Hemizygosity Enables a Mutational Transition Governing Fungal Virulence and Commensalism

Cell Host and Microbe

Volumn 25, Issue 3, 2019, Pages 418-431.e6

  Liang, Shen Huan ^a   Anderson, Matthew Z ^b   Hirakawa, Matthew P ^a   Wang, Joshua M ^b   Frazer, Corey ^a   Alaalm, Leenah M ^a   Thomson, Gregory J ^a   Ene, Iuliana V ^a   Bennett, Richard J ^a  

^a BROWN UNIVERSITY   (United States)

^b OHIO STATE UNIVERSITY   (United States)

Author keywords

Candida albicans; gastrointestinal tract; pathogenesis; phase variation; phenotypic switch; population genetics; transcription factor

Indexed keywords

EFG1 PROTEIN; FUNGAL PROTEIN; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; DNA BINDING PROTEIN; EFG1 PROTEIN, CANDIDA ALBICANS;

ANIMAL EXPERIMENT; ARTICLE; CANDIDA ALBICANS; CELL DIFFERENTIATION; CELL FATE; CELLS BY BODY ANATOMY; COMMENSALISM; CONTROLLED STUDY; FUNGAL CELL; FUNGAL GENOME; FUNGAL VIRULENCE; FUNGUS ISOLATION; FUNGUS MUTATION; GASTROINTESTINAL TRACT; GENE CONVERSION; GENE DOSAGE; GENE EXPRESSION PROFILING; GENETIC MODEL; HEMIZYGOSITY; HOST PATHOGEN INTERACTION; LEUKOCYTE; MOUSE; NONHUMAN; NONSENSE MUTATION; PHENOTYPE; PHENOTYPIC PLASTICITY; PRIORITY JOURNAL; RNA SEQUENCE; SACCHAROMYCES CEREVISIAE; TRANSCRIPTION REGULATION; CANDIDIASIS; GENE EXPRESSION REGULATION; GENETICS; GROWTH, DEVELOPMENT AND AGING; HUMAN; MICROBIOLOGY; MUTATION; PATHOGENICITY; SYMBIOSIS; VIRULENCE;

CANDIDA ALBICANS; CANDIDIASIS; DNA-BINDING PROTEINS; FUNGAL PROTEINS; GASTROINTESTINAL TRACT; GENE DOSAGE; GENE EXPRESSION REGULATION, FUNGAL; HUMANS; MUTATION; SYMBIOSIS; TRANSCRIPTION FACTORS; VIRULENCE;

EID: 85062391789     PISSN: 19313128     EISSN: 19346069     Source Type: Journal    
DOI: 10.1016/j.chom.2019.01.005     Document Type: Article

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