메뉴 건너뛰기




Volumn 13, Issue 8, 2015, Pages 497-508

A functional perspective on phenotypic heterogeneity in microorganisms

Author keywords

[No Author keywords available]

Indexed keywords

CELL DIVISION; CELL FUNCTION; CELL INTERACTION; DNA MODIFICATION; GENE AMPLIFICATION; GENE EXPRESSION; GENE REGULATORY NETWORK; GENETIC DIFFERENCE; GENETIC HETEROGENEITY; GENETIC VARIABILITY; GENOTYPE; MICROBIAL COMMUNITY; MICROBIAL DIVERSITY; MICROBIAL GENETICS; MICROENVIRONMENT; MICROORGANISM; MUTATION RATE; NATURAL SELECTION; NITROGEN FIXATION; NONHUMAN; PHENOTYPE; PHENOTYPIC VARIATION; PHOTOSYNTHESIS; POSITIVE FEEDBACK; PRIORITY JOURNAL; PROMOTER REGION; QUANTITATIVE ANALYSIS; REPORTER GENE; REVIEW; SIGNAL TRANSDUCTION; TYPE III SECRETION SYSTEM; ADAPTATION; BACTERIUM; CLASSIFICATION; ENVIRONMENT; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PHYSIOLOGY; STATISTICS;

EID: 84937251378     PISSN: 17401526     EISSN: 17401534     Source Type: Journal    
DOI: 10.1038/nrmicro3491     Document Type: Review
Times cited : (658)

References (127)
  • 1
    • 35349002270 scopus 로고    scopus 로고
    • Microbial diversity-productivity relationships in aquatic ecosystems
    • Smith, V. H. Microbial diversity-productivity relationships in aquatic ecosystems. FEMS Microbiol. Ecol. 62, 181-186 (2007).
    • (2007) FEMS Microbiol. Ecol. , vol.62 , pp. 181-186
    • Smith, V.H.1
  • 2
    • 50049126125 scopus 로고    scopus 로고
    • Resistance resilience, and redundancy in microbial communities
    • Allison, S. & Martiny, J. Resistance, resilience, and redundancy in microbial communities. Proc. Natl Acad. Sci. USA 105, 11512-11519 (2008).
    • (2008) Proc. Natl Acad. Sci. USA , vol.105 , pp. 11512-11519
    • Allison, S.1    Martiny, J.2
  • 3
    • 0037119587 scopus 로고    scopus 로고
    • Stochastic gene expression in a single cell
    • Elowitz, M. B., Levine, A. J., Siggia, E. D. & Swain, P. S. Stochastic gene expression in a single cell. Science 297, 1183-1186 (2002).
    • (2002) Science , vol.297 , pp. 1183-1186
    • Elowitz, M.B.1    Levine, A.J.2    Siggia, E.D.3    Swain, P.S.4
  • 5
    • 0031029852 scopus 로고    scopus 로고
    • Stochastic mechanisms in gene expression
    • McAdams, H. H. & Arkin, A. Stochastic mechanisms in gene expression. Proc. Natl Acad. Sci. USA 94, 814-819 (1997).
    • (1997) Proc. Natl Acad. Sci. USA , vol.94 , pp. 814-819
    • McAdams, H.H.1    Arkin, A.2
  • 6
    • 0001389945 scopus 로고
    • Enzyme induction as an all-or-none phenomenon
    • Novick, A. & Weiner, M. Enzyme induction as an all-or-none phenomenon. Proc. Natl Acad. Sci. USA 43, 553-566 (1957).
    • (1957) Proc. Natl Acad. Sci. USA , vol.43 , pp. 553-566
    • Novick, A.1    Weiner, M.2
  • 7
    • 53549123008 scopus 로고    scopus 로고
    • Nature nurture, or chance: Stochastic gene expression and its consequences
    • Raj, A. & van Oudenaarden, A. Nature, nurture, or chance: stochastic gene expression and its consequences. Cell 135, 216-226 (2008).
    • (2008) Cell , vol.135 , pp. 216-226
    • Raj, A.1    Van Oudenaarden, A.2
  • 9
    • 25444468618 scopus 로고    scopus 로고
    • Noise in gene expression: Origins, consequences, and control
    • Raser, J. M. & O'Shea, E. K. Noise in gene expression: origins, consequences, and control. Science 309, 2010-2013 (2005).
    • (2005) Science , vol.309 , pp. 2010-2013
    • Raser, J.M.1    O'Shea, E.K.2
  • 10
    • 19544379881 scopus 로고    scopus 로고
    • Stochasticity in gene expression: From theories to phenotypes
    • Kaern, M., Elston, T. C., Blake, W. J. & Collins, J. J. Stochasticity in gene expression: from theories to phenotypes. Nat. Rev. Genet. 6, 451-464 (2005).
    • (2005) Nat. Rev. Genet. , vol.6 , pp. 451-464
    • Kaern, M.1    Elston, T.C.2    Blake, W.J.3    Collins, J.J.4
  • 11
    • 33747174575 scopus 로고    scopus 로고
    • Microbial cell individuality and the underlying sources of heterogeneity
    • Avery, S. V. Microbial cell individuality and the underlying sources of heterogeneity. Nat. Rev. Microbiol. 4, 577-587 (2006).
    • (2006) Nat. Rev. Microbiol. , vol.4 , pp. 577-587
    • Avery, S.V.1
  • 12
    • 79952638264 scopus 로고    scopus 로고
    • Cellular decision making and biological noise: From microbes to mammals
    • Balázsi, G., van Oudenaarden, A. & Collins, J. J. Cellular decision making and biological noise: from microbes to mammals. Cell 144, 910-925 (2011).
    • (2011) Cell , vol.144 , pp. 910-925
    • Balázsi, G.1    Van Oudenaarden, A.2    Collins, J.J.3
  • 13
    • 77952474987 scopus 로고    scopus 로고
    • Cellular heterogeneity: Do differences make a difference?
    • Altschuler, S. J. & Wu, L. F. Cellular heterogeneity: do differences make a difference? Cell 141, 559-563 (2010).
    • (2010) Cell , vol.141 , pp. 559-563
    • Altschuler, S.J.1    Wu, L.F.2
  • 14
    • 84889256682 scopus 로고    scopus 로고
    • Functional roles of pulsing in genetic circuits
    • Levine, J. H., Lin, Y. & Elowitz, M. B. Functional roles of pulsing in genetic circuits. Science 342, 1193-1200 (2013).
    • (2013) Science , vol.342 , pp. 1193-1200
    • Levine, J.H.1    Lin, Y.2    Elowitz, M.B.3
  • 15
    • 33845616177 scopus 로고    scopus 로고
    • Phenotypic consequences of promoter-mediated transcriptional noise
    • Blake, W. J. et al. Phenotypic consequences of promoter-mediated transcriptional noise. Mol. Cell 24, 853-865 (2006).
    • (2006) Mol. Cell , vol.24 , pp. 853-865
    • Blake, W.J.1
  • 17
    • 79251603722 scopus 로고    scopus 로고
    • Non-genetic heterogeneity from stochastic partitioning at cell division
    • Huh, D. & Paulsson, J. Non-genetic heterogeneity from stochastic partitioning at cell division. Nat. Genet. 43, 95-100 (2011).
    • (2011) Nat. Genet. , vol.43 , pp. 95-100
    • Huh, D.1    Paulsson, J.2
  • 18
    • 0034787922 scopus 로고    scopus 로고
    • Playing Dr Jekyll and Mr Hyde: Combined mechanisms of phase variation in bacteria
    • Hallet, B. Playing Dr Jekyll and Mr Hyde: combined mechanisms of phase variation in bacteria. Curr. Opin. Microbiol. 4, 570-581 (2001).
    • (2001) Curr. Opin. Microbiol. , vol.4 , pp. 570-581
    • Hallet, B.1
  • 20
    • 58149147307 scopus 로고    scopus 로고
    • A simple screen to identify promoters conferring high levels of phenotypic noise
    • Freed, N. E. et al. A simple screen to identify promoters conferring high levels of phenotypic noise. PLoS Genet. 4, e1000307 (2008).
    • (2008) PLoS Genet. , vol.4 , pp. e1000307
    • Freed, N.E.1
  • 22
    • 33645073688 scopus 로고    scopus 로고
    • Phenotypic variation in bacteria: The role of feedback regulation
    • Smits, W. K., Kuipers, O. P. & Veening, J.-W. Phenotypic variation in bacteria: the role of feedback regulation. Nat. Rev. Microbiol. 4, 259-271 (2006).
    • (2006) Nat. Rev. Microbiol. , vol.4 , pp. 259-271
    • Smits, W.K.1    Kuipers, O.P.2    Veening, J.-W.3
  • 23
    • 79960396323 scopus 로고    scopus 로고
    • Temporal and spatial oscillations in bacteria
    • Lenz, P. & Søgaard-Andersen, L. Temporal and spatial oscillations in bacteria. Nat. Rev. Microbiol. 9, 565-577 (2011).
    • (2011) Nat. Rev. Microbiol. , vol.9 , pp. 565-577
    • Lenz, P.1    Søgaard-Andersen, L.2
  • 24
    • 56349129406 scopus 로고    scopus 로고
    • Polarity and differential inheritance-universal attributes of life?
    • Macara, I. G. & Mili, S. Polarity and differential inheritance-universal attributes of life? Cell 135, 801-812 (2008).
    • (2008) Cell , vol.135 , pp. 801-812
    • Macara, I.G.1    Mili, S.2
  • 25
    • 33751253408 scopus 로고    scopus 로고
    • Conditional and replicative senescence in Escherichia coli
    • Fredriksson, Å. & Nyström, T. Conditional and replicative senescence in Escherichia coli. Curr. Opin. Microbiol. 9, 612-618 (2006).
    • (2006) Curr. Opin. Microbiol. , vol.9 , pp. 612-618
    • Fredriksson Å.1    Nyström, T.2
  • 26
    • 84861544417 scopus 로고    scopus 로고
    • Bet hedging in yeast by heterogeneous, age-correlated expression of a stress protectant
    • Levy, S. F., Ziv, N. & Siegal, M. L. Bet hedging in yeast by heterogeneous, age-correlated expression of a stress protectant. PLoS Biol. 10, e1001325 (2012).
    • (2012) PLoS Biol. , vol.10 , pp. e1001325
    • Levy, S.F.1    Ziv, N.2    Siegal, M.L.3
  • 27
    • 84890061807 scopus 로고    scopus 로고
    • A super-assembly of Whi3 encodes memory of deceptive encounters by single cells during yeast courtship
    • Caudron, F. & Barral, Y. A super-assembly of Whi3 encodes memory of deceptive encounters by single cells during yeast courtship. Cell 155, 1244-1257 (2013).
    • (2013) Cell , vol.155 , pp. 1244-1257
    • Caudron, F.1    Barral, Y.2
  • 28
    • 80053586227 scopus 로고    scopus 로고
    • Pole age affects cell size and the timing of cell division in Methylobacterium extorquens AM1
    • Bergmiller, T. & Ackermann, M. Pole age affects cell size and the timing of cell division in Methylobacterium extorquens AM1. J. Bacteriol. 193, 5216-5221 (2011).
    • (2011) J. Bacteriol. , vol.193 , pp. 5216-5221
    • Bergmiller, T.1    Ackermann, M.2
  • 29
    • 84871859996 scopus 로고    scopus 로고
    • Dynamic persistence of antibiotic-stressed mycobacteria
    • Wakamoto, Y. et al. Dynamic persistence of antibiotic-stressed mycobacteria. Science 339, 91-95 (2013).
    • (2013) Science , vol.339 , pp. 91-95
    • Wakamoto, Y.1
  • 30
    • 81955167445 scopus 로고    scopus 로고
    • Macromotives and microbehaviors: The social dimension of bacterial phenotypic variability
    • Reuven, P. & Eldar, A. Macromotives and microbehaviors: the social dimension of bacterial phenotypic variability. Curr. Opin. Genet. Dev. 21, 759-767 (2011).
    • (2011) Curr. Opin. Genet. Dev. , vol.21 , pp. 759-767
    • Reuven, P.1    Eldar, A.2
  • 31
    • 70349466529 scopus 로고    scopus 로고
    • Population context determines cell-to-cell variability in endocytosis and virus infection
    • Snijder, B. et al. Population context determines cell-to-cell variability in endocytosis and virus infection. Nature 461, 520-523 (2009).
    • (2009) Nature , vol.461 , pp. 520-523
    • Snijder, B.1
  • 32
    • 27944442272 scopus 로고    scopus 로고
    • Quorum sensing: Cell-to-cell communication in bacteria
    • Waters, C. M. & Bassler, B. L. Quorum sensing: cell-to-cell communication in bacteria. Annu. Rev. Cell Dev. Biol. 21, 319-346 (2005).
    • (2005) Annu. Rev. Cell Dev. Biol. , vol.21 , pp. 319-346
    • Waters, C.M.1    Bassler, B.L.2
  • 33
    • 63749115349 scopus 로고    scopus 로고
    • Bacterial landlines: Contact-dependent signaling in bacterial populations
    • Blango, M. G. & Mulvey, M. A. Bacterial landlines: contact-dependent signaling in bacterial populations. Curr. Opin. Microbiol. 12, 177-181 (2009).
    • (2009) Curr. Opin. Microbiol. , vol.12 , pp. 177-181
    • Blango, M.G.1    Mulvey, M.A.2
  • 34
    • 80052809114 scopus 로고    scopus 로고
    • Varying virulence: Epigenetic control of expression noise and disease processes
    • Miller-Jensen, K., Dey, S. S., Schaffer, D. V. & Arkin, A. P. Varying virulence: epigenetic control of expression noise and disease processes. Trends Biotechnol. 29, 517-525 (2011).
    • (2011) Trends Biotechnol. , vol.29 , pp. 517-525
    • Miller-Jensen, K.1    Dey, S.S.2    Schaffer, D.V.3    Arkin, A.P.4
  • 35
    • 78951470515 scopus 로고    scopus 로고
    • Origins of regulated cell-to-cell variability
    • Snijder, B. & Pelkmans, L. Origins of regulated cell-to-cell variability. Nat. Rev. Mol. Cell. Biol. 12, 119-125 (2011).
    • (2011) Nat. Rev. Mol. Cell. Biol. , vol.12 , pp. 119-125
    • Snijder, B.1    Pelkmans, L.2
  • 36
    • 77955608576 scopus 로고    scopus 로고
    • Individual histories and selection in heterogeneous populations
    • Leibler, S. & Kussell, E. Individual histories and selection in heterogeneous populations. Proc. Natl Acad. Sci. USA 107, 13183-13188 (2010).
    • (2010) Proc. Natl Acad. Sci. USA , vol.107 , pp. 13183-13188
    • Leibler, S.1    Kussell, E.2
  • 37
    • 84888645996 scopus 로고    scopus 로고
    • Memory and modularity in cell-fate decision making
    • Norman, T. M., Lord, N. D., Paulsson, J. & Losick, R. Memory and modularity in cell-fate decision making. Nature 503, 481-486 (2013).
    • (2013) Nature , vol.503 , pp. 481-486
    • Norman, T.M.1    Lord, N.D.2    Paulsson, J.3    Losick, R.4
  • 38
    • 84937252653 scopus 로고    scopus 로고
    • (eds Rose, M. R. & Lauder, G. V) Academic
    • Amundson, R. in Adaptation (eds Rose, M. R. & Lauder, G. V) 11-53 (Academic, 1996).
    • (1996) Adaptation , pp. 11-53
    • Amundson, R.1
  • 40
    • 84908023311 scopus 로고    scopus 로고
    • Bistable expression of virulence genes in Salmonella leads to the formation of an antibiotic-tolerant subpopulation
    • Arnoldini, M. et al. Bistable expression of virulence genes in Salmonella leads to the formation of an antibiotic-tolerant subpopulation. PLoS Biol. 12, e1001928 (2014).
    • (2014) PLoS Biol. , vol.12 , pp. e1001928
    • Arnoldini, M.1
  • 41
    • 50049132233 scopus 로고    scopus 로고
    • Self-destructive cooperation mediated by phenotypic noise
    • Ackermann, M. et al. Self-destructive cooperation mediated by phenotypic noise. Nature 454, 987-990 (2008).
    • (2008) Nature , vol.454 , pp. 987-990
    • Ackermann, M.1
  • 42
    • 14744282987 scopus 로고    scopus 로고
    • Diversity in times of adversity: Probabilistic strategies in microbial survival games
    • Wolf, D. M., Vazirani, V. V. & Arkin, A. P. Diversity in times of adversity: probabilistic strategies in microbial survival games. J. Theor. Biol. 234, 227-253 (2005).
    • (2005) J. Theor. Biol. , vol.234 , pp. 227-253
    • Wolf, D.M.1    Vazirani, V.V.2    Arkin, A.P.3
  • 43
    • 2942555282 scopus 로고    scopus 로고
    • Stochastic gene expression in fluctuating environments
    • Thattai, M. & van Oudenaarden, A. Stochastic gene expression in fluctuating environments. Genetics 530, 523-530 (2004).
    • (2004) Genetics , vol.530 , pp. 523-530
    • Thattai, M.1    Van Oudenaarden, A.2
  • 44
    • 41349119880 scopus 로고    scopus 로고
    • Stochastic switching as a survival strategy in fluctuating environments
    • Acar, M., Mettetal, J. T. & van Oudenaarden, A. Stochastic switching as a survival strategy in fluctuating environments. Nat. Genet. 40, 471-475 (2008).
    • (2008) Nat. Genet. , vol.40 , pp. 471-475
    • Acar, M.1    Mettetal, J.T.2    Van Oudenaarden, A.3
  • 45
    • 25444489027 scopus 로고    scopus 로고
    • Phenotypic diversity, population growth, and information in fluctuating environments
    • Kussell, E. & Leibler, S. Phenotypic diversity, population growth, and information in fluctuating environments. Science 309, 2075-2078 (2005).
    • (2005) Science , vol.309 , pp. 2075-2078
    • Kussell, E.1    Leibler, S.2
  • 46
    • 71449096836 scopus 로고    scopus 로고
    • Strategies for cellular decision-making
    • Perkins, T. J. & Swain, P. S. Strategies for cellular decision-making. Mol. Syst. Biol. 5, 326 (2009).
    • (2009) Mol. Syst. Biol. , vol.5 , pp. 326
    • Perkins, T.J.1    Swain, P.S.2
  • 47
    • 84931864666 scopus 로고    scopus 로고
    • Adaptability of non-genetic diversity in bacterial chemotaxis
    • Frankel, N. W. et al. Adaptability of non-genetic diversity in bacterial chemotaxis. eLife 3, e03526 (2014).
    • (2014) ELife , vol.3 , pp. e03526
    • Frankel, N.W.1
  • 48
    • 54249117585 scopus 로고    scopus 로고
    • Adaptive response of a gene network to environmental changes by fitness-induced attractor selection
    • Kashiwagi, A., Urabe, I., Kaneko, K. & Yomo, T. Adaptive response of a gene network to environmental changes by fitness-induced attractor selection. PLoS ONE 1, e49 (2006).
    • (2006) PLoS ONE , vol.1 , pp. e49
    • Kashiwagi, A.1    Urabe, I.2    Kaneko, K.3    Yomo, T.4
  • 49
    • 0024928639 scopus 로고
    • Hedging one's evolutionary bets, revisited
    • Philippi, T. & Seger, J. Hedging one's evolutionary bets, revisited. Trends Ecol. Evol. 4, 2-5 (1989).
    • (1989) Trends Ecol. Evol. , vol.4 , pp. 2-5
    • Philippi, T.1    Seger, J.2
  • 50
    • 84905395314 scopus 로고    scopus 로고
    • Phenotypic bistability in Escherichia coli's central carbon metabolism
    • Kotte, O., Volkmer, B., Radzikowski, J. L. & Heinemann, M. Phenotypic bistability in Escherichia coli's central carbon metabolism. Mol. Syst. Biol. 10, 736 (2014).
    • (2014) Mol. Syst. Biol. , vol.10 , pp. 736
    • Kotte, O.1    Volkmer, B.2    Radzikowski, J.L.3    Heinemann, M.4
  • 51
    • 77955452979 scopus 로고    scopus 로고
    • Regulation of phenotypic variability by a threshold-based mechanism underlies bacterial persistence
    • Rotem, E. et al. Regulation of phenotypic variability by a threshold-based mechanism underlies bacterial persistence. Proc. Natl Acad. Sci. USA 107, 12541-12546 (2010).
    • (2010) Proc. Natl Acad. Sci. USA , vol.107 , pp. 12541-12546
    • Rotem, E.1
  • 52
    • 77952417100 scopus 로고    scopus 로고
    • Broadly heterogeneous activation of the master regulator for sporulation in Bacillus subtilis
    • Chastanet, A. et al. Broadly heterogeneous activation of the master regulator for sporulation in Bacillus subtilis. Proc. Natl Acad. Sci. USA 107, 8486-8491 (2010).
    • (2010) Proc. Natl Acad. Sci. USA , vol.107 , pp. 8486-8491
    • Chastanet, A.1
  • 53
    • 34547604468 scopus 로고    scopus 로고
    • Noise in gene expression determines cell fate in Bacillus subtilis
    • Maamar, H., Raj, A. & Dubnau, D. Noise in gene expression determines cell fate in Bacillus subtilis. Science 317, 526-529 (2007).
    • (2007) Science , vol.317 , pp. 526-529
    • Maamar, H.1    Raj, A.2    Dubnau, D.3
  • 54
    • 84855493990 scopus 로고    scopus 로고
    • Regulation of phenotypic heterogeneity permits Salmonella evasion of the host caspase-1 inflammatory response
    • Stewart, M. K., Cummings, L. A., Johnson, M. L., Berezow, A. B. & Cookson, B. T. Regulation of phenotypic heterogeneity permits Salmonella evasion of the host caspase-1 inflammatory response. Proc. Natl Acad. Sci. USA 108, 20742-20747 (2011).
    • (2011) Proc. Natl Acad. Sci. USA , vol.108 , pp. 20742-20747
    • Stewart, M.K.1    Cummings, L.A.2    Johnson, M.L.3    Berezow, A.B.4    Cookson, B.T.5
  • 55
    • 85028142271 scopus 로고    scopus 로고
    • Phenotypic heterogeneity is a selected trait in natural yeast populations subject to environmental stress
    • Holland, S. L., Reader, T., Dyer, P. S. & Avery, S. V. Phenotypic heterogeneity is a selected trait in natural yeast populations subject to environmental stress. Environ. Microbiol. 16, 1729-1740 (2014).
    • (2014) Environ. Microbiol. , vol.16 , pp. 1729-1740
    • Holland, S.L.1    Reader, T.2    Dyer, P.S.3    Avery, S.V.4
  • 56
    • 84901049716 scopus 로고    scopus 로고
    • Bet-hedging during bacterial diauxic shift
    • Solopova, A. et al. Bet-hedging during bacterial diauxic shift. Proc. Natl Acad. Sci. USA 111, 7427-7432 (2014).
    • (2014) Proc. Natl Acad. Sci. USA , vol.111 , pp. 7427-7432
    • Solopova, A.1
  • 57
    • 84897627707 scopus 로고    scopus 로고
    • Lost in transition: Start-up of glycolysis yields subpopulations of nongrowing cells
    • Van Heerden, J. H. et al. Lost in transition: start-up of glycolysis yields subpopulations of nongrowing cells. Science 343, 1245114 (2014).
    • (2014) Science , vol.343 , pp. 1245114
    • Van Heerden, J.H.1
  • 58
    • 84893765873 scopus 로고    scopus 로고
    • Different levels of catabolite repression optimize growth in stable and variable environments
    • New, A. M. et al. Different levels of catabolite repression optimize growth in stable and variable environments. PLoS Biol. 12, e1001764 (2014).
    • (2014) PLoS Biol. , vol.12 , pp. e1001764
    • New, A.M.1
  • 60
    • 47649125318 scopus 로고    scopus 로고
    • Tuning gene expression to changing environments: From ra pid responses to evolutionary adaptation
    • López-Maury, L., Marguerat, S. & Bähler, J. Tuning gene expression to changing environments: from ra pid responses to evolutionary adaptation. Nat. Rev. Genet. 9, 583-593 (2008).
    • (2008) Nat. Rev. Genet. , vol.9 , pp. 583-593
    • López-Maury, L.1    Marguerat, S.2    Bähler, J.3
  • 61
    • 84876492379 scopus 로고    scopus 로고
    • Microbial individuality in the natural environment
    • Ackermann, M. Microbial individuality in the natural environment. ISME J. 7, 465-467 (2013).
    • (2013) ISME J. , vol.7 , pp. 465-467
    • Ackermann, M.1
  • 62
    • 42149139936 scopus 로고    scopus 로고
    • Transient heterogeneity in extracellular protease production by Bacillus subtilis
    • Veening, J.-W. et al. Transient heterogeneity in extracellular protease production by Bacillus subtilis. Mol. Syst. Biol. 4, 184 (2008).
    • (2008) Mol. Syst. Biol. , vol.4 , pp. 184
    • Veening, J.-W.1
  • 63
    • 2142854105 scopus 로고    scopus 로고
    • Single-copy green fluorescent protein gene fusions allow accurate measurement of Salmonella gene expression in vitro and during infection of mammalian cells
    • Hautefort, I., Proença, M. J., Hinton, J. C. D. & Jose, M. Single-copy green fluorescent protein gene fusions allow accurate measurement of Salmonella gene expression in vitro and during infection of mammalian cells. Appl. Environ. Microbiol. 69, 7480-7491 (2003).
    • (2003) Appl. Environ. Microbiol. , vol.69 , pp. 7480-7491
    • Hautefort, I.1    Proença, M.J.2    Hinton, J.C.D.3    Jose, M.4
  • 64
    • 35649026345 scopus 로고    scopus 로고
    • Salmonella enterica serovar Typhimurium exploits inflammation to compete with the intestinal microbiota
    • Stecher, B. et al. Salmonella enterica serovar Typhimurium exploits inflammation to compete with the intestinal microbiota. PLoS Biol. 5, 2177-2189 (2007).
    • (2007) PLoS Biol. , vol.5 , pp. 2177-2189
    • Stecher, B.1
  • 65
    • 0033647149 scopus 로고    scopus 로고
    • Heterocyst formation in cyanobacteria
    • Adams, D. G. Heterocyst formation in cyanobacteria. Curr. Opin. Microbiol. 3, 618-624 (2000).
    • (2000) Curr. Opin. Microbiol. , vol.3 , pp. 618-624
    • Adams, D.G.1
  • 67
    • 84867746452 scopus 로고    scopus 로고
    • Metabolic specialization and the assembly of microbial communities
    • Johnson, D. R., Goldschmidt, F., Lilja, E. E. & Ackermann, M. Metabolic specialization and the assembly of microbial communities. ISME J. 6, 1985-1991 (2012).
    • (2012) ISME J. , vol.6 , pp. 1985-1991
    • Johnson, D.R.1    Goldschmidt, F.2    Lilja, E.E.3    Ackermann, M.4
  • 68
    • 84934300609 scopus 로고    scopus 로고
    • Chemical reactivity drives spatiotemporal organization of bacterial metabolism
    • De Lorenzo, V., Sekowska, A. & Danchin, A. Chemical reactivity drives spatiotemporal organization of bacterial metabolism. FEMS Microbiol. Rev. 39, 96-119 (2014).
    • (2014) FEMS Microbiol. Rev. , vol.39 , pp. 96-119
    • De Lorenzo, V.1    Sekowska, A.2    Danchin, A.3
  • 69
    • 0036096415 scopus 로고    scopus 로고
    • Bacteriophage control of Shiga toxin 1 production and release by Escherichia coli
    • Wagner, P. L. et al. Bacteriophage control of Shiga toxin 1 production and release by Escherichia coli. Mol. Microbiol. 44, 957-970 (2002).
    • (2002) Mol. Microbiol. , vol.44 , pp. 957-970
    • Wagner, P.L.1
  • 70
    • 17444366186 scopus 로고    scopus 로고
    • Clostridium difficile toxins: Mechanism of action and role in disease
    • Voth, D. E. & Ballard, J. D. Clostridium difficile toxins: mechanism of action and role in disease. Clin. Microbiol. Rev. 18, 247-263 (2005).
    • (2005) Clin. Microbiol. Rev. , vol.18 , pp. 247-263
    • Voth, D.E.1    Ballard, J.D.2
  • 72
    • 79953708539 scopus 로고    scopus 로고
    • A novel mechanism of programmed cell death in bacteria by toxin-antitoxin systems corrupts peptidoglycan synthesis
    • Mutschler, H., Gebhardt, M., Shoeman, R. L. & Meinhart, A. A novel mechanism of programmed cell death in bacteria by toxin-antitoxin systems corrupts peptidoglycan synthesis. PLoS Biol. 9, e1001033 (2011).
    • (2011) PLoS Biol. , vol.9 , pp. e1001033
    • Mutschler, H.1    Gebhardt, M.2    Shoeman, R.L.3    Meinhart, A.4
  • 73
    • 79960941334 scopus 로고    scopus 로고
    • The cost of virulence: Retarded growth of Salmonella Typhimurium cells expressing type III secretion system 1
    • Sturm, A. et al. The cost of virulence: retarded growth of Salmonella Typhimurium cells expressing type III secretion system 1. PLoS Pathog. 7, e1002143 (2011).
    • (2011) PLoS Pathog. , vol.7 , pp. e1002143
    • Sturm, A.1
  • 74
    • 84876403132 scopus 로고    scopus 로고
    • Going local: Technologies for exploring bacterial microenvironments
    • Wessel, A. K., Hmelo, L., Parsek, M. R. & Whiteley, M. Going local: technologies for exploring bacterial microenvironments. Nat. Rev. Microbiol. 11, 337-348 (2013).
    • (2013) Nat. Rev. Microbiol. , vol.11 , pp. 337-348
    • Wessel, A.K.1    Hmelo, L.2    Parsek, M.R.3    Whiteley, M.4
  • 75
    • 0026613691 scopus 로고
    • Evolutionary games and spatial chaos
    • Nowak, M. A. & May, R. M. Evolutionary games and spatial chaos. Nature 359, 826-829 (1992).
    • (1992) Nature , vol.359 , pp. 826-829
    • Nowak, M.A.1    May, R.M.2
  • 76
    • 0038347102 scopus 로고    scopus 로고
    • Social strife in the microbial world
    • Velicer, G. J. Social strife in the microbial world. Trends Microbiol. 11, 330-337 (2003).
    • (2003) Trends Microbiol. , vol.11 , pp. 330-337
    • Velicer, G.J.1
  • 77
    • 84874126703 scopus 로고    scopus 로고
    • Stabilization of cooperative virulence by the expression of an avirulent phenotype
    • Diard, M. et al. Stabilization of cooperative virulence by the expression of an avirulent phenotype. Nature 494, 353-356 (2013).
    • (2013) Nature , vol.494 , pp. 353-356
    • Diard, M.1
  • 78
    • 0035313866 scopus 로고    scopus 로고
    • The evolution of social behavior in microorganisms
    • Crespi, B. J. The evolution of social behavior in microorganisms. Trends Ecol. Evol. 16, 178-183 (2001).
    • (2001) Trends Ecol. Evol. , vol.16 , pp. 178-183
    • Crespi, B.J.1
  • 80
    • 84871620014 scopus 로고    scopus 로고
    • Cellular cooperation: Insights from microbes
    • Celiker, H. & Gore, J. Cellular cooperation: insights from microbes. Trends Cell Biol. 23, 9-15 (2013).
    • (2013) Trends Cell Biol. , vol.23 , pp. 9-15
    • Celiker, H.1    Gore, J.2
  • 81
    • 0013770258 scopus 로고
    • The genetical evolution of social behaviour. i
    • Hamilton, W. D. The genetical evolution of social behaviour. I. J. Theor. Biol. 7, 1-16 (1964).
    • (1964) J. Theor. Biol. , vol.7 , pp. 1-16
    • Hamilton, W.D.1
  • 82
    • 39149100341 scopus 로고    scopus 로고
    • Physiological heterogeneity in biofilms
    • Stewart, P. S. & Franklin, M. J. Physiological heterogeneity in biofilms. Nat. Rev. Microbiol. 6, 199-210 (2008).
    • (2008) Nat. Rev. Microbiol. , vol.6 , pp. 199-210
    • Stewart, P.S.1    Franklin, M.J.2
  • 83
    • 37349100857 scopus 로고    scopus 로고
    • Bistability and biofilm formation in Bacillus subtilis
    • Chai, Y., Chu, F., Kolter, R. & Losick, R. Bistability and biofilm formation in Bacillus subtilis. Mol. Microbiol. 67, 254-263 (2008).
    • (2008) Mol. Microbiol. , vol.67 , pp. 254-263
    • Chai, Y.1    Chu, F.2    Kolter, R.3    Losick, R.4
  • 84
    • 0035487318 scopus 로고    scopus 로고
    • Counting the uncountable: Statistical approaches to estimating microbial diversity
    • Hughes, J. B., Hellmann, J. J., Ricketts, T. H. & Bohannan, B. J. M. Counting the uncountable: statistical approaches to estimating microbial diversity. Appl. Environ. Microbiol. 67, 4399-4406 (2001).
    • (2001) Appl. Environ. Microbiol. , vol.67 , pp. 4399-4406
    • Hughes, J.B.1    Hellmann, J.J.2    Ricketts, T.H.3    Bohannan, B.J.M.4
  • 85
    • 84868238641 scopus 로고    scopus 로고
    • Marine microbes see a sea of gradients
    • Stocker, R. Marine microbes see a sea of gradients. Science 338, 628-633 (2012).
    • (2012) Science , vol.338 , pp. 628-633
    • Stocker, R.1
  • 86
    • 0033855648 scopus 로고    scopus 로고
    • Ecosystem response of pasture soil communities to fumigation-induced microbial diversity reductions: An examination of the biodiversity-ecosystem function relationship
    • Griffiths, B. S. et al. Ecosystem response of pasture soil communities to fumigation-induced microbial diversity reductions: an examination of the biodiversity-ecosystem function relationship. Oikos 2, 279-294 (2000).
    • (2000) Oikos , vol.2 , pp. 279-294
    • Griffiths, B.S.1
  • 87
    • 33947431625 scopus 로고    scopus 로고
    • Heterogeneity in expression of the Escherichia coli colicin K activity gene cka is controlled by the SOS system and stochastic factors
    • Mrak, P., Podlesek, Z., van Putten, J. P. M. & Zgur-Bertok, D. Heterogeneity in expression of the Escherichia coli colicin K activity gene cka is controlled by the SOS system and stochastic factors. Mol. Genet. Genom. 277, 391-401 (2007).
    • (2007) Mol. Genet. Genom. , vol.277 , pp. 391-401
    • Mrak, P.1    Podlesek, Z.2    Van Putten, J.P.M.3    Zgur-Bertok, D.4
  • 88
    • 84896710626 scopus 로고    scopus 로고
    • The private life of environmental bacteria: Pollutant biodegradation at the single cell level
    • Nikel, P. I., Silva-Rocha, R., Benedetti, I. & de Lorenzo, V. The private life of environmental bacteria: pollutant biodegradation at the single cell level. Environ. Microbiol. 16, 628-642 (2014).
    • (2014) Environ. Microbiol. , vol.16 , pp. 628-642
    • Nikel, P.I.1    Silva-Rocha, R.2    Benedetti, I.3    De Lorenzo, V.4
  • 89
    • 43249103636 scopus 로고    scopus 로고
    • Cell-to-cell stochastic variation in gene expression is a complex genetic trait
    • Ansel, J. et al. Cell-to-cell stochastic variation in gene expression is a complex genetic trait. PLoS Genet. 4, e1000049 (2008).
    • (2008) PLoS Genet. , vol.4 , pp. e1000049
    • Ansel, J.1
  • 90
    • 84893011273 scopus 로고    scopus 로고
    • Natural sequence variants of yeast environmental sensors confer cell-to-cell expression variability
    • Fehrmann, S. et al. Natural sequence variants of yeast environmental sensors confer cell-to-cell expression variability. Mol. Syst. Biol. 9, 695 (2013).
    • (2013) Mol. Syst. Biol. , vol.9 , pp. 695
    • Fehrmann, S.1
  • 91
    • 84879833353 scopus 로고    scopus 로고
    • Single-cell phenomics reveals intra-species variation of phenotypic noise in yeast
    • Yvert, G. et al. Single-cell phenomics reveals intra-species variation of phenotypic noise in yeast. BMC Syst. Biol. 7, 54 (2013).
    • (2013) BMC Syst. Biol. , vol.7 , pp. 54
    • Yvert, G.1
  • 92
    • 33745220278 scopus 로고    scopus 로고
    • Single-cell proteomic analysis of S. Cerevisiae reveals the architecture of biological noise
    • Newman, J. R. S. et al. Single-cell proteomic analysis of S. cerevisiae reveals the architecture of biological noise. Nature 441, 840-846 (2006).
    • (2006) Nature , vol.441 , pp. 840-846
    • Newman, J.R.S.1
  • 93
    • 33745287724 scopus 로고    scopus 로고
    • Noise in protein expression scales with natural protein abundance
    • Bar-Even, A. et al. Noise in protein expression scales with natural protein abundance. Nat. Genet. 38, 636-643 (2006).
    • (2006) Nat. Genet. , vol.38 , pp. 636-643
    • Bar-Even, A.1
  • 94
    • 84857480997 scopus 로고    scopus 로고
    • A genome-wide analysis of promoter-mediated phenotypic noise in Escherichia coli
    • Silander, O. K. et al. A genome-wide analysis of promoter-mediated phenotypic noise in Escherichia coli. PLoS Genet. 8, e1002443 (2012).
    • (2012) PLoS Genet. , vol.8 , pp. e1002443
    • Silander, O.K.1
  • 95
    • 77955102352 scopus 로고    scopus 로고
    • Quantifying E. Coli proteome and transcriptome with single-molecule sensitivity in single cells
    • Taniguchi, Y. et al. Quantifying E. coli proteome and transcriptome with single-molecule sensitivity in single cells. Science 329, 533-538 (2010).
    • (2010) Science , vol.329 , pp. 533-538
    • Taniguchi, Y.1
  • 96
    • 42949131308 scopus 로고    scopus 로고
    • Selection to minimise noise in living systems and its implications for the evolution of gene expression
    • Lehner, B. Selection to minimise noise in living systems and its implications for the evolution of gene expression. Mol. Syst. Biol. 4, 170 (2008).
    • (2008) Mol. Syst. Biol. , vol.4 , pp. 170
    • Lehner, B.1
  • 97
    • 79955613183 scopus 로고    scopus 로고
    • Impact of gene expression noise on organismal fitness and the efficacy of natural selection
    • Wang, Z. & Zhang, J. Impact of gene expression noise on organismal fitness and the efficacy of natural selection. Proc. Natl Acad. Sci. USA 108, E67-E76 (2011).
    • (2011) Proc. Natl Acad. Sci. USA , vol.108 , pp. E67-E76
    • Wang, Z.1    Zhang, J.2
  • 98
    • 0034212551 scopus 로고    scopus 로고
    • Engineering stability in gene networks by autoregulation
    • Becskei, A. & Serrano, L. Engineering stability in gene networks by autoregulation. Nature 405, 590-593 (2000).
    • (2000) Nature , vol.405 , pp. 590-593
    • Becskei, A.1    Serrano, L.2
  • 99
    • 78649708844 scopus 로고    scopus 로고
    • Conflict between noise and plasticity in yeast
    • Lehner, B. Conflict between noise and plasticity in yeast. PLoS Genet. 6, e1001185 (2010).
    • (2010) PLoS Genet. , vol.6 , pp. e1001185
    • Lehner, B.1
  • 100
    • 0017185026 scopus 로고
    • Non-genetic individuality: Chance in the single cell
    • Spudich, J. & Koshland, D. E. Jr. Non-genetic individuality: chance in the single cell. Nature 262, 467-471 (1976).
    • (1976) Nature , vol.262 , pp. 467-471
    • Spudich, J.1    Koshland, D.E.2
  • 101
    • 64749116742 scopus 로고    scopus 로고
    • Using movies to analyse gene circuit dynamics in single cells
    • Locke, J. C. W. & Elowitz, M. B. Using movies to analyse gene circuit dynamics in single cells. Nat. Rev. Microbiol. 7, 383-392 (2009).
    • (2009) Nat. Rev. Microbiol. , vol.7 , pp. 383-392
    • Locke, J.C.W.1    Elowitz, M.B.2
  • 102
    • 15544388848 scopus 로고    scopus 로고
    • Noise propagation in gene networks
    • Pedraza, J. M. & van Oudenaarden, A. Noise propagation in gene networks. Science 307, 1965-1969 (2005).
    • (2005) Science , vol.307 , pp. 1965-1969
    • Pedraza, J.M.1    Van Oudenaarden, A.2
  • 103
    • 72849114230 scopus 로고    scopus 로고
    • Prokaryotic transcriptomics: A new view on regulation, physiology and pathogenicity
    • Sorek, R. & Cossart, P. Prokaryotic transcriptomics: a new view on regulation, physiology and pathogenicity. Nat. Rev. Genet. 11, 9-16 (2010).
    • (2010) Nat. Rev. Genet. , vol.11 , pp. 9-16
    • Sorek, R.1    Cossart, P.2
  • 105
    • 4644226321 scopus 로고    scopus 로고
    • Simultaneous fluorescence in situ hybridization of mRNA and rRNA in environmental bacteria
    • Pernthaler, A. & Amann, R. Simultaneous fluorescence in situ hybridization of mRNA and rRNA in environmental bacteria. Appl. Environ. Microbiol. 70, 5426-5433 (2004).
    • (2004) Appl. Environ. Microbiol. , vol.70 , pp. 5426-5433
    • Pernthaler, A.1    Amann, R.2
  • 106
    • 84905395119 scopus 로고    scopus 로고
    • In situ visualization of newly synthesized proteins in environmental microbes using amino acid tagging and click chemistry
    • Hatzenpichler, R. et al. In situ visualization of newly synthesized proteins in environmental microbes using amino acid tagging and click chemistry. Environ. Microbiol. 16, 2568-2590 (2014).
    • (2014) Environ. Microbiol. , vol.16 , pp. 2568-2590
    • Hatzenpichler, R.1
  • 107
    • 70349531263 scopus 로고    scopus 로고
    • Single-cell ecophysiology of microbes as revealed by Raman microspectroscopy or secondary ion mass spectrometry imaging
    • Wagner, M. Single-cell ecophysiology of microbes as revealed by Raman microspectroscopy or secondary ion mass spectrometry imaging. Annu. Rev. Microbiol. 63, 411-429 (2009).
    • (2009) Annu. Rev. Microbiol. , vol.63 , pp. 411-429
    • Wagner, M.1
  • 108
    • 84856716159 scopus 로고    scopus 로고
    • Detecting metabolic activities in single cells, with emphasis on nanoSIMS
    • Musat, N., Foster, R., Vagner, T., Adam, B. & Kuypers, M. M. M. Detecting metabolic activities in single cells, with emphasis on nanoSIMS. FEMS Microbiol. Rev. 36, 486-511 (2012).
    • (2012) FEMS Microbiol. Rev. , vol.36 , pp. 486-511
    • Musat, N.1    Foster, R.2    Vagner, T.3    Adam, B.4    Kuypers, M.M.M.5
  • 109
    • 0035919654 scopus 로고    scopus 로고
    • Methane-consuming archaea revealed by directly coupled isotopic and phylogenetic analysis
    • Orphan, V. J., House, C. H., Hinrichs, K. U., McKeegan, K. D. & DeLong, E. F. Methane-consuming archaea revealed by directly coupled isotopic and phylogenetic analysis. Science 293, 484-487 (2001).
    • (2001) Science , vol.293 , pp. 484-487
    • Orphan, V.J.1    House, C.H.2    Hinrichs, K.U.3    McKeegan, K.D.4    Delong, E.F.5
  • 110
    • 56649097491 scopus 로고    scopus 로고
    • A single-cell view on the ecophysiology of anaerobic phototrophic bacteria
    • Musat, N. et al. A single-cell view on the ecophysiology of anaerobic phototrophic bacteria. Proc. Natl Acad. Sci. USA 105, 17861-17866 (2008).
    • (2008) Proc. Natl Acad. Sci. USA , vol.105 , pp. 17861-17866
    • Musat, N.1
  • 111
    • 84927158514 scopus 로고    scopus 로고
    • Phenotypic heterogeneity in metabolic traits among single cells of a rare bacterial species in its natural environment quantified with a combination of flow cell sorting and NanoSIMS
    • Zimmermann, M. et al. Phenotypic heterogeneity in metabolic traits among single cells of a rare bacterial species in its natural environment quantified with a combination of flow cell sorting and NanoSIMS. Front. Microbiol. 6, 243 (2015).
    • (2015) Front. Microbiol. , vol.6 , pp. 243
    • Zimmermann, M.1
  • 112
    • 0037180507 scopus 로고    scopus 로고
    • Cultivating the uncultured
    • Elkins, J. et al. Cultivating the uncultured. Proc. Natl Acad. Sci. USA 99, 15681-15686 (2002).
    • (2002) Proc. Natl Acad. Sci. USA , vol.99 , pp. 15681-15686
    • Elkins, J.1
  • 113
    • 76349122940 scopus 로고    scopus 로고
    • Linking environmental heterogeneity and reproductive success at single-cell resolution
    • Remus-Emsermann, M. N. P. & Leveau, J. H. J. Linking environmental heterogeneity and reproductive success at single-cell resolution. ISME J. 4, 215-222 (2010).
    • (2010) ISME J. , vol.4 , pp. 215-222
    • Remus-Emsermann, M.N.P.1    Leveau, J.H.J.2
  • 114
    • 77956415336 scopus 로고    scopus 로고
    • Emergent cooperation in microbial metabolism
    • Wintermute, E. H. & Silver, P. A. Emergent cooperation in microbial metabolism. Mol. Syst. Biol. 6, 407 (2010).
    • (2010) Mol. Syst. Biol. , vol.6 , pp. 407
    • Wintermute, E.H.1    Silver, P.A.2
  • 115
    • 84899480571 scopus 로고    scopus 로고
    • Fitness and stability of obligate cross-feeding interactions that emerge upon gene loss in bacteria
    • Pande, S. et al. Fitness and stability of obligate cross-feeding interactions that emerge upon gene loss in bacteria. ISME J. 8, 953-962 (2014).
    • (2014) ISME J. , vol.8 , pp. 953-962
    • Pande, S.1
  • 117
    • 84855246842 scopus 로고    scopus 로고
    • Synthetic Escherichia coli consortia engineered for syntrophy demonstrate enhanced biomass productivity
    • Bernstein, H. C., Paulson, S. D. & Carlson, R. P. Synthetic Escherichia coli consortia engineered for syntrophy demonstrate enhanced biomass productivity. J. Biotechnol. 157, 159-166 (2012).
    • (2012) J. Biotechnol. , vol.157 , pp. 159-166
    • Bernstein, H.C.1    Paulson, S.D.2    Carlson, R.P.3
  • 118
    • 84906505849 scopus 로고    scopus 로고
    • Model selection for microbial nutrient uptake using a cost-benefit approach
    • Müller, J., Hense, B. A., Marozava, S., Kuttler, C. & Meckenstock, R. U. Model selection for microbial nutrient uptake using a cost-benefit approach. Math. Biosci. 255, 52-70 (2014).
    • (2014) Math. Biosci. , vol.255 , pp. 52-70
    • Müller, J.1    Hense, B.A.2    Marozava, S.3    Kuttler, C.4    Meckenstock, R.U.5
  • 119
    • 80054115962 scopus 로고    scopus 로고
    • A computational exploration of bacterial metabolic diversity identifying metabolic interactions and growth-efficient strain communities
    • Tzamali, E., Poirazi, P., Tollis, I. G. & Reczko, M. A computational exploration of bacterial metabolic diversity identifying metabolic interactions and growth-efficient strain communities. BMC Syst. Biol. 5, 167 (2011).
    • (2011) BMC Syst. Biol. , vol.5 , pp. 167
    • Tzamali, E.1    Poirazi, P.2    Tollis, I.G.3    Reczko, M.4
  • 120
    • 84882748254 scopus 로고    scopus 로고
    • Heterogeneity in protein expression induces metabolic variability in a modeled Escherichia coli population
    • Labhsetwar, P., Cole, J. A., Roberts, E., Price, N. D. & Luthey-Schulten, Z. A. Heterogeneity in protein expression induces metabolic variability in a modeled Escherichia coli population. Proc. Natl Acad. Sci. USA 110, 14006-14011 (2013).
    • (2013) Proc. Natl Acad. Sci. USA , vol.110 , pp. 14006-14011
    • Labhsetwar, P.1    Cole, J.A.2    Roberts, E.3    Price, N.D.4    Luthey-Schulten, Z.A.5
  • 121
    • 84905366865 scopus 로고    scopus 로고
    • Quantifying the effects of the division of labor in metabolic pathways
    • Harvey, E., Heys, J. & Gedeon, T. Quantifying the effects of the division of labor in metabolic pathways. J. Theor. Biol. 360, 222-242 (2014).
    • (2014) J. Theor. Biol. , vol.360 , pp. 222-242
    • Harvey, E.1    Heys, J.2    Gedeon, T.3
  • 122
    • 84887538268 scopus 로고    scopus 로고
    • Analysis of fluorescent reporters indicates heterogeneity in glucose uptake and utilization in clonal bacterial populations
    • Nikolic, N., Barner, T. & Ackermann, M. Analysis of fluorescent reporters indicates heterogeneity in glucose uptake and utilization in clonal bacterial populations. BMC Microbiol. 13, 258 (2013).
    • (2013) BMC Microbiol. , vol.13 , pp. 258
    • Nikolic, N.1    Barner, T.2    Ackermann, M.3
  • 123
    • 84867080098 scopus 로고    scopus 로고
    • Stochasticity of TOL plasmid catabolic promoters sets a bimodal expression regime in Pseudomonas putida mt-2 exposed to m-xylene
    • Silva-Rocha, R. & de Lorenzo, V. Stochasticity of TOL plasmid catabolic promoters sets a bimodal expression regime in Pseudomonas putida mt-2 exposed to m-xylene. Mol. Microbiol. 86, 199-211 (2012).
    • (2012) Mol. Microbiol. , vol.86 , pp. 199-211
    • Silva-Rocha, R.1    De Lorenzo, V.2
  • 124
    • 84922248177 scopus 로고    scopus 로고
    • Phenotypic heterogeneity implements a game theoretic mixed strategy in a clonal microbial population
    • Healey, D. & Gore, J. Phenotypic heterogeneity implements a game theoretic mixed strategy in a clonal microbial population. BioRxiv http://dx.doi. org/10.1101/011049 (2014).
    • (2014) BioRxiv
    • Healey, D.1    Gore, J.2
  • 125
    • 84879268074 scopus 로고    scopus 로고
    • Resolution of conflicting signals at the single-cell level in the regulation of cyanobacterial photosynthesis and nitrogen fixation
    • Mohr, W., Vagner, T., Kuypers, M. M., Ackermann, M. & LaRoche, J. Resolution of conflicting signals at the single-cell level in the regulation of cyanobacterial photosynthesis and nitrogen fixation. PLoS One 8, e66060 (2013).
    • (2013) PLoS One , vol.8 , pp. e66060
    • Mohr, W.1    Vagner, T.2    Kuypers, M.M.3    Ackermann, M.4    Laroche, J.5
  • 126
    • 84937040954 scopus 로고    scopus 로고
    • 15N labeling with NanoSIMS analysis reveals growth-rate dependent metabolic heterogeneity in chemostats
    • 15N labeling with NanoSIMS analysis reveals growth-rate dependent metabolic heterogeneity in chemostats. Environ. Microbiol. http://dx.doi.org/10.1111/1462-2920.12752 (2015).
    • (2015) Environ. Microbiol
    • Kopf, S.H.1
  • 127
    • 84897374963 scopus 로고    scopus 로고
    • The effect of cell growth phase on the regulatory cross-talk between flagellar and Spi1 virulence gene expression
    • Mouslim, C. & Hughes, K. T. The effect of cell growth phase on the regulatory cross-talk between flagellar and Spi1 virulence gene expression. PLoS Pathog. 10, e1003987 (2014).
    • (2014) PLoS Pathog. , vol.10 , pp. e1003987
    • Mouslim, C.1    Hughes, K.T.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.