Mechanistic analyses of the suppression of amyloid β42 aggregation by apomorphine

Bioorganic and Medicinal Chemistry

Volumn 26, Issue 8, 2018, Pages 1538-1546

  Hanaki, Mizuho ^a   Murakami, Kazuma ^a   Katayama, Sumie ^b   Akagi, Ken ichi ^b   Irie, Kazuhiro ^a  

^a KYOTO UNIVERSITY   (Japan)

^b NATIONAL INSTITUTE OF BIOMEDICAL INNOVATION   (Japan)

Author keywords

(R) Apomorphine; Aggregation; Alzheimer's disease; Amyloid protein; LC MS; NMR

Indexed keywords

AMYLOID BETA PROTEIN[1-42]; APOMORPHINE; ARGININE; GLUTAMINE; LYSINE; OLIGOMER; AMYLOID BETA PROTEIN; PROTEIN AGGREGATE;

ARTICLE; AUTOOXIDATION; BETA SHEET; CONTROLLED STUDY; DRUG DETERMINATION; DRUG EFFECT; DRUG MECHANISM; DRUG STRUCTURE; HUMAN; HUMAN CELL; LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY; NEUROTOXICITY; PHYSICAL CHEMISTRY; PROTEIN AGGREGATION; PROTON NUCLEAR MAGNETIC RESONANCE; SH-SY5Y CELL LINE; ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; METABOLISM; STRUCTURE ACTIVITY RELATION; SYNTHESIS; TUMOR CELL LINE;

AMYLOID BETA-PEPTIDES; APOMORPHINE; CELL LINE, TUMOR; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; MOLECULAR STRUCTURE; PROTEIN AGGREGATES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 85041637920     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2018.01.028     Document Type: Article

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