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Volumn 94, Issue 9, 2016, Pages 1039-1051

Marijuana-derived Δ-9-tetrahydrocannabinol suppresses Th1/Th17 cell-mediated delayed-type hypersensitivity through microRNA regulation

Author keywords

Cannabinoid; Hypersensitivity; Inflammation; microRNA; Th1 Th17 regulation; THC

Indexed keywords

CYTOKINE; DRONABINOL; GAMMA INTERFERON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERFERON REGULATORY FACTOR 4; INTERLEUKIN 17; MICRORNA; MICRORNA 29B; RETINOID RELATED ORPHAN RECEPTOR GAMMA; SMAD7 PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR T BET; AUTACOID;

EID: 84962009783     PISSN: 09462716     EISSN: 14321440     Source Type: Journal    
DOI: 10.1007/s00109-016-1404-5     Document Type: Article
Times cited : (36)

References (52)
  • 1
    • 77953255484 scopus 로고    scopus 로고
    • The cytokine milieu in the interplay of pathogenic Th1/Th17 cells and regulatory T cells in autoimmune disease
    • COI: 1:CAS:528:DC%2BC3cXlsFSmtbo%3D
    • Leung S, Liu X, Fang L, Chen X, Guo T, Zhang J (2010) The cytokine milieu in the interplay of pathogenic Th1/Th17 cells and regulatory T cells in autoimmune disease. Cellu Molec Immunol 7(3):182–189
    • (2010) Cellu Molec Immunol , vol.7 , Issue.3 , pp. 182-189
    • Leung, S.1    Liu, X.2    Fang, L.3    Chen, X.4    Guo, T.5    Zhang, J.6
  • 2
    • 0027321298 scopus 로고
    • Generation of rat Th2-like cells in vitro is interleukin-4-dependent and inhibited by interferon-gamma
    • COI: 1:CAS:528:DyaK3sXmt1eqt74%3D, PID: 8406581
    • Noble A, Staynov DZ, Kemeny DM (1993) Generation of rat Th2-like cells in vitro is interleukin-4-dependent and inhibited by interferon-gamma. Immunology 79(4):562–567
    • (1993) Immunology , vol.79 , Issue.4 , pp. 562-567
    • Noble, A.1    Staynov, D.Z.2    Kemeny, D.M.3
  • 3
    • 0027999309 scopus 로고
    • Th1/Th2 cross regulation
    • COI: 1:CAS:528:DyaK2cXmslymtrc%3D, PID: 7967633
    • Fishman MA, Perelson AS (1994) Th1/Th2 cross regulation. J Theor Biol 170(1):25–56
    • (1994) J Theor Biol , vol.170 , Issue.1 , pp. 25-56
    • Fishman, M.A.1    Perelson, A.S.2
  • 4
    • 21344467014 scopus 로고    scopus 로고
    • Th1 and Th2 lymphocytes in autoimmune disease
    • COI: 1:CAS:528:DC%2BD2sXktleit7k%3D, PID: 15952931
    • Crane IJ, Forrester JV (2005) Th1 and Th2 lymphocytes in autoimmune disease. Crit Rev Immunol 25(2):75–102
    • (2005) Crit Rev Immunol , vol.25 , Issue.2 , pp. 75-102
    • Crane, I.J.1    Forrester, J.V.2
  • 5
    • 42249084849 scopus 로고    scopus 로고
    • Either a Th17 or a Th1 effector response can drive autoimmunity: conditions of disease induction affect dominant effector category
    • COI: 1:CAS:528:DC%2BD1cXkvVyrsro%3D
    • Luger D, Silver PB, Tang J, Cua D, Chen Z, Iwakura Y, Bowman EP, Sgambellone NM, Chan CC, Caspi RR (2008) Either a Th17 or a Th1 effector response can drive autoimmunity: conditions of disease induction affect dominant effector category. J Experiment Med 205(4):799–810
    • (2008) J Experiment Med , vol.205 , Issue.4 , pp. 799-810
    • Luger, D.1    Silver, P.B.2    Tang, J.3    Cua, D.4    Chen, Z.5    Iwakura, Y.6    Bowman, E.P.7    Sgambellone, N.M.8    Chan, C.C.9    Caspi, R.R.10
  • 6
    • 61749093508 scopus 로고    scopus 로고
    • IL-17A and IL-17F do not contribute vitally to autoimmune neuro-inflammation in mice
    • COI: 1:CAS:528:DC%2BD1MXmtFChsw%3D%3D, PID: 19075395
    • Haak S, Croxford AL, Kreymborg K, Heppner FL, Pouly S, Becher B, Waisman A (2009) IL-17A and IL-17F do not contribute vitally to autoimmune neuro-inflammation in mice. J Clin Invest 119(1):61–69
    • (2009) J Clin Invest , vol.119 , Issue.1 , pp. 61-69
    • Haak, S.1    Croxford, A.L.2    Kreymborg, K.3    Heppner, F.L.4    Pouly, S.5    Becher, B.6    Waisman, A.7
  • 9
    • 78650304236 scopus 로고    scopus 로고
    • Charting histone modifications and the functional organization of mammalian genomes
    • PID: 21116306
    • Zhou VW, Goren A, Bernstein BE (2011) Charting histone modifications and the functional organization of mammalian genomes. Nat Rev Genet 12(1):7–18
    • (2011) Nat Rev Genet , vol.12 , Issue.1 , pp. 7-18
    • Zhou, V.W.1    Goren, A.2    Bernstein, B.E.3
  • 10
    • 84903837980 scopus 로고    scopus 로고
    • Histone modifications are associated with delta(9)-tetrahydrocannabinol-mediated alterations in antigen-specific T cell responses
    • Yang X, Hegde VL, Rao R, Zhang J, Nagarkatti PS, Nagarkatti M (2014) Histone modifications are associated with delta(9)-tetrahydrocannabinol-mediated alterations in antigen-specific T cell responses. J Biol Chem. doi:10.1074/jbc.M113.545210
    • (2014) J Biol Chem
    • Yang, X.1    Hegde, V.L.2    Rao, R.3    Zhang, J.4    Nagarkatti, P.S.5    Nagarkatti, M.6
  • 11
    • 84903167027 scopus 로고    scopus 로고
    • Staphylococcal enterotoxin B-induced microRNA-155 targets SOCS1 to promote acute inflammatory lung injury
    • PID: 24778118
    • Rao R, Rieder SA, Nagarkatti P, Nagarkatti M (2014) Staphylococcal enterotoxin B-induced microRNA-155 targets SOCS1 to promote acute inflammatory lung injury. Infect Immun 82(7):2971–2979
    • (2014) Infect Immun , vol.82 , Issue.7 , pp. 2971-2979
    • Rao, R.1    Rieder, S.A.2    Nagarkatti, P.3    Nagarkatti, M.4
  • 12
    • 84883162180 scopus 로고    scopus 로고
    • MicroRNA-mediated regulation of T helper cell differentiation and plasticity
    • COI: 1:CAS:528:DC%2BC3sXht1Sjtr%2FM, PID: 23907446
    • Baumjohann D, Ansel KM (2013) MicroRNA-mediated regulation of T helper cell differentiation and plasticity. Nat Rev Immunol 13(9):666–678
    • (2013) Nat Rev Immunol , vol.13 , Issue.9 , pp. 666-678
    • Baumjohann, D.1    Ansel, K.M.2
  • 13
    • 58249088751 scopus 로고    scopus 로고
    • MicroRNAs: target recognition and regulatory functions
    • COI: 1:CAS:528:DC%2BD1MXhs1Kiuro%3D, PID: 19167326
    • Bartel DP (2009) MicroRNAs: target recognition and regulatory functions. Cell 136(2):215–233
    • (2009) Cell , vol.136 , Issue.2 , pp. 215-233
    • Bartel, D.P.1
  • 14
    • 84857771478 scopus 로고    scopus 로고
    • Encoding stability versus flexibility: lessons learned from examining epigenetics in T helper cell differentiation
    • COI: 1:CAS:528:DC%2BC38XhsFCqs7jN, PID: 21748629
    • Oestreich KJ, Weinmann AS (2012) Encoding stability versus flexibility: lessons learned from examining epigenetics in T helper cell differentiation. Curr Top Microbiol Immunol 356:145–164
    • (2012) Curr Top Microbiol Immunol , vol.356 , pp. 145-164
    • Oestreich, K.J.1    Weinmann, A.S.2
  • 15
    • 0024433227 scopus 로고
    • The role of IFN-gamma in delayed-type hypersensitivity mediated by Th1 clones
    • COI: 1:CAS:528:DyaL1MXmtlSnsLY%3D, PID: 2530282
    • Fong TA, Mosmann TR (1989) The role of IFN-gamma in delayed-type hypersensitivity mediated by Th1 clones. J Immunol 143(9):2887–2893
    • (1989) J Immunol , vol.143 , Issue.9 , pp. 2887-2893
    • Fong, T.A.1    Mosmann, T.R.2
  • 16
    • 0036754255 scopus 로고    scopus 로고
    • Antigen-specific T cell sensitization is impaired in IL-17-deficient mice, causing suppression of allergic cellular and humoral responses
    • COI: 1:CAS:528:DC%2BD38XnsFGrsLg%3D, PID: 12354389
    • Nakae S, Komiyama Y, Nambu A, Sudo K, Iwase M, Homma I, Sekikawa K, Asano M, Iwakura Y (2002) Antigen-specific T cell sensitization is impaired in IL-17-deficient mice, causing suppression of allergic cellular and humoral responses. Immunity 17(3):375–387
    • (2002) Immunity , vol.17 , Issue.3 , pp. 375-387
    • Nakae, S.1    Komiyama, Y.2    Nambu, A.3    Sudo, K.4    Iwase, M.5    Homma, I.6    Sekikawa, K.7    Asano, M.8    Iwakura, Y.9
  • 17
    • 85003550846 scopus 로고    scopus 로고
    • Endocannabinoid signaling in innate and adaptive immunity
    • PID: 25585882
    • Chiurchiu V, Battistini L, Maccarrone M (2015) Endocannabinoid signaling in innate and adaptive immunity. Immunology. doi:10.1111/imm.12441
    • (2015) Immunology
    • Chiurchiu, V.1    Battistini, L.2    Maccarrone, M.3
  • 18
    • 14844362003 scopus 로고    scopus 로고
    • Delta-9-tetrahydrocannabinol enhances breast cancer growth and metastasis by suppression of the antitumor immune response
    • COI: 1:CAS:528:DC%2BD2MXitVehsrc%3D, PID: 15749859
    • McKallip RJ, Nagarkatti M, Nagarkatti PS (2005) Delta-9-tetrahydrocannabinol enhances breast cancer growth and metastasis by suppression of the antitumor immune response. J Immunol 174(6):3281–3289
    • (2005) J Immunol , vol.174 , Issue.6 , pp. 3281-3289
    • McKallip, R.J.1    Nagarkatti, M.2    Nagarkatti, P.S.3
  • 19
    • 60549114334 scopus 로고    scopus 로고
    • CB(1) and CB(2) cannabinoid receptors mediate different aspects of delta-9-tetrahydrocannabinol (THC)-induced T helper cell shift following immune activation by Legionella pneumophila infection
    • Newton CA, Chou PJ, Perkins I, Klein TW (2009) CB(1) and CB(2) cannabinoid receptors mediate different aspects of delta-9-tetrahydrocannabinol (THC)-induced T helper cell shift following immune activation by Legionella pneumophila infection. J Neuroimmune Pharmacol: Off J Soc NeuroImmune Pharmacol 4(1):92–102
    • (2009) J Neuroimmune Pharmacol: Off J Soc NeuroImmune Pharmacol , vol.4 , Issue.1 , pp. 92-102
    • Newton, C.A.1    Chou, P.J.2    Perkins, I.3    Klein, T.W.4
  • 20
    • 0036889699 scopus 로고    scopus 로고
    • Delta 9-Tetrahydrocannabinol regulates Th1/Th2 cytokine balance in activated human T cells
    • COI: 1:CAS:528:DC%2BD38Xoslant7k%3D, PID: 12446015
    • Yuan M, Kiertscher SM, Cheng Q, Zoumalan R, Tashkin DP, Roth MD (2002) Delta 9-Tetrahydrocannabinol regulates Th1/Th2 cytokine balance in activated human T cells. J Neuroimmunol 133(1-2):124–131
    • (2002) J Neuroimmunol , vol.133 , Issue.1-2 , pp. 124-131
    • Yuan, M.1    Kiertscher, S.M.2    Cheng, Q.3    Zoumalan, R.4    Tashkin, D.P.5    Roth, M.D.6
  • 21
    • 84924961972 scopus 로고    scopus 로고
    • Delta tetrahydrocannabinol attenuates Staphylococcal enterotoxin B-induced inflammatory lung injury and prevents mortality in mice by modulation of miR-17-92 cluster and induction of T-regulatory cells
    • PID: 24977655
    • Rao R, Nagarkatti PS, Nagarkatti M (2014) Delta tetrahydrocannabinol attenuates Staphylococcal enterotoxin B-induced inflammatory lung injury and prevents mortality in mice by modulation of miR-17-92 cluster and induction of T-regulatory cells. Br J Pharmacol. doi:10.1111/bph.13026
    • (2014) Br J Pharmacol
    • Rao, R.1    Nagarkatti, P.S.2    Nagarkatti, M.3
  • 22
    • 84929192483 scopus 로고    scopus 로고
    • Delta9 tetrahydrocannabinol-mediated epigenetic modifications elicit myeloid-derived suppressor cell activation via STAT3/S100A8
    • Sido JM, Yang X, Nagarkatti PS, Nagarkatti M (2015) Delta9 tetrahydrocannabinol-mediated epigenetic modifications elicit myeloid-derived suppressor cell activation via STAT3/S100A8. J Leukoc Biol. doi:10.1189/jlb.1A1014-479R
    • (2015) J Leukoc Biol
    • Sido, J.M.1    Yang, X.2    Nagarkatti, P.S.3    Nagarkatti, M.4
  • 26
    • 84883149080 scopus 로고    scopus 로고
    • Anti-inflammatory activity of topical THC in DNFB-mediated mouse allergic contact dermatitis independent of CB1 and CB2 receptors
    • COI: 1:CAS:528:DC%2BC3sXhtlentbvK, PID: 23889474
    • Gaffal E, Cron M, Glodde N, Tuting T (2013) Anti-inflammatory activity of topical THC in DNFB-mediated mouse allergic contact dermatitis independent of CB1 and CB2 receptors. Allergy 68(8):994–1000
    • (2013) Allergy , vol.68 , Issue.8 , pp. 994-1000
    • Gaffal, E.1    Cron, M.2    Glodde, N.3    Tuting, T.4
  • 27
    • 84899458904 scopus 로고    scopus 로고
    • Anandamide attenuates Th-17 cell-mediated delayed-type hypersensitivity response by triggering IL-10 production and consequent microRNA induction
    • PID: 24699635
    • Jackson AR, Nagarkatti P, Nagarkatti M (2014) Anandamide attenuates Th-17 cell-mediated delayed-type hypersensitivity response by triggering IL-10 production and consequent microRNA induction. PLoS One 9(4):e93954
    • (2014) PLoS One , vol.9 , Issue.4
    • Jackson, A.R.1    Nagarkatti, P.2    Nagarkatti, M.3
  • 28
    • 84891408224 scopus 로고    scopus 로고
    • Distinct microRNA expression profile and targeted biological pathways in functional myeloid-derived suppressor cells induced by Delta9-tetrahydrocannabinol in vivo: regulation of CCAAT/enhancer-binding protein alpha by microRNA-690
    • COI: 1:CAS:528:DC%2BC2cXlt1am, PID: 24202177
    • Hegde VL, Tomar S, Jackson A, Rao R, Yang X, Singh UP, Singh NP, Nagarkatti PS, Nagarkatti M (2013) Distinct microRNA expression profile and targeted biological pathways in functional myeloid-derived suppressor cells induced by Delta9-tetrahydrocannabinol in vivo: regulation of CCAAT/enhancer-binding protein alpha by microRNA-690. J Biol Chem 288(52):36810–36826
    • (2013) J Biol Chem , vol.288 , Issue.52 , pp. 36810-36826
    • Hegde, V.L.1    Tomar, S.2    Jackson, A.3    Rao, R.4    Yang, X.5    Singh, U.P.6    Singh, N.P.7    Nagarkatti, P.S.8    Nagarkatti, M.9
  • 29
    • 77952493930 scopus 로고    scopus 로고
    • Anandamide suppresses proliferation and cytokine release from primary human T-lymphocytes mainly via CB2 receptors
    • PID: 20098669
    • Cencioni MT, Chiurchiu V, Catanzaro G, Borsellino G, Bernardi G, Battistini L, Maccarrone M (2010) Anandamide suppresses proliferation and cytokine release from primary human T-lymphocytes mainly via CB2 receptors. PLoS One 5(1):e8688
    • (2010) PLoS One , vol.5 , Issue.1
    • Cencioni, M.T.1    Chiurchiu, V.2    Catanzaro, G.3    Borsellino, G.4    Bernardi, G.5    Battistini, L.6    Maccarrone, M.7
  • 30
    • 79954937143 scopus 로고    scopus 로고
    • The endocannabinoid anandamide downregulates IL-23 and IL-12 subunits in a viral model of multiple sclerosis: evidence for a cross-talk between IL-12p70/IL-23 axis and IL-10 in microglial cells
    • COI: 1:CAS:528:DC%2BC3MXltFOrtbs%3D, PID: 21310228
    • Correa F, Hernangomez-Herrero M, Mestre L, Loria F, Docagne F, Guaza C (2011) The endocannabinoid anandamide downregulates IL-23 and IL-12 subunits in a viral model of multiple sclerosis: evidence for a cross-talk between IL-12p70/IL-23 axis and IL-10 in microglial cells. Brain Behav Immun 25(4):736–749
    • (2011) Brain Behav Immun , vol.25 , Issue.4 , pp. 736-749
    • Correa, F.1    Hernangomez-Herrero, M.2    Mestre, L.3    Loria, F.4    Docagne, F.5    Guaza, C.6
  • 31
    • 84893862883 scopus 로고    scopus 로고
    • Cytokines and chemokines in irritant contact dermatitis
    • Lee HY, Stieger M, Yawalkar N, Kakeda M (2013) Cytokines and chemokines in irritant contact dermatitis. Mediat Inflamm 2013:916497
    • (2013) Mediat Inflamm , vol.2013 , pp. 916497
    • Lee, H.Y.1    Stieger, M.2    Yawalkar, N.3    Kakeda, M.4
  • 32
    • 0037100265 scopus 로고    scopus 로고
    • Cutting edge: changes in histone acetylation at the IL-4 and IFN-gamma loci accompany Th1/Th2 differentiation
    • COI: 1:CAS:528:DC%2BD38XlsVSqtbc%3D, PID: 12097365
    • Fields PE, Kim ST, Flavell RA (2002) Cutting edge: changes in histone acetylation at the IL-4 and IFN-gamma loci accompany Th1/Th2 differentiation. J Immunol 169(2):647–650
    • (2002) J Immunol , vol.169 , Issue.2 , pp. 647-650
    • Fields, P.E.1    Kim, S.T.2    Flavell, R.A.3
  • 34
    • 58549094107 scopus 로고    scopus 로고
    • IRF4 is essential for IL-21-mediated induction, amplification, and stabilization of the Th17 phenotype
    • COI: 1:CAS:528:DC%2BD1MXksFSntg%3D%3D, PID: 19088203
    • Huber M, Brustle A, Reinhard K, Guralnik A, Walter G, Mahiny A, von Low E, Lohoff M (2008) IRF4 is essential for IL-21-mediated induction, amplification, and stabilization of the Th17 phenotype. Proc Natl Acad Sci U S A 105(52):20846–20851
    • (2008) Proc Natl Acad Sci U S A , vol.105 , Issue.52 , pp. 20846-20851
    • Huber, M.1    Brustle, A.2    Reinhard, K.3    Guralnik, A.4    Walter, G.5    Mahiny, A.6    von Low, E.7    Lohoff, M.8
  • 35
    • 41449094548 scopus 로고    scopus 로고
    • Phosphoinositide lipid phosphatases: natural regulators of phosphoinositide 3-kinase signaling in T lymphocytes
    • COI: 1:CAS:528:DC%2BD1cXhtVSmt7o%3D, PID: 18073217
    • Harris SJ, Parry RV, Westwick J, Ward SG (2008) Phosphoinositide lipid phosphatases: natural regulators of phosphoinositide 3-kinase signaling in T lymphocytes. J Biol Chem 283(5):2465–2469
    • (2008) J Biol Chem , vol.283 , Issue.5 , pp. 2465-2469
    • Harris, S.J.1    Parry, R.V.2    Westwick, J.3    Ward, S.G.4
  • 36
    • 0029597434 scopus 로고
    • NF-kappa B is activated during acute inflammation in vivo in association with elevated endothelial cell adhesion molecule gene expression and leukocyte recruitment
    • COI: 1:CAS:528:DyaK28XhsFSjurk%3D, PID: 8867672
    • Manning AM, Bell FP, Rosenbloom CL, Chosay JG, Simmons CA, Northrup JL, Shebuski RJ, Dunn CJ, Anderson DC (1995) NF-kappa B is activated during acute inflammation in vivo in association with elevated endothelial cell adhesion molecule gene expression and leukocyte recruitment. J Inflamm 45(4):283–296
    • (1995) J Inflamm , vol.45 , Issue.4 , pp. 283-296
    • Manning, A.M.1    Bell, F.P.2    Rosenbloom, C.L.3    Chosay, J.G.4    Simmons, C.A.5    Northrup, J.L.6    Shebuski, R.J.7    Dunn, C.J.8    Anderson, D.C.9
  • 40
    • 84923343158 scopus 로고    scopus 로고
    • Natural indoles, Indole-3-Carbinol (I3C) and 3,3′-Diindolylmethane (DIM), attenuate staphylococcal enterotoxin B-mediated liver injury by downregulating miR-31 expression and promoting caspase-2-mediated apoptosis
    • PID: 25706292
    • Busbee PB, Nagarkatti M, Nagarkatti PS (2015) Natural indoles, Indole-3-Carbinol (I3C) and 3,3′-Diindolylmethane (DIM), attenuate staphylococcal enterotoxin B-mediated liver injury by downregulating miR-31 expression and promoting caspase-2-mediated apoptosis. PLoS One 10(2):e0118506
    • (2015) PLoS One , vol.10 , Issue.2
    • Busbee, P.B.1    Nagarkatti, M.2    Nagarkatti, P.S.3
  • 41
    • 80052168226 scopus 로고    scopus 로고
    • Targeting cannabinoid receptors as a novel approach in the treatment of graft-versus-host disease: evidence from an experimental murine model
    • COI: 1:CAS:528:DC%2BC3MXhsFaktLjP, PID: 21673072
    • Pandey R, Hegde VL, Nagarkatti M, Nagarkatti PS (2011) Targeting cannabinoid receptors as a novel approach in the treatment of graft-versus-host disease: evidence from an experimental murine model. J Pharmacol Exp Ther 338(3):819–828
    • (2011) J Pharmacol Exp Ther , vol.338 , Issue.3 , pp. 819-828
    • Pandey, R.1    Hegde, V.L.2    Nagarkatti, M.3    Nagarkatti, P.S.4
  • 42
    • 80053165004 scopus 로고    scopus 로고
    • Intradermal immunization in the ear with cholera toxin and its non-toxic beta subunit promotes efficient Th1 and Th17 differentiation dependent on migrating DCs
    • COI: 1:CAS:528:DC%2BC3MXht1Srs77L, PID: 21792876
    • Meza-Sanchez D, Perez-Montesinos G, Sanchez-Garcia J, Moreno J, Bonifaz LC (2011) Intradermal immunization in the ear with cholera toxin and its non-toxic beta subunit promotes efficient Th1 and Th17 differentiation dependent on migrating DCs. Eur J Immunol 41(10):2894–2904
    • (2011) Eur J Immunol , vol.41 , Issue.10 , pp. 2894-2904
    • Meza-Sanchez, D.1    Perez-Montesinos, G.2    Sanchez-Garcia, J.3    Moreno, J.4    Bonifaz, L.C.5
  • 43
    • 4744342396 scopus 로고    scopus 로고
    • The THC-induced suppression of Th1 polarization in response to Legionella pneumophila infection is not mediated by increases in corticosterone and PGE2
    • COI: 1:CAS:528:DC%2BD2cXot12nsbY%3D, PID: 15258190
    • Newton CA, Lu T, Nazian SJ, Perkins I, Friedman H, Klein TW (2004) The THC-induced suppression of Th1 polarization in response to Legionella pneumophila infection is not mediated by increases in corticosterone and PGE2. J Leukoc Biol 76(4):854–861
    • (2004) J Leukoc Biol , vol.76 , Issue.4 , pp. 854-861
    • Newton, C.A.1    Lu, T.2    Nazian, S.J.3    Perkins, I.4    Friedman, H.5    Klein, T.W.6
  • 44
    • 84890159372 scopus 로고    scopus 로고
    • Selective CB2 receptor activation ameliorates EAE by reducing Th17 differentiation and immune cell accumulation in the CNS
    • COI: 1:CAS:528:DC%2BC2cXhtFSrt70%3D, PID: 24342422
    • Kong W, Li H, Tuma RF, Ganea D (2014) Selective CB2 receptor activation ameliorates EAE by reducing Th17 differentiation and immune cell accumulation in the CNS. Cell Immunol 287(1):1–17
    • (2014) Cell Immunol , vol.287 , Issue.1 , pp. 1-17
    • Kong, W.1    Li, H.2    Tuma, R.F.3    Ganea, D.4
  • 45
    • 0024408824 scopus 로고
    • Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones
    • COI: 1:CAS:528:DyaK3cXhtFKqtL0%3D
    • Fiorentino DF, Bond MW, Mosmann TR (1989) Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones. J Experiment Med 170(6):2081–2095
    • (1989) J Experiment Med , vol.170 , Issue.6 , pp. 2081-2095
    • Fiorentino, D.F.1    Bond, M.W.2    Mosmann, T.R.3
  • 47
    • 4644309196 scopus 로고    scopus 로고
    • The functions of animal microRNAs
    • COI: 1:CAS:528:DC%2BD2cXnsFaiu7g%3D, PID: 15372042
    • Ambros V (2004) The functions of animal microRNAs. Nature 431(7006):350–355
    • (2004) Nature , vol.431 , Issue.7006 , pp. 350-355
    • Ambros, V.1
  • 48
    • 84911108527 scopus 로고    scopus 로고
    • Decreased expression of microRNA-21 correlates with the imbalance of Th17 and Treg cells in patients with rheumatoid arthritis
    • COI: 1:CAS:528:DC%2BC2cXhvVCgsb%2FI, PID: 25164131
    • Dong L, Wang X, Tan J, Li H, Qian W, Chen J, Chen Q, Wang J, Xu W, Tao C et al (2014) Decreased expression of microRNA-21 correlates with the imbalance of Th17 and Treg cells in patients with rheumatoid arthritis. J Cell Mol Med 18(11):2213–2224
    • (2014) J Cell Mol Med , vol.18 , Issue.11 , pp. 2213-2224
    • Dong, L.1    Wang, X.2    Tan, J.3    Li, H.4    Qian, W.5    Chen, J.6    Chen, Q.7    Wang, J.8    Xu, W.9    Tao, C.10
  • 50
    • 84912016265 scopus 로고    scopus 로고
    • Serum microRNA-29 levels correlate with disease progression in patients with chronic hepatitis B virus infection
    • COI: 1:CAS:528:DC%2BC2cXhvVCgtLzL, PID: 25138057
    • Huang C, Zheng JM, Cheng Q, Yu KK, Ling QX, Chen MQ, Li N (2014) Serum microRNA-29 levels correlate with disease progression in patients with chronic hepatitis B virus infection. J Dig Dis 15(11):614–621
    • (2014) J Dig Dis , vol.15 , Issue.11 , pp. 614-621
    • Huang, C.1    Zheng, J.M.2    Cheng, Q.3    Yu, K.K.4    Ling, Q.X.5    Chen, M.Q.6    Li, N.7
  • 52
    • 84920767644 scopus 로고    scopus 로고
    • Chronic administration of delta9-tetrahydrocannabinol induces intestinal anti-inflammatory microRNA expression during acute simian immunodeficiency virus infection of rhesus macaques
    • PID: 25378491
    • Chandra LC, Kumar V, Torben W, Vande Stouwe C, Winsauer P, Amedee A, Molina PE, Mohan M (2015) Chronic administration of delta9-tetrahydrocannabinol induces intestinal anti-inflammatory microRNA expression during acute simian immunodeficiency virus infection of rhesus macaques. J Virol 89(2):1168–1181
    • (2015) J Virol , vol.89 , Issue.2 , pp. 1168-1181
    • Chandra, L.C.1    Kumar, V.2    Torben, W.3    Vande Stouwe, C.4    Winsauer, P.5    Amedee, A.6    Molina, P.E.7    Mohan, M.8


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