Aneuploidy and Drug Resistance in Pathogenic Fungi

PLoS Pathogens

Volumn 8, Issue 11, 2012, Pages

  Kwon Chung, Kyung J ^a   Chang, Yun C ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ECHINOCANDIN; FLUCYTOSINE; POLYENE; PYRROLE;

ANEUPLOIDY; ANTIFUNGAL SUSCEPTIBILITY; ARTICLE; CANDIDA; CELL CYCLE PROGRESSION; COMPARATIVE GENOMIC HYBRIDIZATION; CRYPTOCOCCUS; ELECTRON MICROSCOPY; ENDOPLASMIC RETICULUM; ENVIRONMENTAL STRESS; ERG11 GENE; FUNGAL GENE; GENE DUPLICATION; HEREDITY; HUMAN; NONHUMAN; SACCHAROMYCES CEREVISIAE; TAC1 GENE;

ANEUPLOIDY; ANIMALS; DRUG RESISTANCE, FUNGAL; FUNGI; HUMANS; MYCOSES;

FUNGI;

EID: 84870855686     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1003022     Document Type: Article

References (32)

1. Torres EM, Williams BR, Amon A, (2008) Aneuploidy: cells losing their balance. Genetics 179: 737-746.
2. Williams BR, Prabhu VR, Hunter KE, Glazier CM, Whittaker CA, et al. (2008) Aneuploidy affects proliferation and spontaneous immortalization in mammalian cells. Science 322: 703-709.
3. Duesberg P, Stindl R, Hehlmann R, (2001) Origin of multidrug resistance in cells with and without multidrug resistance genes: chromosome reassortments catalyzed by aneuploidy. Proc Natl Acad Sci U S A 98: 11283-11288.
4. Selmecki AM, Dulmage K, Cowen LE, Anderson JB, Berman J, (2009) Acquisition of aneuploidy provides increased fitness during the evolution of antifungal drug resistance. PLoS Genet 5: e1000705 doi:10.1371/journal.pgen.1000705.
5. Sionov E, Lee H, Chang YC, Kwon-Chung KJ, (2010) Cryptococcus neoformans overcomes stress of azole drugs by formation of disomy in specific multiple chromosomes. PLoS Pathog 6: e1000848 doi:10.1371/journal.ppat.1000848.
6. Pavelka N, Rancati G, Li R, (2010) Dr Jekyll and Mr Hyde: role of aneuploidy in cellular adaptation and cancer. Curr Opin Cell Biol 22: 809-815.
7. Rancati G, Pavelka N, Fleharty B, Noll A, Trimble R, et al. (2008) Aneuploidy underlies rapid adaptive evolution of yeast cells deprived of a conserved cytokinesis motor. Cell 135: 879-893.
8. Gresham D, Desai MM, Tucker CM, Jenq HT, Pai DA, et al. (2008) The repertoire and dynamics of evolutionary adaptations to controlled nutrient-limited environments in yeast. PLoS Genet 4: e1000303 doi:10.1371/journal.pgen.1000303.
9. Sionov E, Chang YC, Garraffo HM, Kwon-Chung KJ, (2009) Heteroresistance to fluconazole in Cryptococcus neoformans is intrinsic and associated with virulence. Antimicrob Agents Chemother 53: 2804-2815.
10. Chen G, Bradford WD, Seidel CW, Li R, (2012) Hsp90 stress potentiates rapid cellular adaptation through induction of aneuploidy. Nature 482: 246-250.
11. Polakova S, Blume C, Zarate JA, Mentel M, Jorck-Ramberg D, et al. (2009) Formation of new chromosomes as a virulence mechanism in yeast Candida glabrata. Proc Natl Acad Sci U S A 106: 2688-2693.
12. Hu G, Wang J, Choi J, Jung WH, Liu I, et al. (2011) Variation in chromosome copy number influences the virulence of Cryptococcus neoformans and occurs in isolates from AIDS patients. BMC Genomics 12: 526.
13. Hartwell LH, Dutcher SK, Wood JS, Garvik B, (1982) The fidelity of mitotic chromosome reproduction in S. cerevisiae. Rec Adv Yeast Mol Biol 1: 28-38.
14. Rosenstraus MJ, Chasin LA, (1978) Separation of linked markers in Chinese hamster cell hybrids: mitotic recombination is not involved. Genetics 90: 735-760.
15. Albertson DG, Collins C, McCormick F, Gray JW, (2003) Chromosome aberrations in solid tumors. Nat Genet 34: 369-376.
16. Compton DA, (2011) Mechanisms of aneuploidy. Curr Opin Cell Biol 23: 109-113.
17. Torres EM, Dephoure N, Panneerselvam A, Tucker CM, Whittaker CA, et al. (2010) Identification of aneuploidy-tolerating mutations. Cell 143: 71-83.
18. Ghannoum MA, Rice LB, (1999) Antifungal agents: mode of action, mechanisms of resistance, and correlation of these mechanisms with bacterial resistance. Clin Microbiol Rev 12: 501-517.
19. Marie C, White TC, (2009) Genetic basis of antifungal drug resistance. Curr Fungal Infect Rep 3: 163-169.
20. Selmecki A, Forche A, Berman J, (2010) Genomic plasticity of the human fungal pathogen Candida albicans. Eukaryot Cell 9: 991-1008.
21. vanden Bossche H, Marichal P, Odds FC, Le Jeune L, Coene MC, (1992) Characterization of an azole-resistant Candida glabrata isolate. Antimicrob Agents Chemother 36: 2602-2610.
22. Marichal P, Vanden Bossche H, Odds FC, Nobels G, Warnock DW, et al. (1997) Molecular biological characterization of an azole-resistant Candida glabrata isolate. Antimicrob Agents Chemother 41: 2229-2237.
23. Selmecki A, Forche A, Berman J, (2006) Aneuploidy and isochromosome formation in drug-resistant Candida albicans. Science 313: 367-370.
24. Selmecki A, Gerami-Nejad M, Paulson C, Forche A, Berman J, (2008) An isochromosome confers drug resistance in vivo by amplification of two genes, ERG11 and TAC1. Mol Microbiol 68: 624-641.
25. Mondon P, Petter R, Amalfitano G, Luzzati R, Concia E, et al. (1999) Heteroresistance to fluconazole and voriconazole in Cryptococcus neoformans. Antimicrob Agents Chemother 43: 1856-1861.
26. Varma A, Kwon-Chung KJ, (2010) Heteroresistance of Cryptococcus gattii to fluconazole. Antimicrob Agents Chemother 54: 2303-2311.
27. Ngamskulrungroj P, Chang Y, Hansen B, Bugge C, Fischer E, et al. (2012) Characterization of the chromosome 4 genes that affect fluconazole-induced disomy formation in Cryptococcus neoformans. PLoS ONE 7: e33022 doi:10.1371/journal.pone.0033022.
28. Fernandez C, Lobo MT, Gomez-Coronado D, Lasuncion MA, (2004) Cholestrol is essential for mitosis progression and its deficiency induces polyploid cell formation. Exp Cell Res 300: 109-120.
29. Semighini CP, Averette AF, Perfect JR, Heitman J, (2011) Deletion of Cryptococcus neoformans AIF ortholog promotes chromosome aneuploidy and fluconazole-resistance in a metacaspase-independent manner. PLoS Pathog 7: e1002364 doi:10.1371/journal.ppat.1002364.
30. Ngamskulrungroj P, Chang Y, Hansen B, Bugge C, Fischer E, et al. (2012) Cryptococcus neoformans Yop1, an endoplasmic reticulum curvature-stabilizing protein, participates with Sey1 in influencing fluconazole-induced disomy formation. FEMS Yeast Res doi:10.1111/j/1567-1364.2012.00824.x.
31. Schulz TA, Prinz WA, (2007) Sterol transport in yeast and the oxysterol binding protein homologue (OSH) family. Biochim Biophys Acta 1771: 769-780.
32. Sullivan DP, Ohvo-Rekila H, Baumann NA, Beh CT, Menon AK, (2006) Sterol trafficking between the endoplasmic reticulum and plasma membrane in yeast. Biochem Soc Trans 34: 356-358.