메뉴 건너뛰기




Volumn 165, Issue 8, 2012, Pages 2598-2610

Cannabinoids mediate opposing effects on inflammation-induced intestinal permeability

Author keywords

9 tetrahydrocannabinol and cannabidiol; Caco 2 cells; Cannabinoid CB 1 receptor; Cytokines; Endocannabinoid; Inflammation; Intestinal permeability; Transepithelial electrical resistance (TEER)

Indexed keywords

1 (2,4 DICHLOROPHENYL) 5 (4 IODOPHENYL) 4 METHYL N (1 PIPERIDYL) 1H PYRAZOLE 3 CARBOXAMIDE; 2 ARACHIDONOYLGLYCEROL; 2 CHLORO 5 NITROBENZANILIDE; 6 IODO 3 (4 METHOXYBENZOYL) 2 METHYL 1 (2 MORPHOLINOETHYL)INDOLE; ANANDAMIDE; CANNABIDIOL; CAPSAZEPINE; DRONABINOL; ENDOCANNABINOID; GAMMA INTERFERON; LACTATE DEHYDROGENASE; TUMOR NECROSIS FACTOR ALPHA;

EID: 84859051261     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2011.01589.x     Document Type: Article
Times cited : (109)

References (51)
  • 1
    • 81355156238 scopus 로고    scopus 로고
    • Guide to Receptors and Channels (GRAC)
    • 5th Edition
    • Alexander SPH, Mathie A, Peters JA (2011). Guide to Receptors and Channels (GRAC), 5th Edition. Br J Pharmacol 164 (Suppl. 1): S1-S324.
    • (2011) Br J Pharmacol , vol.164 , Issue.SUPPL. 1
    • Alexander, S.P.H.1    Mathie, A.2    Peters, J.A.3
  • 2
    • 77957230984 scopus 로고    scopus 로고
    • Pharmacological effects of cannabinoids on the Caco-2 cell culture model of intestinal permeability
    • Alhamoruni A, Lee AC, Wright KL, Larvin M, O'Sullivan SE (2010). Pharmacological effects of cannabinoids on the Caco-2 cell culture model of intestinal permeability. J Pharmacol Exp Ther 335: 92-102.
    • (2010) J Pharmacol Exp Ther , vol.335 , pp. 92-102
    • Alhamoruni, A.1    Lee, A.C.2    Wright, K.L.3    Larvin, M.4    O'Sullivan, S.E.5
  • 3
    • 69849111327 scopus 로고    scopus 로고
    • Inflamed pouch mucosa possesses altered tight junctions indicating recurrence of inflammatory bowel disease
    • Amasheh S, Dullat S, Fromm M, Schulzke JD, Buhr HJ, Kroesen AJ (2009). Inflamed pouch mucosa possesses altered tight junctions indicating recurrence of inflammatory bowel disease. Int J Colorectal Dis 24: 1149-1156.
    • (2009) Int J Colorectal Dis , vol.24 , pp. 1149-1156
    • Amasheh, S.1    Dullat, S.2    Fromm, M.3    Schulzke, J.D.4    Buhr, H.J.5    Kroesen, A.J.6
  • 4
    • 0033122716 scopus 로고    scopus 로고
    • Early increase in intestinal permeability in patients with severe acute pancreatitis: Correlation with endotoxemia, organ failure, and mortality
    • Ammori BJ, Leeder PC, King RF, Barclay GR, Martin IG, Larvin M et al. (1999). Early increase in intestinal permeability in patients with severe acute pancreatitis: correlation with endotoxemia, organ failure, and mortality. J Gastrointest Surg 3: 252-262.
    • (1999) J Gastrointest Surg , vol.3 , pp. 252-262
    • Ammori, B.J.1    Leeder, P.C.2    King, R.F.3    Barclay, G.R.4    Martin, I.G.5    Larvin, M.6
  • 5
    • 77951157731 scopus 로고    scopus 로고
    • Cannabinoid receptor 1 blockade ameliorates albuminuria in experimental diabetic nephropathy
    • Barutta F, Corbelli A, Mastrocola R, Gambino R, Di Marzo V, Pinach S et al. (2010). Cannabinoid receptor 1 blockade ameliorates albuminuria in experimental diabetic nephropathy. Diabetes 59: 1046-1054.
    • (2010) Diabetes , vol.59 , pp. 1046-1054
    • Barutta, F.1    Corbelli, A.2    Mastrocola, R.3    Gambino, R.4    Di Marzo, V.5    Pinach, S.6
  • 6
    • 33749007683 scopus 로고    scopus 로고
    • Inflammatory bowel disease and the apical junctional complex
    • DOI 10.1196/annals.1326.017, Inflammatory Bowel Disease: Genetics, Barrier Function, Immunologic Mechanisms, and Microbial Pathways
    • Bruewer M, Samarin S, Nusrat A (2006). Inflammatory bowel disease and the apical junctional complex. Ann N Y Acad Sci 1072: 242-252. (Pubitemid 44448457)
    • (2006) Annals of the New York Academy of Sciences , vol.1072 , pp. 242-252
    • Bruewer, M.1    Samarin, S.2    Nusrat, A.3
  • 7
    • 46249112986 scopus 로고    scopus 로고
    • Cannabidiol, extracted from Cannabis sativa, selectively inhibits inflammatory hypermotility in mice
    • DOI 10.1038/bjp.2008.177, PII BJP2008177
    • Capasso R, Borrelli F, Aviello G, Romano B, Scalisi C, Capasso F et al. (2008). Cannabidiol, extracted from Cannabis sativa, selectively inhibits inflammatory hypermotility in mice. Br J Pharmacol 154: 1001-1008. (Pubitemid 351915071)
    • (2008) British Journal of Pharmacology , vol.154 , Issue.5 , pp. 1001-1008
    • Capasso, R.1    Borrelli, F.2    Aviello, G.3    Romano, B.4    Scalisi, C.5    Capasso, F.6    Izzo, A.A.7
  • 9
    • 13944255930 scopus 로고    scopus 로고
    • The gastrointestinal pharmacology of cannabinoids: An update
    • DOI 10.1016/j.coph.2004.05.007, PII S1471489204001638
    • Coutts AA, Izzo AA (2004). The gastrointestinal pharmacology of cannabinoids: an update. Curr Opin Pharmacol 4: 572-579. (Pubitemid 40267871)
    • (2004) Current Opinion in Pharmacology , vol.4 , Issue.6 , pp. 572-579
    • Coutts, A.A.1    Izzo, A.A.2
  • 12
    • 0141507020 scopus 로고    scopus 로고
    • 1 receptors and tumor necrosis factor-alpha in the gut and systemic anti-inflammatory activity of SR 141716 (Rimonabant) in rodents
    • DOI 10.1038/sj.bjp.0705412
    • Croci T, Landi M, Galzin AM, Marini P (2003). Role of cannabinoid CB1 receptors and tumor necrosis factor-alpha in the gut and systemic anti-inflammatory activity of SR 141716 (rimonabant) in rodents. Br J Pharmacol 140: 115-122. (Pubitemid 37175837)
    • (2003) British Journal of Pharmacology , vol.140 , Issue.1 , pp. 115-122
    • Croci, T.1    Landi, M.2    Galzin, A.-M.3    Marini, P.4
  • 13
    • 33645832524 scopus 로고    scopus 로고
    • Up-regulation of anandamide levels as an endogenous mechanism and a pharmacological strategy to limit colon inflammation
    • DOI 10.1096/fj.05-4943fje
    • D'Argenio G, Valenti M, Scaglione G, Cosenza V, Sorrentini I, Di Marzo V (2006). Up-regulation of anandamide levels as an endogenous mechanism and a pharmacological strategy to limit colon inflammation. FASEB J 20: 568-570. (Pubitemid 46671252)
    • (2006) FASEB Journal , vol.20 , Issue.3 , pp. 568-570
    • D'Argenio, G.1    Valenti, M.2    Scaglione, G.3    Cosenza, V.4    Sorrentini, I.5    Di, M.V.D.6
  • 15
    • 77950660113 scopus 로고    scopus 로고
    • Endocannabinoids as regulators of transient receptor potential (TRP) channels: A further opportunity to develop new endocannabinoid-based therapeutic drugs
    • Di Marzo V, De Petrocellis L (2010). Endocannabinoids as regulators of transient receptor potential (TRP) channels: a further opportunity to develop new endocannabinoid-based therapeutic drugs. Curr Med Chem 17: 1430-1449.
    • (2010) Curr Med Chem , vol.17 , pp. 1430-1449
    • Di Marzo, V.1    De Petrocellis, L.2
  • 16
    • 26944451293 scopus 로고    scopus 로고
    • Review article: Endocannabinoids and their receptors in the enteric nervous system
    • DOI 10.1111/j.1365-2036.2005.02648.x
    • Duncan M, Davison JS, Sharkey KA (2005). Review article: endocannabinoids and their receptors in the enteric nervous system. Aliment Pharmacol Ther 22: 667-683. (Pubitemid 41475329)
    • (2005) Alimentary Pharmacology and Therapeutics , vol.22 , Issue.8 , pp. 667-683
    • Duncan, M.1    Davison, J.S.2    Sharkey, K.A.3
  • 17
    • 51149101671 scopus 로고    scopus 로고
    • Cannabinoid CB2 receptors in the enteric nervous system modulate gastrointestinal contractility in lipopolysaccharide-treated rats
    • Duncan M, Mouihate A, Mackie K, Keenan CM, Buckley NE, Davison JS et al. (2008). Cannabinoid CB2 receptors in the enteric nervous system modulate gastrointestinal contractility in lipopolysaccharide-treated rats. Am J Physiol 295: G78-G87.
    • (2008) Am J Physiol , vol.295
    • Duncan, M.1    Mouihate, A.2    Mackie, K.3    Keenan, C.M.4    Buckley, N.E.5    Davison, J.S.6
  • 19
    • 0028906566 scopus 로고
    • Mast cells express a peripheral cannabinoid receptor with differential sensitivity to anandamide and palmitoylethanolamide
    • Facci L, Dal Toso R, Romanello S, Buriani A, Skaper SD, Leon A (1995). Mast cells express a peripheral cannabinoid receptor with differential sensitivity to anandamide and palmitoylethanolamide. Proc Natl Acad Sci U S A 92: 3376-3380.
    • (1995) Proc Natl Acad Sci U S A , vol.92 , pp. 3376-3380
    • Facci, L.1    Dal Toso, R.2    Romanello, S.3    Buriani, A.4    Skaper, S.D.5    Leon, A.6
  • 20
    • 46249121074 scopus 로고    scopus 로고
    • Effect of cannabidiol on sepsis-induced motility disturbances in mice: Involvement of CB receptors and fatty acid amide hydrolase
    • de Filippis D, Iuvone T, d'amico A, Esposito G, Steardo L, Herman AG et al. (2008). Effect of cannabidiol on sepsis-induced motility disturbances in mice: involvement of CB receptors and fatty acid amide hydrolase. Neurogastroenterol Motil 20: 919-927.
    • (2008) Neurogastroenterol Motil , vol.20 , pp. 919-927
    • De Filippis, D.1    Iuvone, T.2    D'Amico, A.3    Esposito, G.4    Steardo, L.5    Herman, A.G.6
  • 22
    • 33745500230 scopus 로고    scopus 로고
    • Neural contractions in colonic strips from patients with diverticular disease: Role of endocannabinoids and substance P
    • DOI 10.1136/gut.2005.076372
    • Guagnini F, Valenti M, Mukenge S, Matias I, Bianchetti A, Di Palo S et al. (2006). Neural contractions in colonic strips from patients with diverticular disease: role of endocannabinoids and substance P. Gut 55: 946-953. (Pubitemid 43962605)
    • (2006) Gut , vol.55 , Issue.7 , pp. 946-953
    • Guagnini, F.1    Valenti, M.2    Mukenge, S.3    Matias, I.4    Bianchetti, A.5    Di, P.S.6    Ferla, G.7    Di, M.V.8    Croci, T.9
  • 24
    • 0037219120 scopus 로고    scopus 로고
    • Inhibition of interleukin-8 release in the human colonic epithelial cell line HT-29 by cannabinoids
    • DOI 10.1016/S0014-2999(02)02698-5, PII S0014299902026985
    • Ihenetu K, Molleman A, Parsons ME, Whelan CJ (2003). Inhibition of interleukin-8 release in the human colonic epithelial cell line HT-29 by cannabinoids. Eur J Pharmacol 458: 207-215. (Pubitemid 36050722)
    • (2003) European Journal of Pharmacology , vol.458 , Issue.1-2 , pp. 207-215
    • Ihenetu, K.1    Molleman, A.2    Parsons, M.E.3    Whelan, C.J.4
  • 25
    • 34548181608 scopus 로고    scopus 로고
    • The cannabinoid CB(2) receptor: A good friend in the gut
    • Izzo AA (2007). The cannabinoid CB(2) receptor: a good friend in the gut. Neurogastroenterol Motil 19: 704-708.
    • (2007) Neurogastroenterol Motil , vol.19 , pp. 704-708
    • Izzo, A.A.1
  • 26
    • 48249136051 scopus 로고    scopus 로고
    • Emerging role of cannabinoids in gastrointestinal and liver diseases: Basic and clinical aspects
    • Izzo AA, Camilleri M (2008). Emerging role of cannabinoids in gastrointestinal and liver diseases: basic and clinical aspects. Gut 57: 1140-1155.
    • (2008) Gut , vol.57 , pp. 1140-1155
    • Izzo, A.A.1    Camilleri, M.2
  • 28
    • 0033626501 scopus 로고    scopus 로고
    • Localization of CB1-cannabinoid receptor immunoreactivity in the porcine enteric nervous system
    • Kulkarni-Narla A, Brown DR (2000). Localization of CB1-cannabinoid receptor immunoreactivity in the porcine enteric nervous system. Cell Tissue Res 302: 73-80.
    • (2000) Cell Tissue Res , vol.302 , pp. 73-80
    • Kulkarni-Narla, A.1    Brown, D.R.2
  • 29
    • 58749088580 scopus 로고    scopus 로고
    • Cannabinoids inhibit HIV-1 Gp120-mediated insults in brain microvascular endothelial cells
    • Lu TS, Avraham HK, Seng S, Tachado SD, Koziel H, Makriyannis A et al. (2008). Cannabinoids inhibit HIV-1 Gp120-mediated insults in brain microvascular endothelial cells. J Immunol 181: 6406-6416.
    • (2008) J Immunol , vol.181 , pp. 6406-6416
    • Lu, T.S.1    Avraham, H.K.2    Seng, S.3    Tachado, S.D.4    Koziel, H.5    Makriyannis, A.6
  • 31
    • 0023510866 scopus 로고
    • Structural basis for physiological regulation of paracellular pathways in intestinal epithelia
    • Madara JL, Pappenheimer JR (1987). Structural basis for physiological regulation of paracellular pathways in intestinal epithelia. J Membr Biol 100: 149-164. (Pubitemid 18004072)
    • (1987) Journal of Membrane Biology , vol.100 , Issue.2 , pp. 149-164
    • Madara, J.L.1    Pappenheimer, J.R.2
  • 32
    • 0023949917 scopus 로고
    • Functional coupling of tight junctions and microfilaments in T84 monolayers
    • Madara JL, Stafford J, Barenberg D, Carlson S (1988). Functional coupling of tight junctions and microfilaments in T84 monolayers. Am J Physiol 254 (3 Pt 1): G416-G423.
    • (1988) Am J Physiol , vol.254 , Issue.3 PART 1
    • Madara, J.L.1    Stafford, J.2    Barenberg, D.3    Carlson, S.4
  • 34
    • 4444319561 scopus 로고    scopus 로고
    • Effects of cannabinoid receptor-2 activation on accelerated gastrointestinal transit in lipopolysaccharide-treated rats
    • DOI 10.1038/sj.bjp.0705889
    • Mathison R, Ho W, Pittman QJ, Davison JS, Sharkey KA (2004). Effects of cannabinoid receptor-2 activation on accelerated gastrointestinal transit in lipopolysaccharide-treated rats. Br J Pharmacol 142: 1247-1254. (Pubitemid 39178878)
    • (2004) British Journal of Pharmacology , vol.142 , Issue.8 , pp. 1247-1254
    • Mathison, R.1    Ho, W.2    Pittman, Q.J.3    Davison, J.S.4    Sharkey, K.A.5
  • 35
    • 0022481952 scopus 로고
    • Translocation of indigenous bacteria from the gastrointestinal tract of mice after oral ricinoleic acid treatment
    • Morehouse JL, Specian RD, Stewart JJ, Berg RD (1986). Translocation of indigenous bacteria from the gastrointestinal tract of mice after oral ricinoleic acid treatment. Gastroenterology 91: 673-682. (Pubitemid 16045418)
    • (1986) Gastroenterology , vol.91 , Issue.3 , pp. 673-682
    • Morehouse, J.L.1    Specian, R.D.2    Stewart, J.J.3    Berg, R.D.4
  • 36
    • 77952646902 scopus 로고    scopus 로고
    • CB1 cannabinoid receptors promote oxidative/nitrosative stress, inflammation and cell death in a murine nephropathy model
    • Mukhopadhyay P, Pan H, Rajesh M, Bátkai S, Patel V, Harvey-White J et al. (2010). CB1 cannabinoid receptors promote oxidative/nitrosative stress, inflammation and cell death in a murine nephropathy model. Br J Pharmacol 3: 657-668.
    • (2010) Br J Pharmacol , vol.3 , pp. 657-668
    • Mukhopadhyay, P.1    Pan, H.2    Rajesh, M.3    Bátkai, S.4    Patel, V.5    Harvey-White, J.6
  • 37
    • 78650716667 scopus 로고    scopus 로고
    • Fatty acid amide hydrolase is a key regulator of endocannabinoid-induced myocardial tissue injury
    • Mukhopadhyay P, Horváth B, Rajesh M, Matsumoto S, Saito K, Bátkai S et al. (2011). Fatty acid amide hydrolase is a key regulator of endocannabinoid-induced myocardial tissue injury. Free Radic Biol Med 50: 179-195.
    • (2011) Free Radic Biol Med , vol.50 , pp. 179-195
    • Mukhopadhyay, P.1    Horváth, B.2    Rajesh, M.3    Matsumoto, S.4    Saito, K.5    Bátkai, S.6
  • 38
    • 35649008926 scopus 로고    scopus 로고
    • Cannabinoids go nuclear: Evidence for activation of peroxisome proliferator-activated receptors
    • O'Sullivan SE (2007). Cannabinoids go nuclear: evidence for activation of peroxisome proliferator-activated receptors. Br J Pharmacol 152: 576-582.
    • (2007) Br J Pharmacol , vol.152 , pp. 576-582
    • O'Sullivan, S.E.1
  • 39
    • 62449330864 scopus 로고    scopus 로고
    • Cannabidiol attenuates cisplatin-induced nephrotoxicity by decreasing oxidative/nitrosative stress, inflammation, and cell death
    • Pan H, Mukhopadhyay P, Rajesh M, Patel V, Mukhopadhyay B, Gao B et al. (2009). Cannabidiol attenuates cisplatin-induced nephrotoxicity by decreasing oxidative/nitrosative stress, inflammation, and cell death. J Pharmacol Exp Ther 328: 708-714.
    • (2009) J Pharmacol Exp Ther , vol.328 , pp. 708-714
    • Pan, H.1    Mukhopadhyay, P.2    Rajesh, M.3    Patel, V.4    Mukhopadhyay, B.5    Gao, B.6
  • 40
    • 38349158960 scopus 로고    scopus 로고
    • The diverse CB1 and CB2 receptor pharmacology of three plant cannabinoids: Delta9-tetrahydrocannabinol, cannabidiol and delta9- tetrahydrocannabivarin
    • Pertwee RG (2008). The diverse CB1 and CB2 receptor pharmacology of three plant cannabinoids: delta9-tetrahydrocannabinol, cannabidiol and delta9-tetrahydrocannabivarin. Br J Pharmacol 153: 199-215.
    • (2008) Br J Pharmacol , vol.153 , pp. 199-215
    • Pertwee, R.G.1
  • 43
    • 78649984380 scopus 로고    scopus 로고
    • Cannabidiol attenuates cardiac dysfunction, oxidative stress, fibrosis, and inflammatory and cell death signaling pathways in diabetic cardiomyopathy
    • Rajesh M, Mukhopadhyay P, Bátkai S, Patel V, Saito K, Matsumoto S et al. (2010a). Cannabidiol attenuates cardiac dysfunction, oxidative stress, fibrosis, and inflammatory and cell death signaling pathways in diabetic cardiomyopathy. J Am Coll Cardiol 56: 2115-2125.
    • (2010) J Am Coll Cardiol , vol.56 , pp. 2115-2125
    • Rajesh, M.1    Mukhopadhyay, P.2    Bátkai, S.3    Patel, V.4    Saito, K.5    Matsumoto, S.6
  • 44
    • 77952604846 scopus 로고    scopus 로고
    • Cannabinoid-1 receptor activation induces reactive oxygen species-dependent and -independent mitogen-activated protein kinase activation and cell death in human coronary artery endothelial cells
    • Rajesh M, Mukhopadhyay P, Haskó G, Liaudet L, Mackie K, Pacher P (2010b). Cannabinoid-1 receptor activation induces reactive oxygen species-dependent and -independent mitogen-activated protein kinase activation and cell death in human coronary artery endothelial cells. Br J Pharmacol 160: 688-700.
    • (2010) Br J Pharmacol , vol.160 , pp. 688-700
    • Rajesh, M.1    Mukhopadhyay, P.2    Haskó, G.3    Liaudet, L.4    Mackie, K.5    Pacher, P.6
  • 45
    • 35748980586 scopus 로고    scopus 로고
    • Endocannabinoids and the gastrointestinal tract: What are the key questions?
    • Sanger GJ (2007). Endocannabinoids and the gastrointestinal tract: what are the key questions? Br J Pharmacol 152: 663-670.
    • (2007) Br J Pharmacol , vol.152 , pp. 663-670
    • Sanger, G.J.1
  • 47
    • 0031866273 scopus 로고    scopus 로고
    • Intestinal epithelial hyperpermeability
    • DOI 10.1016/S0889-8553(05)70004-2
    • Unno N, Fink MP (1998). Intestinal epithelial hyperpermeability. Mechanisms and relevance to disease. Gastroenterol Clin North Am 27: 289-307. (Pubitemid 28325383)
    • (1998) Gastroenterology Clinics of North America , vol.27 , Issue.2 , pp. 289-307
    • Unno, N.1    Fink, M.P.2
  • 49
    • 0031838139 scopus 로고    scopus 로고
    • Cytochalasin-induced actin disruption of polarized enterocytes can augment internalization of bacteria
    • Wells CL, van de Westerlo EM, Jechorek RP, Haines HM, Erlandsen SL (1998). Cytochalasin-induced actin disruption of polarized enterocytes can augment internalization of bacteria. Infection Immunity 66: 2410-2419. (Pubitemid 28261732)
    • (1998) Infection and Immunity , vol.66 , Issue.6 , pp. 2410-2419
    • Wells, C.L.1    Van De, W.E.M.A.2    Jechorek, R.P.3    Haines, H.M.4    Erlandsen, S.L.5
  • 50
    • 23244457833 scopus 로고    scopus 로고
    • Differential expression of cannabinoid receptors in the human colon: Cannabinoids promote epithelial wound healing
    • DOI 10.1016/j.gastro.2005.05.026, PII S0016508505009297
    • Wright K, Rooney N, Feeney M, Tate J, Robertson D, Welham M et al. (2005). Differential expression of cannabinoid receptors in the human colon: cannabinoids promote epithelial wound healing. Gastroenterology 129: 437-453. (Pubitemid 41096632)
    • (2005) Gastroenterology , vol.129 , Issue.2 , pp. 437-453
    • Wright, K.1    Rooney, N.2    Feeney, M.3    Tate, J.4    Robertson, D.5    Welham, M.6    Ward, S.7
  • 51
    • 38349119136 scopus 로고    scopus 로고
    • Cannabinoid CB2 receptors in the gastrointestinal tract: A regulatory system in states of inflammation
    • Wright KL, Duncan M, Sharkey KA (2008). Cannabinoid CB2 receptors in the gastrointestinal tract: a regulatory system in states of inflammation. Br J Pharmacol 153: 263-270.
    • (2008) Br J Pharmacol , vol.153 , pp. 263-270
    • Wright, K.L.1    Duncan, M.2    Sharkey, K.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.