R-Spondin chromosome rearrangements drive Wnt-dependent tumour initiation and maintenance in the intestine

Nature Communications

Volumn 8, Issue , 2017, Pages

  Han, Teng ^a,b   Schatoff, Emma M ^a,c   Murphy, Charles ^a,b,d   Zafra, Maria Paz ^a   Wilkinson, John E ^e   Elemento, Olivier ^a   Dow, Lukas E ^a,b  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

^b Weill Cornell Medical Center   (United States)

^c MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^d Tri Institutional Training Program in Computational Biology and Medicine   (United States)

^e UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LIGAND; WNT PROTEIN; ACYLTRANSFERASE; LGK974; MEMBRANE PROTEIN; PORCN PROTEIN, MOUSE; PTPRK PROTEIN, MOUSE; PYRAZINE DERIVATIVE; PYRIDINE DERIVATIVE; R-SPONDIN3 PROTEIN, MOUSE; RECEPTOR LIKE PROTEIN TYROSINE PHOSPHATASE; RSPO2 PROTEIN, MOUSE; THROMBOSPONDIN;

CANCER; CHROMOSOME; DIGESTIVE SYSTEM; DISEASE; GENETIC DIFFERENTIATION; INHIBITOR; TUMOR;

ADENOMA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARCINOGENESIS; CELL STRUCTURE; CHROMOSOME REARRANGEMENT; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEAT; COLON CANCER; CONTROLLED STUDY; CYTOPLASM; HYPERPLASIA; IN VIVO STUDY; INTESTINE; INTESTINE CRYPT; INTESTINE MUCOSA; MOUSE; NEOPLASM; NONHUMAN; PROTEIN SECRETION; STEM CELL; TRANSGENIC MOUSE; TUMOR GROWTH; WNT SIGNALING PATHWAY; ANIMAL; C57BL MOUSE; CHROMOSOME; CHROMOSOME ABERRATION; COLON TUMOR; FEMALE; GENE REARRANGEMENT; GENETICS; HUMAN; MALE; METABOLISM; PATHOLOGY;

ACYLTRANSFERASES; ANIMALS; CHROMOSOME ABERRATIONS; CHROMOSOMES; COLONIC NEOPLASMS; FEMALE; GENE REARRANGEMENT; HUMANS; INTESTINES; MALE; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; PYRAZINES; PYRIDINES; RECEPTOR-LIKE PROTEIN TYROSINE PHOSPHATASES, CLASS 2; THROMBOSPONDINS; WNT PROTEINS;

EID: 85027058184     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms15945     Document Type: Article

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