메뉴 건너뛰기




Volumn 2018, Issue , 2018, Pages

Cannabis sativa L. and Nonpsychoactive Cannabinoids: Their Chemistry and Role against Oxidative Stress, Inflammation, and Cancer

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; CANNABINOID; CANNABIS; CYCLOOXYGENASE 2; ENDOCANNABINOID; VANILLOID RECEPTOR 1; VANILLOID RECEPTOR 2; ANTIOXIDANT;

EID: 85058952952     PISSN: 23146133     EISSN: 23146141     Source Type: Journal    
DOI: 10.1155/2018/1691428     Document Type: Review
Times cited : (290)

References (137)
  • 4
    • 84959934791 scopus 로고    scopus 로고
    • The analytical chemistry of Cannabis: Quality assessment, assurance and regulation of medicinal marijuana and cannabinoid preparations
    • B. F. Thomas and M. A. ElSohly, "The analytical chemistry of Cannabis: quality assessment, assurance and regulation of medicinal marijuana and cannabinoid preparations, " Elsevier, Amsterdam, 1st edition, 2015.
    • (2015) Eevier Amsterdam, 1st Edition
    • Thomas, B.F.1    ElSohly, M.A.2
  • 7
    • 85020480616 scopus 로고    scopus 로고
    • Development of a new extraction technique andHPLC method for the analysis of non-psychoactive cannabinoids in fibre-TypeCannabis sativa L. (hemp)
    • V. Brighenti, F. Pellati, M. Steinbach, D. Maran, and S. Benvenuti, "Development of a new extraction technique andHPLC method for the analysis of non-psychoactive cannabinoids in fibre-TypeCannabis sativa L. (hemp), " Journal of Pharmaceutical and Biomedical Analysis, vol. 143, pp. 228-236, 2017.
    • (2017) Journal of Pharmaceutical and Biomedical Analysis , vol.143 , pp. 228-236
    • Brighenti, V.1    Pellati, F.2    Steinbach, M.3    Maran, D.4    Benvenuti, S.5
  • 8
    • 85054832230 scopus 로고    scopus 로고
    • Newmethods for thecomprehensive Analysis of Bioactive Compounds in Cannabis sativa L. (hemp)
    • F. Pellati, V. Brighenti, J. Sperlea, L. Marchetti, D. Bertelli, and S. Benvenuti, "NewMethods for theComprehensive Analysis of Bioactive Compounds in Cannabis sativa L. (hemp), "Molecules, vol. 23, no. 10, 2018.
    • (2018) Molecules , vol.23 , Issue.10
    • Pellati, F.1    Brighenti, V.2    Sperlea, J.3    Marchetti, L.4    Bertelli, D.5    Benvenuti, S.6
  • 9
    • 27844525479 scopus 로고    scopus 로고
    • Chemical constituents of marijuana: The complex mixture of natural cannabinoids
    • M. A. ElSohly and D. Slade, "Chemical constituents of marijuana: The complex mixture of natural cannabinoids, " Life Sciences, vol. 78, no. 5, pp. 539-548, 2005.
    • (2005) Life Sciences , vol.78 , Issue.5 , pp. 539-548
    • ElSohly, M.A.1    Slade, D.2
  • 10
    • 70849088937 scopus 로고    scopus 로고
    • Innovative development and validation of an HPLC/DAD method for the qualitative and quantitative determination of major cannabinoids in cannabis plant material
    • B. De Backer, B. Debrus, P. Lebrun et al., "Innovative development and validation of an HPLC/DAD method for the qualitative and quantitative determination of major cannabinoids in cannabis plant material, " Journal of Chromatography B, vol. 877, no. 32, pp. 4115-4124, 2009.
    • (2009) Journal of Chromatography B , vol.877 , Issue.32 , pp. 4115-4124
    • De Backer, B.1    Debrus, B.2    Lebrun, P.3
  • 11
    • 70349189518 scopus 로고    scopus 로고
    • Non-psychotropic plant cannabinoids: New therapeutic opportunities froman ancient herb
    • A. A. Izzo, F. Borrelli, R. Capasso, V. Di Marzo, and R. Mechoulam, "Non-psychotropic plant cannabinoids: new therapeutic opportunities froman ancient herb, " Trends in Pharmacological Sciences, vol. 30, no. 10, pp. 515-527, 2009.
    • (2009) Trends in Pharmacological Sciences , vol.30 , Issue.10 , pp. 515-527
    • Izzo, A.A.1    Borrelli, F.2    Capasso, R.3    Di Marzo, V.4    Mechoulam, R.5
  • 15
    • 57149123407 scopus 로고    scopus 로고
    • Chemistry and analysis of phytocannabinoids and other Cannabis constituents
    • M. A. ElSohly, Ed Marijuana and the cannabinoids, Humana Press Inc., Totowa, NJ, USA
    • R. Brenneisen, "Chemistry and analysis of phytocannabinoids and other Cannabis constituents, " in Marijuana and the Cannabinoids, M. A. ElSohly, Ed., 49, p. 17, Marijuana and the cannabinoids, Humana Press Inc., Totowa, NJ, USA, 2007.
    • (2007) Marijuana and the Cannabinoids , Issue.49 , pp. 17
    • Brenneisen, R.1
  • 16
    • 85014006843 scopus 로고    scopus 로고
    • Cannabidiol: State of the art and new challenges for therapeutic applications
    • S. Pisanti, A.M. Malfitano, E. Ciaglia et al., "Cannabidiol: State of the art and new challenges for therapeutic applications, " Pharmacology &Therapeutics, vol. 175, pp. 133-150, 2017.
    • (2017) Pharmacology &Therapeutics , vol.175 , pp. 133-150
    • Pisanti, S.1    Malfitano, A.M.2    Ciaglia, E.3
  • 17
    • 85045722596 scopus 로고    scopus 로고
    • Cannabis Phenolics and their Bioactivities
    • F. Pollastro, A. Minassi, and L. G. Fresu, "Cannabis Phenolics and their Bioactivities, " Current Medicinal Chemistry, vol. 25, no. 10, pp. 1160-1185, 2018.
    • (2018) Current Medicinal Chemistry , vol.25 , Issue.10 , pp. 1160-1185
    • Pollastro, F.1    Minassi, A.2    Fresu, L.G.3
  • 18
    • 84901611013 scopus 로고    scopus 로고
    • Cannflavins from hemp sprouts, a novel cannabinoid-free hemp food product, target microsomal prostaglandin E2 synthase-1 and 5-lipoxygenase
    • O. Werz, J. Seegers, A. M. Schaible et al., "Cannflavins from hemp sprouts, a novel cannabinoid-free hemp food product, target microsomal prostaglandin E2 synthase-1 and 5-lipoxygenase, " PharmaNutrition, vol. 2, no. 3, pp. 53-60, 2014.
    • (2014) PharmaNutrition , vol.2 , Issue.3 , pp. 53-60
    • Werz, O.1    Seegers, J.2    Schaible, A.M.3
  • 19
    • 85016156961 scopus 로고    scopus 로고
    • The Bibenzyl Canniprene Inhibits the Production of Pro-Inflammatory Eicosanoids and Selectively Accumulates in Some Cannabis sativa Strains
    • G. Allegrone, F. Pollastro, G. Magagnini et al., "The Bibenzyl Canniprene Inhibits the Production of Pro-Inflammatory Eicosanoids and Selectively Accumulates in Some Cannabis sativa Strains, " Journal of Natural Products, vol. 80, no. 3, pp. 731-734, 2017.
    • (2017) Journal of Natural Products , vol.80 , Issue.3 , pp. 731-734
    • Allegrone, G.1    Pollastro, F.2    Magagnini, G.3
  • 20
    • 77950346282 scopus 로고    scopus 로고
    • Immunity, inflammation, and cancer
    • S. I. Grivennikov, F. R. Greten, and M. Karin, "Immunity, Inflammation, and Cancer, " Cell, vol. 140, no. 6, pp. 883-899, 2010.
    • (2010) Cell , vol.140 , Issue.6 , pp. 883-899
    • Grivennikov, S.I.1    Greten, F.R.2    Karin, M.3
  • 21
    • 85048179830 scopus 로고    scopus 로고
    • Medical Cannabis for the treatment of inflammation
    • D. Namdar and H. Koltai, "Medical Cannabis for the treatment of inflammation, " Nat. Prod. Commun, vol. 13, pp. 249-254, 2018.
    • (2018) Nat. Prod. Commun , vol.13 , pp. 249-254
    • Namdar, D.1    Koltai, H.2
  • 22
    • 33646814424 scopus 로고    scopus 로고
    • Cannabinoid receptors and endocannabinoids: Evidence for newplayers
    • article 34
    • K. Mackie and N. Stella, "Cannabinoid receptors and endocannabinoids: evidence for newplayers, "The AAPS Journal, vol. 8, no. 2, article 34, pp. E298-E306, 2006.
    • (2006) The AAPS Journal , vol.8 , Issue.2 , pp. E298-E306
    • Mackie, K.1    Stella, N.2
  • 23
    • 84927696508 scopus 로고    scopus 로고
    • Effects of proinflammatory cytokines on cannabinoid CB1 and CB2 receptors in immune cells
    • L. Jean-Gilles, M. Braitch, M. L. Latif et al., "Effects of proinflammatory cytokines on cannabinoid CB1 and CB2 receptors in immune cells, " Acta Physiol, vol. 214, pp. 63-74, 2015.
    • (2015) Acta Physiol , vol.214 , pp. 63-74
    • Jean-Gilles, L.1    Braitch, M.2    Latif, M.L.3
  • 24
    • 84955587229 scopus 로고    scopus 로고
    • Clinical/therapeutic approaches for cannabinoid ligands in central and peripheral nervous system diseases: Mini review
    • K. Fijal and M. Filip, "Clinical/therapeutic approaches for cannabinoid ligands in central and peripheral nervous system diseases: Mini review, " Clinical Neuropharmacology, vol. 39, no. 2, pp. 94-101, 2016.
    • (2016) Clinical Neuropharmacology , vol.39 , Issue.2 , pp. 94-101
    • Fijal, K.1    Filip, M.2
  • 25
    • 84983784415 scopus 로고    scopus 로고
    • Interaction between cannabinoid system and toll-Like Receptors Controls Inflammation
    • Article ID 5831315
    • K. L. Mccoy, "Interaction between Cannabinoid System and Toll-Like Receptors Controls Inflammation, " Mediators of Inflammation, vol. 2016, Article ID 5831315, 18 pages, 2016.
    • (2016) Mediators of Inflammation , vol.2016 , pp. 18
    • McCoy, K.L.1
  • 27
    • 84925488635 scopus 로고    scopus 로고
    • Cannabidiol (CBD) and its analogs: A review of their effects on inflammation
    • S. Burstein, "Cannabidiol (CBD) and its analogs: A review of their effects on inflammation, " Bioorganic & Medicinal Chemistry, vol. 23, no. 7, pp. 1377-1385, 2015.
    • (2015) Bioorganic & Medicinal Chemistry , vol.23 , Issue.7 , pp. 1377-1385
    • Burstein, S.1
  • 28
    • 77952593814 scopus 로고    scopus 로고
    • The effects of .9-Tetrahydrocannabinol and cannabidiol alone and in combination on damage, inflammation and in vitro motility disturbances in rat colitis
    • J. M. Jamontt, A. Molleman, R. G. Pertwee, and M. E. Parsons, "The effects of .9-Tetrahydrocannabinol and cannabidiol alone and in combination on damage, inflammation and in vitro motility disturbances in rat colitis, " British Journal of Pharmacology, vol. 160, no. 3, pp. 712-723, 2010.
    • (2010) British Journal of Pharmacology , vol.160 , Issue.3 , pp. 712-723
    • Jamontt, J.M.1    Molleman, A.2    Pertwee, R.G.3    Parsons, M.E.4
  • 29
    • 82755165068 scopus 로고    scopus 로고
    • Cannabidiol reduces intestinal inflammation through the control of neuroimmune axis
    • D. de Filippis, G. Esposito, C. Cirillo et al., "Cannabidiol reduces intestinal inflammation through the control of neuroimmune axis, " PLoS ONE, vol. 6, no. 12, 2011.
    • (2011) PLoS ONE , vol.6 , Issue.12
    • De Filippis, D.1    Esposito, G.2    Cirillo, C.3
  • 30
    • 84962009783 scopus 로고    scopus 로고
    • Marijuana-derived .-9-Tetrahydrocannabinol suppresses Th1/Th17 cell-mediated delayed-Type hypersensitivity through microRNA regulation
    • J. M. Sido, A. R. Jackson, P. S. Nagarkatti, and M. Nagarkatti, "Marijuana-derived .-9-Tetrahydrocannabinol suppresses Th1/Th17 cell-mediated delayed-Type hypersensitivity through microRNA regulation, " Journal of Molecular Medicine, vol. 94, no. 9, pp. 1039-1051, 2016.
    • (2016) Journal of Molecular Medicine , vol.94 , Issue.9 , pp. 1039-1051
    • Sido, J.M.1    Jackson, A.R.2    Nagarkatti, P.S.3    Nagarkatti, M.4
  • 31
    • 0032540995 scopus 로고    scopus 로고
    • Effects of cannabinoid receptor ligands on LPSinduced pulmonary inflammation in mice
    • E. Berdyshev, E. Boichot, M. Corbel, N. Germain, and V. Lagente, "Effects of cannabinoid receptor ligands on LPSinduced pulmonary inflammation in mice, " Life Sciences, vol. 63, no. 8, pp. 125-129, 1998.
    • (1998) Life Sciences , vol.63 , Issue.8 , pp. 125-129
    • Berdyshev, E.1    Boichot, E.2    Corbel, M.3    Germain, N.4    Lagente, V.5
  • 32
    • 84931009328 scopus 로고    scopus 로고
    • Exposure to .9-Tetrahydrocannabinol impairs the differentiation of human monocyte-derived dendritic cells and their capacity for T cell activation
    • M. D. Roth, J. T. Castaneda, and S. M. Kiertscher, "Exposure to .9-Tetrahydrocannabinol impairs the differentiation of human monocyte-derived dendritic cells and their capacity for T cell activation, " Journal of Neuroimmune Pharmacology, vol. 10, no. 2, pp. 333-343, 2015.
    • (2015) Journal of Neuroimmune Pharmacology , vol.10 , Issue.2 , pp. 333-343
    • Roth, M.D.1    Castaneda, J.T.2    Kiertscher, S.M.3
  • 33
    • 84880364900 scopus 로고    scopus 로고
    • Impaired NFAT and NF.B activation are involved in suppression of CD40 ligand expression by .9-Tetrahydrocannabinol in human CD4+ T cells
    • T. Ngaotepprutaram, B. L. Kaplan, and N. E. Kaminski, "Impaired NFAT and NF.B activation are involved in suppression of CD40 ligand expression by .9-Tetrahydrocannabinol in human CD4+ T cells, " Toxicology and Applied Pharmacology, vol. 273, no. 1, pp. 209-218, 2013.
    • (2013) Toxicology and Applied Pharmacology , vol.273 , Issue.1 , pp. 209-218
    • Ngaotepprutaram, T.1    Kaplan, B.L.2    Kaminski, N.E.3
  • 34
    • 0035012848 scopus 로고    scopus 로고
    • Effects of cannabinoids on LPS-stimulated inflammatory mediator release from macrophages: Involvement of eicosanoids
    • Y.-H. Chang, S. T. Lee, and W.-W. Lin, "Effects of cannabinoids on LPS-stimulated inflammatory mediator release from macrophages: involvement of eicosanoids, " Journal of Cellular Biochemistry, vol. 81, no. 4, pp. 715-723, 2001.
    • (2001) Journal of Cellular Biochemistry , vol.81 , Issue.4 , pp. 715-723
    • Chang, Y.-H.1    Lee, S.T.2    Lin, W.-W.3
  • 35
    • 79955646963 scopus 로고    scopus 로고
    • Evaluation of the cyclooxygenase inhibiting effects of sixmajor cannabinoids isolated fromCannabis sativa
    • L. R. Ruhaak, J. Felth, P. C. Karlsson, J. J. Rafter, R. Verpoorte, and L. Bohlin, "Evaluation of the cyclooxygenase inhibiting effects of sixmajor cannabinoids isolated fromCannabis sativa, " Biological &Pharmaceutical Bulletin, vol. 34, no. 5, pp. 774-778, 2011.
    • (2011) Biological &Pharmaceutical Bulletin , vol.34 , Issue.5 , pp. 774-778
    • Ruhaak, L.R.1    Felth, J.2    Karlsson, P.C.3    Rafter, J.J.4    Verpoorte, R.5    Bohlin, L.6
  • 36
    • 0028178494 scopus 로고
    • 9-Tetrahydrocannabinol (THC)modulates IL-1 bioactivity in human monocyte/macrophage cell lines
    • S. C. Shivers, C. Newton, H. Friedman, and T. W. Klein, ".9-Tetrahydrocannabinol (THC)modulates IL-1 bioactivity in human monocyte/macrophage cell lines, " Life Sciences, vol. 54, no. 17, pp. 1281-1289, 1994.
    • (1994) Life Sciences , vol.54 , Issue.17 , pp. 1281-1289
    • Shivers, S.C.1    Newton, C.2    Friedman, H.3    Klein, T.W.4
  • 37
    • 20544444202 scopus 로고    scopus 로고
    • Targeting cannabinoid receptors to treat leukemia: Role of cross-Talk between extrinsic and intrinsic pathways in .9-Tetrahydrocannabinol (THC)-induced apoptosis of Jurkat cells
    • C. Lombard, M. Nagarkatti, and P. S. Nagarkatti, "Targeting cannabinoid receptors to treat leukemia: Role of cross-Talk between extrinsic and intrinsic pathways in 9-Tetrahydrocannabinol (THC)-induced apoptosis of Jurkat cells, " Leukemia Research, vol. 29, no. 8, pp. 915-922, 2005.
    • (2005) Leukemia Research , vol.29 , Issue.8 , pp. 915-922
    • Lombard, C.1    Nagarkatti, M.2    Nagarkatti, P.S.3
  • 38
    • 33748417610 scopus 로고    scopus 로고
    • 9-Tetrahydrocannabinolinduced apoptosis in Jurkat leukemia T cells is regulated by translocation of bad to mitochondria
    • W. Jia, V. L. Hegde, N. P. Singh et al., ".9-Tetrahydrocannabinolinduced apoptosis in Jurkat leukemia T cells is regulated by translocation of bad to mitochondria, " Molecular Cancer Research, vol. 4, no. 8, pp. 549-562, 2006.
    • (2006) Molecular Cancer Research , vol.4 , Issue.8 , pp. 549-562
    • Jia, W.1    Hegde, V.L.2    Singh, N.P.3
  • 39
    • 1642268380 scopus 로고    scopus 로고
    • Oral anti-inflammatory activity of cannabidiol, a non-psychoactive constituent of cannabis, in acute carrageenan-induced inflammation in the rat paw
    • B. Costa, M. Colleoni, S. Conti et al., "Oral anti-inflammatory activity of cannabidiol, a non-psychoactive constituent of cannabis, in acute carrageenan-induced inflammation in the rat paw, " Naunyn-Schmiedebergs Archives of Pharmacology, vol. 369, no. 3, pp. 294-299, 2004.
    • (2004) Naunyn-Schmiedebergs Archives of Pharmacology , vol.369 , Issue.3 , pp. 294-299
    • Costa, B.1    Colleoni, M.2    Conti, S.3
  • 40
    • 84907557918 scopus 로고    scopus 로고
    • Down-regulation of cyclooxygenase-2 (cox-2) by cannabidiolic acid in human breast cancer cells
    • S. Takeda, H. Okazaki, E. Ikeda et al., "Down-regulation of cyclooxygenase-2 (cox-2) by cannabidiolic acid in human breast cancer cells, " Journal of Toxicological Sciences, vol. 39, no. 5, pp. 711-716, 2014.
    • (2014) Journal of Toxicological Sciences , vol.39 , Issue.5 , pp. 711-716
    • Takeda, S.1    Okazaki, H.2    Ikeda, E.3
  • 41
    • 32344437376 scopus 로고    scopus 로고
    • New cannabidiol derivatives: Synthesis, binding to cannabinoid receptor, and evaluation of their antiinflammatory activity
    • S. Ben-Shabat, L. O. Hanu.s, G. Katzavian, and R. Gallily, "New cannabidiol derivatives: Synthesis, binding to cannabinoid receptor, and evaluation of their antiinflammatory activity, " Journal ofMedicinal Chemistry, vol. 49, no. 3, pp. 1113-1117, 2006.
    • (2006) Journal OfMedicinal Chemistry , vol.49 , Issue.3 , pp. 1113-1117
    • Ben-Shabat, S.1    Hanu, L.O.2    Katzavian, S.G.3    Gallily, R.4
  • 42
    • 0025786050 scopus 로고
    • Marijuana components stimulate human peripheral blood mononuclear cell secretion of interferon-gamma and suppress interleukin-1 alpha in vitro
    • B. Watzl, P. Scuderi, and R. R. Watson, "Marijuana components stimulate human peripheral blood mononuclear cell secretion of interferon-gamma and suppress interleukin-1 alpha in vitro, " International Journal of Immunopharmacology, vol. 13, no. 8, pp. 1091-1097, 1991.
    • (1991) International Journal of Immunopharmacology , vol.13 , Issue.8 , pp. 1091-1097
    • Watzl, B.1    Scuderi, P.2    Watson, R.R.3
  • 44
    • 84875726038 scopus 로고    scopus 로고
    • Beneficial effect of the non-psychotropic plant cannabinoid cannabigerol on experimental inflammatory bowel disease
    • F. Borrelli, I. Fasolino, B. Romano et al., "Beneficial effect of the non-psychotropic plant cannabinoid cannabigerol on experimental inflammatory bowel disease, " Biochemical Pharmacology, vol. 85, no. 9, pp. 1306-1316, 2013.
    • (2013) Biochemical Pharmacology , vol.85 , Issue.9 , pp. 1306-1316
    • Borrelli, F.1    Fasolino, I.2    Romano, B.3
  • 45
    • 84861313729 scopus 로고    scopus 로고
    • Inhibitory effect of cannabichromene, a major non-psychotropic cannabinoid extracted from Cannabis sativa, on inflammation-induced hypermotility inmice
    • A. A. Izzo, R. Capasso, G. Aviello et al., "Inhibitory effect of cannabichromene, a major non-psychotropic cannabinoid extracted from Cannabis sativa, on inflammation-induced hypermotility inmice, " British Journal of Pharmacology, vol. 166, no. 4, pp. 1444-1460, 2012.
    • (2012) British Journal of Pharmacology , vol.166 , Issue.4 , pp. 1444-1460
    • Izzo, A.A.1    Capasso, R.2    Aviello, G.3
  • 46
    • 0021871840 scopus 로고
    • Isolation from cannabis sativa L. of cannflavin-A novel inhibitor of prostaglandin production
    • M. L. Barrett, D. Gordon, and F. J. Evans, "Isolation from cannabis sativa L. of cannflavin-A novel inhibitor of prostaglandin production, " Biochemical Pharmacology, vol. 34, no. 11, pp. 2019-2024, 1985.
    • (1985) Biochemical Pharmacology , vol.34 , Issue.11 , pp. 2019-2024
    • Barrett, M.L.1    Gordon, D.2    Evans, F.J.3
  • 47
    • 77954379641 scopus 로고    scopus 로고
    • Limonene suppresses lipopolysaccharide-induced production of nitric oxide, prostaglandin E2, and pro-inflammatory cytokines in RAW 264.7 macrophages
    • W.-J. Yoon, N. H. Lee, and C.-G. Hyun, "Limonene suppresses lipopolysaccharide-induced production of nitric oxide, prostaglandin E2, and pro-inflammatory cytokines in RAW 264.7 macrophages, " Journal of Oleo Science, vol. 59, no. 8, pp. 415-421, 2010.
    • (2010) Journal of Oleo Science , vol.59 , Issue.8 , pp. 415-421
    • Yoon, W.-J.1    Lee, N.H.2    Hyun, C.-G.3
  • 51
    • 84859051261 scopus 로고    scopus 로고
    • Cannabinoids mediate opposing effects on inflammationinduced intestinal permeability
    • A. Alhamoruni, K. L. Wright, M. Larvin, and S. E. OSullivan, "Cannabinoids mediate opposing effects on inflammationinduced intestinal permeability, " British Journal of Pharmacology, vol. 165, no. 8, pp. 2598-2610, 2012.
    • (2012) British Journal of Pharmacology , vol.165 , Issue.8 , pp. 2598-2610
    • Alhamoruni, A.1    Wright, K.L.2    Larvin, M.3    OSullivan, S.E.4
  • 52
    • 85032825924 scopus 로고    scopus 로고
    • Cannabidiol and palmitoylethanolamide are antiinflammatory in the acutely inflamed human colon
    • D. G. Couch, C. Tasker, E. Theophilidou, J. N. Lund, and S. E. OSullivan, "Cannabidiol and palmitoylethanolamide are antiinflammatory in the acutely inflamed human colon, " Clinical Science, vol. 131, no. 21, pp. 2611-2626, 2017.
    • (2017) Clinical Science , vol.131 , Issue.21 , pp. 2611-2626
    • Couch, D.G.1    Tasker, C.2    Theophilidou, E.3    Lund, J.N.4    OSullivan, S.E.5
  • 53
    • 85037033439 scopus 로고    scopus 로고
    • Cannabidiol restores intestinal barrier dysfunction and inhibits the apoptotic process induced by Clostridium difficile toxin A in Caco-2 cells
    • S. Gigli, L. Seguella, M. Pesce et al., "Cannabidiol restores intestinal barrier dysfunction and inhibits the apoptotic process induced by Clostridium difficile toxin A in Caco-2 cells, " United European Gastroenterology Journal, vol. 5, no. 8, pp. 1108-1115, 2017.
    • (2017) United European Gastroenterology Journal , vol.5 , Issue.8 , pp. 1108-1115
    • Gigli, S.1    Seguella, L.2    Pesce, M.3
  • 54
    • 85058974342 scopus 로고    scopus 로고
    • Preventing negative shifts in gut microbiota with Cannabis therapy: Implications for colorectal cancer
    • R.-V. Kalaydina, B. Qorri, and M. R. Szewczuk, "Preventing negative shifts in gut microbiota with Cannabis therapy: implications for colorectal cancer, " Adv. Res. Gastroentero. Hepatol, vol. 7, pp. 1-5, 2017.
    • (2017) Adv. Res. Gastroentero. Hepatol , vol.7 , pp. 1-5
    • Kalaydina, R.-V.1    Qorri, B.2    Szewczuk, M.R.3
  • 55
    • 0028823316 scopus 로고
    • Cannabinoids activate an inwardly rectifying potassium conductance and inhibit Q-Type calcium currents in AtT20 cells transfected with rat brain cannabinoid receptor
    • K. Mackie, Y. Lai, R. Westenbroek, and R. Mitchell, "Cannabinoids activate an inwardly rectifying potassium conductance and inhibit Q-Type calcium currents in AtT20 cells transfected with rat brain cannabinoid receptor, " The Journal of Neuroscience, vol. 15, no. 10, pp. 6552-6561, 1995.
    • (1995) The Journal of Neuroscience , vol.15 , Issue.10 , pp. 6552-6561
    • Mackie, K.1    Lai, Y.2    Westenbroek, R.3    Mitchell, R.4
  • 56
    • 34147165471 scopus 로고    scopus 로고
    • Direct suppression of CNS autoimmune inflammation via the cannabinoid receptor CB1 on neurons and CB2 on autoreactive T cells
    • K. Maresz, G. Pryce, E.D. Ponomarev et al., "Direct suppression of CNS autoimmune inflammation via the cannabinoid receptor CB1 on neurons and CB2 on autoreactive T cells, " Nature Medicine, vol. 13, no. 4, pp. 492-497, 2007.
    • (2007) Nature Medicine , vol.13 , Issue.4 , pp. 492-497
    • Maresz, K.1    Pryce, G.2    Ponomarev, E.D.3
  • 58
    • 77957906635 scopus 로고    scopus 로고
    • Fatty acid amide hydrolase in prostate cancer: Association with disease severity and outcome, CB1 receptor expression and regulation by IL-4
    • Article ID e12275
    • L. Thors, A. Bergh, E. Persson et al., "Fatty acid amide hydrolase in prostate cancer: Association with disease severity and outcome, CB1 receptor expression and regulation by IL-4, " PLoS ONE, vol. 5, no. 8, Article ID e12275, 2010.
    • (2010) PLoS ONE , vol.5 , Issue.8
    • Thors, L.1    Bergh, A.2    Persson, E.3
  • 59
    • 0035877059 scopus 로고    scopus 로고
    • Progesterone up-regulates anandamide hydrolase in human lymphocytes: Role of cytokines and implications for fertility
    • M. Maccarrone, H. Valensise, M. Bari, N. Lazzarin, C. Romanini, and A. Finazzi-Agro, "Progesterone up-regulates anandamide hydrolase in human lymphocytes: Role of cytokines and implications for fertility, " The Journal of Immunology, vol. 166, no. 12, pp. 7183-7189, 2001.
    • (2001) The Journal of Immunology , vol.166 , Issue.12 , pp. 7183-7189
    • Maccarrone, M.1    Valensise, H.2    Bari, M.3    Lazzarin, N.4    Romanini, C.5    Finazzi-Agro, A.6
  • 60
    • 45649085439 scopus 로고    scopus 로고
    • The endocannabinoid system modulates a transient TNF pathway that induces neural stem cell proliferation
    • A. Rubio-Araiz, A. Aŕevalo-Martin, O. Gomez-Torres et al., "The endocannabinoid system modulates a transient TNF pathway that induces neural stem cell proliferation, " Molecular and Cellular Neuroscience, vol. 38, no. 3, pp. 374-380, 2008.
    • (2008) Molecular and Cellular Neuroscience , vol.38 , Issue.3 , pp. 374-380
    • Rubio-Araiz, A.1    Aŕevalo-Martin, A.2    Gomez-Torres, O.3
  • 61
    • 35348946336 scopus 로고    scopus 로고
    • CB2-receptor stimulation attenuates TNF-.-induced human endothelial cell activation, transendothelial migration of monocytes, and monocyte-endothelial adhesion
    • M. Rajesh, P. Mukhopadhyay, S. Batkai et al., "CB2-receptor stimulation attenuates TNF-.-induced human endothelial cell activation, transendothelial migration of monocytes, and monocyte-endothelial adhesion, " American Journal of Physiology-Heart and Circulatory Physiology, vol. 293, no. 4, pp. H2210-H2218, 2007.
    • (2007) American Journal of Physiology-Heart and Circulatory Physiology , vol.293 , Issue.4 , pp. H2210-H2218
    • Rajesh, M.1    Mukhopadhyay, P.2    Batkai, S.3
  • 63
    • 85005992359 scopus 로고    scopus 로고
    • Neuroinflammation, neurodegeneration and regeneration in multiple sclerosis: Intercorrelated manifestations of the immune response
    • T. Koudriavtseva and C. Mainero, "Neuroinflammation, neurodegeneration and regeneration in multiple sclerosis: Intercorrelated manifestations of the immune response, " Neural Regeneration Research, vol. 11, no. 11, pp. 1727-1730, 2016.
    • (2016) Neural Regeneration Research , vol.11 , Issue.11 , pp. 1727-1730
    • Koudriavtseva, T.1    Mainero, C.2
  • 64
    • 85032702141 scopus 로고    scopus 로고
    • Neuroinflammation as a therapeutic target in neurodegenerative diseases
    • V. Baekelandt and E. Lobbestael, Eds, Academic Press, Cambridge
    • R. Gordon and T. M. Woodruff, "Neuroinflammation as a therapeutic target in neurodegenerative diseases, " in Diseasemodifying targets in neurodegenerative disorders, V. Baekelandt and E. Lobbestael, Eds., pp. 49-80, Academic Press, Cambridge, 2017.
    • (2017) Diseasemodifying Targets in Neurodegenerative Disorders , pp. 49-80
    • Gordon, R.1    Woodruff, T.M.2
  • 65
    • 84926370173 scopus 로고    scopus 로고
    • Neuroinflammation in Alzheimers disease
    • M. T. Heneka, M. J. Carson, J. El. Khoury et al., "Neuroinflammation in Alzheimers disease, " The Lancet Neurology, vol. 14, no. 4, pp. 388-405, 2015.
    • (2015) The Lancet Neurology , vol.14 , Issue.4 , pp. 388-405
    • Heneka, M.T.1    Carson, M.J.2    El Khoury, J.3
  • 66
    • 85054148726 scopus 로고    scopus 로고
    • Linking neuroinflammation and neurodegeneration in parkinsons disease
    • Article ID 4784268
    • Geraldine Gelders, Veerle Baekelandt, and Anke Van der Perren, "Linking Neuroinflammation and Neurodegeneration in Parkinsons Disease, " Journal of Immunology Research, vol. 2018, Article ID 4784268, 12 pages, 2018.
    • (2018) Journal of Immunology Research , vol.2018 , pp. 12
    • Gelders, G.1    Baekelandt, V.2    Van Der Perren Anke3
  • 67
    • 84858667311 scopus 로고    scopus 로고
    • Neuroinflammation in Parkinsons disease
    • E. C. Hirsch, S. Vyas, and S. Hunot, "Neuroinflammation in Parkinsons disease, " Parkinsonism & Related Disorders, vol. 18, no. 1, pp. S210-S212, 2012.
    • (2012) Parkinsonism & Related Disorders , vol.18 , Issue.1 , pp. S210-S212
    • Hirsch, E.C.1    Vyas, S.2    Hunot, S.3
  • 68
    • 34248639557 scopus 로고    scopus 로고
    • The role of cd4 t cells in the pathogenesis of multiple sclerosis
    • T. Chitnis, "The Role of CD4 T Cells in the Pathogenesis of Multiple Sclerosis, " International Review of Neurobiology, vol. 79, pp. 43-72, 2007.
    • (2007) International Review of Neurobiology , vol.79 , pp. 43-72
    • Chitnis, T.1
  • 71
    • 84893798834 scopus 로고    scopus 로고
    • Cannabinoid effects on amyloid fibril and aggregate formation, neuronal and microglial-Activated neurotoxicity in vitro
    • E. Janefjord, J. L. V. Maag, B. S. Harvey, and S. D. Smid, "Cannabinoid effects on amyloid fibril and aggregate formation, neuronal and microglial-Activated neurotoxicity in vitro, " Cellular and Molecular Neurobiology, vol. 34, no. 1, pp. 31-42, 2014.
    • (2014) Cellular and Molecular Neurobiology , vol.34 , Issue.1 , pp. 31-42
    • Janefjord, E.1    Maag, J.L.V.2    Harvey, B.S.3    Smid, S.D.4
  • 72
    • 76249095734 scopus 로고    scopus 로고
    • Cannabinoids delta(9)-Tetrahydrocannabinol and cannabidiol differentially inhibit the lipopolysaccharide-Activated NF-kappaB and interferon-beta/STAT proinflammatory pathways in BV-2 microglial cells
    • E. Kozela, M. Pietr, A. Juknat, N. Rimmerman, R. Levy, and Z. Vogel, "Cannabinoids delta(9)-Tetrahydrocannabinol and cannabidiol differentially inhibit the lipopolysaccharide-Activated NF-kappaB and interferon-beta/STAT proinflammatory pathways in BV-2 microglial cells, " The Journal of Biological Chemistry, vol. 285, no. 3, pp. 1616-1626, 2010.
    • (2010) The Journal of Biological Chemistry , vol.285 , Issue.3 , pp. 1616-1626
    • Kozela, E.1    Pietr, M.2    Juknat, A.3    Rimmerman, N.4    Levy, R.5    Vogel, Z.6
  • 73
    • 0030940056 scopus 로고    scopus 로고
    • Receptor mediation in cannabinoid stimulated arachidonic acid mobilization and anandamide syn thesis
    • S. A. Hunter and S. H. Burstein, "Receptor mediation in cannabinoid stimulated arachidonic acid mobilization and anandamide synthesis, " Life Sciences, vol. 60, no. 18, pp. 1563-1573, 1997.
    • (1997) Life Sciences , vol.60 , Issue.18 , pp. 1563-1573
    • Hunter, S.A.1    Burstein, S.H.2
  • 74
    • 84886873610 scopus 로고    scopus 로고
    • Cannabidiol, a non-psychoactive cannabinoid compound, inhibits proliferation and invasion in u87-mg and t98g glioma cells through a multitarget effect
    • Article IDe76918
    • M. Solinas, P. Massi, V. Cinquina et al., "Cannabidiol, a Non-Psychoactive Cannabinoid Compound, Inhibits Proliferation and Invasion in U87-MG and T98G Glioma Cells through a Multitarget Effect, " PLoS ONE, vol. 8, no. 10, Article IDe76918, 2013.
    • (2013) PLoS ONE , vol.8 , Issue.10
    • Solinas, M.1    Massi, P.2    Cinquina, V.3
  • 75
    • 79956293339 scopus 로고    scopus 로고
    • Cannabidiol and other cannabinoids reduce microglial activation in vitro and in vivo: Relevance to alzheimers disease
    • A. M. Mart?n-Moreno, D. Reigada, B. G. Ram?rez et al., "Cannabidiol and other cannabinoids reduce microglial activation in vitro and in vivo: Relevance to alzheimers disease, " Molecular Pharmacology, vol. 79, no. 6, pp. 964-973, 2011.
    • (2011) Molecular Pharmacology , vol.79 , Issue.6 , pp. 964-973
    • Martn-Moreno, A.M.1    Reigada, D.2    Ramrez, B.G.3
  • 76
    • 82655189157 scopus 로고    scopus 로고
    • Cannabidiol reduces A-induced neuroinflammation and promotes hippocampal neurogenesis through PPAR involvement
    • Article ID e28668
    • G. Esposito, C. Scuderi, M. Valenza et al., "Cannabidiol reduces A-induced neuroinflammation and promotes hippocampal neurogenesis through PPAR involvement, " PLoS ONE, vol. 6, no. 12, Article ID e28668, 2011.
    • (2011) PLoS ONE , vol.6 , Issue.12
    • Esposito, G.1    Scuderi, C.2    Valenza, M.3
  • 77
    • 34848832040 scopus 로고    scopus 로고
    • Nonpsychoactive cannabidiol prevents prion accumulation and protects neurons against prion toxicity
    • S. Dirikoc, S. A. Priola, M. Marella, N. Zsurger, and J. Chabry, "Nonpsychoactive cannabidiol prevents prion accumulation and protects neurons against prion toxicity, " The Journal of Neuroscience, vol. 27, no. 36, pp. 9537-9544, 2007.
    • (2007) The Journal of Neuroscience , vol.27 , Issue.36 , pp. 9537-9544
    • Dirikoc, S.1    Priola, S.A.2    Marella, M.3    Zsurger, N.4    Chabry, J.5
  • 78
    • 85058949514 scopus 로고    scopus 로고
    • Chemical composition and in vitro neuroprotective activity of fibre-Type Cannabis sativa L. (hemp)
    • L. Corsi, F. Pellati, V. Brighenti, N. Plessi, and S. Benvenuti, "Chemical composition and in vitro neuroprotective activity of fibre-Type Cannabis sativa L. (hemp), " Current Bioactive Compounds, vol. 14, 2018.
    • (2018) Current Bioactive Compounds , vol.14
    • Corsi, L.1    Pellati, F.2    Brighenti, V.3    Plessi, N.4    Benvenuti, S.5
  • 80
    • 84906333244 scopus 로고    scopus 로고
    • Transcaryophyllene suppresses hypoxia-induced neuroinflammatory responses by inhibiting NF-B activation in microglia
    • K. Guo, X. Mou, J. Huang, N. Xiong, and H. Li, "Transcaryophyllene suppresses hypoxia-induced neuroinflammatory responses by inhibiting NF-B activation in microglia, " Journal of Molecular Neuroscience, vol. 54, no. 1, pp. 41-48, 2014.
    • (2014) Journal of Molecular Neuroscience , vol.54 , Issue.1 , pp. 41-48
    • Guo, K.1    Mou, X.2    Huang, J.3    Xiong, N.4    Li, H.5
  • 81
    • 85014167897 scopus 로고    scopus 로고
    • In vivo evidence for therapeutic properties of cannabidiol (CBD) for Alzheimers Disease
    • ticle 20
    • G. Watt and T. Karl, "In vivo evidence for therapeutic properties of cannabidiol (CBD) for Alzheimers Disease, " Front. Pharmacol, vol. 8, article 20, 2017.
    • (2017) Front. Pharmacol , vol.8
    • Watt, G.1    Karl, T.2
  • 82
    • 84904262310 scopus 로고    scopus 로고
    • Cannabidiol promotes amyloid precursor protein ubiquitination and reduction of beta amyloid expression in SHSY5YAPP+ cells through PPAR involvement
    • C. Scuderi, L. Steardo, and G. Esposito, "Cannabidiol promotes amyloid precursor protein ubiquitination and reduction of beta amyloid expression in SHSY5YAPP+ cells through PPAR involvement, " Phytotherapy Research, vol. 28, no. 7, pp. 1007-1013, 2014.
    • (2014) Phytotherapy Research , vol.28 , Issue.7 , pp. 1007-1013
    • Scuderi, C.1    Steardo, L.2    Esposito, G.3
  • 83
    • 85044385733 scopus 로고    scopus 로고
    • Cannabidiol reverses deficits in hippocampal ltp in a model of alzheimers disease
    • B. Hughes and C. E. Herron, "Cannabidiol Reverses Deficits in Hippocampal LTP in a Model of Alzheimers Disease, " Neurochemical Research, 2018.
    • (2018) Neurochemical Research
    • Hughes, B.1    Herron, C.E.2
  • 84
    • 47849098044 scopus 로고    scopus 로고
    • Inflammation: Gearing the journey to cancer
    • K. Kundu and Y. J. Surh, "Inflammation: gearing the journey to cancer, " Mutat. Res, vol. 659, pp. 15-30, 2008.
    • (2008) Mutat. Res , vol.659 , pp. 15-30
    • Kundu, K.1    Surh, Y.J.2
  • 85
    • 47949096781 scopus 로고    scopus 로고
    • Cancerrelated inflammation
    • A. Mantovani, P. Allavena, A. Sica, and F. Balkwill, "Cancerrelated inflammation, " Nature, vol. 454, no. 7203, pp. 436-444, 2008.
    • (2008) Nature , vol.454 , Issue.7203 , pp. 436-444
    • Mantovani, A.1    Allavena, P.2    Sica, A.3    Balkwill, F.4
  • 86
    • 0022891340 scopus 로고
    • Tumors: Wounds that do not heal: Similarities between tumor stroma generation and wound healing
    • H. F. Dvorak, "Tumors: wounds that do not heal: similarities between tumor stroma generation and wound healing, " The New England Journal ofMedicine, vol. 315, no. 26, pp. 1650-1659, 1986.
    • (1986) The New England Journal OfMedicine , vol.315 , Issue.26 , pp. 1650-1659
    • Dvorak, H.F.1
  • 87
    • 84942292465 scopus 로고    scopus 로고
    • Inflammation and cancer: Advances and new agents
    • S. M. Crusz and F. R. Balkwill, "Inflammation and cancer: Advances and new agents, " Nature Reviews Clinical Oncology, vol. 12, pp. 584-596, 2015.
    • (2015) Nature Reviews Clinical Oncology , vol.12 , pp. 584-596
    • Crusz, S.M.1    Balkwill, F.R.2
  • 88
    • 75849117800 scopus 로고    scopus 로고
    • Inflammation and oncogenesis: A vicious connection
    • S. I. Grivennikov and M. Karin, "Inflammation and oncogenesis: A vicious connection, " Curr. Opin. Genet. Dev, vol. 20, pp. 65-71, 2010.
    • (2010) Curr. Opin. Genet. Dev , vol.20 , pp. 65-71
    • Grivennikov, S.I.1    Karin, M.2
  • 89
    • 84860816141 scopus 로고    scopus 로고
    • Oncogenic EGFR signaling activates an mTORC2-NF-B pathway that promotes chemotherapy resistance
    • K. Tanaka, I. Babic, D. Nathanson et al., "Oncogenic EGFR signaling activates an mTORC2-NF-B pathway that promotes chemotherapy resistance, " Cancer Discovery, vol. 1, no. 6, pp. 524-538, 2011.
    • (2011) Cancer Discovery , vol.1 , Issue.6 , pp. 524-538
    • Tanaka, K.1    Babic, I.2    Nathanson, D.3
  • 90
    • 67650227488 scopus 로고    scopus 로고
    • The epidermal growth factor receptor: A link between inflammation and liver cancer
    • C. Berasain, M. J. Perugorria, M.U. Latasa et al., "The Epidermal Growth Factor Receptor: A Link Between Inflammation and Liver Cancer, " Experimental Biology and Medicine, vol. 234, no. 7, pp. 713-725, 2009.
    • (2009) Experimental Biology and Medicine , vol.234 , Issue.7 , pp. 713-725
    • Berasain, C.1    Perugorria, M.J.2    Latasa, M.U.3
  • 91
    • 84926410281 scopus 로고    scopus 로고
    • Modulation of the tumor microenvironment and inhibition of EGF/EGFR pathway: Novel anti-Tumor mechanisms of Cannabidiol in breast cancer
    • M. Elbaz, M. W. Nasser, J. Ravi et al., "Modulation of the tumor microenvironment and inhibition of EGF/EGFR pathway: Novel anti-Tumor mechanisms of Cannabidiol in breast cancer, "Molecular Oncology, vol. 9, no. 4, pp. 906-919, 2015.
    • (2015) Molecular Oncology , vol.9 , Issue.4 , pp. 906-919
    • Elbaz, M.1    Nasser, M.W.2    Ravi, J.3
  • 92
    • 84929338552 scopus 로고    scopus 로고
    • The differential characterization of GPR55 receptor in human peripheral blood reveals a distinctive expression in monocytes and NK cells and a proinflammatory role in these innate cells
    • V. Chiurchiu, M. Lanuti, M. De Bardi, L. Battistini, and M. Maccarrone, "The differential characterization of GPR55 receptor in human peripheral blood reveals a distinctive expression in monocytes and NK cells and a proinflammatory role in these innate cells, " International Immunology, vol. 27, no. 3, pp. 153-160, 2015.
    • (2015) International Immunology , vol.27 , Issue.3 , pp. 153-160
    • Chiurchiu, V.1    Lanuti, M.2    De Bardi, M.3    Battistini, L.4    Maccarrone, M.5
  • 93
    • 51049102995 scopus 로고    scopus 로고
    • Loss of cannabinoid receptor 1 accelerates intestinal tumor growth
    • D. Wang, H. Wang, W. Ning, M. G. Backlund, S. K. Dey, and R. N. DuBois, "Loss of cannabinoid receptor 1 accelerates intestinal tumor growth, " Cancer Research, vol. 68, no. 15, pp. 6468-6476, 2008.
    • (2008) Cancer Research , vol.68 , Issue.15 , pp. 6468-6476
    • Wang, D.1    Wang, H.2    Ning, W.3    Backlund, M.G.4    Dey, S.K.5    DuBois, R.N.6
  • 94
    • 84928204268 scopus 로고    scopus 로고
    • Cannabinoid receptor 1 promotes hepatocellular carcinoma initiation and progression throughmultiple mechanisms
    • B. Mukhopadhyay, K. Schuebel, P. Mukhopadhyay et al., "Cannabinoid receptor 1 promotes hepatocellular carcinoma initiation and progression throughmultiple mechanisms, " Hepatology, vol. 61, no. 5, pp. 1615-1626, 2015.
    • (2015) Hepatology , vol.61 , Issue.5 , pp. 1615-1626
    • Mukhopadhyay, B.1    Schuebel, K.2    Mukhopadhyay, P.3
  • 95
    • 84892617188 scopus 로고    scopus 로고
    • Expression and functional relevance of cannabinoid receptor 1 in hodgkin lymphoma
    • Article ID e81675
    • A. H. Benz, C. Renne, E. Maronde et al., "Expression and functional relevance of cannabinoid receptor 1 in hodgkin lymphoma, " PLoS ONE, vol. 8, no. 12, Article ID e81675, 2013.
    • (2013) PLoS ONE , vol.8 , Issue.12
    • Benz, A.H.1    Renne, C.2    Maronde, E.3
  • 96
    • 85058721576 scopus 로고    scopus 로고
    • Cannabinoid receptor type 1 immunoreactivity and disease severity in human epithelial ovarian tumors
    • E. M. Messalli, F. Grauso, R. Luise, A. Angelini, and R. Rossiello, "Cannabinoid receptor type 1 immunoreactivity and disease severity in human epithelial ovarian tumors, " American Journal of Obstetrics & Gynecology, vol. 211, no. 3, pp. 234-e6, 2014.
    • (2014) American Journal of Obstetrics & Gynecology , vol.211 , Issue.3 , pp. 234-234e6
    • Messalli, E.M.1    Grauso, F.2    Luise, R.3    Angelini, A.4    Rossiello, R.5
  • 99
    • 84872704122 scopus 로고    scopus 로고
    • Expression of the cannabinoid type i receptor and prognosis following surgery in colorectal cancer
    • C. K. Jung, W. K. Kang, J. M. Park et al., "Expression of the cannabinoid type I receptor and prognosis following surgery in colorectal cancer, " Oncology Letters, vol. 5, no. 3, pp. 870-876, 2013.
    • (2013) Oncology Letters , vol.5 , Issue.3 , pp. 870-876
    • Jung, C.K.1    Kang, W.K.2    Park, J.M.3
  • 102
    • 17344380844 scopus 로고    scopus 로고
    • Anti-Tumoral action of cannabinoids: Involvement of sustained ceramide accumulation and extracellular signal-regulated kinase activation
    • I. Galve-Roperh, C. Sanchez, M. L. Cortes, T. G. Del Pulgar, M. Izquierdo, and M. Guzman, "Anti-Tumoral action of cannabinoids: Involvement of sustained ceramide accumulation and extracellular signal-regulated kinase activation, " Nature Medicine, vol. 6, no. 3, pp. 313-319, 2000.
    • (2000) Nature Medicine , vol.6 , Issue.3 , pp. 313-319
    • Galve-Roperh, I.1    Sanchez, C.2    Cortes, M.L.3    Del Pulgar, T.G.4    Izquierdo, M.5    Guzman, M.6
  • 103
    • 0035422139 scopus 로고    scopus 로고
    • Inhibition of glioma growth in vivo by selective activation of the CB2 cannabinoid receptor
    • C. Sanchez, M. L. de Ceballos, T. Gomez del Pulgar et al., "Inhibition of glioma growth in vivo by selective activation of the CB2 cannabinoid receptor, " Cancer Res, vol. 61, pp. 5784-5789, 2001.
    • (2001) Cancer Res , vol.61 , pp. 5784-5789
    • Sanchez, C.1    De Ceballos, M.L.2    Gomez Del Pulgar, T.3
  • 104
    • 0037253496 scopus 로고    scopus 로고
    • Inhibition of skin tumor growth and angiogenesis in vivo by activation of cannabinoid receptors
    • M. L. Casanova, C. Blazquez, J. Martinez-Palacio et al., "Inhibition of skin tumor growth and angiogenesis in vivo by activation of cannabinoid receptors, "The Journal of Clinical Investigation, vol. 111, no. 1, pp. 43-50, 2003.
    • (2003) The Journal of Clinical Investigation , vol.111 , Issue.1 , pp. 43-50
    • Casanova, M.L.1    Blazquez, C.2    Martinez-Palacio, J.3
  • 106
    • 33746138649 scopus 로고    scopus 로고
    • Cannabinoids induce apoptosis of pancreatic tumor cells via endoplasmic reticulumstress-related genes
    • A. Carracedo, M. Gironella, M. Lorente et al., "Cannabinoids induce apoptosis of pancreatic tumor cells via endoplasmic reticulumstress-related genes, " Cancer Research, vol. 66, no. 13, pp. 6748-6755, 2006.
    • (2006) Cancer Research , vol.66 , Issue.13 , pp. 6748-6755
    • Carracedo, A.1    Gironella, M.2    Lorente, M.3
  • 107
    • 59449111015 scopus 로고    scopus 로고
    • Cannabinoid receptor activation induces apoptosis through tumor necrosis factor alpha-mediated ceramide de novo synthesis in colon cancer cells
    • F. Cianchi, L. Papucci, N. Schiavone et al., "Cannabinoid receptor activation induces apoptosis through tumor necrosis factor alpha-mediated ceramide de novo synthesis in colon cancer cells, " Clinical Cancer Research, vol. 14, no. 23, pp. 7691-7700, 2008.
    • (2008) Clinical Cancer Research , vol.14 , Issue.23 , pp. 7691-7700
    • Cianchi, F.1    Papucci, L.2    Schiavone, N.3
  • 108
    • 0036278032 scopus 로고    scopus 로고
    • Targeting the endocannabinoid system in cancer therapy: A call for further research
    • M. Bifulco and V. Di Marzo, "Targeting the endocannabinoid system in cancer therapy: A call for further research, " Nature Medicine, vol. 8, no. 6, pp. 547-550, 2002.
    • (2002) Nature Medicine , vol.8 , Issue.6 , pp. 547-550
    • Bifulco, M.1    Di Marzo, V.2
  • 109
    • 33745013193 scopus 로고    scopus 로고
    • Cannabinoids and cancer: Pros and cons of an antitumour strategy
    • M. Bifulco, C. Laezza, S. Pisanti, and P. Gazzerro, "Cannabinoids and cancer: Pros and cons of an antitumour strategy, " British Journal of Pharmacology, vol. 148, no. 2, pp. 123-135, 2006.
    • (2006) British Journal of Pharmacology , vol.148 , Issue.2 , pp. 123-135
    • Bifulco, M.1    Laezza, C.2    Pisanti, S.3    Gazzerro, P.4
  • 111
    • 0033524644 scopus 로고    scopus 로고
    • Identification and cloning of three novel humanG protein-coupled receptor genes GPR52, ?GPR53 and GPR55: GPR55 is extensively expressed in human brain
    • M. Sawzdargo, T. Nguyen, D. K. Lee et al., "Identification and cloning of three novel humanG protein-coupled receptor genes GPR52, ?GPR53 and GPR55: GPR55 is extensively expressed in human brain, " Brain Research, vol. 64, no. 2, pp. 193-198, 1999.
    • (1999) Brain Research , vol.64 , Issue.2 , pp. 193-198
    • Sawzdargo, M.1    Nguyen, T.2    Lee, D.K.3
  • 112
    • 0038024615 scopus 로고    scopus 로고
    • The G-protein-coupled receptors in the human genome form five main families. Phylogenetic analysis, paralogon groups, and fingerprints, "molecular
    • R. Fredriksson, M. C. Lagerstrom, L.-G. Lundin, and H. B. Schioth, "The G-protein-coupled receptors in the human genome form five main families. Phylogenetic analysis, paralogon groups, and fingerprints, "Molecular Pharmacology, vol. 63, no. 6, pp. 1256-1272, 2003.
    • (2003) Pharmacology , vol.63 , Issue.6 , pp. 1256-1272
    • Fredriksson, R.1    Lagerstrom, M.C.2    Lundin, L.-G.3    Schioth, H.B.4
  • 113
    • 84879714148 scopus 로고    scopus 로고
    • OrphanGproteinreceptor GPR55 as an emerging target in cancer therapy and management
    • D. Leyva-Illades and S. DeMorrow, "OrphanGproteinreceptor GPR55 as an emerging target in cancer therapy and management, " Cancer Management and Research, vol. 5, no. 1, pp. 147-155, 2013.
    • (2013) Cancer Management and Research , vol.5 , Issue.1 , pp. 147-155
    • Leyva-Illades, D.1    DeMorrow, S.2
  • 114
    • 77952660029 scopus 로고    scopus 로고
    • GPR55 ligands promote receptor coupling to multiple signalling pathways
    • C. M. Henstridge, N. A. Balenga, R. Schroder et al., "GPR55 ligands promote receptor coupling to multiple signalling pathways, " British Journal of Pharmacology, vol. 160, no. 3, pp. 604-614, 2010.
    • (2010) British Journal of Pharmacology , vol.160 , Issue.3 , pp. 604-614
    • Henstridge, C.M.1    Balenga, N.A.2    Schroder, R.3
  • 116
    • 77952954092 scopus 로고    scopus 로고
    • Lysophosphatidylinositol induces rapid phosphorylation of p38 mitogen-Activated protein kinase and activating transcription factor 2 in HEK293 cells expressing GPR55 and IM-9 lymphoblastoid cells
    • S. Oka, S. Kimura, T. Toshida, R. Ota, A. Yamashita, and T. Sugiura, "Lysophosphatidylinositol induces rapid phosphorylation of p38 mitogen-Activated protein kinase and activating transcription factor 2 in HEK293 cells expressing GPR55 and IM-9 lymphoblastoid cells, "The Journal of Biochemistry, vol. 147, no. 5, pp. 671-678, 2010.
    • (2010) The Journal of Biochemistry , vol.147 , Issue.5 , pp. 671-678
    • Oka, S.1    Kimura, S.2    Toshida, T.3    Ota, R.4    Yamashita, A.5    Sugiura, T.6
  • 117
    • 78651393400 scopus 로고    scopus 로고
    • The orphanGprotein-coupled receptorGPR55 promotes cancer cell proliferation via ERK
    • C. Andradas, M. M. Caffarel, E. Perez-Gomez et al., "The orphanGprotein-coupled receptorGPR55 promotes cancer cell proliferation via ERK, " Oncogene, vol. 30, no. 2, pp. 245-252, 2011.
    • (2011) Oncogene , vol.30 , Issue.2 , pp. 245-252
    • Andradas, C.1    Caffarel, M.M.2    Perez-Gomez, E.3
  • 118
    • 84878019365 scopus 로고    scopus 로고
    • The orphan receptor GPR55 drives skin carcinogenesis and is upregulated in human squamous cell carcinomas
    • E. Perez-Gomez, C. Andradas, J. M. Flores et al., "The orphan receptor GPR55 drives skin carcinogenesis and is upregulated in human squamous cell carcinomas, " Oncogene, vol. 32, no. 20, pp. 2534-2542, 2013.
    • (2013) Oncogene , vol.32 , Issue.20 , pp. 2534-2542
    • Perez-Gomez, E.1    Andradas, C.2    Flores, J.M.3
  • 119
    • 35649015179 scopus 로고    scopus 로고
    • The orphan receptor GPR55 is a novel cannabinoid receptor
    • E. Ryberg, N. Larsson, S. Sjogren et al., "The orphan receptor GPR55 is a novel cannabinoid receptor, " British Journal of Pharmacology, vol. 152, no. 7, pp. 1092-1101, 2007.
    • (2007) British Journal of Pharmacology , vol.152 , Issue.7 , pp. 1092-1101
    • Ryberg, E.1    Larsson, N.2    Sjogren, S.3
  • 120
    • 70350376735 scopus 로고    scopus 로고
    • Atypical responsiveness of the orphan receptorgpr55 to cannabinoid ligands
    • A. Kapur, P. Zhao, H. Sharir et al., "Atypical responsiveness of the orphan receptorGPR55 to cannabinoid ligands, "TheJournal of Biological Chemistry, vol. 284, no. 43, pp. 29817-29827, 2009.
    • (2009) TheJournal of Biological Chemistry , vol.284 , Issue.43 , pp. 29817-29827
    • Kapur, A.1    Zhao, P.2    Sharir, H.3
  • 121
    • 79960115996 scopus 로고    scopus 로고
    • Cannabidiol induces programmed cell death in breast cancer cells by coordinating the cross-Talk between apoptosis and autophagy
    • A. Shrivastava, P. M. Kuzontkoski, J. E. Groopman, and A. Prasad, "Cannabidiol Induces Programmed Cell Death in Breast Cancer Cells by Coordinating the Cross-Talk between Apoptosis and Autophagy, "Molecular CancerTherapeutics, vol. 10, no. 7, pp. 1161-1172, 2011.
    • (2011) Molecular CancerTherapeutics , vol.10 , Issue.7 , pp. 1161-1172
    • Shrivastava, A.1    Kuzontkoski, P.M.2    Groopman, J.E.3    Prasad, A.4
  • 122
    • 77954334575 scopus 로고    scopus 로고
    • Endocannabinoid-like N-Arachidonoyl serine is a novel proangiogenic mediator
    • X. Zhang, Y. Maor, J. F. Wang, G. Kunos, and J. E. Groopman, "Endocannabinoid-like N-Arachidonoyl serine is a novel proangiogenic mediator, " British Journal of Pharmacology, vol. 160, no. 7, pp. 1583-1594, 2010.
    • (2010) British Journal of Pharmacology , vol.160 , Issue.7 , pp. 1583-1594
    • Zhang, X.1    Maor, Y.2    Wang, J.F.3    Kunos, G.4    Groopman, J.E.5
  • 124
    • 39449132224 scopus 로고    scopus 로고
    • Vanilloid transient receptor potential cation channels: An overview
    • R. Vennekens, G. Owsianik, and B. Nilius, "Vanilloid transient receptor potential cation channels: An overview, " Current Pharmaceutical Design, vol. 14, no. 1, pp. 18-31, 2008.
    • (2008) Current Pharmaceutical Design , vol.14 , Issue.1 , pp. 18-31
    • Vennekens, R.1    Owsianik, G.2    Nilius, B.3
  • 125
    • 84886091614 scopus 로고    scopus 로고
    • What do we know about the transient receptor potential vanilloid 2 (TRPV2) ion channel?
    • A. Peralvarez-Mar?n, P. Doñate-Macian, and R. Gaudet, "What do we know about the transient receptor potential vanilloid 2 (TRPV2) ion channel?" FEBS Journal, vol. 280, no. 21, pp. 5471-5487, 2013.
    • (2013) FEBS Journal , vol.280 , Issue.21 , pp. 5471-5487
    • Peralvarez-Marn, A.1    Doñate-Macian, P.2    Gaudet, R.3
  • 126
    • 0034751335 scopus 로고    scopus 로고
    • Molecular targets for cannabidiol and its synthetic analogues: Effect on vanilloid VR1 receptors and on the cellular uptake and enzymatic hydrolysis of anandamide
    • T. Bisogno, L. Hanus, L. De Petrocellis et al., "Molecular targets for cannabidiol and its synthetic analogues: Effect on vanilloid VR1 receptors and on the cellular uptake and enzymatic hydrolysis of anandamide, " British Journal of Pharmacology, vol. 134, no. 4, pp. 845-852, 2001.
    • (2001) British Journal of Pharmacology , vol.134 , Issue.4 , pp. 845-852
    • Bisogno, T.1    Hanus, L.2    De Petrocellis, L.3
  • 127
    • 46749129338 scopus 로고    scopus 로고
    • TRPV2 is activated by cannabidiol and mediates CGRP release in cultured rat dorsal root Ganglion neurons
    • N. Qin, M. P. Neeper, Y. Liu, T. L. Hutchinson, M. L. Lubin, and C. M. Flores, "TRPV2 is activated by cannabidiol and mediates CGRP release in cultured rat dorsal root Ganglion neurons, " The Journal of Neuroscience, vol. 28, no. 24, pp. 6231-6238, 2008.
    • (2008) The Journal of Neuroscience , vol.28 , Issue.24 , pp. 6231-6238
    • Qin, N.1    Neeper, M.P.2    Liu, Y.3    Hutchinson, T.L.4    Lubin, M.L.5    Flores, C.M.6
  • 128
    • 33747624175 scopus 로고    scopus 로고
    • Antitumor activity of plant cannabinoids with emphasis on the effect of cannabidiol on human breast carcinoma
    • A. Ligresti, A. S. Moriello, K. Starowicz et al., "Antitumor activity of plant cannabinoids with emphasis on the effect of cannabidiol on human breast carcinoma, " The Journal of Pharmacology and Experimental Therapeutics, vol. 318, no. 3, pp. 1375-1387, 2006.
    • (2006) The Journal of Pharmacology and Experimental Therapeutics , vol.318 , Issue.3 , pp. 1375-1387
    • Ligresti, A.1    Moriello, A.S.2    Starowicz, K.3
  • 130
    • 59149085858 scopus 로고    scopus 로고
    • Transient receptor potential type vanilloid 1 suppresses skin carcinogenesis
    • A. M. Bode, Y.-Y. Cho, D. Zheng et al., "Transient receptor potential type vanilloid 1 suppresses skin carcinogenesis, " Cancer Research, vol. 69, no. 3, pp. 905-913, 2009.
    • (2009) Cancer Research , vol.69 , Issue.3 , pp. 905-913
    • Bode, A.M.1    Cho, Y.-Y.2    Zheng, D.3
  • 131
    • 35748935064 scopus 로고    scopus 로고
    • The type 1 insulinlike growth factor receptor is over-expressed in bladder cancer
    • M. A. Rochester, N. Patel, B.W. Turney et al., "The type 1 insulinlike growth factor receptor is over-expressed in bladder cancer, " BJU International, vol. 100, no. 6, pp. 1396-1401, 2007.
    • (2007) BJU International , vol.100 , Issue.6 , pp. 1396-1401
    • Rochester, M.A.1    Patel, N.2    Turney, B.W.3
  • 132
    • 69449089475 scopus 로고    scopus 로고
    • Triggering of transient receptor potential vanilloid type 1 (TRPV1) by capsaicin induces Fas/CD95-mediated apoptosis of urothelial cancer cells in anATM-dependentmanner
    • C. Amantini, P. Ballarini, S. Caprodossi et al., "Triggering of transient receptor potential vanilloid type 1 (TRPV1) by capsaicin induces Fas/CD95-mediated apoptosis of urothelial cancer cells in anATM-dependentmanner, " Carcinogenesis, vol. 30, no. 8, pp. 1320-1329, 2009.
    • (2009) Carcinogenesis , vol.30 , Issue.8 , pp. 1320-1329
    • Amantini, C.1    Ballarini, P.2    Caprodossi, S.3
  • 133
    • 84866075641 scopus 로고    scopus 로고
    • CB2and TRPV1 receptors mediate cannabinoid actions on MDR1 expression in multidrug resistant cells
    • J. C. Arnold, P. Hone, M. L. Holland, and J.D. Allen, "CB2and TRPV1 receptors mediate cannabinoid actions on MDR1 expression in multidrug resistant cells, " Pharmacological Reports, vol. 64, no. 3, pp. 751-757, 2012.
    • (2012) Pharmacological Reports , vol.64 , Issue.3 , pp. 751-757
    • Arnold, J.C.1    Hone, P.2    Holland, M.L.3    Allen, J.D.4
  • 134
    • 84872128254 scopus 로고    scopus 로고
    • Triggering of the TRPV2 channel by cannabidiol sensitizes glioblastoma cells to cytotoxic chemotherapeutic agents
    • M. Nabissi, M. B. Morelli, M. Santoni, and G. Santoni, "Triggering of the TRPV2 channel by cannabidiol sensitizes glioblastoma cells to cytotoxic chemotherapeutic agents, " Carcinogenesis, vol. 34, no. 1, pp. 48-57, 2013.
    • (2013) Carcinogenesis , vol.34 , Issue.1 , pp. 48-57
    • Nabissi, M.1    Morelli, M.B.2    Santoni, M.3    Santoni, G.4
  • 135
    • 84864460084 scopus 로고    scopus 로고
    • The transient receptor potential vanilloid-2 cation channel impairs glioblastoma stem-like cell proliferation and promotes differentiation
    • M. B. Morelli, M. Nabissi, C. Amantini et al., "The transient receptor potential vanilloid-2 cation channel impairs glioblastoma stem-like cell proliferation and promotes differentiation, " International Journal of Cancer, vol. 131, no. 7, pp. E1067-E1077, 2012.
    • (2012) International Journal of Cancer , vol.131 , Issue.7 , pp. E1067-E1077
    • Morelli, M.B.1    Nabissi, M.2    Amantini, C.3
  • 136
    • 79960835512 scopus 로고    scopus 로고
    • Pathways mediating the effects of cannabidiol on the reduction of breast cancer cell proliferation, invasion, and metastasis
    • S. D. McAllister, R. Murase, R. T. Christian et al., "Pathways mediating the effects of cannabidiol on the reduction of breast cancer cell proliferation, invasion, and metastasis, " Breast Cancer Research and Treatment, vol. 129, no. 1, pp. 37-47, 2011.
    • (2011) Breast Cancer Research and Treatment , vol.129 , Issue.1 , pp. 37-47
    • McAllister, S.D.1    Murase, R.2    Christian, R.T.3
  • 137
    • 23144464750 scopus 로고    scopus 로고
    • Id family of helix-loophelix proteins in cancer
    • J. Perk, A. Iavarone, and R. Benezra, "Id family of helix-loophelix proteins in cancer, " Nature Reviews Cancer, vol. 5, no. 8, pp. 603-614, 2005.
    • (2005) Nature Reviews Cancer , vol.5 , Issue.8 , pp. 603-614
    • Perk, J.1    Iavarone, A.2    Benezra, R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.