Health benefits of tea

Herbal Medicine: Biomolecular and Clinical Aspects: Second Edition

Volumn , Issue , 2011, Pages 239-261

  Serafini, Mauro ^a   Del Rio, Daniele ^b   N'Dri, Yao Denis ^b   Bettuzzi, Saverio ^b   Peluso, Ilaria ^a  

^a Area of Nutrition Sciences   (Italy)

^b UNIVERSITY OF PARMA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 85056948271     PISSN: None     EISSN: None     Source Type: Book    
DOI: None     Document Type: Chapter

References (165)

1. Abuel Wafa, Y., F. A. Benavente, F. A. Talavera et al. 2005. Acute hepatitis induced by Camellia sinensis (green tea). An Med Interna 22:298.
2. Adachi, M., H. Saito, H. Kobayashi et al. 2003. Hepatic injury in 12 patients taking the herbal weight loss AIDS Chaso or Onshido. Ann Intern Med 139:488-92.
3. Baba, S., N. Osakabe, A. Yasuda et al. 2000. Bioavailability of (-)-epicatechin upon intake of chocolate and cocoa in human volunteers. Free Radic Res 33:635-41.
4. Babu, P. V., and D. Liu. 2008. Green tea catechins and cardiovascular health: An update. Curr Med Chem 15(18):1840-50.
5. Balasubramanian, S., T. Efimova, and R. L. Eckert. 2002. Green tea polyphenol stimulates a Ras, MEKK1, MEK3, and p38 cascade to increase activator protein 1 factor-dependent involucrin gene expression in normal human keratinocytes. J Biol Chem 277(3):1828-36.
6. Balentine, D. A., S. A. Wiseman, and L. C. M. Bouwens. 1997. The chemistry of tea flavonoids. Crit Rev Food Sci Nutr 37:693-704.
7. Basler, J. W., and G. A. Piazza. 2004. Nonsteroidal anti-inflammatory drugs and cyclooxygenase-2 selective inhibitors for prostate cancer chemoprevention. J Urol 171:S59-62.
8. Benzie, I. F., Y. T. Szeto, J. J. Strain et al. 1999. Consumption of green tea causes rapid increase in plasma antioxidant power in humans. Nutr Cancer 34(1):83-7.
9. Bertipaglia de Santana, M., M. G. Mandarino, J. R. Cardoso et al. 2008. Association between soy and green tea (Camellia sinensis) diminishes hypercholesterolemia and increases total plasma antioxidant potential in dyslipidemic subjects. Nutrition 24(6):562-8.
10. Bettuzzi, S., M. Brausi, F. Rizzi et al. 2006. Chemoprevention of human prostate cancer by oral administration of green tea catechins in volunteers with high-grade prostate intraepithelial neoplasia: A preliminary report from a one-year proof-of-principle study. Cancer Res 66:1234-40.
11. Bettuzzi, S., P. Davalli, S. Davoli et al. 2009. Genetic inactivation of ApoJ/clusterin: Effects on prostate tumourigenesis and metastatic spread. Oncogene 28(49):4344-52.
12. Biesalski, H. K. 2007. Polyphenols and inflammation: Basic interactions. Curr Opin Clin Nutr Metab Care 10(6):724-8.
13. Bode, A. M., and Z. Dong. 2003. Signal transduction pathways: Targets for green and black tea polyphenols 1. J Biochem Mol Biol 36(1):66-77.
14. Bode, A. M., and Z. Dong. 2009. Epigallocatechin 3-gallate and green tea catechins: United they work, divided they fail. Cancer Prev Res (Phila Pa) 2(6):514-7.
15. Boehm, K., F. Borrelli, E. Ernst et al. 2009. Green tea (Camellia sinensis) for the prevention of cancer. Cochrane Database Syst Rev (3):CD005004.
16. Bonkovsky, H. L. 2006. Hepatoxicity associated with supplements containing Chinese green tea (Camellia sinensis). Ann Intern Med 144:68-9.
17. Brausi, M., F. Rizzi, and S. Bettuzzi. 2008. Chemoprevention of human prostate cancer by green tea catechins: Two years later. A follow-up update. Eur Urol 54:472-73.
18. Briel, M., I. Ferreira-Gonzalez, J. J. You et al. 2009. Association between change in high density lipoprotein cholesterol and cardiovascular disease morbidity and mortality: Systematic review and meta-regression analysis. BMJ 338:b92.
19. Brown, D. A. 2006. Lipid rafts, detergent-resistant membranes, and raft targeting signals. Physiology (Bethesda) 21:430-9.
20. Butt, M. S., and M. T. Sultan. 2009. Green tea: Nature's defense against malignancies. Crit Rev Food Sci Nutr 49(5):463-73.
21. Cabrera, C., R. Artacho, and R. Giménez. 2006. Beneficial effects of green tea-a review. J Am Coll Nutr 25(2):79-99.
22. Calder, P. C., R. Albers, J. M. Antoine et al. 2009. Inflammatory disease processes and interactions with nutrition. Br J Nutr 101(Suppl. 1):S1-45.
23. Caporali, A., P. Davalli, S. Astancolle et al. 2004. The chemopreventive action of catechins in the TRAMP mouse model of prostate carcinogenesis is accompanied by clusterin over-expression. Carcinogenesis 25:2217-24.
24. Caslake, M. J., and C. J. Packard. 2003. Lipoprotein-associated phospholipase A2 (platelet-activating factor acetylhydrolase) and cardiovascular disease. Curr Opin Lipidol 14(4):347-52.
25. Chen, X. L., G. Dodd, S. Thomas et al. 2006. Activation of Nrf2/ARE pathway protects endothelial cells from oxidant injury and inhibits inflammatory gene expression. Am J Physiol Heart Circ Physiol 290(5):H1862-70.
26. Cherubini, A., M. F. Beal, and B. Frei. 1999. Black tea increases the resistance of human plasma to lipid peroxidation in vitro, but not ex vivo. Free Radic Biol Med 27:381-7.
27. Chung, F. L., J. Schwartz, C. R. Herzog et al. 2003. Tea and cancer prevention: Studies in animals and humans. J Nutr 133(10):3268S-74S.
28. Chung, F. L., M. Wang, A. Rivenson et al. 1998. Inhibition of lung carcinogenesis by black tea in Fischer rats treated with a tobacco-specific carcinogen: Caffeine as an important constituent. Cancer Res 58:4096-101.
29. Constans, J., and C. Conri. 2006. Circulating markers of endothelial function in cardiovascular disease. Clin Chim Acta 368(1-2):33-47.
30. Crespy, V., and G. Williamson. 2004. A review of the health effects of green tea catechins in vivo animal models. J Nutr 134(12 Suppl.):3431S-40S.
31. Crouvezier, S., B. Powell, D. Keir et al. 2001. The effects of phenolic components of tea on the production of pro- and anti-inflammatory cytokines by human leukocytes in vitro. Cytokine 13(5):280-6.
32. Crozier, A., I. B. Jaganath, and M. N. Clifford. 2009. Dietary phenolics: Chemistry, bioavailability and effects on health. Nat Prod Rep 26(8):1001-43.
33. de Maat, M. P., H. Pijl, C. Kluft et al. 2000. Consumption of black and green tea had no effect on inflammation, haemostasis, and endothelial markers in smoking healthy individuals. Eur J Clin Nutr 54(10):757-63.
34. Del Rio, D., L. Calani, C. Cordero et al. 2010. Bioavailability and catabolism of green tea flavan-3-ols in humans. Nutrition 26(11-12):1110-6.
35. Del Rio, D., A. J. Stewart, W. Mullen et al. 2004. HPLC-MSn analysis of phenolic compounds and purine alkaloids in green and black tea. J Agric Food Chem 52:2807-15.
36. Dreosti, I. E., M. J. Wargovich, and C. S. Yang. 1997. Inhibition of carcinogenesis by tea: The evidence from experimental studies. Crit Rev Food Sci Nutr 37:761-70.
37. Duffy, S. J., J. F. Keaney Jr., M. Holbrook et al. 2001. Short- and long-term black tea consumption reverses endothelial dysfunction in patients with coronary artery disease. Circulation 104(2):151-6.
38. Duthie, G. G., and A. Crozier. 2003. Beverages. In Plants: Diet and Health, ed. G. Goldberg, 147-182. London: British Nutrition Foundation, Chapman Hall.
39. Erba, D., P. Riso, A. Bordoni et al. 2005. Effectiveness of moderate green tea consumption on antioxidative status and plasma lipid profile in humans. J Nutr Biochem 16(3):144-9.
40. Fearon, W. F., and D. T. Fearon. 2008. Inflammation and cardiovascular disease: Role of the interleukin-1 receptor antagonist. Circulation 117(20):2577-9.
41. Fernandez-Panchon, M. S., D. Villano, A. M. Troncoso et al. 2008. Antioxidant activity of phenolic compounds: From in vitro results to in vivo evidence. Crit Rev Food Sci Nutr 48(7):649-71.
42. Finger, A., S. Kuhr, and U. H. Engelhardt. 1992. Chromatography of tea constituents. J Chromatogr 624:293-315.
43. Frankel, E. N., and J. W. Finley. 2008. How to standardize the multiplicity of methods to evaluate natural antioxidants. J Agric Food Chem 56(13):4901-8.
44. Freese, R., S. Basu, E. Hietanen et al. 1999. Green tea extract decreases plasma malondialdehyde concentration but does not affect other indicators of oxidative stress, nitric oxide production, or hemostatic factors during a high-linoleic acid diet in healthy females. Eur J Nutr 38(3):149-57.
45. Frei, B., and J. V. Higdon. 2003. Antioxidant activity of tea polyphenols in vivo: Evidence from animal studies. J Nutr 133(10):3275S-84S.
46. Garcia-Moran, S., F. Saez-Royuela, E. Gento et al. 2004. Acute hepatitis associated with Camellia thea and Orthosiphon stamineus ingestion. Gastroenterol Hepatol 27:559-60.
47. Gardner, E. J., C. H. Ruxton, and A. R. Leeds. 2007. Black tea-helpful or harmful? A review of the evidence. Eur J Clin Nutr 61(1):3-18.
48. Gensler, H. L., B. N. Timmermann, S. Valcic et al. 1996. Prevention of photocarcinogenesis by topical administration of pure epigallocatechin gallate isolated from green tea. Nutr Cancer 26:325-35.
49. Gloro, R., I. Hourmand-Ollivier, B. Mosquet et al. 2005. Fulminant hepatitis during self-medication with hydroalcoholic extract of green tea. Eur J Gastroenterol Hepatol 17:1135-37.
50. Goldberg, D. M., J. Yan, and G. J. Soleas. 2003. Absorption of three wine-related polyphenols in three different matrices by healthy subjects. Clin Biochem 36:79-87.
51. Gopalakrishnan, A., and T. A. N. Kong. 2008. Anticarcinogenesis by dietary phytochemicals: Cytoprotection by Nrf2 in normal cells and cytotoxicity by modulation of transcription factors NF-kappa B and AP-1 in abnormal cancer cells. Food Chem Toxicol 46(4):1257-70.
52. Gow, P. J., R. M. Jones, J. L. Dobson et al. 2004. Etiology and outcome of fulminant hepatic failure managed at an Australian liver transplant unit. J Gastroenterol Hepatol 19:154-9.
53. Haas, G. P., and W. A. Sakr. 1997. Epidemiology of prostate cancer. CA Cancer J Clin 47:273-87.
54. Halliwell, B. 2009. The wanderings of a free radical. Free Radic Biol Med 46(5):531-42.
55. Halliwell, B., and C. E. Cross. 1994. Oxygen-derived species: Their relation to human disease and environmental stress. Environ Health Perspect 102:5-12.
56. Henning, S. M., Y. Niu, N. H. Lee et al. 2004. Bioavailability and antioxidant activity of tea flavanols after consumption of green tea, black tea, or a green tea extract supplement. Am J Clin Nutr 80(6):1558-64.
57. Henning, S. M., Y. Niu, Y. Liu et al. 2005. Bioavailability and antioxidant effect of epigallocatechin gallate administered in purified form versus as green tea extract in healthy individuals. J Nutr Biochem 16(10):610-6.
58. Hodgson, J. M., K. D. Croft, T. A. Mori et al. 2002. Regular ingestion of tea does not inhibit in vivo lipid peroxidation in humans. J Nutr 132(1):55-8.
59. Hodgson, J. M., I. B. Puddey, K. D. Croft et al. 2000. Acute effects of ingestion of black and green tea on lipoprotein oxidation. Am J Clin Nutr 71:1103-7.
60. Hodgson, J. M., I. B. Puddey, T. A. Mori et al. 2001. Effects of regular ingestion of black tea on haemostasis and cell adhesion molecules in humans. Eur J Clin Nutr 55(10):881-6.
61. Hou, Z., S. Sang, H. You et al. 2005. Mechanism of action of (-)-epigallocatechin-3-gallate: Auto-oxidationdependent inactivation of epidermal growth factor receptor and direct effects on growth inhibition in human esophageal cancer KYSE 150 cells. Cancer Res 65(17):8049-56.
62. Huang, M. T., C. T. Ho, Z. Y. Wang et al. 1992. Inhibitory effect of topical application of a green tea polyphenol fraction on tumor initiation and promotion in mouse skin. Carcinogenesis 13:947-54.
63. Huang, M. T., J. G. Xie, Z. Y. Wang et al. 1997. Effects of tea, decaffeinated tea, and caffeine on UVB lightinduced complete carcinogenesis in SKH-1 mice: Demonstration of caffeine as a biologically important constituent of tea. Cancer Res 57:2623-9.
64. Hunt, B. J. 2000. The endothelium in atherogenesis. Lupus 9(3):189-93.
65. Ihm, S. H., J. O. Lee, S. J. Kim et al. 2009. Catechin prevents endothelial dysfunction in the prediabetic stage of OLETF rats by reducing vascular NADPH oxidase activity and expression. Atherosclerosis 206(1):47-53.
66. Inami, S., M. Takano, M. Yamamoto et al. 2007. Tea catechin consumption reduces circulating oxidized lowdensity lipoprotein. Int Heart J 48(6):725-32.
67. Ishikawa, T., M. Suzukawa, T. Ito et al. 1997. Effect of tea flavonoid supplementation on the susceptibility of low-density lipoprotein to oxidative modification. Am J Clin Nutr 66(2):261-6.
68. Iwai, N., H. Ohshiro, Y. Kurozawa et al. 2002. Relationship between coffee and green tea consumption and allcause mortality in a cohort of a rural Japanese population. J Epidemiol 12:191-8.
69. Jian, L., L. P. Xie, A. H. Lee et al. 2004. Protective effect of green tea against prostate cancer: A case-control study in southeast China. Int J Cancer 108:130-5.
70. Kabouridis, P. S., and E. C. Jury. 2008. Lipid rafts and T-lymphocyte function: Implications for autoimmunity. FEBS Lett 582(27):3711-8.
71. Katiyar, S. K., and H. Mukhtar. 1996. Tea in chemoprevention of cancer: Epidemiologic and experimental studies. Int J Oncol 8:221-38.
72. Khan, N., F. Afaq, M. Saleem et al. 2006. Targeting multiple signaling pathways by green tea polyphenol (-)-epigallocatechin-3-gallate. Cancer Res 66(5):2500-5.
73. Kimura, M., K. Umegaki, Y. Kasuya et al. 2002. The relation between single/double or repeated tea catechin ingestions and plasma antioxidant activity in humans. Eur J Clin Nutr 56(12):1186-93.
74. Kuriyama, S. 2008. The relation between green tea consumption and cardiovascular disease as evidenced by epidemiological studies. J Nutr 138(8):1548S-53S.
75. Kyle, J. A., P. C. Morrice, G. McNeill et al. 2007. Effects of infusion time and addition of milk on content and absorption of polyphenols from black tea. J Agric Food Chem 55(12):4889-94.
76. Lambert, J. D., and C. S. Yang. 2003. Mechanisms of cancer prevention by tea constituents. J Nutr 133(10):3262S-7S.
77. Lampe, J. W. 2003. Spicing up a vegetarian diet: Chemopreventive effects of phytochemicals. Am J Clin Nutr 78:579S-83S.
78. Langley-Evans, S. C. 2000. Consumption of black tea elicits an increase in plasma antioxidant potential in humans. Int J Food Sci Nutr 51(5):309-15.
79. Lee, J. M., and J. A. Johnson. 2004. An important role of Nrf2-ARE pathway in the cellular defense mechanism. J Biochem Mol Biol 37(2):139-43.
80. Lee, M. J., P. Maliakal, L. Chen et al. 2002. Pharmacokinetics of tea catechins after ingestion of green tea and (-)-epigallocatechin-3-gallate by humans: Formation of different metabolites and individual variability. Cancer Epidemiol Biomarkers Prev 11:1025-32.
81. Leenen, R., A. J. Roodenburg, L. B. Tijburg et al. 2000. A single dose of tea with or without milk increases plasma antioxidant activity in humans. Eur J Clin Nutr 54(1):87-92.
82. Li, C., M. J. Lee, S. Sheng et al. 2000. Structural identification of two metabolites of catechins and their kinetics in human urine and blood after tea ingestion. Chem Res Toxicol 13:177-84.
83. Liu, H., R. Colavitti, I. I. Rovira et al. 2005. Redox-dependent transcriptional regulation. Circ Res 97(10):967-74.
84. Manach, C., A. Scalbert, C. Morand et al. 2004. Polyphenols: Food sources and bioavailability. Am J Clin Nutr 79:727-47.
85. Manach, C., G. Williamson, C. Morand et al. 2005. Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies. Am J Clin Nutr 81(1 Suppl.):230S-42S.
86. Mann, G. E., J. Niehueser-Saran, A. Watson et al. 2007. Nrf2/ARE regulated antioxidant gene expression in endothelial and smooth muscle cells in oxidative stress: Implications for atherosclerosis and preeclampsia. Sheng Li Xue Bao 59(2):117-27.
87. Mann, G. E., D. J. Rowlands, F. Y. Li et al. 2007. Activation of endothelial nitric oxide synthase by dietary isoflavones: Role of NO in Nrf2-mediated antioxidant gene expression. Cardiovasc Res 75(2):261-74.
88. Maron, D. J., G. P. Lu, N. S. Cai et al. 2003. Cholesterol-lowering effect of a theaflavin-enriched green tea extract: A randomized controlled trial. Arch Intern Med 163(12):1448-53.
89. Maxwell, S., and G. Thorpe. 1996. Tea flavonoids have little short term impact on serum antioxidant activity. Br Med J 313:229.
90. Mayeaux Jr., E. J., and C. Dunton. 2008. Modern management of external genital warts. J Low Genit Tract Dis 12(3):185-92.
91. McAnlis, G. T., J. McEneny, J. Pearce et al. 1998. Black tea consumption does not protect low density lipoprotein from oxidative modification. Eur J Clin Nutr 52(3):202-6.
92. McKay, D. L., and J. B. Blumberg. 2002. The role of tea in human health: An update. J Am Coll Nutr 21(1):1-13.
93. Meng, X., M. J. Lee, C. Li et al. 2001. Formation and identification of 4′-O-methyl-(-)-epigallocatechin in humans. Drug Metab Dispos 29:789-93.
94. Middleton Jr., E., C. Kandaswami, and T. C. Theoharides. 2000. The effects of plant flavonoids on mammalian cells: Implications for inflammation, heart disease, and cancer. Pharmacol Rev 52(4):673-751.
95. Mineharu, Y., A. Koizumi, Y. Wada et al. 2009. Coffee, green tea, black tea and oolong tea consumption and risk of mortality from cardiovascular disease in Japanese men and women. J Epidemiol Community Health Dec 8. Epub, jech.2009.097311.
96. Molavi, B., and J. L. Mehta. 2004. Oxidative stress in cardiovascular disease: Molecular basis of its deleterious effects, its detection, and therapeutic considerations. Curr Opin Cardiol 19(5):488-93.
97. Molinari, M., K. D. Watt, T. Kruszyna et al. 2006. Acute liver failure induced by green tea extracts: Case report and review of the literature. Liver Transpl 12(12):1892-5.
98. Moore, R. J., K. G. Jackson, and A. M. Minihane. 2009. Green tea (Camellia sinensis) catechins and vascular function. Br J Nutr 15:1-13.
99. Mukamal, K. J., K. MacDermott, J. A. Vinson et al. 2007. A 6-month randomized pilot study of black tea and cardiovascular risk factors. Am Heart J 154(4):724.e1-6.
100. Mullen, W., G. Borges, J. L. Donovan et al. 2009. Milk decreases urinary excretion but not plasma pharmacokinetics of cocoa flavan-3-ol metabolites in humans. Am J Clin Nutr 89:1784-91.
101. Na, H. K., and Y. J. Surh. 2008. Modulation of Nrf2-mediated antioxidant and detoxifying enzyme induction by the green tea polyphenol EGCG. Food Chem Toxicol 46(4):1271-8.
102. Nakachi, K., S. Matsuyama, S. Miyake et al. 2000. Preventive effects of drinking green tea on cancer and cardiovascular disease: Epidemiological evidence for multiple targeting prevention. Biofactors 13:49-54.
103. Nantz, M. P., C. A. Rowe, J. F. Bukowski, and S. S. Percival. 2009. Standardized capsule of Camellia sinensislowers cardiovascular risk factors in a randomized, double-blind, placebo-controlled study. Nutrition 25(2):147-54.
104. O'Reilly, J. D., A. I. Mallet, G. T. McAnlis et al. 2001. Consumption of flavonoids in onions and black tea: Lack of effect on F2-isoprostanes and autoantibodies to oxidized LDL in healthy humans. Am J Clin Nutr 73(6):1040-4.
105. Packianathan, S., R. G. Mehta, R. R. Mehta et al. 2004. Designing a randomized phase I/II prostate cancer chemoprevention trial using 1alpha-hydroxy-24-ethyl-cholecalciferol, an analogue of vitamin D3. Cancer J 10:357-67.
106. Panza, V. S., E. Wazlawik, G. Ricardo Schätz et al. 2008. Consumption of green tea favorably affects oxidative stress markers in weight-trained men. Nutrition 24(5):433-42.
107. Park, A. M., and Z. Dong. 2003. Signal transduction pathways: Targets for green and black tea polyphenols. J Biochem Mol Biol 36(1):66-77.
108. Park, C. S., W. Kim, J. S. Woo et al. 2009. Green tea consumption improves endothelial function but not circulating endothelial progenitor cells in patients with chronic renal failure. Int J Cardiol Epub, doi:10.1016/j. ijcard.2009.09.471.
109. Patra, S. K., F. Rizzi, A. Silva et al. 2008. Molecular targets of (-)-epigallocatechin-3-gallate (EGCG): Specificity and interaction with membrane lipid rafts. J Physiol Pharmacol 59(Suppl. 9):217-35.
110. Pietta, P., P. Simonetti, C. Gardana et al. 1998. Relationship between rate and extent of catechin absorption and plasma antioxidant status. Biochem Mol Biol Int 46(5):895-903.
111. Princen, H. M., W. van Duyvenvoorde, R. Buytenhek et al. 1998. No effect of consumption of green and black tea on plasma lipid and antioxidant levels and on LDL oxidation in smokers. Arterioscler Thromb Vasc Biol 18(5):833-41.
112. Rahman, I., S. K. Biswas, and P. A. Kirkham. 2006. Regulation of inflammation and redox signaling by dietary polyphenols. Biochem Pharmacol 72(11):1439-52.
113. Richard, D., K. Kefi, U. Barbe et al. 2009. Weight and plasma lipid control by decaffeinated green tea. Pharmacol Res 59(5):351-4.
114. Rietveld, A., and S. Wiseman. 2003. Antioxidant effects of tea: Evidence from human clinical trials. J Nutr 133(10):3285S-92S.
115. Ryu, O. H., J. Lee, K. W. Lee et al. 2006. Effects of green tea consumption on inflammation, insulin resistance and pulse wave velocity in type 2 diabetes patients. Diabetes Res Clin Pract 71(3):356-8.
116. Saeki, K., N. Kobayashi, Y. Inazawa et al. 2002. Oxidation-triggered c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein (MAP) kinase pathways for apoptosis in human leukaemic cells stimulated by epigallocatechin-3-gallate (EGCG): A distinct pathway from those of chemically induced and receptormediated apoptosis. Biochem J 368(Pt 3):705-20.
117. Sang, S., M. J. Lee, I. Yang et al. 2008. Human urinary metabolite profile of tea polyphenols analyzed by liquid chromatography/electrospray ionization tandem mass spectrometry with data-dependent acquisition. Rapid Commun Mass Spectrom 22:1567-78.
118. Santangelo, C., R. VarÏ, B. Scazzocchio et al. 2007. Polyphenols, intracellular signalling and inflammation. Ann Ist Super Sanita 43(4):394-405.
119. Sato, Y., H. Nakatsuka, T. Watanabe et al. 1989. Possible contribution of green tea drinking habits to the prevention of stroke. Tohoku J Exp Med 157:337-43.
120. Scaltriti, M., L. Belloni, A. Caporali et al. 2006. Molecular classification of green tea catechin-sensitive and green tea catechin-resistant prostate cancer in the TRAMP mice model by quantitative real-time PCR gene profiling. Carcinogenesis 27:1047-53.
121. Seddik, M., D. Lucidarme, C. Creusy et al. 2001. Is Exolise hepatotoxic? Gastroenterol Clin Biol 25:834-5.
122. Seeram, N. P., M. Aviram, Y. Zhang et al. 2008. Comparison of antioxidant potency of commonly consumed polyphenol-rich beverages in the United States. J Agric Food Chem 56:1415-22.
123. Sengupta, P., B. Baird, and D. Holowka. 2007. Lipid rafts, fluid/fluid phase separation, and their relevance to plasma membrane structure and function. Semin Cell Dev Biol 18(5):583-90.
124. Serafini, M., and D. Del Rio. 2004. Understanding the association between dietary antioxidants, red-ox status and disease: Is the total antioxidant capacity the right tool? Redox Rep 9:145-52.
125. Serafini, M., A. Ghiselli, and A. Ferro-Luzzi. 1994. Red wine, tea, and antioxidants. Lancet 344:626.
126. Serafini, M., A. Ghiselli, and A. Ferro-Luzzi. 1996. In vivo antioxidant effect of green and black tea in man. Eur J Clin Nutr 50(1):28-32.
127. Serafini, M., D. Villano, G. Spera et al. 2006. Redox molecules and cancer prevention: The importance of understanding the role of the antioxidant network. Nutr Cancer 56(2):232-40.
128. Sgro, C., F. Clinard, K. Ouazir et al. 2002. Incidence of drug-induced hepatic injuries: A French populationbased study. Hepatology 36:451-5.
129. Sharma, V., and L. J. Rao. 2009. A thought on the biological activities of black tea. Crit Rev Food Sci Nutr 49(5):379-404.
130. Sporn, M. B., N. M. Dunlop, D. L. Newton et al. 1976. Prevention of chemical carcinogenesis by vitamin A and its synthetic analogs (retinoids). Fed Proc 35:1332-8.
131. Stalmach, A., S. Troufflard, M. Serafini et al. 2009. Absorption, metabolism and excretion of Choladi green tea flavan-3-ols by humans. Mol Nutr Food Res 53:S44-S53.
132. Stangl, V., H. Dreger, K. Stangl et al. 2007. Molecular targets of tea polyphenols in the cardiovascular system. Cardiovasc Res 73(2):348-58.
133. Steinberg, D., and J. L. Witzum. 1990. Lipoproteins and atherogenesis: Current concepts. JAMA 264:3047-52.
134. Steptoe, A., E. L. Gibson, R. Vuononvirta et al. 2007. The effects of chronic tea intake on platelet activation and inflammation: A double-blind placebo controlled trial. Atherosclerosis 193(2):277-82.
135. Stockfleth, E., H. Beti, R. Orasan et al. 2008. Topical Polyphenon E in the treatment of external genital and perianal warts: A randomized controlled trial. Br J Dermatol 158(6):1329-38.
136. Sueoka, N., M. Suganuma, E. Sueoka et al. 2001. A new function of green tea: Prevention of lifestyle-related diseases. Ann N Y Acad Sci 928:274-80.
137. Sung, H., J. Nah, S. Chun et al. 2000. In vivo antioxidant effect of green tea. Eur J Clin Nutr 54:527-9.
138. Surh, Y. J., J. K. Kundu, and H. K. Na. 2008. Nrf2 as a master redox switch in turning on the cellular signaling involved in the induction of cytoprotective genes by some chemopreventive phytochemicals. Planta Med 74(13):1526-39.
139. Surh, Y. J., J. K. Kundu, H. K. Na et al. 2005. Redox-sensitive transcription factors as prime targets for chemoprevention with anti-inflammatory and antioxidative phytochemicals. J Nutr 135(12 Suppl.): 2993S-3001S.
140. Tachibana, H. 2009. Molecular basis for cancer chemoprevention by green tea polyphenol EGCG. Forum Nutr 61:156-69.
141. Tatti, S., E. Stockfleth, K. R. Beutner et al. 2009. Polyphenon E(R): A new treatment for external anogenital warts. Br J Dermatol 162(1):176-184
142. Thompson, I. M., P. J. Goodman, C. M. Tangen et al. 2003. The influence of finasteride on the development of prostate cancer. N Engl J Med 349:215-24.
143. Tipoe, G. L., T. M. Leung, M. W. Hung et al. 2007. Green tea polyphenols as an anti-oxidant and anti-inflammatory agent for cardiovascular protection. Cardiovasc Hematol Disord Drug Targets 7(2):135-44.
144. Van Amelsvoort, J. M., K. H. Van Hof, J. N. Mathot et al. 2001. Plasma concentrations of individual tea catechins after a single oral dose in humans. Xenobiotica 31:891-901.
145. van Het Hof, K. H., H. S. de Boer, S. A. Wiseman et al. 1997. Consumption of green or black tea does not increase resistance of low-density lipoprotein to oxidation in humans. Am J Clin Nutr 66:1125-32.
146. Vial, T., G. Bernard, B. Lewden et al. 2003. Acute hepatitis due to Exolise, a Camellia sinensis-derived drug. Gastroenterol Clin Biol 27:1166-7.
147. Vita, J. A. 2005. Polyphenols and cardiovascular disease: Effects on endothelial and platelet function. Am J Clin Nutr 81(1 Suppl.):292S-7S.
148. Wang, Z. Y., W. A. Khan, D. R. Bickers et al. 1989. Protection against polycyclic aromatic hydrocarboninduced skin tumor initiation in mice by green tea polyphenols. Carcinogenesis 10:411-5.
149. Wang, J., and P. Sporns. 2000. MALDI-TOF analysis of food flavonols glycoside. J Agric Food Chem 48:1657-62.
150. Wheeler, D. S., J. D. Catravas, K. Odoms et al. 2004. Epigallocatechin-3-gallate, a green tea-derived polyphenol, inhibits IL-1 beta-dependent proinflammatory signal transduction in cultured respiratory epithelial cells. J Nutr 134(5):1039-44.
151. Widlansky, M. E., S. J. Duffy, N. M. Hamburg et al. 2005. Effects of black tea consumption on plasma catechins and markers of oxidative stress and inflammation in patients with coronary artery disease. Free Radic Biol Med 38(4):499-506.
152. William, W. N., J. V. Heymach, E. S. Kim et al. 2009. Molecular targets for cancer chemoprevention. Nat Rev Drug Discov 8:213-25.
153. Williamson, G., and C. Manach. 2005. Bioavailability and bioefficacy of polyphenols in humans. II. Review of 93 intervention studies. Am J Clin Nutr 81(1 Suppl.):243S-55S.
154. Wolfram, S. 2007. Effects of green tea and EGCG on cardiovascular and metabolic health. J Am Coll Nutr 26(4):373S-88S.
155. Yang, C. S. 1997. Inhibition of carcinogenesis by tea. Nature 389:134-5.
156. Yang, C. S., J. Ju, G. Lu et al. 2008. Cancer prevention by tea and tea polyphenols. Asia Pac J Clin Nutr 17(Suppl. 1):245-8.
157. Yang, C. S., J. D. Lambert, J. Ju et al. 2007. Tea and cancer prevention: Molecular mechanisms and human relevance. Toxicol Appl Pharmacol 224(3):265-73.
158. Yang, C. S., J. D. Lambert, and S. Sang. 2009. Antioxidative and anti-carcinogenic activities of tea polyphenols. Arch Toxicol 83(1):11-21.
159. Yang, C. S., P. Maliakal, X. Meng. 2002. Inhibition of carcinogenesis by tea. Annu Rev Pharmacol Toxicol 42:25-54.
160. Yang, C. S., and Z. Y. Wang. 1993. Tea and cancer. J Natl Cancer Inst 85:1038-49.
161. Yang, C. S., X. Wang, G. Lu et al. 2009. Cancer prevention by tea: Animal studies, molecular mechanisms and human relevance. Nat Rev Cancer 9(6):429-39.
162. Yoon, J. H., and S. J. Baek. 2005. Molecular targets of dietary polyphenols with anti-inflammatory properties. Yonsei Med J 46(5):585-96.
163. Yoshizawa, S., T. Horiuchi, H. Fukiji et al. 1987. Antitumor promoting activity of (-)-epigallocatechin gallate, the main constituent of "tannin" in green tea. Phytother Res 1:44-7.
164. Young, J. F., L. O. Dragstedt, J. Haraldsdóttir et al. 2002. Green tea extract only affects markers of oxidative status postprandially: Lasting antioxidant effect of flavonoid-free diet. Br J Nutr 87(4):343-55.
165. Yu, R., J. J. Jiao, J. L. Duh et al. 1997. Activation of mitogen-activated protein kinases by green tea polyphenols: Potential signaling pathways in the regulation of antioxidant-responsive element-mediated phase II enzyme gene expression. Carcinogenesis 18(2):451-6.