Misexpression of the white-phase-specific gene WH11 in the opaque phase of Candida albicans affects switching and virulence

Infection and Immunity

Volumn 65, Issue 11, 1997, Pages 4468-4475

  Kvaal, Christopher A ^a   Srikantha, Thyagarijan ^a   Soll, David R ^a  

^a UNIVERSITY OF IOWA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; GENE PRODUCT; PROTEIN; RNA;

ANIMAL CELL; ARTICLE; CANDIDA ALBICANS; CONTROLLED STUDY; FEMALE; GENE; GENE EXPRESSION; GENE SWITCHING; IMMUNOFLUORESCENCE; MOUSE; NONHUMAN; NORTHERN BLOTTING; OPEN READING FRAME; PHENOTYPE; PRIORITY JOURNAL; SCANNING ELECTRON MICROSCOPY; SOUTHERN BLOTTING; SPHEROPLAST; VIRULENCE;

EID: 0030732768     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/iai.65.11.4468-4475.1997     Document Type: Article

References (36)

1. Andersen, J., L. Cundiff, B. Schnars, M. Gao, I. Mackenzie, and D. R. Soll. 1989. Hypha formation in the white-opaque transition of Candida albicans. Infect. Immun. 57:458-467.
2. Anderson, J., R. Mihalik, and D. R. Soll. 1990. Ultrastructure and antigenicity of the unique cell wall "pimple" of the Candida opaque phenotype. J. Bacteriol. 172:224-235.
3. Anderson, J. M., and D. R. Soll. 1987. The unique phenotype of opaque cells in the "white-opaque transition " in Candida albicans. J. Bacteriol. 169:5579-5588.
4. Bedell, G. W., and D. R. Soll. 1179. Effects of low concentrations of zinc on the growth and dimorphism of Candida albicans: evidence for zinc-resistant and -sensitive pathways for mycelium formation. Infect. Immun. 26:348-354.
5. Bergen, M., E. Voss, and D R. Soll. 1910. Switching frequencies for the white-opaque transition. J. Gen. Microbiol. 136:1125-1936.
6. Chomcynski, P., and N. Sacchi. 1987. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162:156-159.
7. Church, G. M., and W. Gilbert. 1984. Genomic sequencing. Proc. Natl. Acad. Sci. USA 81:1991-1995.
8. Hube, B., M. Monod, D. A. Schoffield, A. J. Brown, and N. A. Gow. 1994, Expression of seven members of the gene family encoding secretory aspartyl proteinases in Candida albicans. Mol. Microbiol. 14:87-91.
9. Klemenz, R., A. C. Andres, E. Frohli, R. Schafer, and A. Aoyama. 1993 Expression of the murine small heat shock proteins hsp 25 and alpha B crystallin in the absence of strew. J. Cell Biol. 120:631-645.
10. Kolotila, M. P., and R. D. Diamond. 1990. Effects of neutrophils and in vitro oxidants on survival and phenotypic switching of Candida albicans WO-1. Infect. Immun. 58:1174-1179.
11. Lee, K. L., H. R. Buckley, and C. C. Campbell. 1975. An amino acid liquid synthetic medium for development of mycelial and yeast forms of Candida albicans. Sabouraudia 13:148-153.
12. Lockhart, S., and D. R. Soll. Unpublished observations.
13. Mehlen, P., A. Mehlen, D. Guillet, X. Preville, and A. P. Arrigo. 1993. Tumor necrosis factor-alpha induces changes in the phosphorylation, cellular localization, and oligomerization of human hsp27. a stress protein that confers cellular resistance to this cytokinc. J. Cell. Biochem. 58:248-259.
14. Merck, K. B., P. J. Groenen, C. E. Voorter, W. A. de Haard-Hoekman, J. Horwitz, H. Bloemendal, and W. W. de Jong. 1993 Structural and functional similarities of bovine alpha-crystallin and mouse small heat-shock protein. A family of chaperones. J. Biol. Chem. 268:1046-1052.
15. Morrow, B., T. Ray, C. Payne, and D. R. Soll. Unpublished observations.
16. Morrow, B., T. Srikantha. J. Anderson, and D. R. Soll. 1993 Coordinate regulation of two opaque-specific genes during white-opaque switching in Candida albicans. Infect. Immun. 61:1823-1828.
17. Morrow, B., T. Srikantha, and D. R. Soll. 1992. Transcription of the gene for a pepsinogen. PEPI, is regulated by white-opaque switching in Candida albicans. Mol. Cell. Biol. 12:2997-3005.
18. Praekelt, U. M., and P. A. Meacock. 1990. HAP12, a new small heat shock gene of Sacchammyces cerevisiae: analysis of structure, regulation and function. Mol. Gen. Genet. 223:97-106.
19. Ray, T. L., and C. D. Payne. 1990. Candida albicans acid proteinase: a role in virulence, p. 163-178. In E. M. Ayoub, G. H Cassell. C. J. Branche, and T. J. Henry (ed.), Candida albicans acid proteinase: a role in virulence. American Society for Microbiology, Washington, D.C.
20. Rikkerink, E. H. A., B. B. Magee, and P. T. Magee. 1988. Opaque-white phenotype transition: a programmed morphological transition in Candida albicans. J. Bacleriol. 170:895-899.
21. Schröppel, K., T. Srikantha, M. DeCock, D. Wessels, S. Lockhart, and D. R. Soll. 1996. Cytoplasmic localization of the white phase-specific WH11 gene product of Candida albicans. Microbiology 142:2245-2254.
22. Sherman, F., G. R. Fink, and J. B. Hicks. 1986. laboratory course manual for methods in yeast genetics. Cold Spring Harbor laboratory. Cold Spring Harbor, N.Y.
23. Slutsky, B., M. Staebell, J. Anderson, L. Risen, M. Pfaller, and D. R. Soll. 1987. "White-opaque transition": a second high-frequency switching system in Candida albicans. J. Bacteriol. 169:189-197.
24. Soll, D. R. 1992. High frequency switching in Candida albicans. Clin. Microbiol. Rev. 5:183-203.
25. Soll, D. R. 1997. The emerging molecular biology of switching in Candida albicans. ASM News 62:415-420.
26. Soll, D. R. 1997. Gene regulation during high frequency switching in Candida albicans Microbiology 143:279-288.
27. Soll, D. R., J. Anderson, and M. Bergen. 1991. The developmental biology of the white-opaque transition in Candida albicans. p. 20-45. In R. Prasad (ed.), Candida albicans: cellular and molecular biology. Springer-Verlag. New York, N.Y.
28. Soll, D. R., T. Srikantha, A. Chandrasekhar, B. Morrow, K. Schroppel, and S. Lockhart. 1995. Gene regulation in the white-opaque transition of Candida albicans. Can. J. Bot. 73(Suppl.1):S1049-S1057.
29. Srikantha, T., A. Chandrasekhar, and D. R. Soll. 1995 Functional analysis of the promoter of the phase-specific WH11 gene of Candida albicans. Mol. Cell. Biol. 15:1797-1805.
30. Srikantha, T., A. Klupach, W. W. Loregg, L. K. Tsai, L. A. Laughlin, J. A. Gorman, and D. R. Soll. 1996. The sea pansey Renilla reniformis luciferase serves as a sensitive bioluminescent reporter for differential gene expression in Candida albicans. J. Bacteriol. 178:121-129.
31. Srikanlha, T., and D. R. Soll. 1993. A white-specific gene in the whiteopaque switching system of Candida albicans. Gene 131:.53-60.
32. Srikantha, T., L. Tsai, and D. R. Soll. 1997. The WH11 gene of Candida albicans is regulated in two distinct development programs through the same transcription activation domains. J. Bacteriol. 179:3837-3844.
33. Stone, R. L., B. B. Matarcse, P. T. Magee, and D. A. Bernlohr. 1990. Cloning, sequencing and chromosomal assignment of a gene from Saccharomyces cerevisiae which is negatively regulated by glucose and positively by lipids. Gene 96:171-176.
34. Sundstrom, P., D. Smith, and P. S. Sypherd. 1990. Sequence analysis and expression of the two genes for elongation factor 1 alpha from the dimorphic yeast Candida albicans. J. Bacteriol. 172:2036-2045.
35. Varela, J. C., U. M. Praekelt, P. A. Meacock, R. J. Planta, and W. H. Mager. 1995. The Saccharomyces cerevisiae HSP12 gene is activated by the highosmolarity glycerol pathway and negatively regulated by protein kinase A. Mol. Cell. Biol. 15:6232-6245.
36. White, T. C., S. H. Miyasaki, and N. Agabian. 1993 Three distinct secreted aspartyl proteinases in Candida alicans. J. Bacleriol. 175:6126-6133.