CB2and TRPV1 receptors mediate cannabinoid actions on MDR1 expression in multidrug resistant cells

Pharmacological Reports

Volumn 64, Issue 3, 2012, Pages 751-757

  Arnold, Jonathon C ^a   Hone, Phoebe ^a   Holland, Michelle L ^a   Allen, John D ^b  

^a UNIVERSITY OF SYDNEY   (Australia)

^b CENTENARY INSTITUTE   (Australia)

Author keywords

Cannabinoids; P glycoprotein

Indexed keywords

CANNABIDIOL; CANNABINOID; CANNABINOID 2 RECEPTOR; DRONABINOL; GLYCOPROTEIN P; MESSENGER RNA; MULTIDRUG RESISTANCE PROTEIN 1; RHODAMINE 123; VANILLOID RECEPTOR 1; MULTIDRUG RESISTANCE PROTEIN; TETRAHYDROCANNABINOL; TRPV1 RECEPTOR; VANILLOID RECEPTOR;

ARTICLE; BIOACCUMULATION; DOSE TIME EFFECT RELATION; DRUG EFFECT; GENE AMPLIFICATION; GENE EXPRESSION REGULATION; GENE INDUCTION; GENETIC TRANSCRIPTION; INCUBATION TIME; LEUKEMIA CELL; MULTIDRUG RESISTANCE; MULTIDRUG RESISTANCE 1 GENE; NUCLEOTIDE SEQUENCE; PROTEIN FUNCTION; PROTEIN TRANSPORT; TUMOR GENE; UPREGULATION; DRUG RESISTANCE; GENETICS; HUMAN; METABOLISM; TIME; TUMOR CELL LINE;

CANNABIDIOL; CELL LINE, TUMOR; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; GENE AMPLIFICATION; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; P-GLYCOPROTEIN; RECEPTOR, CANNABINOID, CB2; RHODAMINE 123; RNA, MESSENGER; TETRAHYDROCANNABINOL; TIME FACTORS; TRPV CATION CHANNELS;

EID: 84866075641     PISSN: 22995684     EISSN: 22995684     Source Type: Journal    
DOI: 10.1016/S1734-1140(12)70871-X     Document Type: Article

References (29)

1. Aleman C, Annereau JP, Liang XJ, Cardarelli CO, Taylor B, Yin JJ, Aszalos A, Gottesman MM: P-glycoprotein, expressed in multidrug resistant cells, is not responsible for alterations in membrane fluidity or membrane potential. Cancer Res, 2003, 63, 3084-3091.
2. Beck WT, Mueller TJ, Tanzer LR: Altered surface membrane glycoproteins in Vinca alkaloid-resistant human leukemic lymphoblasts. Cancer Res, 1979, 39, 2070-2076.
3. Biedler JL, Riehm H: Cellular resistance to actinomycin D in Chinese hamster cells in vitro: cross-resistance, radioautographic, and cytogenetic studies. Cancer Res, 1970, 30, 1174-1184.
4. Bisogno T, Hanus L, De Petrocellis L, Tchilibon S, Ponde DE, Brandi I, Moriello AS, Davis JB et al.: Molecular targets for cannabidiol and its synthetic analogues: effect on vanilloid VR1 receptors and on the cellular uptake and enzymatic hydrolysis of anandamide. Br J Pharmacol, 2001, 134, 845-852.
5. Chin KV, Tanaka S, Darlington G, Pastan I, Gottesman MM: Heat shock and arsenite increase expression of the multidrug resistance (MDR1) gene in human renal carcinoma cells. J Biol Chem, 1990, 265, 221-226.
6. Fan SF, Yazulla S: Biphasic modulation of voltagedependent currents of retinal cones by cannabinoid CB1 receptor agonist WIN 55212-2. Vis Neurosci, 2003, 20, 177-188.
7. Felder CC, Joyce KE, Briley EM, Mansouri J, Mackie K, Blond O, Lai Y, Ma AL et al.: Comparison of the pharmacology and signal transduction of the human cannabinoid CB1 and CB2 receptors. Mol Pharmacol, 1995, 48, 443-450.
8. Fojo A, Akiyama S, Gottesman MM, Pastan I: Reduced drug accumulation in multiply drug-resistant human KB carcinoma cell lines. Cancer Res, 1985, 45, 3002-3007.
9. Gottesman MM, Fojo T, Bates SE: Multidrug resistance in cancer: role of ATP-dependent transporters. Nat Rev Cancer, 2002, 2, 48-58.
10. Holland ML, Allen JD, Arnold JC: Interaction of plant cannabinoids with the multidrug transporter ABCC1 (MRP1). Eur J Pharmacol, 2008, 591, 128-131.
11. Holland ML, Lau DT, Allen JD, Arnold JC: The multidrug transporter ABCG2 (BCRP) is inhibited by plant-derived cannabinoids. Br J Pharmacol, 2007, 152, 815-824.
12. Holland ML, Panetta JA, Hoskins JM, Bebawy M, Roufogalis BD, Allen JD, Arnold JC: The effects of cannabinoids on P-glycoprotein transport and expression in multidrug resistant cells. Biochem Pharmacol, 2006, 71, 1146-1154.
13. Juliano RL, Ling V: A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants. Biochim Biophys Acta, 1976, 455, 152-162.
14. Karl T, Cheng D, Garner B, Arnold JC: The therapeutic potential of the endocannabinoid system for Alzheimer's disease. Expert Opin Ther Targets, 2012, 16, 407-420.
15. Lam PM, McDonald J, Lambert DG: Characterization and comparison of recombinant human and rat TRPV1 receptors: effects of exo- and endocannabinoids. Br J Anaesth, 2005, 94, 649-656.
16. Long LE, Chesworth R, Huang XF, McGregor IS, Arnold JC, Karl T: Transmembrane domain Nrg1 mutant mice show altered susceptibility to the neurobehavioural actions of repeated THC exposure in adolescence. Int J Neuropsychopharmacol, 2012, 1-13.
17. Milojkovic M, Stojnev S, Jovanovic I, Ljubisavljevic S, Stefanovic V, Sunder-Plassman R: Frequency of the C1236T, G2677T/A and C3435T MDR1 gene polymorphisms in the Serbian population. Pharmacol Rep, 2011, 63, 808-814.
18. Parker LA, Kwiatkowska M, Burton P, Mechoulam R: Effect of cannabinoids on lithium-induced vomiting in the Suncus murinus (house musk shrew). Psychopharmacology (Berl), 2004, 171, 156-161.
19. 9-tetrahydrocannabivarin. Br J Pharmacol, 2008, 153, 199-215.
20. Pfaffl MW: A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res, 2001, 29, e45.
21. Richert ND, Aldwin L, Nitecki D, Gottesman MM, Pastan I: Stability and covalent modification of P-glycoprotein in multidrug-resistant KB cells. Biochemistry, 1988, 27, 7607-7613.
22. Rozen S, Skaletsky H: Primer3 on the WWW for general users and for biologist programmers. Methods Mol Biol, 2000, 132, 365-386.
23. Schinkel AH, Mayer U, Wagenaar E, Mol CA, van Deemter L, Smit JJ, van der Valk MA, Voordouw AC et al.: Normal viability and altered pharmacokinetics in mice lacking mdr1-type (drug-transporting) P-glycoproteins. Proc Natl Acad Sci USA, 1997, 94, 4028-4033.
24. 9-tetrahydrocannabinol in p-glycoprotein and breast cancer resistance protein knockout mice. PLoS One, 2012, 7, e35937.
25. Sulcova E, Mechoulam R, Fride E: Biphasic effects of anandamide. Pharmacol Biochem Behav, 1998, 59, 347-352.
26. Tzavara ET, Wade M, Nomikos GG: Biphasic effects of cannabinoids on acetylcholine release in the hippocampus: site and mechanism of action. J Neurosci, 2003, 23, 9374-9384.
27. Ueda K, Cornwell MM, Gottesman MM, Pastan I, Roninson IB, Ling V, Riordan JR: The mdr1 gene, responsible for multidrug-resistance, codes for P-glycoprotein. Biochem Biophys Res Commun, 1986, 141, 956-962.
28. Wang Z, Ravula R, Cao M, Chow M, Huang Y: Transporter-mediated multidrug resistance and its modulation by Chinese medicines and other herbal products. Curr Drug Discov Technol, 2010, 7, 54-66.
29. 9- tetrahydrocannabinol promotes hypertrophy and macrophage infiltration in adipose tissue. Horm Metab Res, 2012, 44, 105-113.