Discovery of a "White-Gray-Opaque" Tristable Phenotypic Switching System in Candida albicans: Roles of Non-genetic Diversity in Host Adaptation

PLoS Biology

Volumn 12, Issue 4, 2014, Pages

  Tao, Li ^a   Du, Han ^a   Guan, Guobo ^a   Dai, Yu ^a   Nobile, Clarissa J ^b   Liang, Weihong ^a,c   Cao, Chengjun ^a,c   Zhang, Qiuyu ^a,c   Zhong, Jin ^a   Huang, Guanghua ^a  

^a INSTITUTE OF MICROBIOLOGY   (China)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ASPARTIC PROTEINASE; CARBON DIOXIDE; N ACETYLGLUCOSAMINE; SECRETED ASPARTYL PROTEINASE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR EFG1; TRANSCRIPTION FACTOR WOR1; UNCLASSIFIED DRUG; DNA BINDING PROTEIN; EFG1 PROTEIN, CANDIDA ALBICANS; FUNGAL PROTEIN;

ADAPTATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANDIDA ALBICANS; CONTROLLED STUDY; EFG1 GENE; FEMALE; FUNGAL CELL; FUNGAL MATING TYPE GENE; FUNGAL STRUCTURES; FUNGAL VIRULENCE; GENE EXPRESSION; HOST PATHOGEN INTERACTION; INVASIVE CANDIDIASIS; MOUSE; NEWBORN; NONHUMAN; PATHOGEN LOAD; PHENOTYPIC VARIATION; REGULATOR GENE; SKIN CANDIDIASIS; TRANSCRIPTOMICS; WOR1 GENE; ANIMAL; BIOSYNTHESIS; CANDIDIASIS; GENE EXPRESSION REGULATION; GENETIC VARIABILITY; GENETICS; METABOLISM; PATHOGENICITY; PATHOLOGY; PHENOTYPE; PHYSIOLOGY;

ACETYLGLUCOSAMINE; ADAPTATION, PHYSIOLOGICAL; ANIMALS; ASPARTIC ACID PROTEASES; CANDIDA ALBICANS; CANDIDIASIS; CARBON DIOXIDE; DNA-BINDING PROTEINS; FUNGAL PROTEINS; GENE EXPRESSION REGULATION, FUNGAL; GENES, MATING TYPE, FUNGAL; GENETIC VARIATION; HOST-PATHOGEN INTERACTIONS; MICE; PHENOTYPE; TRANSCRIPTION FACTORS;

EID: 84900398729     PISSN: 15449173     EISSN: 15457885     Source Type: Journal    
DOI: 10.1371/journal.pbio.1001830     Document Type: Article

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