-
1
-
-
47349104402
-
Glial reactions in Parkinson's disease
-
McGeer PL, McGeer EG. Glial reactions in Parkinson's disease. Mov Disord 2008; 23 (4): 474-83.
-
(2008)
Mov Disord
, vol.23
, Issue.4
, pp. 474-483
-
-
McGeer, P.L.1
McGeer, E.G.2
-
3
-
-
17044447638
-
Familial Parkinson's disease. Alpha-synuclein and parkin
-
Mizuno Y, Hattori N, Kitada T, et al. Familial Parkinson's disease. Alpha-synuclein and parkin. Adv Neurol 2001; 86: 13-21.
-
(2001)
Adv Neurol
, vol.86
, pp. 13-21
-
-
Mizuno, Y.1
Hattori, N.2
Kitada, T.3
-
4
-
-
0037208691
-
Is the cause of Parkinson's disease environmental or hereditary? Evidence from twin studies
-
Tanner CM. Is the cause of Parkinson's disease environmental or hereditary? Evidence from twin studies. Adv Neurol 2003; 91: 133-42.
-
(2003)
Adv Neurol
, vol.91
, pp. 133-142
-
-
Tanner, C.M.1
-
5
-
-
39049179635
-
Cellular and molecular mechanisms of Parkinson's disease: Neurotoxins, causative genes, and inflammatory cytokines
-
Nagatsu T, Sawada M. Cellular and molecular mechanisms of Parkinson's disease: neurotoxins, causative genes, and inflammatory cytokines. Cell Mol Neurobiol 2006; 26 (4-6): 781-802.
-
(2006)
Cell Mol Neurobiol
, vol.26
, Issue.46
, pp. 781-802
-
-
Nagatsu, T.1
Sawada, M.2
-
6
-
-
0023740773
-
Rate of cell death in parkinsonism indicates active neuropathological process
-
McGeer PL, Itagaki S, Akiyama H, et al. Rate of cell death in parkinsonism indicates active neuropathological process. Ann Neurol 1988; 24 (4): 574-6.
-
(1988)
Ann Neurol
, vol.24
, Issue.4
, pp. 574-576
-
-
McGeer, P.L.1
Itagaki, S.2
Akiyama, H.3
-
7
-
-
35348966882
-
Neuroinflammatory mechanisms in Parkinson's disease: Potential environmental triggers, pathways, and targets for early therapeutic intervention
-
Tansey MG, McCoy MK, Frank-Cannon TC. Neuroinflammatory mechanisms in Parkinson's disease: potential environmental triggers, pathways, and targets for early therapeutic intervention. Exper Neurol 2007; 208 (1): 1-25.
-
(2007)
Exper Neurol
, vol.208
, Issue.1
, pp. 1-25
-
-
Tansey, M.G.1
McCoy, M.K.2
Frank-Cannon, T.C.3
-
8
-
-
0036690599
-
Regulating factors for microglial activation
-
Nakamura Y. Regulating factors for microglial activation. Biol Pharma Bull 2002; 25 (8): 945-53.
-
(2002)
Biol Pharma Bull
, vol.25
, Issue.8
, pp. 945-953
-
-
Nakamura, Y.1
-
9
-
-
70449534695
-
CNS infiltration of peripheral immune cells: D-Day for neurodegenerative disease
-
Rezai-Zadeh K, Gate D, Town T. CNS infiltration of peripheral immune cells: D-Day for neurodegenerative disease? J Neuroimmune Pharmacol 2009; 4 (4): 462-75.
-
(2009)
J Neuroimmune Pharmacol
, vol.4
, Issue.4
, pp. 462-475
-
-
Rezai-Zadeh, K.1
Gate, D.2
Town, T.3
-
10
-
-
1942454250
-
Inflammation and neurodegeneration in Parkinson's disease
-
McGeer PL, McGeer EG. Inflammation and neurodegeneration in Parkinson's disease. Parkinsonism Relat Disord 2004; 10 (Suppl 1): S3-7.
-
(2004)
Parkinsonism Relat Disord
, vol.10
, pp. 3-7
-
-
McGeer, P.L.1
McGeer, E.G.2
-
11
-
-
77955385260
-
Mitochondrial dysfunction: A potential link between neuroinflammation and neurodegeneration?
-
Witte ME, Geurts JJ, de Vries HE, et al. Mitochondrial dysfunction: a potential link between neuroinflammation and neurodegeneration? Mitochondrion 2010; 10 (5): 411-8.
-
(2010)
Mitochondrion
, vol.10
, Issue.5
, pp. 411-418
-
-
Witte, M.E.1
Geurts, J.J.2
De Vries, H.E.3
-
12
-
-
0031881687
-
Lipopolysaccharide intranigral injection induces inflammatory reaction and damage in nigrostriatal dopaminergic system
-
Castaño A, Herrera AJ, Cano J, et al. Lipopolysaccharide intranigral injection induces inflammatory reaction and damage in nigrostriatal dopaminergic system. J Neurochem 1998; 70 (4): 1584-92.
-
(1998)
J Neurochem
, vol.70
, Issue.4
, pp. 1584-1592
-
-
Castaño, A.1
Herrera, A.J.2
Cano, J.3
-
14
-
-
3042793602
-
The role of iron and copper molecules in the neuronal vulnerability of locus coeruleus and substantia nigra during aging
-
Zecca L, Stroppolo A, Gatti A, et al. The role of iron and copper molecules in the neuronal vulnerability of locus coeruleus and substantia nigra during aging. Proc Natl Acad Sci USA 2004; 101 (26): 9843-8.
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, Issue.26
, pp. 9843-9848
-
-
Zecca, L.1
Stroppolo, A.2
Gatti, A.3
-
15
-
-
0029751104
-
Oxidative stress and the pathogenesis of Parkinson's disease
-
Jenner P, Olanow CW. Oxidative stress and the pathogenesis of Parkinson's disease. Neurology 1996; 47 (6 Suppl 3): S161-70.
-
(1996)
Neurology
, vol.47
, Issue.6
, pp. 161-170
-
-
Jenner, P.1
Olanow, C.W.2
-
16
-
-
0032704101
-
Antioxidants, oxidative stress, and degenerative neurological disorders
-
Floyd RA. Antioxidants, oxidative stress, and degenerative neurological disorders. Proc Soc Exp Biol Med Soc Exp Biol Med (New York, NY) 1999; 222 (3): 236-45.
-
(1999)
Proc Soc Exp Biol Med Soc Exp Biol Med (New York, NY)
, vol.222
, Issue.3
, pp. 236-245
-
-
Floyd, R.A.1
-
17
-
-
36248938279
-
The pathogenesis of cell death in Parkinson's disease-2007
-
Olanow CW. The pathogenesis of cell death in Parkinson's disease-2007. Mov Disord 2007; 22 (Suppl 17): S335-42.
-
(2007)
Mov Disord
, vol.22
, pp. 335-342
-
-
Olanow, C.W.1
-
18
-
-
33847759064
-
Systemic LPS causes chronic neuroinflammation and progressive neurodegeneration
-
Qin L, Wu X, Block ML, et al. Systemic LPS causes chronic neuroinflammation and progressive neurodegeneration. Glia 2007; 55 (5): 453-62.
-
(2007)
Glia
, vol.55
, Issue.5
, pp. 453-462
-
-
Qin, L.1
Wu, X.2
Block, M.L.3
-
19
-
-
33748702290
-
Blocking soluble tumor necrosis factor signaling with dominant-negative tumor necrosis factor inhibitor attenuates loss of dopaminergic neurons in models of Parkinson's disease
-
McCoy MK, Martinez TN, Ruhn KA, et al. Blocking soluble tumor necrosis factor signaling with dominant-negative tumor necrosis factor inhibitor attenuates loss of dopaminergic neurons in models of Parkinson's disease. J Neurosci 2006; 26 (37): 9365-75.
-
(2006)
J Neurosci
, vol.26
, Issue.37
, pp. 9365-9375
-
-
McCoy, M.K.1
Martinez, T.N.2
Ruhn, K.A.3
-
21
-
-
33846308531
-
Microglial activation as a priming event leading to paraquat-induced dopaminergic cell degeneration
-
Purisai MG, McCormack AL, Cumine S, et al. Microglial activation as a priming event leading to paraquat-induced dopaminergic cell degeneration. Neurobiol Dis 2007; 25 (2): 392-400.
-
(2007)
Neurobiol Dis
, vol.25
, Issue.2
, pp. 392-400
-
-
Purisai, M.G.1
McCormack, A.L.2
Cumine, S.3
-
22
-
-
30744472146
-
In vivo imaging of microglial activation with [11C](R)-PK11195 PET in idiopathic Parkinson's disease
-
Gerhard A, Pavese N, Hotton G, et al. In vivo imaging of microglial activation with [11C](R)-PK11195 PET in idiopathic Parkinson's disease. Neurobiol Dis 2006; 21 (2): 404-12.
-
(2006)
Neurobiol Dis
, vol.21
, Issue.2
, pp. 404-412
-
-
Gerhard, A.1
Pavese, N.2
Hotton, G.3
-
23
-
-
33645809729
-
Interleukin-1 mediates Alzheimer and Lewy body pathologies
-
Griffin WST, Liu L, Li Y, et al. Interleukin-1 mediates Alzheimer and Lewy body pathologies. J Neuroinflammat 2006; 3: 5.
-
(2006)
J Neuroinflammat
, vol.3
, pp. 5
-
-
Griffin, W.S.T.1
Liu, L.2
Li, Y.3
-
24
-
-
51449099473
-
Synuclein activates microglia in a model of Parkinson's disease
-
Su X, Maguire-Zeiss KA, Giuliano R, et al. Synuclein activates microglia in a model of Parkinson's disease. Neurobiol Aging 2008; 29 (11): 1690-701.
-
(2008)
Neurobiol Aging
, vol.29
, Issue.11
, pp. 1690-1701
-
-
Su, X.1
Maguire-Zeiss, K.A.2
Giuliano, R.3
-
25
-
-
40849118624
-
Alpha-synuclein activates stress signaling protein kinases in THP-1 cells and microglia
-
Klegeris A, Pelech S, Giasson BI, et al. Alpha-synuclein activates stress signaling protein kinases in THP-1 cells and microglia. Neurobiol Aging 2008; 29 (5): 739-52.
-
(2008)
Neurobiol Aging
, vol.29
, Issue.5
, pp. 739-752
-
-
Klegeris, A.1
Pelech, S.2
Giasson, B.I.3
-
26
-
-
33749836242
-
Alpha-synuclein expression modulates microglial activation phenotype
-
Austin SA, Floden AM, Murphy EJ, et al. Alpha-synuclein expression modulates microglial activation phenotype. J Neurosci: official J Soci Neurosci 2006; 26 (41): 10558-63.
-
(2006)
J Neurosci: Official J Soci Neurosci
, vol.26
, Issue.41
, pp. 10558-10563
-
-
Austin, S.A.1
Floden, A.M.2
Murphy, E.J.3
-
27
-
-
84888380685
-
Activation of microglia induces symptoms of Parkinson's disease in wild-type, but not in IL-1 knockout mice
-
Tanaka S, Ishii A, Ohtaki H, et al. Activation of microglia induces symptoms of Parkinson's disease in wild-type, but not in IL-1 knockout mice. J Neuroinflammation. 2013; 10: 143.
-
(2013)
J Neuroinflammation.
, vol.10
, pp. 143
-
-
Tanaka, S.1
Ishii, A.2
Ohtaki, H.3
-
28
-
-
84867629199
-
Non-motor symptoms in patients with Parkinson's disease-correlations with inflammatory cytokines in serum
-
Lindqvist D, Kaufman E, Brundin L, et al. Non-motor symptoms in patients with Parkinson's disease-correlations with inflammatory cytokines in serum. PloS one. 2012; 7 (10): e47387.
-
(2012)
PloS One
, vol.7
, Issue.10
, pp. 47387
-
-
Lindqvist, D.1
Kaufman, E.2
Brundin, L.3
-
29
-
-
47749110631
-
Human neuromelanin induces neuroinflammation and neurodegeneration in the rat substantia nigra: Implications for Parkinson's disease
-
Zecca L, Wilms H, Geick S, et al. Human neuromelanin induces neuroinflammation and neurodegeneration in the rat substantia nigra: implications for Parkinson's disease. Acta neuropathologica. 2008; 116 (1): 47-55.
-
(2008)
Acta Neuropathologica
, vol.116
, Issue.1
, pp. 47-55
-
-
Zecca, L.1
Wilms, H.2
Geick, S.3
-
30
-
-
33646378453
-
Neuromelanin induces oxidative stress in mitochondria through release of iron: Mechanism behind the inhibition of 26S proteasome
-
Shamoto-Nagai M, Maruyama W, Yi H, et al. Neuromelanin induces oxidative stress in mitochondria through release of iron: mechanism behind the inhibition of 26S proteasome. J Neural Trans 2006; 113 (5): 633-44.
-
(2006)
J Neural Trans
, vol.113
, Issue.5
, pp. 633-644
-
-
Shamoto-Nagai, M.1
Maruyama, W.2
Yi, H.3
-
31
-
-
0042433192
-
Neuromelanin associated redox-active iron is increased in the substantia nigra of patients with Parkinson's disease
-
Faucheux BA, Martin M-E, Beaumont C, et al. Neuromelanin associated redox-active iron is increased in the substantia nigra of patients with Parkinson's disease. J Neurochem 2003; 86 (5): 1142-8.
-
(2003)
J Neurochem
, vol.86
, Issue.5
, pp. 1142-1148
-
-
Faucheux, B.A.1
Martin, M.-E.2
Beaumont, C.3
-
32
-
-
1642555537
-
Iron involvement in neural damage and microgliosis in models of neurodegenerative diseases
-
Shoham S, Youdim MB. Iron involvement in neural damage and microgliosis in models of neurodegenerative diseases. Cell Mol Biol 2000; 46 (4): 743-60.
-
(2000)
Cell Mol Biol
, vol.46
, Issue.4
, pp. 743-760
-
-
Shoham, S.1
Youdim, M.B.2
-
34
-
-
58849107919
-
Infiltration of CD4+ lymphocytes into the brain contributes to neurodegeneration in a mouse model of Parkinson disease
-
Brochard V, Combadiere B, et al. Infiltration of CD4+ lymphocytes into the brain contributes to neurodegeneration in a mouse model of Parkinson disease. J Clin Invest 2009; 119 (1): 182-92.
-
(2009)
J Clin Invest
, vol.119
, Issue.1
, pp. 182-192
-
-
Brochard, V.1
Combadiere, B.2
-
35
-
-
58849107919
-
Infiltration of CD4+ lymphocytes into the brain contributes to neurodegeneration in a mouse model of Parkinson disease
-
Brochard V, Combadière B, Prigent A, et al. Infiltration of CD4+ lymphocytes into the brain contributes to neurodegeneration in a mouse model of Parkinson disease. J Clin Invest 2009; 119 (1): 182-92.
-
(2009)
J Clin Invest
, vol.119
, Issue.1
, pp. 182-192
-
-
Brochard, V.1
Combadière, B.2
Prigent, A.3
-
36
-
-
64249169415
-
Nitrated {alpha}-synuclein-induced alterations in microglial immunity are regulated by CD4+ T cell subsets
-
Reynolds AD, Stone DK, Mosley RL, et al. Nitrated {alpha}-synuclein-induced alterations in microglial immunity are regulated by CD4+ T cell subsets. J Immunol 2009; 182 (7): 4137-49.
-
(2009)
J Immunol
, vol.182
, Issue.7
, pp. 4137-4149
-
-
Reynolds, A.D.1
Stone, D.K.2
Mosley, R.L.3
-
37
-
-
77951882307
-
Regulatory T cells attenuate Th17 cell-mediated nigrostriatal dopaminergic neurodegeneration in a model of Parkinson's disease
-
Reynolds AD, Stone DK, Hutter JA, et al. Regulatory T cells attenuate Th17 cell-mediated nigrostriatal dopaminergic neurodegeneration in a model of Parkinson's disease. J Immunol (Baltimore, Md: 1950). 2010; 184 (5): 2261-71.
-
(2010)
J Immunol (Baltimore, Md: 1950)
, vol.184
, Issue.5
, pp. 2261-2271
-
-
Reynolds, A.D.1
Stone, D.K.2
Hutter, J.A.3
-
38
-
-
68249145501
-
Innate and adaptive immunity for the pathobiology of Parkinson's disease
-
Stone DK, Reynolds AD, Mosley RL, et al. Innate and adaptive immunity for the pathobiology of Parkinson's disease. Antioxid Redox Signaling 2009; 11 (9): 2151-66.
-
(2009)
Antioxid Redox Signaling
, vol.11
, Issue.9
, pp. 2151-2166
-
-
Stone, D.K.1
Reynolds, A.D.2
Mosley, R.L.3
-
39
-
-
36249032567
-
Neuroprotective activities of CD4+CD25+ regulatory T cells in an animal model of Parkinson's disease
-
Reynolds AD, Banerjee R, Liu J, et al. Neuroprotective activities of CD4+CD25+ regulatory T cells in an animal model of Parkinson's disease. J Leukocyte Biol 2007; 82 (5): 1083-94.
-
(2007)
J Leukocyte Biol
, vol.82
, Issue.5
, pp. 1083-1094
-
-
Reynolds, A.D.1
Banerjee, R.2
Liu, J.3
-
40
-
-
0035881234
-
Regulatory T cells induced by 1 alpha,25-dihydroxyvitamin D3 and mycophenolate mofetil treatment mediate transplantation tolerance
-
Gregori S, Casorati M, Amuchastegui S, et al. Regulatory T cells induced by 1 alpha,25-dihydroxyvitamin D3 and mycophenolate mofetil treatment mediate transplantation tolerance. J Immunol (Baltimore, Md: 1950). 2001; 167 (4): 1945-53.
-
(2001)
J Immunol (Baltimore, Md: 1950)
, vol.167
, Issue.4
, pp. 1945-1953
-
-
Gregori, S.1
Casorati, M.2
Amuchastegui, S.3
-
41
-
-
48349146711
-
Human interleukin-10 gene transfer is protective in a rat model of Parkinson's disease
-
Johnston LC, Su X, Maguire-Zeiss K, et al. Human interleukin-10 gene transfer is protective in a rat model of Parkinson's disease. Mol Ther: J Am Soc Gene Ther 2008; 16 (8): 1392-9.
-
(2008)
Mol Ther: J Am Soc Gene Ther
, vol.16
, Issue.8
, pp. 1392-1399
-
-
Johnston, L.C.1
Su, X.2
Maguire-Zeiss, K.3
-
42
-
-
32044442102
-
Microglial phenotype: Is the commitment reversible?
-
Schwartz M, Butovsky O, Brück W, et al. Microglial phenotype: is the commitment reversible? Trends Neurosci 2006; 29 (2): 68-74.
-
(2006)
Trends Neurosci
, vol.29
, Issue.2
, pp. 68-74
-
-
Schwartz, M.1
Butovsky, O.2
Brück, W.3
-
43
-
-
0034788215
-
Increase in peripheral CD4 bright +CD8 dull+ T cells in Parkinson disease
-
Hisanaga K, Asagi M, Itoyama Y, et al. Increase in peripheral CD4 bright +CD8 dull+ T cells in Parkinson disease. Arch Neurol 2001; 58 (10): 1580-3.
-
(2001)
Arch Neurol
, vol.58
, Issue.10
, pp. 1580-1583
-
-
Hisanaga, K.1
Asagi, M.2
Itoyama, Y.3
-
44
-
-
27744603906
-
Alterations of T-lymphocyte populations in Parkinson disease
-
Baba Y, Kuroiwa A, Uitti RJ, et al. Alterations of T-lymphocyte populations in Parkinson disease. Parkinsonism Relat Disord 2005; 11 (8): 493-8.
-
(2005)
Parkinsonism Relat Disord
, vol.11
, Issue.8
, pp. 493-498
-
-
Baba, Y.1
Kuroiwa, A.2
Uitti, R.J.3
-
45
-
-
5444228135
-
Cellular pathology of Parkinson's disease: Astrocytes, microglia and inflammation
-
Teismann P, Schulz JB. Cellular pathology of Parkinson's disease: astrocytes, microglia and inflammation. Cell Tissue Res 2004; 318 (1): 149-61.
-
(2004)
Cell Tissue Res
, vol.318
, Issue.1
, pp. 149-161
-
-
Teismann, P.1
Schulz, J.B.2
-
46
-
-
13144255682
-
Blood-brain barrier dysfunction in parkinsonian midbrain in vivo
-
Kortekaas R, Leenders KL, van Oostrom JCH, et al. Blood-brain barrier dysfunction in parkinsonian midbrain in vivo. Ann Neurol 2005; 57 (2): 176-9.
-
(2005)
Ann Neurol
, vol.57
, Issue.2
, pp. 176-179
-
-
Kortekaas, R.1
Leenders, K.L.2
Van Oostrom, J.C.H.3
-
47
-
-
25844442898
-
6-Hydroxydopamine-induced alterations in blood-brain barrier permeability
-
Carvey PM, Zhao CH, Hendey B, et al. 6-Hydroxydopamine-induced alterations in blood-brain barrier permeability. Eur J Neurosci 2005; 22 (5): 1158-68.
-
(2005)
Eur J Neurosci
, vol.22
, Issue.5
, pp. 1158-1168
-
-
Carvey, P.M.1
Zhao, C.H.2
Hendey, B.3
-
48
-
-
0036939328
-
Macrophages and Microglia Produce Local Trophic Gradients That Stimulate Axonal Sprouting Toward but Not beyond the Wound Edge
-
Batchelor PE, Porritt MJ, Martinello P, et al. Macrophages and Microglia Produce Local Trophic Gradients That Stimulate Axonal Sprouting Toward but Not beyond the Wound Edge. Mol Cell Neurosci 2002; 21 (3): 436-53.
-
(2002)
Mol Cell Neurosci
, vol.21
, Issue.3
, pp. 436-453
-
-
Batchelor, P.E.1
Porritt, M.J.2
Martinello, P.3
-
49
-
-
84856770572
-
Lipopolysaccharide-induced nigral inflammation leads to increased IL-1beta tissue content and expression of astrocytic glial cell line-derived neurotrophic factor
-
Iravani MM, Sadeghian M, Leung CC, et al. Lipopolysaccharide-induced nigral inflammation leads to increased IL-1beta tissue content and expression of astrocytic glial cell line-derived neurotrophic factor. Neurosci Lett 2012; 510 (2): 138-42.
-
(2012)
Neurosci Lett
, vol.510
, Issue.2
, pp. 138-142
-
-
Iravani, M.M.1
Sadeghian, M.2
Leung, C.C.3
-
50
-
-
0038249170
-
Direct brain infusion of glial cell line-derived neurotrophic factor in Parkinson disease
-
Gill SS, Patel NK, Hotton GR, et al. Direct brain infusion of glial cell line-derived neurotrophic factor in Parkinson disease. Nat Med 2003; 9 (5): 589-95.
-
(2003)
Nat Med
, vol.9
, Issue.5
, pp. 589-595
-
-
Gill, S.S.1
Patel, N.K.2
Hotton, G.R.3
-
51
-
-
33644833272
-
Randomized controlled trial of intraputamenal glial cell line-derived neurotrophic factor infusion in Parkinson disease
-
Lang AE, Gill S, Patel NK, et al. Randomized controlled trial of intraputamenal glial cell line-derived neurotrophic factor infusion in Parkinson disease. Ann Neurol 2006; 59 (3): 459-66.
-
(2006)
Ann Neurol
, vol.59
, Issue.3
, pp. 459-466
-
-
Lang, A.E.1
Gill, S.2
Patel, N.K.3
-
52
-
-
80955179603
-
Amantadine protects dopamine neurons by a dual action: Reducing activation of microglia and inducing expression of GDNF in astroglia [corrected]
-
Ossola B, Schendzielorz N, Chen SH, et al. Amantadine protects dopamine neurons by a dual action: reducing activation of microglia and inducing expression of GDNF in astroglia [corrected]. Neuropharmacology 2011; 61 (4): 574-82.
-
(2011)
Neuropharmacology
, vol.61
, Issue.4
, pp. 574-582
-
-
Ossola, B.1
Schendzielorz, N.2
Chen, S.H.3
-
53
-
-
50549085408
-
Neuroinflammation and oxidation/nitration of alpha-synuclein linked to dopaminergic neurodegeneration
-
Gao H-M, Kotzbauer PT, Uryu K, et al. Neuroinflammation and oxidation/nitration of alpha-synuclein linked to dopaminergic neurodegeneration. J Neurosci: official J Soc Neurosci 2008; 28 (30): 7687-98.
-
(2008)
J Neurosci: Official J Soc Neurosci
, vol.28
, Issue.30
, pp. 7687-7698
-
-
Gao, H.-M.1
Kotzbauer, P.T.2
Uryu, K.3
-
54
-
-
0033933048
-
Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase
-
Shimura H, Hattori N, Kubo Si, et al. Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase. Nat Genet 2000; 25 (3): 302-5.
-
(2000)
Nat Genet
, vol.25
, Issue.3
, pp. 302-305
-
-
Shimura, H.1
Hattori, N.2
Kubo, S.3
-
55
-
-
80051767315
-
Lipopolysaccharide and tumor necrosis factor regulate Parkin expression via nuclear factor-kappa B
-
Tran TA, Nguyen AD, Chang J, et al. Lipopolysaccharide and tumor necrosis factor regulate Parkin expression via nuclear factor-kappa B. PloS one. 2011; 6 (8): e23660.
-
(2011)
PloS One
, vol.6
, Issue.8
, pp. 23660
-
-
Tran, T.A.1
Nguyen, A.D.2
Chang, J.3
-
56
-
-
80054787664
-
What genetics tells us about the causes and mechanisms of Parkinson's disease
-
Corti O, Lesage S, Brice A. What genetics tells us about the causes and mechanisms of Parkinson's disease. Physiol Rev 2011; 91 (4): 1161-218.
-
(2011)
Physiol Rev
, vol.91
, Issue.4
, pp. 1161-1218
-
-
Corti, O.1
Lesage, S.2
Brice, A.3
-
57
-
-
19944432606
-
Genetic screening for a single common LRRK2 mutation in familial Parkinson's disease
-
Nichols WC, Pankratz N, Hernandez D, et al. Genetic screening for a single common LRRK2 mutation in familial Parkinson's disease. Lancet 2005; 365 (9457): 410-2.
-
(2005)
Lancet
, vol.365
, Issue.9457
, pp. 410-412
-
-
Nichols, W.C.1
Pankratz, N.2
Hernandez, D.3
-
58
-
-
33644929033
-
LRRK2 mutations in Spanish patients with Parkinson disease: Frequency, clinical features, and incomplete penetrance
-
Gaig C, Ezquerra M, Marti MJ, et al. LRRK2 mutations in Spanish patients with Parkinson disease: frequency, clinical features, and incomplete penetrance. Arch Neurol 2006; 63 (3): 377-82.
-
(2006)
Arch Neurol
, vol.63
, Issue.3
, pp. 377-382
-
-
Gaig, C.1
Ezquerra, M.2
Marti, M.J.3
-
59
-
-
79956199220
-
Parkinson's disease-linked LRRK2 is expressed in circulating and tissue immune cells and upregulated following recognition of microbial structures
-
Hakimi M, Selvanantham T, Swinton E, et al. Parkinson's disease-linked LRRK2 is expressed in circulating and tissue immune cells and upregulated following recognition of microbial structures. J Neural Trans 2011; 118 (5): 795-808.
-
(2011)
J Neural Trans
, vol.118
, Issue.5
, pp. 795-808
-
-
Hakimi, M.1
Selvanantham, T.2
Swinton, E.3
-
60
-
-
80054933395
-
The kinase LRRK2 is a regulator of the transcription factor NFAT that modulates the severity of inflammatory bowel disease
-
Liu Z, Lee J, Krummey S, et al. The kinase LRRK2 is a regulator of the transcription factor NFAT that modulates the severity of inflammatory bowel disease. Nat Immunol 2011; 12 (11): 1063-70.
-
(2011)
Nat Immunol
, vol.12
, Issue.11
, pp. 1063-1070
-
-
Liu, Z.1
Lee, J.2
Krummey, S.3
-
61
-
-
0036773634
-
NFAT1 and NFAT2 are positive regulators of IL-4 gene transcription
-
Monticelli S, Rao A. NFAT1 and NFAT2 are positive regulators of IL-4 gene transcription. Eur J Immunol 2002; 32 (10): 2971-8.
-
(2002)
Eur J Immunol
, vol.32
, Issue.10
, pp. 2971-2978
-
-
Monticelli, S.1
Rao, A.2
-
62
-
-
84875140407
-
Genetic correction of a LRRK2 mutation in human iPSCs links parkinsonian neurodegeneration to ERK-dependent changes in gene expression
-
Reinhardt P, Schmid B, Burbulla LF, et al. Genetic correction of a LRRK2 mutation in human iPSCs links parkinsonian neurodegeneration to ERK-dependent changes in gene expression. Cell Stem Cell. 2013; 12 (3): 354-67.
-
(2013)
Cell Stem Cell
, vol.12
, Issue.3
, pp. 354-367
-
-
Reinhardt, P.1
Schmid, B.2
Burbulla, L.F.3
-
63
-
-
84902545816
-
Identification of blood serum micro-RNAs associated with idiopathic and LRRK2 Parkinson's disease
-
Botta-Orfila T, Morato X, Compta Y, et al. Identification of blood serum micro-RNAs associated with idiopathic and LRRK2 Parkinson's disease. J Neurosci Res 2014; 92 (8): 1071-7.
-
(2014)
J Neurosci Res
, vol.92
, Issue.8
, pp. 1071-1077
-
-
Botta-Orfila, T.1
Morato, X.2
Compta, Y.3
-
64
-
-
63049083734
-
A Nurr1/CoREST pathway in microglia and astrocytes protects dopaminergic neurons from inflammation-induced death
-
Saijo K, Winner B, Carson CT, et al. A Nurr1/CoREST pathway in microglia and astrocytes protects dopaminergic neurons from inflammation-induced death. Cell 2009; 137 (1): 47-59.
-
(2009)
Cell
, vol.137
, Issue.1
, pp. 47-59
-
-
Saijo, K.1
Winner, B.2
Carson, C.T.3
-
65
-
-
0037226797
-
Mutations in NR4A2 associated with familial Parkinson disease
-
Le W-D, Xu P, Jankovic J, et al. Mutations in NR4A2 associated with familial Parkinson disease. Nat Genet 2003; 33 (1): 85-9.
-
(2003)
Nat Genet
, vol.33
, Issue.1
, pp. 85-89
-
-
Le, W.-D.1
Xu, P.2
Jankovic, J.3
-
66
-
-
77956646167
-
Common genetic variation in the HLA region is associated with late-onset sporadic Parkinson's disease
-
Hamza TH, Zabetian CP, Tenesa A, et al. Common genetic variation in the HLA region is associated with late-onset sporadic Parkinson's disease. Nat Genet 2010; 42 (9): 781-5.
-
(2010)
Nat Genet
, vol.42
, Issue.9
, pp. 781-785
-
-
Hamza, T.H.1
Zabetian, C.P.2
Tenesa, A.3
-
69
-
-
79951811351
-
Imputation of sequence variants for identification of genetic risks for Parkinson's disease: A meta-analysis of genome-wide association studies
-
Nalls MA, Plagnol V, Hernandez DG, et al. Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies. Lancet 2011; 377 (9766): 641-9.
-
(2011)
Lancet
, vol.377
, Issue.9766
, pp. 641-649
-
-
Nalls, M.A.1
Plagnol, V.2
Hernandez, D.G.3
-
70
-
-
77955759020
-
Association of the human leucocyte antigen region with susceptibility to Parkinson's disease
-
Saiki M, Baker A, Williams-Gray CH, et al. Association of the human leucocyte antigen region with susceptibility to Parkinson's disease. J Neurol, Neurosurg, Psych 2010; 81 (8): 890-1.
-
(2010)
J Neurol, Neurosurg, Psych
, vol.81
, Issue.8
, pp. 890-891
-
-
Saiki, M.1
Baker, A.2
Williams-Gray, C.H.3
-
72
-
-
0032710609
-
Inducible nitric oxide synthase stimulates dopaminergic neurodegeneration in the MPTP model of Parkinson disease
-
Liberatore GT, Jackson-Lewis V, Vukosavic S, et al. Inducible nitric oxide synthase stimulates dopaminergic neurodegeneration in the MPTP model of Parkinson disease. Nat Med 1999; 5 (12): 1403-9.
-
(1999)
Nat Med
, vol.5
, Issue.12
, pp. 1403-1409
-
-
Liberatore, G.T.1
Jackson-Lewis, V.2
Vukosavic, S.3
-
73
-
-
0037947448
-
NADPH oxidase mediates oxidative stress in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease
-
Wu D-C, Teismann P, Tieu K, et al. NADPH oxidase mediates oxidative stress in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease. Proc Natl Acad Sci USA 2003; 100 (10): 6145-50.
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, Issue.10
, pp. 6145-6150
-
-
Wu, D.-C.1
Teismann, P.2
Tieu, K.3
-
74
-
-
79955921784
-
Neuroinflammation and alpha-synuclein dysfunction potentiate each other, driving chronic progression of neurodegeneration in a mouse model of Parkinson's disease
-
Gao HM, Zhang F, Zhou H, et al. Neuroinflammation and alpha-synuclein dysfunction potentiate each other, driving chronic progression of neurodegeneration in a mouse model of Parkinson's disease. Environ Health Perspect 2011; 119 (6): 807-14.
-
(2011)
Environ Health Perspect
, vol.119
, Issue.6
, pp. 807-814
-
-
Gao, H.M.1
Zhang, F.2
Zhou, H.3
-
75
-
-
36749015082
-
Selective inhibition of NF-kappaB activation prevents dopaminergic neuronal loss in a mouse model of Parkinson's disease
-
Ghosh A, Roy A, Liu X, et al. Selective inhibition of NF-kappaB activation prevents dopaminergic neuronal loss in a mouse model of Parkinson's disease. Proc Natl Acad Sci USA 2007; 104 (47): 18754-9.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, Issue.47
, pp. 18754-18759
-
-
Ghosh, A.1
Roy, A.2
Liu, X.3
-
76
-
-
0038389514
-
COX-2 and neurodegeneration in Parkinson's disease
-
Teismann P, Vila M, Choi DK, et al. COX-2 and neurodegeneration in Parkinson's disease. Ann New York Acad Sci 2003; 991: 272-7.
-
(2003)
Ann New York Acad Sci
, vol.991
, pp. 272-277
-
-
Teismann, P.1
Vila, M.2
Choi, D.K.3
-
77
-
-
4344645719
-
Selective COX-2 inhibition prevents progressive dopamine neuron degeneration in a rat model of Parkinson's disease
-
Sánchez-Pernaute R, Ferree A, Cooper O, et al. Selective COX-2 inhibition prevents progressive dopamine neuron degeneration in a rat model of Parkinson's disease. J Neuroinflammation 2004; 1 (1): 6.
-
(2004)
J Neuroinflammation
, vol.1
, Issue.1
, pp. 6
-
-
Sánchez-Pernaute, R.1
Ferree, A.2
Cooper, O.3
-
78
-
-
84872854169
-
Anti-inflammatory properties rather than anti-oxidant capability is the major mechanism of neuroprotection by sodium salicylate in a chronic rotenone model of Parkinson's disease
-
Thakur P, Nehru B. Anti-inflammatory properties rather than anti-oxidant capability is the major mechanism of neuroprotection by sodium salicylate in a chronic rotenone model of Parkinson's disease. Neuroscience 2013; 231: 420-31.
-
(2013)
Neuroscience
, vol.231
, pp. 420-431
-
-
Thakur, P.1
Nehru, B.2
-
79
-
-
84862619730
-
Meloxicam ameliorates motor dysfunction and dopaminergic neurodegeneration by maintaining Akt-signaling in a mouse Parkinson's disease model
-
Tasaki Y, Yamamoto J, Omura T, et al. Meloxicam ameliorates motor dysfunction and dopaminergic neurodegeneration by maintaining Akt-signaling in a mouse Parkinson's disease model. Neurosci Lett 2012; 521 (1): 15-9.
-
(2012)
Neurosci Lett
, vol.521
, Issue.1
, pp. 15-19
-
-
Tasaki, Y.1
Yamamoto, J.2
Omura, T.3
-
80
-
-
28544451467
-
Nonsteroidal antiinflammatory drug use and the risk for Parkinson's disease
-
Chen H, Jacobs E, Schwarzschild MA, et al. Nonsteroidal antiinflammatory drug use and the risk for Parkinson's disease. Ann Neurol 2005; 58 (6): 963-7.
-
(2005)
Ann Neurol
, vol.58
, Issue.6
, pp. 963-967
-
-
Chen, H.1
Jacobs, E.2
Schwarzschild, M.A.3
-
81
-
-
0041653249
-
Nonsteroidal anti-inflammatory drugs and the risk of Parkinson disease
-
Chen H, Zhang SM, Hernán MA, et al. Nonsteroidal anti-inflammatory drugs and the risk of Parkinson disease. Arch Neurol 2003; 60 (8): 1059-64.
-
(2003)
Arch Neurol
, vol.60
, Issue.8
, pp. 1059-1064
-
-
Chen, H.1
Zhang, S.M.2
Hernán, M.A.3
-
83
-
-
79251536194
-
Use of non-steroidal anti-inflammatory drugs and risk of Parkinson's disease: Nested case-control study
-
Driver JA, Logroscino G, Lu L, et al. Use of non-steroidal anti-inflammatory drugs and risk of Parkinson's disease: nested case-control study. BMJ (Clin Res ed). 2011;342:d198.
-
(2011)
BMJ (Clin Res Ed)
, vol.342
, pp. d198
-
-
Driver, J.A.1
Logroscino, G.2
Lu, L.3
-
84
-
-
33646089430
-
Nonsteroidal anti-inflammatory drugs and the incidence of Parkinson disease
-
Hernán MA, Logroscino G, García Rodríguez LA. Nonsteroidal anti-inflammatory drugs and the incidence of Parkinson disease. Neurology 2006; 66 (7): 1097-9.
-
(2006)
Neurology
, vol.66
, Issue.7
, pp. 1097-1099
-
-
Hernán, M.A.1
Logroscino, G.2
García Rodríguez, L.A.3
-
85
-
-
69949164871
-
NSAID use and the risk of Parkinson's disease: Systematic review and meta-analysis of observational studies
-
Samii A, Etminan M, Wiens MO, et al. NSAID use and the risk of Parkinson's disease: systematic review and meta-analysis of observational studies. Drugs Aging 2009; 26 (9): 769-79.
-
(2009)
Drugs Aging
, vol.26
, Issue.9
, pp. 769-779
-
-
Samii, A.1
Etminan, M.2
Wiens, M.O.3
-
86
-
-
84860813005
-
Non-steroidal anti-inflammatory drugs as disease-modifying agents for Parkinson's disease: Evidence from observational studies
-
Rees K, Stowe R, Patel S, et al. Non-steroidal anti-inflammatory drugs as disease-modifying agents for Parkinson's disease: evidence from observational studies. Cochrane database Syst Rev 2011 (11): Cd008454.
-
(2011)
Cochrane Database Syst Rev
, Issue.11
, pp. 008454
-
-
Rees, K.1
Stowe, R.2
Patel, S.3
|