메뉴 건너뛰기




Volumn 11, Issue , 2018, Pages

Cannabinoids in glioblastoma therapy: New applications for old drugs

Author keywords

Cannabidiol; Cannabinoid receptors; Cannabinoids; Glioblastoma; Molecular mechanisms; Novel therapeutic strategies; THC

Indexed keywords

CANNABIDIOL; CANNABINOID; CANNABINOID RECEPTOR; CASPASE 3; CASPASE 8; CASPASE 9; CYCLIN A; CYCLIN DEPENDENT KINASE INHIBITOR 2A; FOCAL ADHESION KINASE; HEAT SHOCK PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; REACTIVE OXYGEN METABOLITE; STAT3 PROTEIN; TEMOZOLOMIDE;

EID: 85048994110     PISSN: 16625099     EISSN: None     Source Type: Journal    
DOI: 10.3389/fnmol.2018.00159     Document Type: Short Survey
Times cited : (74)

References (54)
  • 1
    • 68049117331 scopus 로고    scopus 로고
    • Glioblastoma multiforme: A review of where we have been and where we are going
    • Adamson, C., Kanu, O. O., Mehta, A. I., Di, C., Lin, N., Mattox, A. K., et al. (2009). Glioblastoma multiforme: a review of where we have been and where we are going. Expert Opin. Investig. Drugs 18, 1061–1083. doi: 10.1517/13543780903052764
    • (2009) Expert Opin. Investig. Drugs , vol.18 , pp. 1061-1083
    • Adamson, C.1    Kanu, O.O.2    Mehta, A.I.3    Di, C.4    Lin, N.5    Mattox, A.K.6
  • 2
    • 34250323489 scopus 로고    scopus 로고
    • Cannabinoids induce glioma stem-like cell differentiation and inhibit gliomagenesis
    • Aguado, T., Carracedo, A., Julien, B., Velasco, G., Milman, G., Mechoulam, R., et al. (2007). Cannabinoids induce glioma stem-like cell differentiation and inhibit gliomagenesis. J. Biol. Chem. 282, 6854–6862. doi: 10.1074/jbc. M608900200
    • (2007) J. Biol. Chem. , vol.282 , pp. 6854-6862
    • Aguado, T.1    Carracedo, A.2    Julien, B.3    Velasco, G.4    Milman, G.5    Mechoulam, R.6
  • 4
    • 37349095918 scopus 로고    scopus 로고
    • Down-regulation of tissue inhibitor of metalloproteinases-1 in gliomas: A new marker of cannabinoid antitumoral activity?
    • Blázquez, C., Carracedo, A., Salazar, M., Lorente, M., Egia, A., González-Feria, L., et al. (2008a). Down-regulation of tissue inhibitor of metalloproteinases-1 in gliomas: a new marker of cannabinoid antitumoral activity? Neuropharmacology 54, 235–243. doi: 10.1016/j.neuropharm.2007. 06.021
    • (2008) Neuropharmacology , vol.54 , pp. 235-243
    • Blázquez, C.1    Carracedo, A.2    Salazar, M.3    Lorente, M.4    Egia, A.5    González-Feria, L.6
  • 5
    • 40949083594 scopus 로고    scopus 로고
    • Cannabinoids inhibit glioma cell invasion by down-regulating matrix metalloproteinase-2 expression
    • Blázquez, C., Salazar, M., Carracedo, A., Lorente, M., Egia, A., González-Feria, L., et al. (2008b). Cannabinoids inhibit glioma cell invasion by down-regulating matrix metalloproteinase-2 expression. Cancer Res. 68, 1945–1952. doi: 10.1158/0008-5472.CAN-07-5176
    • (2008) Cancer Res , vol.68 , pp. 1945-1952
    • Blázquez, C.1    Salazar, M.2    Carracedo, A.3    Lorente, M.4    Egia, A.5    González-Feria, L.6
  • 6
    • 4143086166 scopus 로고    scopus 로고
    • Cannabinoids inhibit the vascular endothelial growth factor pathway in gliomas
    • Blázquez, C., González-Feria, L., Alvarez, L., Haro, A., Casanova, M. L., and Guzmán, M. (2004). Cannabinoids inhibit the vascular endothelial growth factor pathway in gliomas. Cancer Res. 64, 5617–5623. doi: 10.1158/0008-5472. can-03-3927
    • (2004) Cancer Res , vol.64 , pp. 5617-5623
    • Blázquez, C.1    González-Feria, L.2    Alvarez, L.3    Haro, A.4    Casanova, M.L.5    Guzmán, M.6
  • 7
    • 85029511577 scopus 로고    scopus 로고
    • Cannabidiol, a novel inverse agonist for GPR12
    • Brown, K. J., Laun, A. S., and Song, Z. H. (2017). Cannabidiol, a novel inverse agonist for GPR12. Biochem. Biophys. Res. Commun. 493, 451–454. doi: 10.1016/j.bbrc.2017.09.001
    • (2017) Biochem. Biophys. Res. Commun. , vol.493 , pp. 451-454
    • Brown, K.J.1    Laun, A.S.2    Song, Z.H.3
  • 8
    • 33645763253 scopus 로고    scopus 로고
    • The stress-regulated protein p8 mediates cannabinoid-induced apoptosis of tumor cells
    • Carracedo, A., Lorente, M., Egia, A., Blázquez, C., García, S., Giroux, V., et al. (2006). The stress-regulated protein p8 mediates cannabinoid-induced apoptosis of tumor cells. Cancer Cell 9, 301–312. doi: 10.1016/j.ccr.2006.03.005
    • (2006) Cancer Cell , vol.9 , pp. 301-312
    • Carracedo, A.1    Lorente, M.2    Egia, A.3    Blázquez, C.4    García, S.5    Giroux, V.6
  • 9
    • 84934323718 scopus 로고    scopus 로고
    • Cannabinoid receptor CB1 regulates STAT3 activity and its expression dictates the responsiveness to SR141716 treatment in human glioma patients’ cells
    • Ciaglia, E., Torelli, G., Pisanti, S., Picardi, P., D’Alessandro, A., Laezza, C., et al. (2015). Cannabinoid receptor CB1 regulates STAT3 activity and its expression dictates the responsiveness to SR141716 treatment in human glioma patients’ cells. Oncotarget 6, 15464–15481. doi: 10.18632/oncotarget.3895
    • (2015) Oncotarget , vol.6 , pp. 15464-15481
    • Ciaglia, E.1    Torelli, G.2    Pisanti, S.3    Picardi, P.4    D’Alessandro, A.5    Laezza, C.6
  • 10
    • 77952287702 scopus 로고    scopus 로고
    • Opposite changes in cannabinoid CB1 and CB2 receptor expression in human gliomas
    • De Jesús, M. L., Hostalot, C., Garibi, J. M., Sallés, J., Meana, J. J., and Callado, L. F. (2010). Opposite changes in cannabinoid CB1 and CB2 receptor expression in human gliomas. Neurochem. Int. 56, 829–833. doi: 10.1016/j.neuint. 2010.03.007
    • (2010) Neurochem. Int. , vol.56 , pp. 829-833
    • de Jesús, M.L.1    Hostalot, C.2    Garibi, J.M.3    Sallés, J.4    Meana, J.J.5    Callado, L.F.6
  • 13
    • 51449092478 scopus 로고    scopus 로고
    • Delta 9-tetrahydrocannabinol inhibits cell cycle progression by downregulation of E2F1 in human glioblastoma multiforme cells
    • Galanti, G., Fisher, T., Kventsel, I., Shoham, J., Gallily, R., Mechoulam, R., et al. (2008). Delta 9-tetrahydrocannabinol inhibits cell cycle progression by downregulation of E2F1 in human glioblastoma multiforme cells. Acta Oncol. 47, 1062–1070. doi: 10.1080/02841860701678787
    • (2008) Acta Oncol , vol.47 , pp. 1062-1070
    • Galanti, G.1    Fisher, T.2    Kventsel, I.3    Shoham, J.4    Gallily, R.5    Mechoulam, R.6
  • 15
    • 0037184060 scopus 로고    scopus 로고
    • Cannabinoids protect astrocytes from ceramide-induced apoptosis through the phosphatidylinositol 3-kinase/protein kinase B pathway
    • Gómez Del Pulgar, T., De Ceballos, M. L., Guzmán, M., and Velasco, G. (2002). Cannabinoids protect astrocytes from ceramide-induced apoptosis through the phosphatidylinositol 3-kinase/protein kinase B pathway. J. Biol. Chem. 277, 36527–36533. doi: 10.1074/jbc.M205797200
    • (2002) J. Biol. Chem. , vol.277 , pp. 36527-36533
    • Gómez Del Pulgar, T.1    de Ceballos, M.L.2    Guzmán, M.3    Velasco, G.4
  • 17
    • 84898662031 scopus 로고    scopus 로고
    • Cannabidiol enhances microglial phagocytosis via transient receptor potential (TRP) channel activation
    • Hassan, S., Eldeeb, K., Millns, P. J., Bennett, A. J., Alexander, S. P., and Kendall, D. A. (2014). Cannabidiol enhances microglial phagocytosis via transient receptor potential (TRP) channel activation. Br. J. Pharmacol. 171, 2426–2439. doi: 10.1111/bph.12615
    • (2014) Br. J. Pharmacol. , vol.171 , pp. 2426-2439
    • Hassan, S.1    Eldeeb, K.2    Millns, P.J.3    Bennett, A.J.4    Alexander, S.P.5    Kendall, D.A.6
  • 18
    • 84987922569 scopus 로고    scopus 로고
    • Dihydroceramide accumulation mediates cytotoxic autophagy of cancer cells via autolysosome destabilization
    • Hernández-Tiedra, S., Fabriàs, G., Dávila, D., Salanueva, I. J., Casas, J., Montes, L. R., et al. (2016). Dihydroceramide accumulation mediates cytotoxic autophagy of cancer cells via autolysosome destabilization. Autophagy 12, 2213–2229. doi: 10.1080/15548627.2016.1213927
    • (2016) Autophagy , vol.12 , pp. 2213-2229
    • Hernández-Tiedra, S.1    Fabriàs, G.2    Dávila, D.3    Salanueva, I.J.4    Casas, J.5    Montes, L.R.6
  • 19
    • 18444376760 scopus 로고    scopus 로고
    • International Union of Pharmacology. XXVII. Classification of cannabinoid receptors
    • Howlett, A. C., Barth, F., Bonner, T. I., Cabral, G., Casellas, P., Devane, W. A., et al. (2002). International Union of Pharmacology. XXVII. Classification of cannabinoid receptors. Pharmacol. Rev. 54, 161–202. doi: 10.1124/pr. 54.2.161
    • (2002) Pharmacol. Rev. , vol.54 , pp. 161-202
    • Howlett, A.C.1    Barth, F.2    Bonner, T.I.3    Cabral, G.4    Casellas, P.5    Devane, W.A.6
  • 20
    • 85031773617 scopus 로고    scopus 로고
    • Cannabidiol attenuates seizures and social deficits in a mouse model of Dravet syndrome. Proc. Natl. Acad. Sci
    • Kaplan, J. S., Stella, N., Catterall, W. A., and Westenbroek, R. E. (2017). Cannabidiol attenuates seizures and social deficits in a mouse model of Dravet syndrome. Proc. Natl. Acad. Sci. U S A 114, 11229–11234. doi: 10.1073/pnas. 1711351114
    • (2017) U S A , vol.114 , pp. 11229-11234
    • Kaplan, J.S.1    Stella, N.2    Catterall, W.A.3    Westenbroek, R.E.4
  • 21
    • 84995451065 scopus 로고    scopus 로고
    • Preclinical and clinical assessment of cannabinoids as anti-cancer agents
    • Ladin, D. A., Soliman, E., Griffin, L., and Van Dross, R. (2016). Preclinical and clinical assessment of cannabinoids as anti-cancer agents. Front. Pharmacol. 7:361. doi: 10.3389/fphar.2016.00361
    • (2016) Front. Pharmacol. , vol.7
    • Ladin, D.A.1    Soliman, E.2    Griffin, L.3    van Dross, R.4
  • 22
    • 85020289313 scopus 로고    scopus 로고
    • GPR3 and GPR6, novel molecular targets for cannabidiol
    • Laun, A. S., and Song, Z. H. (2017). GPR3 and GPR6, novel molecular targets for cannabidiol. Biochem. Biophys. Res. Commun. 490, 17–21. doi: 10.1016/j.bbrc. 2017.05.165
    • (2017) Biochem. Biophys. Res. Commun. , vol.490 , pp. 17-21
    • Laun, A.S.1    Song, Z.H.2
  • 23
    • 84956473634 scopus 로고    scopus 로고
    • Glioma stem cells: Signaling, microenvironment and therapy
    • Liebelt, B. D., Shingu, T., Zhou, X., Ren, J., Shin, S. A., and Hu, J. (2016). Glioma stem cells: signaling, microenvironment and therapy. Stem Cells Int. 2016:7849890. doi: 10.1155/2016/7849890
    • (2016) Stem Cells Int , vol.2016
    • Liebelt, B.D.1    Shingu, T.2    Zhou, X.3    Ren, J.4    Shin, S.A.5    Hu, J.6
  • 24
    • 84966687479 scopus 로고    scopus 로고
    • The 2016 world health organization classification of tumors of the central nervous system: A summary
    • Louis, D. N., Perry, A., Reifenberger, G., von Deimling, A., Figarella-Branger, D., Cavenee, W. K., et al. (2016). The 2016 world health organization classification of tumors of the central nervous system: a summary. Acta Neuropathol. 131, 803–820. doi: 10.1007/s00401-016-1545-1
    • (2016) Acta Neuropathol , vol.131 , pp. 803-820
    • Louis, D.N.1    Perry, A.2    Reifenberger, G.3    von Deimling, A.4    Figarella-Branger, D.5    Cavenee, W.K.6
  • 25
    • 84949845531 scopus 로고    scopus 로고
    • An introduction to the endogenous cannabinoid system
    • Lu, H. C., and Mackie, K. (2016). An introduction to the endogenous cannabinoid system. Biol. Psychiatry 79, 516–525. doi: 10.1016/j.biopsych.2015.07.028
    • (2016) Biol. Psychiatry , vol.79 , pp. 516-525
    • Lu, H.C.1    Mackie, K.2
  • 26
    • 85041799018 scopus 로고    scopus 로고
    • Role of microenvironment in glioma invasion: What we learned from in vitro models
    • Manini, I., Caponnetto, F., Bartolini, A., Ius, T., Mariuzzi, L., Di Loreto, C., et al. (2018). Role of microenvironment in glioma invasion: what we learned from in vitro models. Int. J. Mol. Sci. 19:E147. doi: 10.3390/ijms19010147
    • (2018) Int. J. Mol. Sci. , vol.19
    • Manini, I.1    Caponnetto, F.2    Bartolini, A.3    Ius, T.4    Mariuzzi, L.5    Di Loreto, C.6
  • 27
    • 73949139182 scopus 로고    scopus 로고
    • Cannabidiol enhances the inhibitory effects of delta9-tetrahydrocannabinol on human glioblastoma cell proliferation and survival
    • Marcu, J. P., Christian, R. T., Lau, D., Zielinski, A. J., Horowitz, M. P., Lee, J., et al. (2010). Cannabidiol enhances the inhibitory effects of delta9-tetrahydrocannabinol on human glioblastoma cell proliferation and survival. Mol. Cancer Ther. 9, 180–189. doi: 10.1158/1535-7163.MCT-09-0407
    • (2010) Mol. Cancer Ther. , vol.9 , pp. 180-189
    • Marcu, J.P.1    Christian, R.T.2    Lau, D.3    Zielinski, A.J.4    Horowitz, M.P.5    Lee, J.6
  • 28
    • 79952254562 scopus 로고    scopus 로고
    • Molecular mechanisms involved in the antitumor activity of cannabinoids on gliomas: Role for oxidative stress
    • Massi, P., Valenti, M., Solinas, M., and Parolaro, D. (2010). Molecular mechanisms involved in the antitumor activity of cannabinoids on gliomas: role for oxidative stress. Cancers 2, 1013–1026. doi: 10.3390/cancers2021013
    • (2010) Cancers , vol.2 , pp. 1013-1026
    • Massi, P.1    Valenti, M.2    Solinas, M.3    Parolaro, D.4
  • 29
    • 0014933381 scopus 로고
    • Marihuana chemistry
    • Mechoulam, R. (1970). Marihuana chemistry. Science 168, 1159–1166. doi: 10.1126/science.168.3936.1159
    • (1970) Science , vol.168 , pp. 1159-1166
    • Mechoulam, R.1
  • 30
    • 0036019381 scopus 로고    scopus 로고
    • Discovery of endocannabinoids and some random thoughts on their possible roles in neuroprotection and aggression
    • Mechoulam, R. (2002). Discovery of endocannabinoids and some random thoughts on their possible roles in neuroprotection and aggression. Prostaglandins Leukot. Essent. Fatty Acids 66, 93–99. doi: 10.1054/plef.2001. 0340
    • (2002) Prostaglandins Leukot. Essent. Fatty Acids , vol.66 , pp. 93-99
    • Mechoulam, R.1
  • 31
    • 0037111841 scopus 로고    scopus 로고
    • Cannabinoids promote oligodendrocyte progenitor survival: Involvement of cannabinoid receptors and phosphatidylinositol-3 kinase/Akt signaling
    • Molina-Holgado, E., Vela, J. M., Arévalo-Martin, A., Almazán, G., Molina-Holgado, F., Borrell, J., et al. (2002). Cannabinoids promote oligodendrocyte progenitor survival: involvement of cannabinoid receptors and phosphatidylinositol-3 kinase/Akt signaling. J. Neurosci. 22, 9742–9753. doi: 10.1523/JNEUROSCI.22-22-09742.2002
    • (2002) J. Neurosci. , vol.22 , pp. 9742-9753
    • Molina-Holgado, E.1    Vela, J.M.2    Arévalo-Martin, A.3    Almazán, G.4    Molina-Holgado, F.5    Borrell, J.6
  • 32
    • 84938985384 scopus 로고    scopus 로고
    • Cannabidiol stimulates Aml-1a-dependent glial differentiation and inhibits glioma stem-like cells proliferation by inducing autophagy in a TRPV2-dependent manner
    • Nabissi, M., Morelli, M. B., Amantini, C., Liberati, S., Santoni, M., Ricci-Vitiani, L., et al. (2015). Cannabidiol stimulates Aml-1a-dependent glial differentiation and inhibits glioma stem-like cells proliferation by inducing autophagy in a TRPV2-dependent manner. Int. J. Cancer 137, 1855–1869. doi: 10.1002/ijc. 29573
    • (2015) Int. J. Cancer , vol.137 , pp. 1855-1869
    • Nabissi, M.1    Morelli, M.B.2    Amantini, C.3    Liberati, S.4    Santoni, M.5    Ricci-Vitiani, L.6
  • 33
    • 84872128254 scopus 로고    scopus 로고
    • Triggering of the TRPV2 channel by cannabidiol sensitizes glioblastoma cells to cytotoxic chemotherapeutic agents
    • Nabissi, M., Morelli, M. B., Santoni, M., and Santoni, G. (2013). Triggering of the TRPV2 channel by cannabidiol sensitizes glioblastoma cells to cytotoxic chemotherapeutic agents. Carcinogenesis 34, 48–57. doi: 10.1093/carcin/bgs328
    • (2013) Carcinogenesis , vol.34 , pp. 48-57
    • Nabissi, M.1    Morelli, M.B.2    Santoni, M.3    Santoni, G.4
  • 34
    • 73149109062 scopus 로고    scopus 로고
    • Monoacylglycerol lipase regulates a fatty acid network that promotes cancer pathogenesis
    • Nomura, D. K., Long, J. Z., Niessen, S., Hoover, H. S., Ng, S. W., and Cravatt, B. F. (2010). Monoacylglycerol lipase regulates a fatty acid network that promotes cancer pathogenesis. Cell 140, 49–61. doi: 10.1016/j.cell.2009.11.027
    • (2010) Cell , vol.140 , pp. 49-61
    • Nomura, D.K.1    Long, J.Z.2    Niessen, S.3    Hoover, H.S.4    Ng, S.W.5    Cravatt, B.F.6
  • 35
    • 84902489371 scopus 로고    scopus 로고
    • The epidemiology of glioma in adults: A ‘‘state of the science’’ review
    • Ostrom, Q. T., Bauchet, L., Davis, F. G., Deltour, I., Fisher, J. L., Langer, C. E., et al. (2014). The epidemiology of glioma in adults: a ‘‘state of the science’’ review. Neuro Oncol. 16, 896–913. doi: 10.1093/neuonc/nou087
    • (2014) Neuro Oncol , vol.16 , pp. 896-913
    • Ostrom, Q.T.1    Bauchet, L.2    Davis, F.G.3    Deltour, I.4    Fisher, J.L.5    Langer, C.E.6
  • 36
    • 84884474728 scopus 로고    scopus 로고
    • Pharmacological actions of cannabinoids
    • R. G. Pertwee (Berlin, Heidelberg: Springer
    • Pertwee, R. G. (2005). ‘‘Pharmacological actions of cannabinoids,’’ in Cannabinoids. Handbook of Experimental Pharmacology, ed. R. G. Pertwee (Berlin, Heidelberg: Springer), 1–51.
    • (2005) Cannabinoids. Handbook of Experimental Pharmacology , pp. 1-51
    • Pertwee, R.G.1
  • 37
    • 17444373124 scopus 로고    scopus 로고
    • Endocannabinoid metabolism in human glioblastomas and meningiomas compared to human non-tumour brain tissue
    • Petersen, G., Moesgaard, B., Schmid, P. C., Schmid, H. H., Broholm, H., Kosteljanetz, M., et al. (2005). Endocannabinoid metabolism in human glioblastomas and meningiomas compared to human non-tumour brain tissue. J. Neurochem. 93, 299–309. doi: 10.1111/j.1471-4159.2005.03013.x
    • (2005) J. Neurochem. , vol.93 , pp. 299-309
    • Petersen, G.1    Moesgaard, B.2    Schmid, P.C.3    Schmid, H.H.4    Broholm, H.5    Kosteljanetz, M.6
  • 38
    • 84891836326 scopus 로고    scopus 로고
    • Systematic review of the literature on clinical and experimental trials on the antitumor effects of cannabinoids in gliomas
    • Rocha, F. C., Dos Santos Júnior, J. G., Stefano, S. C., and Da Silveira, D. X. (2014). Systematic review of the literature on clinical and experimental trials on the antitumor effects of cannabinoids in gliomas. J. Neurooncol. 116, 11–24. doi: 10.1007/s11060-013-1277-1
    • (2014) J. Neurooncol. , vol.116 , pp. 11-24
    • Rocha, F.C.1    Dos Santos Júnior, J.G.2    Stefano, S.C.3    da Silveira, D.X.4
  • 39
    • 85009468154 scopus 로고    scopus 로고
    • Cannabidiol claims and misconceptions
    • Russo, E. B. (2017). Cannabidiol claims and misconceptions. Trends Pharmacol. Sci. 38, 198–201. doi: 10.1016/j.tips.2016.12.004
    • (2017) Trends Pharmacol. Sci. , vol.38 , pp. 198-201
    • Russo, E.B.1
  • 40
    • 66449115318 scopus 로고    scopus 로고
    • Cannabinoid action induces autophagy-mediated cell death through stimulation of ER stress in human glioma cells
    • Salazar, M., Carracedo, A., Salanueva, I. J., Hernández-Tiedra, S., Lorente, M., Egia, A., et al. (2009). Cannabinoid action induces autophagy-mediated cell death through stimulation of ER stress in human glioma cells. J. Clin. Invest. 119, 1359–1372. doi: 10.1172/jci37948
    • (2009) J. Clin. Invest. , vol.119 , pp. 1359-1372
    • Salazar, M.1    Carracedo, A.2    Salanueva, I.J.3    Hernández-Tiedra, S.4    Lorente, M.5    Egia, A.6
  • 41
    • 67349101287 scopus 로고    scopus 로고
    • Predominant CB2 receptor expression in endothelial cells of glioblastoma in humans
    • Schley, M., Ständer, S., Kerner, J., Vajkoczy, P., Schüpfer, G., Dusch, M., et al. (2009). Predominant CB2 receptor expression in endothelial cells of glioblastoma in humans. Brain Res. Bull. 79, 333–337. doi: 10.1016/j. brainresbull.2009.01.011
    • (2009) Brain Res. Bull. , vol.79 , pp. 333-337
    • Schley, M.1    Ständer, S.2    Kerner, J.3    Vajkoczy, P.4    Schüpfer, G.5    Dusch, M.6
  • 44
    • 84917737275 scopus 로고    scopus 로고
    • The combination of cannabidiol and Delta9-tetrahydrocannabinol enhances the anticancer effects of radiation in an orthotopic murine glioma model
    • Scott, K. A., Dalgleish, A. G., and Liu, W. M. (2014). The combination of cannabidiol and Delta9-tetrahydrocannabinol enhances the anticancer effects of radiation in an orthotopic murine glioma model. Mol. Cancer Ther. 13, 2955–2967. doi: 10.1158/1535-7163.mct-14-0402
    • (2014) Mol. Cancer Ther. , vol.13 , pp. 2955-2967
    • Scott, K.A.1    Dalgleish, A.G.2    Liu, W.M.3
  • 45
    • 84946056099 scopus 로고    scopus 로고
    • Inhibiting heat shock proteins can potentiate the cytotoxic effect of cannabidiol in human glioma cells
    • Scott, K. A., Dennis, J. L., Dalgleish, A. G., and Liu, W. M. (2015). Inhibiting heat shock proteins can potentiate the cytotoxic effect of cannabidiol in human glioma cells. Anticancer Res. 35, 5827–5837.
    • (2015) Anticancer Res , vol.35 , pp. 5827-5837
    • Scott, K.A.1    Dennis, J.L.2    Dalgleish, A.G.3    Liu, W.M.4
  • 46
    • 84975763949 scopus 로고    scopus 로고
    • Polypharmacological properties and therapeutic potential of beta-caryophyllene: A dietary phytocannabinoid of pharmaceutical promise
    • Sharma, C., Al Kaabi, J. M., Nurulain, S. M., Goyal, S. N., Kamal, M. A., and Ojha, S. (2016). Polypharmacological properties and therapeutic potential of beta-caryophyllene: a dietary phytocannabinoid of pharmaceutical promise. Curr. Pharm. Des. 22, 3237–3264. doi: 10.2174/1381612822666160311 115226
    • (2016) Curr. Pharm. Des. , vol.22 , pp. 3237-3264
    • Sharma, C.1    Al Kaabi, J.M.2    Nurulain, S.M.3    Goyal, S.N.4    Kamal, M.A.5    Ojha, S.6
  • 47
    • 84925593582 scopus 로고    scopus 로고
    • Reactive oxygen species-mediated therapeutic response and resistance in glioblastoma
    • Singer, E., Judkins, J., Salomonis, N., Matlaf, L., Soteropoulos, P., Mcallister, S., et al. (2015). Reactive oxygen species-mediated therapeutic response and resistance in glioblastoma. Cell Death Dis. 6:e1601. doi: 10.1038/cddis.2014.566
    • (2015) Cell Death Dis , vol.6
    • Singer, E.1    Judkins, J.2    Salomonis, N.3    Matlaf, L.4    Soteropoulos, P.5    McAllister, S.6
  • 49
    • 84886873610 scopus 로고    scopus 로고
    • Cannabidiol, a non-psychoactive cannabinoid compound, inhibits proliferation and invasion in U87-MG and T98G glioma cells through a multitarget effect
    • Solinas, M., Massi, P., Cinquina, V., Valenti, M., Bolognini, D., Gariboldi, M., et al. (2013). Cannabidiol, a non-psychoactive cannabinoid compound, inhibits proliferation and invasion in U87-MG and T98G glioma cells through a multitarget effect. PLoS One 8:e76918. doi: 10.1371/journal.pone.0076918
    • (2013) Plos One , vol.8
    • Solinas, M.1    Massi, P.2    Cinquina, V.3    Valenti, M.4    Bolognini, D.5    Gariboldi, M.6
  • 50
    • 84874840668 scopus 로고    scopus 로고
    • Id-1 is a key transcriptional regulator of glioblastoma aggressiveness and a novel therapeutic target
    • Soroceanu, L., Murase, R., Limbad, C., Singer, E., Allison, J., Adrados, I., et al. (2013). Id-1 is a key transcriptional regulator of glioblastoma aggressiveness and a novel therapeutic target. Cancer Res. 73, 1559–1569. doi: 10.1158/0008-5472.can-12-1943
    • (2013) Cancer Res , vol.73 , pp. 1559-1569
    • Soroceanu, L.1    Murase, R.2    Limbad, C.3    Singer, E.4    Allison, J.5    Adrados, I.6
  • 51
    • 20044366163 scopus 로고    scopus 로고
    • Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma
    • Stupp, R., Mason, W. P., Van Den Bent, M. J., Weller, M., Fisher, B., Taphoorn, M. J., et al. (2005). Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl. J. Med. 352, 987–996. doi: 10.1056/NEJMoa043330
    • (2005) N Engl. J. Med. , vol.352 , pp. 987-996
    • Stupp, R.1    Mason, W.P.2    van Den Bent, M.J.3    Weller, M.4    Fisher, B.5    Taphoorn, M.J.6
  • 54
    • 84862831067 scopus 로고    scopus 로고
    • Alteration of endocannabinoid system in human gliomas
    • Wu, X., Han, L., Zhang, X., Li, L., Jiang, C., Qiu, Y., et al. (2012). Alteration of endocannabinoid system in human gliomas. J. Neurochem. 120, 842–849. doi: 10.1111/j.1471-4159.2011.07625.x
    • (2012) J. Neurochem. , vol.120 , pp. 842-849
    • Wu, X.1    Han, L.2    Zhang, X.3    Li, L.4    Jiang, C.5    Qiu, Y.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.