Modeling invasive lobular breast carcinoma by CRISPR/Cas9-mediated somatic genome editing of the mammary gland

Genes and Development

Volumn 30, Issue 12, 2016, Pages 1470-1480

  Annunziato, Stefano ^a   Kas, Sjors M ^a   Nethe, Micha ^a   Yücel, Hatice ^a   Del Bravo, Jessica ^a   Pritchard, Colin ^a   Ali, Rahmen Bin ^a   Van Gerwen, Bas ^a   Siteur, Bjørn ^a   Drenth, Anne Paulien ^a   Schut, Eva ^a   Van De Ven, Marieke ^a   Boelens, Mirjam C ^a   Klarenbeek, Sjoerd ^a   Huijbers, Ivo J ^a   Van Miltenburg, Martine H ^a   Jonkers, Jos ^a  

^a NETHERLANDS CANCER INSTITUTE   (Netherlands)

Author keywords

Breast cancer; CRISPR Cas9; Intraductal injection; Invasive lobular carcinoma; Mouse models; Somatic gene editing

Indexed keywords

CRE RECOMBINASE; CRISPR ASSOCIATED PROTEIN; E1A ASSOCIATED P300 PROTEIN; GENOMIC DNA; GUIDE RNA; LENTIVIRUS VECTOR; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; UVOMORULIN; CADHERIN;

ADULT; ALLELE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BREAST CARCINOMA; BREAST EPITHELIUM CELL; CANCER MODEL; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEAT; CONTROLLED STUDY; FEMALE; GENE TARGETING; GENETIC PROCEDURES; HUMAN GENOME; IMMUNOHISTOCHEMISTRY; MAMMARY GLAND; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; SOMATIC GENOME EDITING; TUMOR SUPPRESSOR GENE; ANIMAL; BREAST TUMOR; CRISPR CAS SYSTEM; DISEASE MODEL; GENE EDITING; GENE SILENCING; GENETICS; HUMAN; LUNG CARCINOMA; PATHOPHYSIOLOGY;

ANIMALS; BREAST NEOPLASMS; CADHERINS; CARCINOMA, LOBULAR; CRISPR-CAS SYSTEMS; DISEASE MODELS, ANIMAL; FEMALE; GENE EDITING; GENE SILENCING; GENES, TUMOR SUPPRESSOR; HUMANS; MAMMARY GLANDS, HUMAN; MICE;

EID: 84975744697     PISSN: 08909369     EISSN: 15495477     Source Type: Journal    
DOI: 10.1101/gad.279190.116     Document Type: Article

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