Neuroinflammation, neurodegeneration and regeneration in multiple sclerosis: Intercorrelated manifestations of the immune response

Neural Regeneration Research

Volumn 11, Issue 11, 2016, Pages 1727-1730

  Koudriavtseva, Tatiana ^a   Mainero, Caterina ^b,c  

^a UNIVERSITY OF ROME TOR VERGATA   (Italy)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Immune response; Innate immunity; Multiple sclerosis; Neurodegeneration; Neuroinflammation; Regeneration

Indexed keywords

CHEMOKINE; CYTOKINE; MYELIN; NEUROPEPTIDE; NEUROTRANSMITTER; NEUROTROPHIN;

ARTICLE; BRAIN ATROPHY; CELL INFILTRATION; DISEASE COURSE; GLIOSIS; HOMEOSTASIS; HUMAN; IMMUNE RESPONSE; INNATE IMMUNITY; METABOLIC STRESS; MULTIPLE SCLEROSIS; NERVE DEGENERATION; NERVE REGENERATION; NERVOUS SYSTEM INFLAMMATION; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; OXIDATIVE STRESS; POSITRON EMISSION TOMOGRAPHY;

EID: 85005992359     PISSN: 16735374     EISSN: 18767958     Source Type: Journal    
DOI: 10.4103/1673-5374.194804     Document Type: Article

References (12)

1. Amor S, Peferoen LA, Vogel DY, Breur M, van der Valk P, Baker D, van Noort JM (2014) Inflammation in neurodegenerative diseases-- an update. Immunology 142:151-166.
2. Frischer JM, Bramow S, Dal-Bianco A, Lucchinetti CF, Rauschka H, Schmidbauer M, Laursen H, Sorensen PS, Lassmann H (2009) The relation between inflammation and neurodegeneration in multiple sclerosis brains. Brain 132:1175-1189.
3. Gonzalez R, Hamblin MH, Lee JP (2016) Neural stem cell transplantation and CNS diseases. CNS Neurol Disord Drug Targets doi:10.2174/1871527315666160815164247.
4. Herranz E, Gianni C, Louapre C, Treaba CA, Govindarajan ST, Ouellette R, Loggia ML, Sloane JA, Madigan N, Izquierdo-Garcia D, Ward N, Mangeat G, Granberg T, Klawiter EC, Catana C, Hooker JM, Taylor N, Ionete C, Kinkel RP, Mainero C (2016) The neuroinflammatory component of gray matter pathology in multiple sclerosis. Ann Neurol doi:10.1002/ana.24791.
5. Hu X, Leak RK, Shi Y, Suenaga J, Gao Y, Zheng P, Chen J (2015) Microglial and macrophage polarization-new prospects for brain repair. Nat Rev Neurol 11:56-64.
6. Hutchinson M (2015) Neurodegeneration in multiple sclerosis is a process separate from inflammation: No. Mult Scler 21:1628-1631.
7. Lassmann H (2007) Multiple sclerosis: is there neurodegeneration independent from inflammation? J Neurol Sci 259:3-6.
8. Louapre C, Lubetzki C (2015) Neurodegeneration in multiple sclerosis is a process separate from inflammation: Yes. Mult Scler 21:1626-1628.
9. Moll NM, Rietsch AM, Thomas S, Ransohoff AJ, Lee JC, Fox R, Chang A, Ransohoff RM, Fisher E (2011) Multiple sclerosis normal- appearing white matter: pathology-imaging correlations. Ann Neurol 70:764-773.
10. Ransohoff RM, Brown MA (2012) Innate immunity in the central nervous system. J Clin Invest 122:1164-1171.
11. Rawji KS, Mishra MK, Yong VW (2016) Regenerative capacity of macrophages for remyelination. Front Cell Dev Biol 4:47.
12. Russi AE, Walker-Caulfield ME, Brown MA (2016) Mast cell inflammasome activity in the meninges regulates EAE disease severity. Clin Immunol doi: 10.1016/j.clim.2016.04.009.