Optimized base editors enable efficient editing in cells, organoids and mice

Nature Biotechnology

Volumn 36, Issue 9, 2018, Pages 888-896

  Zafra, Maria Paz ^a   Schatoff, Emma M ^a,b   Katti, Alyna ^a,c   Foronda, Miguel ^a   Breinig, Marco ^d   Schweitzer, Anabel Y ^d   Simon, Amber ^a   Han, Teng ^a,c   Goswami, Sukanya ^a   Montgomery, Emma ^a   Thibado, Jordana ^c   Kastenhuber, Edward R ^e,f   Sánchez Rivera, Francisco J ^e   Shi, Junwei ^g,h   Vakoc, Christopher R ^g   Lowe, Scott W ^e   Tschaharganeh, Darjus F ^d   Dow, Lukas E ^a,c  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

^b University Hospital ^*  (United States)

^c Weill Cornell Medical Center   (United States)

^d GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^e MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^f Gerstner Sloan Kettering Graduate School of Biomedical Sciences   (United States)

^g Simons Center for Quantitative Biology   (United States)

^h UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL CULTURE; EFFICIENCY;

ADULT MICE; BASE CONVERSION; CODON OPTIMIZATION; HUMAN CELL LINES; NUCLEAR LOCALIZATION SEQUENCES; SINGLE NUCLEOTIDES; TARGET MODIFICATION; VECTOR SYSTEMS;

MAMMALS;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; CELL LINE; CONTROLLED STUDY; EDITOR; FEMALE; IN VIVO STUDY; LETTER; LIVER; MALE; MOUSE; NONHUMAN; ORGANOID; SINGLE NUCLEOTIDE POLYMORPHISM; ANIMAL; CRISPR CAS SYSTEM; GENE EDITING; GENETIC VARIATION; HUMAN;

ANIMALS; CELL LINE; CRISPR-CAS SYSTEMS; GENE EDITING; GENETIC VARIATION; HUMANS; MICE;

EID: 85053081382     PISSN: 10870156     EISSN: 15461696     Source Type: Journal    
DOI: 10.1038/nbt.4194     Document Type: Article

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