What do we know about the transient receptor potential vanilloid 2 (TRPV2) ion channel?

FEBS Journal

Volumn 280, Issue 21, 2013, Pages 5471-5487

  Perálvarez Marín, Alex ^a   Doñate Macian, Pau ^a   Gaudet, Rachelle ^b  

^a UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^b HARVARD UNIVERSITY   (United States)

Author keywords

calcium signalling; cancer; endocrinology; immunology; ion channels; muscle physiology; neuroscience; pharmacology; somatosensation; TRPV2

Indexed keywords

1 [2 (4 METHOXYPHENYL) 2 [3 (4 METHOXYPHENYL)PROPOXY]ETHYL] 1H IMIDAZOLE; CANNABIDIOL; CANNABIDIVARIN; CANNABIGEROL; CANNABIGIVARIN; CANNABINOID RECEPTOR AGONIST; CANNABINOL; DELTA 9 TETRAHYDROCANNABIVARIN; DRONABINOL; LYSOPHOSPHATIDYLCHOLINE; PROBENECID; RUTHENIUM RED; TETRAHYDROCANNABINOL ACID; TETRAHYDROCANNABIVARIN; TRANILAST; UNCLASSIFIED DRUG; VANILLOID RECEPTOR 2;

AMINO TERMINAL SEQUENCE; BLADDER CANCER; CONFERENCE PAPER; ENDOCRINE SYSTEM; EVOLUTION; GLIOBLASTOMA; GLIOMA; HUMAN; IMMUNITY; IN VITRO STUDY; MODULATION; MUSCLE FUNCTION; NERVOUS SYSTEM; NONHUMAN; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN FAMILY; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN STRUCTURE; SIGNAL TRANSDUCTION; TRANSITIONAL CELL CARCINOMA;

CALCIUM SIGNALLING; CANCER; ENDOCRINOLOGY; IMMUNOLOGY; ION CHANNELS; MUSCLE PHYSIOLOGY; NEUROSCIENCE; PHARMACOLOGY; SOMATOSENSATION; TRPV2;

ANIMALS; CALCIUM CHANNELS; CARDIOTONIC AGENTS; CARDIOVASCULAR DISEASES; GENE EXPRESSION REGULATION; HUMANS; MICE; MOLECULAR TARGETED THERAPY; TRPV CATION CHANNELS;

EID: 84886091614     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/febs.12302     Document Type: Conference Paper

References (138)

1. Nilius B, &, Owsianik G, (2011) The transient receptor potential family of ion channels. Genome Biol 12, 218.
2. Ramsey IS, Delling M, &, Clapham DE, (2006) An introduction to TRP channels. Annu Rev Physiol 68, 619-647.
3. Venkatachalam K, &, Montell C, (2007) TRP channels. Annu Rev Biochem 76, 387-417.
4. Wu L-J, Sweet T-B, &, Clapham DE, (2010) International Union of Basic and Clinical Pharmacology. LXXVI. Current progress in the mammalian TRP ion channel family. Pharmacol Rev 62, 381-404.
5. Montell C, Birnbaumer L, &, Flockerzi V, (2002) The TRP channels, a remarkably functional family. Cell 108, 595-598.
6. Montell C, (2005) The TRP superfamily of cation channels. Sci STKE 272, re3.
7. Latorre R, Zaelzer C, &, Brauchi S, (2009) Structure-functional intimacies of transient receptor potential channels. Q Rev Biophys 42, 201-246.
8. Minke B, (1977) Drosophila mutant with a transducer defect. Eur Biophys J 3, 59-64.
9. Montell C, &, Rubin GM, (1989) Molecular characterization of the Drosophila trp locus: a putative integral membrane protein required for phototransduction. Neuron 2, 1313-1323.
10. Almén MS, Nordström KJV, Fredriksson R, &, Schiöth HB, (2009) Mapping the human membrane proteome: a majority of the human membrane proteins can be classified according to function and evolutionary origin. BMC Biol 7, 50.
11. Levine JD, &, Alessandri-Haber N, (2007) TRP channels: targets for the relief of pain. Biochim Biophys Acta 1772, 989-1003.
12. Chung M-K, Jung SJ, &, Oh SB, (2011) Role of TRP channels in pain sensation. Adv Exp Med Biol 704, 615-636.
13. Colbert HA, Smith TL, &, Bargmann CI, (1997) OSM-9, a novel protein with structural similarity to channels, is required for olfaction, mechanosensation, and olfactory adaptation in Caenorhabditis elegans. J Neurosci 17, 8259-8269.
14. Xiao R, &, Xu XS, (2010) C. elegans TRP Channels. Adv Exp Med Biol 704, 323-339.
15. Kim J, Chung YD, Park D-Y, Choi S, Shin DW, Soh H, Lee HW, Son W, Yim J, Park C-S, et al,. (2003) A TRPV family ion channel required for hearing in Drosophila. Nature 424, 81-84.
16. Clapham DE, (2007) Mammalian TRP channels. Cell 129, 220.
17. Hellwig N, Albrecht N, Harteneck C, Schultz G, &, Schaefer M, (2005) Homo- and heteromeric assembly of TRPV channel subunits. J Cell Sci 118, 917-928.
18. Park U, Vastani N, Guan Y, Raja SN, Koltzenburg M, &, Caterina MJ, (2011) TRP vanilloid 2 knock-out mice are susceptible to perinatal lethality but display normal thermal and mechanical nociception. J Neurosci 31, 11425-11436.
19. Caterina MJ, (2000) Impaired nociception and pain sensation in mice lacking the capsaicin receptor. Science 288, 306-313.
20. Moqrich A, (2005) Impaired thermosensation in mice lacking TRPV3, a heat and camphor sensor in the skin. Science 307, 1468-1472.
21. Lee H, Iida T, Mizuno A, Suzuki M, &, Caterina MJ, (2005) Altered thermal selection behavior in mice lacking transient receptor potential vanilloid 4. J Neurosci 25, 1304-1310.
22. Huang SM, Li X, Yu Y, Wang J, &, Caterina MJ, (2011) TRPV3 and TRPV4 ion channels are not major contributors to mouse heat sensation. Mol Pain 7, 37.
23. Sokolchik I, Tanabe T, Baldi PF, &, Sze JY, (2005) Polymodal sensory function of the Caenorhabditis elegans OCR-2 channel arises from distinct intrinsic determinants within the protein and is selectively conserved in mammalian TRPV proteins. J Neurosci 25, 1015-1023.
24. Gong Z, Son W, Chung YD, Kim J, Shin DW, McClung CA, Lee Y, Lee HW, Chang D-J, Kaang B-K, et al,. (2004) Two interdependent TRPV channel subunits, inactive and Nanchung, mediate hearing in Drosophila. J Neurosci 24, 9059-9066.
25. Caterina MJ, Rosen TA, Tominaga M, Brake AJ, &, Julius D, (1999) A capsaicin-receptor homologue with a high threshold for noxious heat. Nature 398, 436-440.
26. Kanzaki M, Zhang YQ, Mashima H, Li L, Shibata H, &, Kojima I, (1999) Translocation of a calcium-permeable cation channel induced by insulin-like growth factor-I. Nat Cell Biol 1, 165-170.
27. Harteneck C, Plant TD, &, Schultz G, (2000) From worm to man: three subfamilies of TRP channels. Trends Neurosci 23, 159-166.
28. Ferrer-Montiel A, Fernández-Carvajal A, Planells-Cases R, Fernández-Ballester G, González-Ros JM, Messeguer A, &, González-Muñiz R, (2012) Advances in modulating thermosensory TRP channels. Expert Opin Ther Pat 22, 999-1017.
29. Xu H, Delling M, Jun JC, &, Clapham DE, (2006) Oregano, thyme and clove-derived flavors and skin sensitizers activate specific TRP channels. Nat Neurosci 9, 628-635.
30. Suzuki M, Mizuno A, Kodaira K, &, Imai M, (2003) Impaired pressure sensation in mice lacking TRPV4. J Biol Chem 278, 22664-22668.
31. Mizuno A, Matsumoto N, Imai M, &, Suzuki M, (2003) Impaired osmotic sensation in mice lacking TRPV4. Am J Physiol Cell Physiol 285, C96-101.
32. Tabuchi K, Suzuki M, Mizuno A, &, Hara A, (2005) Hearing impairment in TRPV4 knockout mice. Neurosci Lett 382, 304-308.
33. Rutter AR, Ma Q-P, Leveridge M, &, Bonnert TP, (2005) Heteromerization and colocalization of TrpV1 and TrpV2 in mammalian cell lines and rat dorsal root ganglia. NeuroReport 16, 1735-1739.
34. Cheng W, Yang F, Takanishi CL, &, Zheng J, (2007) Thermosensitive TRPV channel subunits coassemble into heteromeric channels with intermediate conductance and gating properties. J Gen Physiol 129, 191-207.
35. Liapi A, &, Wood JN, (2005) Extensive co-localization and heteromultimer formation of the vanilloid receptor-like protein TRPV2 and the capsaicin receptor TRPV1 in the adult rat cerebral cortex. Eur J Neurosci 22, 825-834.
36. Saito S, &, Shingai R, (2006) Evolution of thermoTRP ion channel homologs in vertebrates. Physiol Genomics 27, 219-230.
37. Li M, Yu Y, &, Yang J, (2011) Structural biology of TRP channels. Adv Exp Med Biol 704, 1-23.
38. Gaudet R, (2008) TRP channels entering the structural era. J Physiol 586, 3565-3575.
39. McCleverty CJ, Koesema E, Patapoutian A, Lesley SA, &, Kreusch A, (2006) Crystal structure of the human TRPV2 channel ankyrin repeat domain. Protein Sci 15, 2201-2206.
40. Cuajungco MP, Grimm C, Oshima K, D'hoedt D, Nilius B, Mensenkamp AR, Bindels RJM, Plomann M, &, Heller S, (2006) PACSINs bind to the TRPV4 cation channel. PACSIN 3 modulates the subcellular localization of TRPV4. J Biol Chem 281, 18753-18762.
41. Neeper MP, Liu Y, Hutchinson TL, Wang Y, Flores CM, &, Qin N, (2007) Activation properties of heterologously expressed mammalian TRPV2: evidence for species dependence. J Biol Chem 282, 15894-15902.
42. Jin X, Touhey J, &, Gaudet R, (2006) Structure of the N-terminal ankyrin repeat domain of the TRPV2 ion channel. J Biol Chem 281, 25006-25010.
43. Gaudet R, (2008) A primer on ankyrin repeat function in TRP channels and beyond. Mol BioSyst 4, 372-379.
44. Michaely P, Tomchick DR, Machius M, &, Anderson RGW, (2002) Crystal structure of a 12 ANK repeat stack from human ankyrinR. EMBO J 21, 6387-6396.
45. Yao J, Liu B, &, Qin F, (2011) Modular thermal sensors in temperature-gated transient receptor potential (TRP) channels. Proc Natl Acad Sci USA 108, 11109-11114.
46. Krogh A, Larsson B, Von Heijne G, &, Sonnhammer EL, (2001) Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes. J Mol Biol 305, 567-580.
47. Hessa T, Meindl-Beinker NM, Bernsel A, Kim H, Sato Y, Lerch-Bader M, Nilsson I, White SH, &, Von Heijne G, (2007) Molecular code for transmembrane-helix recognition by the Sec61 translocon. Nature 450, 1026-1030.
48. Jordt S-E, &, Julius D, (2002) Molecular basis for species-specific sensitivity to 'hot' chili peppers. Cell 108, 421-430.
49. Boukalova S, Marsakova L, Teisinger J, &, Vlachova V, (2010) Conserved residues within the putative S4-S5 region serve distinct functions among thermosensitive vanilloid transient receptor potential (TRPV) channels. J Biol Chem 285, 41455-41462.
50. Wirkner K, Hognestad H, Jahnel R, Hucho F, &, Illes P, (2005) Characterization of rat transient receptor potential vanilloid 1 receptors lacking the N-glycosylation site N604. NeuroReport 16, 997-1001.
51. Jahnel R, Bender O, Münter LM, Dreger M, Gillen C, &, Hucho F, (2003) Dual expression of mouse and rat VRL-1 in the dorsal root ganglion derived cell line F-11 and biochemical analysis of VRL-1 after heterologous expression. Eur J Biochem 270, 4264-4271.
52. Morenilla-Palao C, Pertusa M, Meseguer V, Cabedo H, &, Viana F, (2009) Lipid raft segregation modulates TRPM8 channel activity. J Biol Chem 284, 9215-9224.
53. Erler I, Al-Ansary DMM, Wissenbach U, Wagner TFJ, Flockerzi V, &, Niemeyer BA, (2006) Trafficking and assembly of the cold-sensitive TRPM8 channel. J Biol Chem 281, 38396-38404.
54. Lin Y, &, Sun Z, (2012) Antiaging gene Klotho enhances glucose-induced insulin secretion by up-regulating plasma membrane levels of TRPV2 in MIN6-cells. Endocrinology 153, 3029-3039.
55. Voets T, &, Nilius B, (2003) The pore of TRP channels: trivial or neglected? Cell Calcium 33, 299-302.
56. Owsianik G, Talavera K, Voets T, &, Nilius B, (2006) Permeation and selectivity of TRP channels. Annu Rev Physiol 68, 685-717.
57. Penna A, Juvin V, Chemin J, Compan V, Monet M, &, Rassendren F-A, (2006) PI3-kinase promotes TRPV2 activity independently of channel translocation to the plasma membrane. Cell Calcium 39, 495-507.
58. 2+-dependent desensitization of TRPV2 channels is mediated by hydrolysis of phosphatidylinositol 4,5-bisphosphate. J Neurosci 30, 13338-13347.
59. Holakovska B, Grycova L, Bily J, &, Teisinger J, (2011) Characterization of calmodulin binding domains in TRPV2 and TRPV5 C-tails. Amino Acids 40, 741-748.
60. García-Sanz N, Fernández-Carvajal A, Morenilla-Palao C, Planells-Cases R, Fajardo-Sánchez E, Fernández-Ballester G, &, Ferrer-Montiel A, (2004) Identification of a tetramerization domain in the C terminus of the vanilloid receptor. J Neurosci 24, 5307-5314.
61. Becker D, Müller M, Leuner K, &, Jendrach M, (2008) The C-terminal domain of TRPV4 is essential for plasma membrane localization. Mol Membr Biol 25, 139-151.
62. Valente P, García-Sanz N, Gomis A, Fernández-Carvajal A, Fernández-Ballester G, Viana F, Belmonte C, &, Ferrer-Montiel A, (2008) Identification of molecular determinants of channel gating in the transient receptor potential box of vanilloid receptor I. FASEB J 22, 3298-3309.
63. García-Sanz N, Valente P, Gomis A, Fernández-Carvajal A, Fernández-Ballester G, Viana F, Belmonte C, &, Ferrer-Montiel A, (2007) A role of the transient receptor potential domain of vanilloid receptor I in channel gating. J Neurosci 27, 11641-11650.
64. Barnhill JC, Stokes AJ, Koblan-Huberson M, Shimoda LMN, Muraguchi A, Adra CN, &, Turner H, (2004) RGA protein associates with a TRPV ion channel during biosynthesis and trafficking. J Cell Biochem 91, 808-820.
65. Stokes AJ, Wakano C, Del Carmen KA, Koblan-Huberson M, &, Turner H, (2005) Formation of a physiological complex between TRPV2 and RGA protein promotes cell surface expression of TRPV2. J Cell Biochem 94, 669-683.
66. Kobayashi Y, Katanosaka Y, Iwata Y, Matsuoka M, Shigekawa M, &, Wakabayashi S, (2006) Identification and characterization of GSRP-56, a novel Golgi-localized spectrin repeat-containing protein. Exp Cell Res 312, 3152-3164.
67. Phelps CB, Procko E, Lishko PV, Wang RR, &, Gaudet R, (2007) Insights into the roles of conserved and divergent residues in the ankyrin repeats of TRPV ion channels. Channels (Austin) 1, 148-151.
68. Phelps CB, Wang RR, Choo SS, &, Gaudet R, (2010) Differential regulation of TRPV1, TRPV3, and TRPV4 sensitivity through a conserved binding site on the ankyrin repeat domain. J Biol Chem 285, 731-740.
69. Myers BR, Bohlen CJ, &, Julius D, (2008) A yeast genetic screen reveals a critical role for the pore helix domain in TRP channel gating. Neuron 58, 362-373.
70. Lishko PV, Procko E, Jin X, Phelps CB, &, Gaudet R, (2007) The ankyrin repeats of TRPV1 bind multiple ligands and modulate channel sensitivity. Neuron 54, 905-918.
71. Rohacs T, Thyagarajan B, &, Lukacs V, (2008) Phospholipase C mediated modulation of TRPV1 channels. Mol Neurobiol 37, 153-163.
72. Cao E, Cordero-Morales JF, Liu B, Qin F, &, Julius D, (2013) TRPV1 channels are intrinsically heat sensitive and negatively regulated by phosphoinositide lipids. Neuron 77, 667-679.
73. Prescott ED, &, Julius D, (2003) A modular PIP2 binding site as a determinant of capsaicin receptor sensitivity. Science 300, 1284-1288.
74. Gordon-Shaag A, Zagotta WN, &, Gordon SE, (2008) Mechanism of Ca(2+)-dependent desensitization in TRP channels. Channels (Austin) 2, 125-129.
75. Shin Y-C, Shin S-Y, So I, Kwon D, &, Jeon J-H, (2011) TRIP database: a manually curated database of protein-protein interactions for mammalian TRP channels. Nucleic Acids Res 39, D356-D361.
76. Shin Y-C, Shin S-Y, Chun JN, Cho HS, Lim JM, Kim H-G, So I, Kwon D, &, Jeon J-H, (2012) TRIP database 2.0: a manually curated information hub for accessing TRP channel interaction network. PLoS One 7, e47165.
77. Link TM, Park U, Vonakis BM, Raben DM, Soloski MJ, &, Caterina MJ, (2010) TRPV2 has a pivotal role in macrophage particle binding and phagocytosis. Nat Immunol 11, 232-239.
78. Santoni G, Farfariello V, Liberati S, Morelli MB, Nabissi M, Santoni M, &, Amantini C, (2013) The role of transient receptor potential vanilloid type-2 ion channels in innate and adaptive immune responses. Front Immunol 4, 34.
79. Vriens J, Appendino G, &, Nilius B, (2009) Pharmacology of vanilloid transient receptor potential cation channels. Mol Pharmacol 75, 1262-1279.
80. Qin N, Neeper MP, Liu Y, Hutchinson TL, Lubin ML, &, Flores CM, (2008) TRPV2 is activated by cannabidiol and mediates CGRP release in cultured rat dorsal root ganglion neurons. J Neurosci 28, 6231-6238.
81. De Petrocellis L, Ligresti A, Moriello AS, Allarà M, Bisogno T, Petrosino S, Stott CG, &, Di Marzo V, (2011) Effects of cannabinoids and cannabinoid-enriched Cannabis extracts on TRP channels and endocannabinoid metabolic enzymes. Br J Pharmacol 163, 1479-1494.
82. Hu H-Z, Gu Q, Wang C, Colton CK, Tang J, Kinoshita-Kawada M, Lee L-Y, Wood JD, &, Zhu MX, (2004) 2-Aminoethoxydiphenyl borate is a common activator of TRPV1, TRPV2, and TRPV3. J Biol Chem 279, 35741-35748.
83. Juvin V, Penna A, Chemin J, Lin YL, &, Rassendren FA, (2007) Pharmacological characterization and molecular determinants of the activation of transient receptor potential V2 channel orthologs by 2-aminoethoxydiphenyl borate. Mol Pharmacol 72, 1258-1268.
84. Chung MK, Güler AD, &, Caterina MJ, (2005) Biphasic currents evoked by chemical or thermal activation of the heat-gated ion channel, TRPV3. J Biol Chem 280, 15928-15941.
85. Leffler A, Linte RM, Nau C, Reeh P, &, Babes A, (2007) A high-threshold heat-activated channel in cultured rat dorsal root ganglion neurons resembles TRPV2 and is blocked by gadolinium. Eur J Neurosci 26, 12-22.
86. Stotz SC, Vriens J, Martyn D, Clardy J, &, Clapham DE, (2008) Citral sensing by transient [corrected] receptor potential channels in dorsal root ganglion neurons. PLoS One 3, e2082.
87. Bang S, Kim KY, Yoo S, Lee S-H, &, Hwang SW, (2007) Transient receptor potential V2 expressed in sensory neurons is activated by probenecid. Neurosci Lett 425, 120-125.
88. Robbins N, Koch SE, Tranter M, &, Rubinstein J, (2011) The history and future of probenecid. Cardiovasc Toxicol 12, 1-9.
89. Nie L, Oishi Y, Doi I, Shibata H, &, Kojima I, (1997) Inhibition of proliferation of MCF-7 breast cancer cells by a blocker of Ca(2+)-permeable channel. Cell Calcium 22, 75-82.
90. Aoyagi K, Ohara Imaizumi M, Nishiwaki C, Nakamichi Y, &, Nagamatsu S, (2010) Insulin/phosphoinositide 3-kinase pathway accelerates the glucose-induced first-phase insulin secretion through TrpV2 recruitment in pancreatic β-cells. Biochem J 432, 375-386.
91. Hisanaga E, Nagasawa M, Ueki K, Kulkarni RN, Mori M, &, Kojima I, (2009) Regulation of calcium-permeable TRPV2 channel by insulin in pancreatic beta-cells. Diabetes 58, 174-184.
92. Mihara H, Boudaka A, Shibasaki K, Yamanaka A, Sugiyama T, &, Tominaga M, (2010) Involvement of TRPV2 activation in intestinal movement through nitric oxide production in mice. J Neurosci 30, 16536-16544.
93. Shibasaki K, Murayama N, Ono K, Ishizaki Y, &, Tominaga M, (2010) TRPV2 enhances axon outgrowth through its activation by membrane stretch in developing sensory and motor neurons. J Neurosci 30, 4601-4612.
94. Ahluwalia J, Rang H, &, Nagy I, (2002) The putative role of vanilloid receptor-like protein-1 in mediating high threshold noxious heat-sensitivity in rat cultured primary sensory neurons. Eur J Neurosci 16, 1483-1489.
95. Ichikawa H, &, Sugimoto T, (2000) Vanilloid receptor 1-like receptor-immunoreactive primary sensory neurons in the rat trigeminal nervous system. Neuroscience 101, 719-725.
96. Yamamoto Y, &, Taniguchi K, (2005) Immunolocalization of VR1 and VRL1 in rat larynx. Auton Neurosci 117, 62-65.
97. Ma Q-P, (2001) Vanilloid receptor homologue, VRL1, is expressed by both A- and C-fiber sensory neurons. NeuroReport 12, 3693.
98. Lewinter RD, Skinner K, Julius D, &, Basbaum AI, (2004) Immunoreactive TRPV-2 (VRL-1), a capsaicin receptor homolog, in the spinal cord of the rat. J Comp Neurol 470, 400-408.
99. Koike S, Uno T, Bamba H, Shibata T, Okano H, &, Hisa Y, (2004) Distribution of vanilloid receptors in the rat laryngeal innervation. Acta Otolaryngol 124, 515-519.
100. Hamamoto T, Takumida M, Hirakawa K, Takeno S, &, Tatsukawa T, (2008) Localization of transient receptor potential channel vanilloid subfamilies in the mouse larynx. Acta Otolaryngol 128, 685-693.
101. Hamamoto T, Takumida M, Hirakawa K, Tatsukawa T, &, Ishibashi T, (2009) Localization of transient receptor potential vanilloid (TRPV) in the human larynx. Acta Otolaryngol 129, 560-568.
102. Gibbs JL, Melnyk JL, &, Basbaum AI, (2011) Differential TRPV1 and TRPV2 channel expression in dental pulp. J Dent Res 90, 765-770.
103. Wainwright A, Rutter AR, Seabrook GR, Reilly K, &, Oliver KR, (2004) Discrete expression of TRPV2 within the hypothalamo-neurohypophysial system: implications for regulatory activity within the hypothalamic-pituitary-adrenal axis. J Comp Neurol 474, 24-42.
104. Nedungadi TP, Carreño FR, Walch JD, Bathina CS, &, Cunningham JT, (2012) Region-specific changes in transient receptor potential vanilloid channel expression in the vasopressin magnocellular system in hepatic cirrhosis-induced hyponatraemia. J Neuroendocrinol 24, 642-652.
105. Muraki K, Iwata Y, Katanosaka Y, Ito T, Ohya S, Shigekawa M, &, Imaizumi Y, (2003) TRPV2 is a component of osmotically sensitive cation channels in murine aortic myocytes. Circ Res 93, 829-838.
106. Cahoy JD, Emery B, Kaushal A, Foo LC, Zamanian JL, Christopherson KS, Xing Y, Lubischer JL, Krieg PA, Krupenko SA, et al,. (2008) A transcriptome database for astrocytes, neurons, and oligodendrocytes: a new resource for understanding brain development and function. J Neurosci 28, 264-278.
107. Cavanaugh DJ, Chesler AT, Jackson AC, Sigal YM, Yamanaka H, Grant R, O'Donnell D, Nicoll RA, Shah NM, Julius D, et al,. (2011) Trpv1 reporter mice reveal highly restricted brain distribution and functional expression in arteriolar smooth muscle cells. J Neurosci 31, 5067-5077.
108. Nedungadi TP, Dutta M, Bathina CS, Caterina MJ, &, Cunningham JT, (2012) Expression and distribution of TRPV2 in rat brain. Exp Neurol 237, 223-237.
109. Chang Q, Hoefs S, van der Kemp AW, Topala CN, Bindels RJ, &, Hoenderop JG, (2005) The beta-glucuronidase klotho hydrolyzes and activates the TRPV5 channel. Science 310, 490-493.
110. Cha S-K, Ortega B, Kurosu H, Rosenblatt KP, Kuro-O M, &, Huang C-L, (2008) Removal of sialic acid involving Klotho causes cell-surface retention of TRPV5 channel via binding to galectin-1. Proc Natl Acad Sci USA 105, 9805-9810.
111. Zhang D, Spielmann A, Wang L, Ding G, Huang F, Gu Q, &, Schwarz W, (2012) Mast-cell degranulation induced by physical stimuli involves the activation of transient-receptor-potential channel TRPV2. Physiol Res 61, 113-124.
112. Stokes AJ, Shimoda LMN, Koblan-Huberson M, Adra CN, &, Turner H, (2004) A TRPV2-PKA signaling module for transduction of physical stimuli in mast cells. J Exp Med 200, 137-147.
113. Saunders CI, Kunde DA, Crawford A, &, Geraghty DP, (2007) Expression of transient receptor potential vanilloid 1 (TRPV1) and 2 (TRPV2) in human peripheral blood. Mol Immunol 44, 1429-1435.
114. Nagasawa M, Nakagawa Y, Tanaka S, &, Kojima I, (2007) Chemotactic peptide fMetLeuPhe induces translocation of the TRPV2 channel in macrophages. J Cell Physiol 210, 692-702.
115. Boels K, Glassmeier G, Herrmann D, Riedel IB, Hampe W, Kojima I, Schwarz JR, &, Schaller HC, (2001) The neuropeptide head activator induces activation and translocation of the growth-factor-regulated Ca(2+)-permeable channel GRC. J Cell Sci 114, 3599-3606.
116. Nagasawa M, &, Kojima I, (2012) Translocation of calcium-permeable TRPV2 channel to the podosome: its role in the regulation of podosome assembly. Cell Calcium 51, 186-193.
117. Linder S, &, Aepfelbacher M, (2003) Podosomes: adhesion hot-spots of invasive cells. Trends Cell Biol 13, 376-385.
118. Yamashiro K, Sasano T, Tojo K, Namekata I, Kurokawa J, Sawada N, Suganami T, Kamei Y, Tanaka H, Tajima N, et al,. (2010) Role of transient receptor potential vanilloid 2 in LPS-induced cytokine production in macrophages. Biochem Biophys Res Commun 398, 284-289.
119. Park KS, Kim Y, Lee Y-H, Earm YE, &, Ho W-K, (2003) Mechanosensitive cation channels in arterial smooth muscle cells are activated by diacylglycerol and inhibited by phospholipase C inhibitor. Circ Res 93, 557-564.
120. 2+ entry in human pulmonary artery endothelial cells. Am J Physiol Lung Cell Mol Physiol 285, L1233-45.
121. 2+ entry and transient receptor potential canonical and vanilloid-related proteins in rat distal pulmonary venous smooth muscle. Am J Physiol Lung Cell Mol Physiol 299, L621-L630.
122. 2+-permeable growth factor-regulated channel. J Cell Biol 161, 957-967.
123. 2+ influx via TRPV2 ameliorates muscular dystrophy in animal models. Hum Mol Genet 18, 824-834.
124. Gailly P, (2012) TRP channels in normal and dystrophic skeletal muscle. Curr Opin Pharmacol 12, 326-334.
125. Zanou N, Iwata Y, Schakman O, Lebacq J, Wakabayashi S, &, Gailly P, (2009) Essential role of TRPV2 ion channel in the sensitivity of dystrophic muscle to eccentric contractions. FEBS Lett 583, 3600-3604.
126. Lehen'kyi V, &, Prevarskaya N, (2012) TRPV2 (transient receptor potential cation channel, subfamily V, member 2). Atlas Genet Cytogenet Oncol Haematol 16, 563-567.
127. Vriens J, Janssens A, Prenen J, Nilius B, &, Wondergem R, (2004) TRPV channels and modulation by hepatocyte growth factor/scatter factor in human hepatoblastoma (HepG2) cells. Cell Calcium 36, 19-28.
128. Liu G, Xie C, Sun F, Xu X, Yang Y, Zhang T, Deng Y, Wang D, Huang Z, Yang L, et al,. (2010) Clinical significance of transient receptor potential vanilloid 2 expression in human hepatocellular carcinoma. Cancer Genet Cytogenet 197, 54-59.
129. Caprodossi S, Lucciarini R, Amantini C, Nabissi M, Canesin G, Ballarini P, Di Spilimbergo A, Cardarelli MA, Servi L, Mammana G, et al,. (2008) Transient receptor potential vanilloid type 2 (TRPV2) expression in normal urothelium and in urothelial carcinoma of human bladder: correlation with the pathologic stage. Eur Urol 54, 612-620.
130. Yamada T, Ueda T, Shibata Y, Ikegami Y, Saito M, Ishida Y, Ugawa S, Kohri K, &, Shimada S, (2010) TRPV2 activation induces apoptotic cell death in human T24 bladder cancer cells: a potential therapeutic target for bladder cancer. Urology 76, 509.e1-7.
131. Monet M, Lehen'kyi V, Gackiere F, Firlej V, Vandenberghe M, Roudbaraki M, Gkika D, Pourtier A, Bidaux G, Slomianny C, et al,. (2010) Role of cationic channel TRPV2 in promoting prostate cancer migration and progression to androgen resistance. Cancer Res 70, 1225-1235.
132. Monet M, Gkika D, Lehen'kyi V, Pourtier A, Abeele FV, Bidaux G, Juvin V, Rassendren F, Humez S, &, Prevarsakaya N, (2009) Lysophospholipids stimulate prostate cancer cell migration via TRPV2 channel activation. Biochim Biophys Acta 1793, 528-539.
133. Nabissi M, Morelli MB, Amantini C, Farfariello V, Ricci-Vitiani L, Caprodossi S, Arcella A, Santoni M, Giangaspero F, De Maria R, et al,. (2010) TRPV2 channel negatively controls glioma cell proliferation and resistance to Fas-induced apoptosis in ERK-dependent manner. Carcinogenesis 31, 794-803.
134. Morelli MB, Nabissi M, Amantini C, Farfariello V, Ricci-Vitiani L, di Martino S, Pallini R, Larocca LM, Caprodossi S, Santoni M, et al,. (2012) The transient receptor potential vanilloid-2 cation channel impairs glioblastoma stem-like cell proliferation and promotes differentiation. Int J Cancer 131, E1067-E1077.
135. Nabissi M, Morelli MB, Santoni M, &, Santoni G, (2013) Triggering of the TRPV2 channel by cannabidiol sensitizes glioblastoma cells to cytotoxic chemotherapeutic agents. Carcinogenesis 34, 48-57.
136. Katoh K, Misawa K, Kuma KI, &, Miyata T, (2002) MAFFT: a novel method for rapid multiple sequence alignment based on fast Fourier transform. Nucleic Acids Res 30, 3059-3066.
137. Waterhouse AM, Procter JB, Martin DMA, Clamp M, &, Barton GJ, (2009) Jalview Version 2-a multiple sequence alignment editor and analysis workbench. Bioinformatics 25, 1189-1191.
138. Ashkenazy H, Erez E, Martz E, Pupko T, &, Ben-Tal N, (2010) ConSurf 2010: calculating evolutionary conservation in sequence and structure of proteins and nucleic acids. Nucleic Acids Res 38, W529-33.