28 , pp. 171-182
    • Sun, M.1    Yang, C.2    Zheng, J.3    Wang, M.4    Chen, M.5    Le, D.Q.S.6
  • 38
    • 72949118673 scopus 로고    scopus 로고
    • High aldehyde dehydrogenase and expression of cancer stem cell markers selects for breast cancer cells with enhanced malignant and metastatic ability
    • Croker, A.K., Goodale, D., Chu, J., Postenka, C., Hedley, B.D., Hess, D.A., et al. High aldehyde dehydrogenase and expression of cancer stem cell markers selects for breast cancer cells with enhanced malignant and metastatic ability. J Cell Mol Med 13 (2009), 2236–2252.
    • (2009) J Cell Mol Med , vol.13 , pp. 2236-2252
    • Croker, A.K.1    Goodale, D.2    Chu, J.3    Postenka, C.4    Hedley, B.D.5    Hess, D.A.6
  • 39
    • 84955587881 scopus 로고    scopus 로고
    • Stage-specific embryonic antigen-3 (SSEA-3) and beta3GalT5 are cancer specific and significant markers for breast cancer stem cells
    • Cheung, S.K., Chuang, P.K., Huang, H.W., Hwang-Verslues, W.W., Cho, C.H., Yang, W.B., et al. Stage-specific embryonic antigen-3 (SSEA-3) and beta3GalT5 are cancer specific and significant markers for breast cancer stem cells. Proc Natl Acad Sci USA 113 (2016), 960–965.
    • (2016) Proc Natl Acad Sci USA , vol.113 , pp. 960-965
    • Cheung, S.K.1    Chuang, P.K.2    Huang, H.W.3    Hwang-Verslues, W.W.4    Cho, C.H.5    Yang, W.B.6
  • 40
    • 77953163539 scopus 로고    scopus 로고
    • CD44posCD49fhiCD133/2hi defines xenograft-initiating cells in estrogen receptor-negative breast cancer
    • Meyer, M.J., Fleming, J.M., Lin, A.F., Hussnain, S.A., Ginsburg, E., Vonderhaar, B.K., CD44posCD49fhiCD133/2hi defines xenograft-initiating cells in estrogen receptor-negative breast cancer. Cancer Res 70 (2010), 4624–4633.
    • (2010) Cancer Res , vol.70 , pp. 4624-4633
    • Meyer, M.J.1    Fleming, J.M.2    Lin, A.F.3    Hussnain, S.A.4    Ginsburg, E.5    Vonderhaar, B.K.6
  • 41
    • 84976315191 scopus 로고    scopus 로고
    • KRT19 directly interacts with beta-catenin/RAC1 complex to regulate NUMB-dependent NOTCH signaling pathway and breast cancer properties
    • Saha, S.K., Choi, H.Y., Kim, B.W., Dayem, A.A., Yang, G.M., Kim, K.S., et al. KRT19 directly interacts with beta-catenin/RAC1 complex to regulate NUMB-dependent NOTCH signaling pathway and breast cancer properties. Oncogene 36 (2017), 332–349.
    • (2017) Oncogene , vol.36 , pp. 332-349
    • Saha, S.K.1    Choi, H.Y.2    Kim, B.W.3    Dayem, A.A.4    Yang, G.M.5    Kim, K.S.6
  • 42
    • 85024405486 scopus 로고    scopus 로고
    • Interaction of glycosphingolipids GD3 and GD2 with growth factor receptors maintains breast cancer stem cell phenotype
    • Liang, Y.J., Wang, C.Y., Wang, I.A., Chen, Y.W., Li, L.T., Lin, C.Y., et al. Interaction of glycosphingolipids GD3 and GD2 with growth factor receptors maintains breast cancer stem cell phenotype. Oncotarget 8:29 (2017), 47454–47473.
    • (2017) Oncotarget , vol.8 , Issue.29 , pp. 47454-47473
    • Liang, Y.J.1    Wang, C.Y.2    Wang, I.A.3    Chen, Y.W.4    Li, L.T.5    Lin, C.Y.6
  • 43
    • 85018219170 scopus 로고    scopus 로고
    • Evolution of cancer stem-like cells in endocrine-resistant metastatic breast cancers is mediated by stromal microvesicles
    • Sansone, P., Berishaj, M., Rajasekhar, V.K., Ceccarelli, C., Chang, Q., Strillacci, A., et al. Evolution of cancer stem-like cells in endocrine-resistant metastatic breast cancers is mediated by stromal microvesicles. Cancer Res 77 (2017), 1927–1941.
    • (2017) Cancer Res , vol.77 , pp. 1927-1941
    • Sansone, P.1    Berishaj, M.2    Rajasekhar, V.K.3    Ceccarelli, C.4    Chang, Q.5    Strillacci, A.6
  • 45
    • 85018217578 scopus 로고    scopus 로고
    • Cancer stem cells regulate cancer-associated fibroblasts via activation of hedgehog signaling in mammary gland tumors
    • Valenti, G., Quinn, H.M., Heynen, G., Lan, L., Holland, J.D., Vogel, R., et al. Cancer stem cells regulate cancer-associated fibroblasts via activation of hedgehog signaling in mammary gland tumors. Cancer Res 77 (2017), 2134–2147.
    • (2017) Cancer Res , vol.77 , pp. 2134-2147
    • Valenti, G.1    Quinn, H.M.2    Heynen, G.3    Lan, L.4    Holland, J.D.5    Vogel, R.6
  • 46
    • 85015973172 scopus 로고    scopus 로고
    • Constitutive NOTCH3 signaling promotes the growth of basal breast cancers
    • Choy, L., Hagenbeek, T.J., Solon, M., French, D., Finkle, D., Shelton, A., et al. Constitutive NOTCH3 signaling promotes the growth of basal breast cancers. Cancer Res 77 (2017), 1439–1452.
    • (2017) Cancer Res , vol.77 , pp. 1439-1452
    • Choy, L.1    Hagenbeek, T.J.2    Solon, M.3    French, D.4    Finkle, D.5    Shelton, A.6
  • 47
    • 85047340322 scopus 로고    scopus 로고
    • Dual PI3K and Wnt pathway inhibition is a synergistic combination against triple negative breast cancer
    • Solzak, J.P., Atale, R.V., Hancock, B.A., Sinn, A.L., Pollok, K.E., Jones, D.R., et al. Dual PI3K and Wnt pathway inhibition is a synergistic combination against triple negative breast cancer. NPJ Breast Cancer, 3, 2017, 17.
    • (2017) NPJ Breast Cancer , vol.3 , pp. 17
    • Solzak, J.P.1    Atale, R.V.2    Hancock, B.A.3    Sinn, A.L.4    Pollok, K.E.5    Jones, D.R.6
  • 48
    • 84928381832 scopus 로고    scopus 로고
    • Activation of NRF2 by p62 and proteasome reduction in sphere-forming breast carcinoma cells
    • Ryoo, I.G., Choi, B.H., Kwak, M.K., Activation of NRF2 by p62 and proteasome reduction in sphere-forming breast carcinoma cells. Oncotarget 6 (2015), 8167–8184.
    • (2015) Oncotarget , vol.6 , pp. 8167-8184
    • Ryoo, I.G.1    Choi, B.H.2    Kwak, M.K.3
  • 49
    • 64749093574 scopus 로고    scopus 로고
    • Association of reactive oxygen species levels and radioresistance in cancer stem cells
    • Diehn, M., Cho, R.W., Lobo, N.A., Kalisky, T., Dorie, M.J., Kulp, A.N., et al. Association of reactive oxygen species levels and radioresistance in cancer stem cells. Nature 458 (2009), 780–783.
    • (2009) Nature , vol.458 , pp. 780-783
    • Diehn, M.1    Cho, R.W.2    Lobo, N.A.3    Kalisky, T.4    Dorie, M.J.5    Kulp, A.N.6
  • 50
    • 85041207092 scopus 로고    scopus 로고
    • Epigenetic silencing of TAP1 in aldefluor(+) breast cancer stem cells contributes to their enhanced immune evasion
    • Sultan, M., Vidovic, D., Paine, A.S., Huynh, T.T., Coyle, K.M., Thomas, M.L., et al. Epigenetic silencing of TAP1 in aldefluor(+) breast cancer stem cells contributes to their enhanced immune evasion. Stem Cells 36 (2018), 641–654.
    • (2018) Stem Cells , vol.36 , pp. 641-654
    • Sultan, M.1    Vidovic, D.2    Paine, A.S.3    Huynh, T.T.4    Coyle, K.M.5    Thomas, M.L.6
  • 51
    • 84991336327 scopus 로고    scopus 로고
    • A preliminary study of the role of extracellular -5′- nucleotidase in breast cancer stem cells and epithelial-mesenchymal transition
    • Yu, J., Liao, X., Li, L., Lv, L., Zhi, X., Yu, J., et al. A preliminary study of the role of extracellular -5′- nucleotidase in breast cancer stem cells and epithelial-mesenchymal transition. Vitro Cell Dev Biol Anim 53 (2017), 132–140.
    • (2017) Vitro Cell Dev Biol Anim , vol.53 , pp. 132-140
    • Yu, J.1    Liao, X.2    Li, L.3    Lv, L.4    Zhi, X.5    Yu, J.6
  • 54
    • 78449234396 scopus 로고    scopus 로고
    • Hyaluronan-CD44 interaction promotes c-Src-mediated twist signaling, microRNA-10b expression, and RhoA/RhoC up-regulation, leading to Rho-kinase-associated cytoskeleton activation and breast tumor cell invasion
    • Bourguignon, L.Y., Wong, G., Earle, C., Krueger, K., Spevak, C.C., Hyaluronan-CD44 interaction promotes c-Src-mediated twist signaling, microRNA-10b expression, and RhoA/RhoC up-regulation, leading to Rho-kinase-associated cytoskeleton activation and breast tumor cell invasion. J Biol Chem 285 (2010), 36721–36735.
    • (2010) J Biol Chem , vol.285 , pp. 36721-36735
    • Bourguignon, L.Y.1    Wong, G.2    Earle, C.3    Krueger, K.4    Spevak, C.C.5
  • 55
    • 0037063999 scopus 로고    scopus 로고
    • Hyaluronan oligosaccharides inhibit anchorage-independent growth of tumor cells by suppressing the phosphoinositide 3-kinase/Akt cell survival pathway
    • Ghatak, S., Misra, S., Toole, B.P., Hyaluronan oligosaccharides inhibit anchorage-independent growth of tumor cells by suppressing the phosphoinositide 3-kinase/Akt cell survival pathway. J Biol Chem 277 (2002), 38013–38020.
    • (2002) J Biol Chem , vol.277 , pp. 38013-38020
    • Ghatak, S.1    Misra, S.2    Toole, B.P.3
  • 56
    • 0033941950 scopus 로고    scopus 로고
    • CD44 acts both as a growth- and invasiveness-promoting molecule and as a tumor-suppressing cofactor
    • Herrlich, P., Morrison, H., Sleeman, J., Orian-Rousseau, V., König, H., Weg-Remers, S., et al. CD44 acts both as a growth- and invasiveness-promoting molecule and as a tumor-suppressing cofactor. Ann NY Acad Sci 910 (2000), 106–118.
    • (2000) Ann NY Acad Sci , vol.910 , pp. 106-118
    • Herrlich, P.1    Morrison, H.2    Sleeman, J.3    Orian-Rousseau, V.4    König, H.5    Weg-Remers, S.6
  • 57
    • 70350362953 scopus 로고    scopus 로고
    • Hyaluronan-CD44 interaction with protein kinase C(epsilon) promotes oncogenic signaling by the stem cell marker Nanog and the Production of microRNA-21, leading to down-regulation of the tumor suppressor protein PDCD4, anti-apoptosis, and chemotherapy resistance in breast tumor cells
    • Bourguignon, L.Y., Spevak, C.C., Wong, G., Xia, W., Gilad, E., Hyaluronan-CD44 interaction with protein kinase C(epsilon) promotes oncogenic signaling by the stem cell marker Nanog and the Production of microRNA-21, leading to down-regulation of the tumor suppressor protein PDCD4, anti-apoptosis, and chemotherapy resistance in breast tumor cells. J Biol Chem 284 (2009), 26533–26546.
    • (2009) J Biol Chem , vol.284 , pp. 26533-26546
    • Bourguignon, L.Y.1    Spevak, C.C.2    Wong, G.3    Xia, W.4    Gilad, E.5
  • 58
    • 84961959080 scopus 로고    scopus 로고
    • CD44 targeted chemotherapy for co-eradication of breast cancer stem cells and cancer cells using polymeric nanoparticles of salinomycin and paclitaxel
    • Muntimadugu, E., Kumar, R., Saladi, S., Rafeeqi, T.A., Khan, W., CD44 targeted chemotherapy for co-eradication of breast cancer stem cells and cancer cells using polymeric nanoparticles of salinomycin and paclitaxel. Colloids Surf B Biointerfaces 143 (2016), 532–546.
    • (2016) Colloids Surf B Biointerfaces , vol.143 , pp. 532-546
    • Muntimadugu, E.1    Kumar, R.2    Saladi, S.3    Rafeeqi, T.A.4    Khan, W.5
  • 59
    • 33750306612 scopus 로고    scopus 로고
    • Most early disseminated cancer cells detected in bone marrow of breast cancer patients have a putative breast cancer stem cell phenotype
    • Balic, M., Lin, H., Young, L., Hawes, D., Giuliano, A., McNamara, G., et al. Most early disseminated cancer cells detected in bone marrow of breast cancer patients have a putative breast cancer stem cell phenotype. Clin Cancer Res 12 (2006), 5615–5621.
    • (2006) Clin Cancer Res , vol.12 , pp. 5615-5621
    • Balic, M.1    Lin, H.2    Young, L.3    Hawes, D.4    Giuliano, A.5    McNamara, G.6
  • 61
    • 78149262994 scopus 로고    scopus 로고
    • Cancer stem cells from human breast tumors are involved in spontaneous metastases in orthotopic mouse models
    • Liu, H., Patel, M.R., Prescher, J.A., Patsialou, A., Qian, D., Lin, J., et al. Cancer stem cells from human breast tumors are involved in spontaneous metastases in orthotopic mouse models. Proc Natl Acad Sci USA 107 (2010), 18115–18120.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 18115-18120
    • Liu, H.1    Patel, M.R.2    Prescher, J.A.3    Patsialou, A.4    Qian, D.5    Lin, J.6
  • 62
    • 45049086574 scopus 로고    scopus 로고
    • The clinicopathologic and prognostic significance of CD44+/CD24(-/low) and CD44-/CD24+ tumor cells in invasive breast carcinomas
    • Mylona, E., Giannopoulou, I., Fasomytakis, E., Nomikos, A., Magkou, C., Bakarakos, P., et al. The clinicopathologic and prognostic significance of CD44+/CD24(-/low) and CD44-/CD24+ tumor cells in invasive breast carcinomas. Hum Pathol 39 (2008), 1096–1102.
    • (2008) Hum Pathol , vol.39 , pp. 1096-1102
    • Mylona, E.1    Giannopoulou, I.2    Fasomytakis, E.3    Nomikos, A.4    Magkou, C.5    Bakarakos, P.6
  • 63
    • 33846425793 scopus 로고    scopus 로고
    • The prognostic role of a gene signature from tumorigenic breast-cancer cells
    • Liu, R., Wang, X., Chen, G.Y., Dalerba, P., Gurney, A., Hoey, T., et al. The prognostic role of a gene signature from tumorigenic breast-cancer cells. N Engl J Med 356 (2007), 217–226.
    • (2007) N Engl J Med , vol.356 , pp. 217-226
    • Liu, R.1    Wang, X.2    Chen, G.Y.3    Dalerba, P.4    Gurney, A.5    Hoey, T.6
  • 64
    • 84948699662 scopus 로고    scopus 로고
    • The presence of EpCAM(-)/CD49f(+) cells in breast cancer is associated with a poor clinical outcome
    • Ye, F., Qiu, Y., Li, L., Yang, L., Cheng, F., Zhang, H., et al. The presence of EpCAM(-)/CD49f(+) cells in breast cancer is associated with a poor clinical outcome. J Breast Cancer 18 (2015), 242–248.
    • (2015) J Breast Cancer , vol.18 , pp. 242-248
    • Ye, F.1    Qiu, Y.2    Li, L.3    Yang, L.4    Cheng, F.5    Zhang, H.6
  • 65
    • 84892938139 scopus 로고    scopus 로고
    • CD133-targeted paclitaxel delivery inhibits local tumor recurrence in a mouse model of breast cancer
    • Swaminathan, S.K., Roger, E., Toti, U., Niu, L., Ohlfest, J.R., Panyam, J., CD133-targeted paclitaxel delivery inhibits local tumor recurrence in a mouse model of breast cancer. J Control Release 171 (2013), 280–287.
    • (2013) J Control Release , vol.171 , pp. 280-287
    • Swaminathan, S.K.1    Roger, E.2    Toti, U.3    Niu, L.4    Ohlfest, J.R.5    Panyam, J.6
  • 66
    • 84872847383 scopus 로고    scopus 로고
    • RNA aptamers targeting cancer stem cell marker CD133
    • Shigdar, S., Qiao, L., Zhou, S.F., Xiang, D., Wang, T., Li, Y., et al. RNA aptamers targeting cancer stem cell marker CD133. Cancer Lett 330 (2013), 84–95.
    • (2013) Cancer Lett , vol.330 , pp. 84-95
    • Shigdar, S.1    Qiao, L.2    Zhou, S.F.3    Xiang, D.4    Wang, T.5    Li, Y.6
  • 67
    • 35848955428 scopus 로고    scopus 로고
    • ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome
    • Ginestier, C., Hur, M.H., Charafe-Jauffret, E., Monville, F., Dutcher, J., Brown, M., et al. ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome. Cell Stem Cell 1 (2007), 555–567.
    • (2007) Cell Stem Cell , vol.1 , pp. 555-567
    • Ginestier, C.1    Hur, M.H.2    Charafe-Jauffret, E.3    Monville, F.4    Dutcher, J.5    Brown, M.6
  • 68
    • 79951818699 scopus 로고    scopus 로고
    • Aldehyde dehydrogenase activity of breast cancer stem cells is primarily due to isoform ALDH1A3 and its expression is predictive of metastasis
    • Marcato, P., Dean, C.A., Pan, D., Araslanova, R., Gillis, M., Joshi, M., et al. Aldehyde dehydrogenase activity of breast cancer stem cells is primarily due to isoform ALDH1A3 and its expression is predictive of metastasis. Stem Cells Dev 29 (2011), 32–45.
    • (2011) Stem Cells Dev , vol.29 , pp. 32-45
    • Marcato, P.1    Dean, C.A.2    Pan, D.3    Araslanova, R.4    Gillis, M.5    Joshi, M.6
  • 70
    • 0035282432 scopus 로고    scopus 로고
    • Involvement of chemokine receptors in breast cancer metastasis
    • Müller, A., Homey, B., Soto, H., Ge, N., Catron, D., Buchanan, M.E., et al. Involvement of chemokine receptors in breast cancer metastasis. Nature 410 (2001), 50–56.
    • (2001) Nature , vol.410 , pp. 50-56
    • Müller, A.1    Homey, B.2    Soto, H.3    Ge, N.4    Catron, D.5    Buchanan, M.E.6
  • 71
    • 77953681593 scopus 로고    scopus 로고
    • Breast cancer stromal fibroblasts promote the generation of CD44+CD24- cells through SDF-1/CXCR4 interaction
    • Huang, M., Li, Y., Zhang, H., Nan, F., Breast cancer stromal fibroblasts promote the generation of CD44+CD24- cells through SDF-1/CXCR4 interaction. J Exp Clin Cancer Res, 29, 2010, 80.
    • (2010) J Exp Clin Cancer Res , vol.29 , pp. 80
    • Huang, M.1    Li, Y.2    Zhang, H.3    Nan, F.4
  • 72
    • 84869087515 scopus 로고    scopus 로고
    • Scavenging of CXCL12 by CXCR7 promotes tumor growth and metastasis of CXCR4-positive breast cancer cells
    • Luker, K.E., Lewin, S.A., Mihalko, L.A., Schmidt, B.T., Winkler, J.S., Coggins, N.L., et al. Scavenging of CXCL12 by CXCR7 promotes tumor growth and metastasis of CXCR4-positive breast cancer cells. Oncogene 31 (2012), 4750–4758.
    • (2012) Oncogene , vol.31 , pp. 4750-4758
    • Luker, K.E.1    Lewin, S.A.2    Mihalko, L.A.3    Schmidt, B.T.4    Winkler, J.S.5    Coggins, N.L.6
  • 73
    • 84901677321 scopus 로고    scopus 로고
    • Quantitative phosphoproteomic analysis reveals system-wide signaling pathways downstream of SDF-1/CXCR4 in breast cancer stem cells
    • Yi, T., Zhai, B., Yu, Y., Kiyotsugu, Y., Raschle, T., Etzkorn, M., et al. Quantitative phosphoproteomic analysis reveals system-wide signaling pathways downstream of SDF-1/CXCR4 in breast cancer stem cells. Proc Natl Acad Sci USA 111 (2014), E2182–E2190.
    • (2014) Proc Natl Acad Sci USA , vol.111 , pp. E2182-E2190
    • Yi, T.1    Zhai, B.2    Yu, Y.3    Kiyotsugu, Y.4    Raschle, T.5    Etzkorn, M.6
  • 74
    • 81255138201 scopus 로고    scopus 로고
    • Reduced miR-128 in breast tumor-initiating cells induces chemotherapeutic resistance via Bmi-1 and ABCC5
    • Zhu, Y., Yu, F., Jiao, Y., Feng, J., Tang, W., Yao, H., et al. Reduced miR-128 in breast tumor-initiating cells induces chemotherapeutic resistance via Bmi-1 and ABCC5. Clin Cancer Res 17 (2011), 7105–7115.
    • (2011) Clin Cancer Res , vol.17 , pp. 7105-7115
    • Zhu, Y.1    Yu, F.2    Jiao, Y.3    Feng, J.4    Tang, W.5    Yao, H.6
  • 75
    • 68049120477 scopus 로고    scopus 로고
    • Host-derived tumor endothelial marker 8 promotes the growth of melanoma
    • Cullen, M., Seaman, S., Chaudhary, A., Yang, M.Y., Hilton, M.B., Logsdon, D., et al. Host-derived tumor endothelial marker 8 promotes the growth of melanoma. Cancer Res 69 (2009), 6021–6026.
    • (2009) Cancer Res , vol.69 , pp. 6021-6026
    • Cullen, M.1    Seaman, S.2    Chaudhary, A.3    Yang, M.Y.4    Hilton, M.B.5    Logsdon, D.6
  • 76
    • 79954858874 scopus 로고    scopus 로고
    • RNA aptamer against a cancer stem cell marker epithelial cell adhesion molecule
    • Shigdar, S., Lin, J., Yu, Y., Pastuovic, M., Wei, M., Duan, W., RNA aptamer against a cancer stem cell marker epithelial cell adhesion molecule. Cancer Sci 102 (2011), 991–998.
    • (2011) Cancer Sci , vol.102 , pp. 991-998
    • Shigdar, S.1    Lin, J.2    Yu, Y.3    Pastuovic, M.4    Wei, M.5    Duan, W.6
  • 77
    • 84954484132 scopus 로고    scopus 로고
    • EpCAM aptamer-mediated survivin silencing sensitized cancer stem cells to doxorubicin in a breast cancer model
    • Wang, T., Gantier, M.P., Xiang, D., Bean, A.G., Bruce, M., Zhou, S.F., et al. EpCAM aptamer-mediated survivin silencing sensitized cancer stem cells to doxorubicin in a breast cancer model. Theranostics 5 (2015), 1456–1472.
    • (2015) Theranostics , vol.5 , pp. 1456-1472
    • Wang, T.1    Gantier, M.P.2    Xiang, D.3    Bean, A.G.4    Bruce, M.5    Zhou, S.F.6
  • 78
    • 84966473543 scopus 로고    scopus 로고
    • Epithelial-to-mesenchymal transition leads to loss of EpCAM and different physical properties in circulating tumor cells from metastatic breast cancer
    • Hyun, K.A., Koo, G.B., Han, H., Sohn, J., Choi, W., Kim, S., et al. Epithelial-to-mesenchymal transition leads to loss of EpCAM and different physical properties in circulating tumor cells from metastatic breast cancer. Oncotarget 7 (2016), 24677–24687.
    • (2016) Oncotarget , vol.7 , pp. 24677-24687
    • Hyun, K.A.1    Koo, G.B.2    Han, H.3    Sohn, J.4    Choi, W.5    Kim, S.6
  • 79
    • 84922129231 scopus 로고    scopus 로고
    • Identification of multipotent mammary stem cells by protein C receptor expression
    • Wang, D., Cai, C., Dong, X., Yu, Q.C., Zhang, X.O., Yang, L., et al. Identification of multipotent mammary stem cells by protein C receptor expression. Nature 517 (2015), 81–84.
    • (2015) Nature , vol.517 , pp. 81-84
    • Wang, D.1    Cai, C.2    Dong, X.3    Yu, Q.C.4    Zhang, X.O.5    Yang, L.6
  • 80
    • 84861801520 scopus 로고    scopus 로고
    • Ganglioside GD2 identifies breast cancer stem cells and promotes tumorigenesis
    • Battula, V.L., Shi, Y., Evans, K.W., Wang, R.Y., Spaeth, E.L., Jacamo, R.O., et al. Ganglioside GD2 identifies breast cancer stem cells and promotes tumorigenesis. J Clin Invest 122 (2012), 2066–2078.
    • (2012) J Clin Invest , vol.122 , pp. 2066-2078
    • Battula, V.L.1    Shi, Y.2    Evans, K.W.3    Wang, R.Y.4    Spaeth, E.L.5    Jacamo, R.O.6
  • 81
    • 84930542981 scopus 로고    scopus 로고
    • GD3 synthase regulates epithelial-mesenchymal transition and metastasis in breast cancer
    • Sarkar, T.R., Battula, V.L., Werden, S.J., Vijay, G.V., Ramirez-Pena, E.Q., Taube, J.H., et al. GD3 synthase regulates epithelial-mesenchymal transition and metastasis in breast cancer. Oncogene 34 (2015), 2958–2967.
    • (2015) Oncogene , vol.34 , pp. 2958-2967
    • Sarkar, T.R.1    Battula, V.L.2    Werden, S.J.3    Vijay, G.V.4    Ramirez-Pena, E.Q.5    Taube, J.H.6
  • 82
    • 85020190996 scopus 로고    scopus 로고
    • IKK inhibition by BMS-345541 suppresses breast tumorigenesis and metastases by targeting GD2+ cancer stem cells
    • Battula, V.L., Nguyen, K., Sun, J., Pitner, M.K., Yuan, B., Bartholomeusz, C., et al. IKK inhibition by BMS-345541 suppresses breast tumorigenesis and metastases by targeting GD2+ cancer stem cells. Oncotarget 8 (2017), 36936–36949.
    • (2017) Oncotarget , vol.8 , pp. 36936-36949
    • Battula, V.L.1    Nguyen, K.2    Sun, J.3    Pitner, M.K.4    Yuan, B.5    Bartholomeusz, C.6
  • 83
    • 66349097441 scopus 로고    scopus 로고
    • Development of mammary tumors by conditional expression of GLI1
    • Fiaschi, M., Rozell, B., Bergstrom, A., Toftgard, R., Development of mammary tumors by conditional expression of GLI1. Cancer Res 69 (2009), 4810–4817.
    • (2009) Cancer Res , vol.69 , pp. 4810-4817
    • Fiaschi, M.1    Rozell, B.2    Bergstrom, A.3    Toftgard, R.4
  • 84
    • 79957895813 scopus 로고    scopus 로고
    • Hedgehog overexpression is associated with stromal interactions and predicts for poor outcome in breast cancer
    • O'Toole, S.A., Machalek, D.A., Shearer, R.F., Millar, E.K., Nair, R., Schofield, P., et al. Hedgehog overexpression is associated with stromal interactions and predicts for poor outcome in breast cancer. Cancer Res 71 (2011), 4002–4014.
    • (2011) Cancer Res , vol.71 , pp. 4002-4014
    • O'Toole, S.A.1    Machalek, D.A.2    Shearer, R.F.3    Millar, E.K.4    Nair, R.5    Schofield, P.6
  • 85
    • 84855436875 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1alpha promotes primary tumor growth and tumor-initiating cell activity in breast cancer
    • Schwab, L.P., Peacock, D.L., Majumdar, D., Ingels, J.F., Jensen, L.C., Smith, K.D., et al. Hypoxia-inducible factor 1alpha promotes primary tumor growth and tumor-initiating cell activity in breast cancer. Breast Cancer Res, 14, 2012, R6.
    • (2012) Breast Cancer Res , vol.14 , pp. R6
    • Schwab, L.P.1    Peacock, D.L.2    Majumdar, D.3    Ingels, J.F.4    Jensen, L.C.5    Smith, K.D.6
  • 87
    • 84866431367 scopus 로고    scopus 로고
    • Biomarker and pharmacologic evaluation of the gamma-secretase inhibitor PF-03084014 in breast cancer models
    • Zhang, C.C., Pavlicek, A., Zhang, Q., Lira, M.E., Painter, C.L., Yan, Z., et al. Biomarker and pharmacologic evaluation of the gamma-secretase inhibitor PF-03084014 in breast cancer models. Clin Cancer Res 18 (2012), 5008–5019.
    • (2012) Clin Cancer Res , vol.18 , pp. 5008-5019
    • Zhang, C.C.1    Pavlicek, A.2    Zhang, Q.3    Lira, M.E.4    Painter, C.L.5    Yan, Z.6
  • 88
    • 77951730125 scopus 로고    scopus 로고
    • Sulforaphane, a dietary component of broccoli/broccoli sprouts, inhibits breast cancer stem cells
    • Li, Y., Zhang, T., Korkaya, H., Liu, S., Lee, H.F., Newman, B., et al. Sulforaphane, a dietary component of broccoli/broccoli sprouts, inhibits breast cancer stem cells. Clin Cancer Res 16 (2010), 2580–2590.
    • (2010) Clin Cancer Res , vol.16 , pp. 2580-2590
    • Li, Y.1    Zhang, T.2    Korkaya, H.3    Liu, S.4    Lee, H.F.5    Newman, B.6
  • 89
    • 84863764614 scopus 로고    scopus 로고
    • Nrf2 redirects glucose and glutamine into anabolic pathways in metabolic reprogramming
    • Mitsuishi, Y., Taguchi, K., Kawatani, Y., Shibata, T., Nukiwa, T., Aburatani, H., et al. Nrf2 redirects glucose and glutamine into anabolic pathways in metabolic reprogramming. Cancer Cell 22 (2012), 66–79.
    • (2012) Cancer Cell , vol.22 , pp. 66-79
    • Mitsuishi, Y.1    Taguchi, K.2    Kawatani, Y.3    Shibata, T.4    Nukiwa, T.5    Aburatani, H.6
  • 90
    • 84887495550 scopus 로고    scopus 로고
    • Acquisition of epithelial-mesenchymal transition and cancer stem cell phenotypes is associated with activation of the PI3K/Akt/mTOR pathway in prostate cancer radioresistance
    • Chang, L., Graham, P.H., Hao, J., Ni, J., Bucci, J., Cozzi, P.J., et al. Acquisition of epithelial-mesenchymal transition and cancer stem cell phenotypes is associated with activation of the PI3K/Akt/mTOR pathway in prostate cancer radioresistance. Cell Death Dis, 4, 2013, e875.
    • (2013) Cell Death Dis , vol.4
    • Chang, L.1    Graham, P.H.2    Hao, J.3    Ni, J.4    Bucci, J.5    Cozzi, P.J.6
  • 91
    • 84875748505 scopus 로고    scopus 로고
    • Targeting the PI3K/Akt/mTOR pathway for breast cancer therapy
    • Cidado, J., Park, B.H., Targeting the PI3K/Akt/mTOR pathway for breast cancer therapy. J Mammary Gland Biol Neoplasia. 17 (2012), 205–216.
    • (2012) J Mammary Gland Biol Neoplasia. , vol.17 , pp. 205-216
    • Cidado, J.1    Park, B.H.2
  • 92
    • 51849111524 scopus 로고    scopus 로고
    • NVP-BEZ235, a dual PI3K/mTOR inhibitor, prevents PI3K signaling and inhibits the growth of cancer cells with activating PI3K mutations
    • Serra, V., Markman, B., Scaltriti, M., Eichhorn, P.J., Valero, V., Guzman, M., et al. NVP-BEZ235, a dual PI3K/mTOR inhibitor, prevents PI3K signaling and inhibits the growth of cancer cells with activating PI3K mutations. Cancer Res 68 (2008), 8022–8030.
    • (2008) Cancer Res , vol.68 , pp. 8022-8030
    • Serra, V.1    Markman, B.2    Scaltriti, M.3    Eichhorn, P.J.4    Valero, V.5    Guzman, M.6
  • 93
    • 85021842962 scopus 로고    scopus 로고
    • Rapalogs can promote cancer cell stemness in vitro in a Galectin-1 and H-ras-dependent manner
    • Posada, I.M.D., Lectez, B., Sharma, M., Oetken-Lindholm, C., Yetukuri, L., Zhou, Y., et al. Rapalogs can promote cancer cell stemness in vitro in a Galectin-1 and H-ras-dependent manner. Oncotarget 8 (2017), 44550–44566.
    • (2017) Oncotarget , vol.8 , pp. 44550-44566
    • Posada, I.M.D.1    Lectez, B.2    Sharma, M.3    Oetken-Lindholm, C.4    Yetukuri, L.5    Zhou, Y.6
  • 94
    • 32944469169 scopus 로고    scopus 로고
    • Beta1 integrin inhibitory antibody induces apoptosis of breast cancer cells, inhibits growth, and distinguishes malignant from normal phenotype in three dimensional cultures and in vivo
    • Park, C.C., Zhang, H., Pallavicini, M., Gray, J.W., Baehner, F., Park, C.J., et al. Beta1 integrin inhibitory antibody induces apoptosis of breast cancer cells, inhibits growth, and distinguishes malignant from normal phenotype in three dimensional cultures and in vivo. Cancer Res 66 (2006), 1526–1535.
    • (2006) Cancer Res , vol.66 , pp. 1526-1535
    • Park, C.C.1    Zhang, H.2    Pallavicini, M.3    Gray, J.W.4    Baehner, F.5    Park, C.J.6
  • 95
    • 84896543534 scopus 로고    scopus 로고
    • Selective inhibition of breast cancer stem cells by gold nanorods mediated plasmonic hyperthermia
    • Xu, Y., Wang, J., Li, X., Liu, Y., Dai, L., Wu, X., et al. Selective inhibition of breast cancer stem cells by gold nanorods mediated plasmonic hyperthermia. Biomaterials 35 (2014), 4667–4677.
    • (2014) Biomaterials , vol.35 , pp. 4667-4677
    • Xu, Y.1    Wang, J.2    Li, X.3    Liu, Y.4    Dai, L.5    Wu, X.6
  • 96
    • 85032221908 scopus 로고    scopus 로고
    • Dual-targeting Wnt and uPA receptors using peptide conjugated ultra-small nanoparticle drug carriers inhibited cancer stem-cell phenotype in chemo-resistant breast cancer
    • Miller-Kleinhenz, J., Guo, X., Qian, W., Zhou, H., Bozeman, E.N., Zhu, L., et al. Dual-targeting Wnt and uPA receptors using peptide conjugated ultra-small nanoparticle drug carriers inhibited cancer stem-cell phenotype in chemo-resistant breast cancer. Biomaterials 152 (2018), 47–62.
    • (2018) Biomaterials , vol.152 , pp. 47-62
    • Miller-Kleinhenz, J.1    Guo, X.2    Qian, W.3    Zhou, H.4    Bozeman, E.N.5    Zhu, L.6
  • 97
    • 79960608623 scopus 로고    scopus 로고
    • Interstitial flow influences direction of tumor cell migration through competing mechanisms
    • Polacheck, W.J., Charest, J.L., Kamm, R.D., Interstitial flow influences direction of tumor cell migration through competing mechanisms. Proc Natl Acad Sci USA 108 (2011), 11115–11120.
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 11115-11120
    • Polacheck, W.J.1    Charest, J.L.2    Kamm, R.D.3
  • 98
    • 68749099671 scopus 로고    scopus 로고
    • Identification of selective inhibitors of cancer stem cells by high-throughput screening
    • Gupta, P.B., Onder, T.T., Jiang, G., Tao, K., Kuperwasser, C., Weinberg, R.A., et al. Identification of selective inhibitors of cancer stem cells by high-throughput screening. Cell 138 (2009), 645–659.
    • (2009) Cell , vol.138 , pp. 645-659
    • Gupta, P.B.1    Onder, T.T.2    Jiang, G.3    Tao, K.4    Kuperwasser, C.5    Weinberg, R.A.6
  • 99
    • 84865133667 scopus 로고    scopus 로고
    • BMP4 administration induces differentiation of CD133+ hepatic cancer stem cells, blocking their contributions to hepatocellular carcinoma
    • Zhang, L., Sun, H., Zhao, F., Lu, P., Ge, C., Li, H., et al. BMP4 administration induces differentiation of CD133+ hepatic cancer stem cells, blocking their contributions to hepatocellular carcinoma. Cancer Res 72 (2012), 4276–4285.
    • (2012) Cancer Res , vol.72 , pp. 4276-4285
    • Zhang, L.1    Sun, H.2    Zhao, F.3    Lu, P.4    Ge, C.5    Li, H.6
  • 100
    • 85048235565 scopus 로고    scopus 로고
    • The Critical, Clinical Role of Interferon-Beta in Regulating Cancer Stem Cell Properties in Triple-Negative Breast Cancer
    • Doherty, M.R., Jackson, M.W., The Critical, Clinical Role of Interferon-Beta in Regulating Cancer Stem Cell Properties in Triple-Negative Breast Cancer. DNA Cell Biol 37 (2018), 513–516.
    • (2018) DNA Cell Biol , vol.37 , pp. 513-516
    • Doherty, M.R.1    Jackson, M.W.2


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