Total biosynthesis of diterpene aphidicolin, a specific inhibitor of DNA polymerase α: Heterologous expression of four biosynthetic genes in Aspergillus oryzae

Bioscience, Biotechnology and Biochemistry

Volumn 75, Issue 9, 2011, Pages 1813-1817

  Fujii, Ryuya ^a   Minami, Atsushi ^a   Tsukagoshi, Tae ^a   Sato, Natsuko ^b   Sahara, Takehiko ^b   Ohgiya, Satoru ^b   Gomi, Katsuya ^c   Oikawa, Hideaki ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

^b NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY AIST   (Japan)

^c TOHOKU UNIVERSITY   (Japan)

Author keywords

Aphidicolin; Aspergillus oryzae; Diterpene; Heterologous expression; Total biosynthesis

Indexed keywords

APHIDICOLIN; ASPERGILLUS ORYZAE; BIOSYNTHETIC GENE; DITERPENES; DNA POLYMERASE; GENE CLUSTERS; GERANYLGERANYL DIPHOSPHATE; HETEROLOGOUS EXPRESSION; MONOOXYGENASES; NATURAL PRODUCTS; SECONDARY METABOLITES; SPECIFIC INHIBITORS; SYNTHASES; TERPENOIDS; TRANSFORMANTS;

ASPERGILLUS; BIOCHEMISTRY; BIOSYNTHESIS; METABOLITES; OLEFINS; YEAST;

GENE EXPRESSION;

3 DEOXYAPHIDICOLIN; 3-DEOXYAPHIDICOLIN; APHIDICOLIN; DITERPENE; DNA DIRECTED DNA POLYMERASE BETA; ENZYME INHIBITOR; FARNESYL TRANS TRANSFERASE; MIXED FUNCTION OXIDASE; TERPENE; TERPENE SYNTHASE; TRANSFERASE;

ARTICLE; ASPERGILLUS ORYZAE; BIOSYNTHESIS; CHEMISTRY; DRUG ANTAGONISM; ENZYMOLOGY; FUNGAL GENE; GENE VECTOR; GENETIC ENGINEERING; GENETIC TRANSFORMATION; GENETICS; MASS FRAGMENTOGRAPHY; METABOLISM; METHODOLOGY; MULTIGENE FAMILY; PROMOTER REGION; SACCHAROMYCES CEREVISIAE;

ALKYL AND ARYL TRANSFERASES; APHIDICOLIN; ASPERGILLUS ORYZAE; DITERPENES; DNA POLYMERASE I; ENZYME INHIBITORS; FARNESYLTRANSTRANSFERASE; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; GENES, FUNGAL; GENETIC ENGINEERING; GENETIC VECTORS; MIXED FUNCTION OXYGENASES; MULTIGENE FAMILY; PROMOTER REGIONS, GENETIC; SACCHAROMYCES CEREVISIAE; TERPENES; TRANSFORMATION, GENETIC;

ASPERGILLUS ORYZAE; PUSA; SACCHAROMYCES CEREVISIAE;

EID: 80053166085     PISSN: 09168451     EISSN: 13476947     Source Type: Journal    
DOI: 10.1271/bbb.110366     Document Type: Article

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