Candida albicans hyphal formation and the expression of the Efg1-regulated proteinases Sap4 to Sap6 are required for the invasion of parenchymal organs

Infection and Immunity

Volumn 70, Issue 7, 2002, Pages 3689-3700

  Felk, Angelika ^a   Kretschmar, Marianne ^a   Albrecht, Antje ^a   Schaller, Martin ^a   Beinhauer, Sabine ^a   Nichterlein, Thomas ^a   Sanglard, Dominique ^a   Korting, Hans C ^a   Schäfer, Wilhelm ^a   Hube, Bernhard ^a  

^a ROBERT KOCH INSTITUTE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ASPARTIC PROTEINASE; MUTANT PROTEIN; PROTEIN SAP1; PROTEIN SAP2; PROTEIN SAP3; PROTEIN SAP4; PROTEIN SAP5; PROTEIN SAP6; PROTEIN SAP9; PROTEINASE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR EFG1; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANDIDA ALBICANS; CANDIDIASIS; CELL TYPE; CONTROLLED STUDY; ENZYME RELEASE; EOSINOPHIL; FUNGAL GENE; FUNGUS HYPHAE; LIVER; MORPHOLOGY; MOUSE; NONHUMAN; PANCREAS; PARENCHYMA; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; VIRULENCE;

ANIMALS; ASPARTIC ENDOPEPTIDASES; CANDIDA ALBICANS; CANDIDIASIS; DISEASE MODELS, ANIMAL; DNA-BINDING PROTEINS; FUNGAL PROTEINS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE EXPRESSION REGULATION, FUNGAL; INJECTIONS, INTRAPERITONEAL; LIVER; MICE; MICE, INBRED BALB C; TRANSCRIPTION FACTORS;

EID: 0036081594     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.70.7.3689-3700.2002     Document Type: Article

References (44)

1. The expression of the secreted aspartic proteinases Sap4 to Sap6 from Candida albicans in murine macrophages
2. Regulatory networks controlling Candida albicans morphogenesis
3. A characterization of pH-regulated dimorphism in Candida albicans
4. Putative virulence factors of Candida albicans
5. Evidence that members of the secretory aspartic proteinase gene family, in particular SAP2, are virulence factors for Candida vaginitis
6. Transcription factors in Candida albicans-environmental control of morphogenesis
7. Isogenic strain construction and gene mapping in Candida albicans
8. Linkage of adhesion, filamentous growth, and virulence in Candida albicans to a single gene, INTI
9. Isolation of the Candida albicans gene for orotidine-5′-phosphate decarboxylase by complementation of S. cerevisiae ura3 and E. coli pyrF mutations
10. Growth kinetics and morphology of colonies of the filamentous form of Candida albicans
11. The ALS gene family of Candida albicans
12. Expression of seven members of the gene family encoding secretory aspartyl proteinases in Candida albicans
13. Disruption of each of the secreted aspartic proteinase genes SAP1, SAP2, and SAP3 of Candida albicans attenuates virulence
14. Secreted lipases of Candida albicans: Cloning, characterisation and expression analysis of a new gene family with at least ten members
15. Candida albicans proteinases: Resolving the mystery of a gene family
16. Evidence implicating phospholipase as a virulence factor of Candida albicans
17. Candida albicans hyphal formation and virulence: Is there a clearly defined role?
18. Enzymic characteristics of secreted aspartic proteases of Candida albicans
19. Germ tubes and proteinase activity contribute to virulence of Candida albicans in murine peritonitis
20. Individual acid aspartic proteinases (Saps) 1-6 of Candida albicans are not essential for invasion and colonisation of the gastrointestinal tract in mice
21. Altered expression of selectable marker URA3 in gene-disrupted Candida albicans strains complicates interpretation of virulence studies
22. Nonfilamentous C albicans mutants are avirulent
23. The glyoxylate cycle is required for fungal virulence
24. Purified Candida albicans proteinase in the serological diagnosis of systemic candidosis
25. Molecular cloning and characterization of a Candida albicans gene (EFB1) coding for the elongation factor EF-1 beta
26. Multiplicity of genes encoding secreted aspartic proteinases in Candida species
27. Differential regulation of SAP8 and SAP9, which encode two new members of the secreted aspartic proteinase family in Candida albicans
28. CIp10, an efficient and convenient integrating vector for Candida albicans
29. In vivo analysis of secreted aspartic proteinase expression in human oral candidiasis
30. Candida species and virulence
31. Role of hyphal formation in interactions of Candida albicans with endothelial cells
32. Candidiasis visualised by proteinase-directed immunofluorescence
33. A triple deletion of the secreted aspartic proteinase genes SAP4, SAP5, and SAP6 of Candida albicans causes attenuated virulence
34. Differential expression of secreted aspartyl proteinases in a model of human oral candidosis and in patient samples from the oral cavity
35. Secreted aspartic proteinase (Sap) activity contributes to tissue damage in a model of human oral candidiasis
36. Repression of hyphal proteinase expression by the mitogen-activated protein (MAP) kinase phosphatase Cpplp of Candida albicans is independent of the MAP kinase Cek1p
37. Contact sensing in Candida albicans: A possible aid to epithelial penetration
38. Gene regulation during high-frequency switching in Candida albicans
39. Differential activation of a Candida albicans virulence gene family during infection
40. Efg1p, an essential regulator of morphogenesis of the human pathogen Candida albicans, is a member of a conserved class of bHLH proteins regulating morphogenetic processes in fungi
41. Adhesins in Candida albicans
42. Candida albicans secreted aspartyl proteinases: Isoenzyme pattern is determined by cell type, and levels are determined by environmental factors
43. Migration of the fungal pathogen Candida albicans across endothelial monolayers