The use of viscoelastic haemostatic assays in the management of major bleeding: A British Society for Haematology Guideline

British Journal of Haematology

Volumn 182, Issue 6, 2018, Pages 789-806

  Curry, Nicola S ^a,b   Davenport, Ross ^c   Pavord, Sue ^a,b   Mallett, Susan V ^d   Kitchen, Dianne ^e   Klein, Andrew A ^f   Maybury, Helena ^g   Collins, Peter W ^h   Laffan, Mike ⁱ  

^a OXFORD UNIVERSITY HOSPITALS NHS FOUNDATION TRUST   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^d ROYAL FREE LONDON NHS FOUNDATION TRUST   (United Kingdom)

^e UK NEQAS (Coagulation)   (United Kingdom)

^f PAPWORTH HOSPITAL   (United Kingdom)

^g LEICESTER ROYAL INFIRMARY   (United Kingdom)

^h CARDIFF UNIVERSITY   (United Kingdom)

ⁱ IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

major bleeding; Sonoclot; thromboelastography; thromboelastometry; viscoelastic tests

Indexed keywords

ASSAY; BLEEDING; BLOOD CLOTTING DISORDER; BLOOD TRANSFUSION; HEART SURGERY; HEMOSTATIC TECHNIQUE; HUMAN; INJURY; LETTER; LIVER DISEASE; LIVER SURGERY; MEASUREMENT ACCURACY; MEASUREMENT PRECISION; OBSTETRIC HEMORRHAGE; POSTPARTUM HEMORRHAGE; PRACTICE GUIDELINE; PREDICTION; PRIORITY JOURNAL; QUALITY CONTROL; VISCOELASTIC HAEMOSTATIC ASSAY; DEVICES; DISEASE MANAGEMENT; HEMATOLOGY; HEMOSTASIS; PROCEDURES; STANDARDS; THROMBOELASTOGRAPHY; UNITED KINGDOM;

VISCOELASTIC SUBSTANCE;

DISEASE MANAGEMENT; HEMATOLOGY; HEMORRHAGE; HEMOSTASIS; HEMOSTATIC TECHNIQUES; HUMANS; THROMBELASTOGRAPHY; UNITED KINGDOM; VISCOELASTIC SUBSTANCES;

EID: 85052994248     PISSN: 00071048     EISSN: 13652141     Source Type: Journal    
DOI: 10.1111/bjh.15524     Document Type: Letter

References (128)

1. Abuelkasem, E., Lu, S., Tanaka, K., Planinsic, R. & Sakai, T. (2016) Comparison between thromboelastography and thromboelastometry in hyperfibrinolysis detection during adult liver transplantation. BJA: British Journal of Anaesthesia, 116, 507–512
2. Agarwal, S., Senzolo, M., Melikian, C., Burroughs, A. & Mallett, S.V. (2008) The prevalence of a heparin-like effect shown on the thromboelastograph in patients undergoing liver transplantation. Liver Transplantation, 14, 855–860
3. Ak, K., Isbir, C.S., Tetik, S., Atalan, N., Tekeli, A., Aljodi, M., Civelek, A. & Arsan, S. (2009) Thromboelastography-based transfusion algorithm reduces blood product use after elective CABG: a prospective randomized study. Journal of Cardiac Surgery, 24, 404–410
4. Alamo, J.M., Leon, A., Mellado, P., Bernal, C., Marin, L.M., Cepeda, C., Suarez, G., Serrano, J., Padillo, J. & Gomez, M.A. (2013) Is “intra-operating room” thromboelastometry useful in liver transplantation? A case-control study in 303 patients. Transplantation Proceedings, 45, 3637–3639
5. Anderson, L., Quasim, I., Steven, M., Moise, S.F., Schraag, S. & Sinclair, A. (2014) Interoperator and intraoperator variability of whole blood coagulation assays: a comparison of thromboelastography and rotational thromboelastometry. Journal of Cardiothoracic and Vascular Anesthesia, 28, 1550–1557
6. Andreasen, J.B., Hvas, A.-M., Christiansen, K. & Ravn, H.B. (2011) Can ROTEM analysis be applied for haemostatic monitoring in paediatric congenital heart surgery? Cardiology in the Young, 21, 684–691
7. Aoki, K., Sugimoto, A., Nagasawa, A., Saito, M. & Ohzeki, H. (2012) Optimization of thromboelastography-guided platelet transfusion in cardiovascular surgery. General Thoracic and Cardiovascular Surgery, 60, 411–416
8. Armstrong, S., Fernando, R., Ashpole, K., Simons, R. & Columb, M. (2011) Assessment of coagulation in the obstetric population using ROTEM thromboelastometry. International Journal of Obstetric Anesthesia, 20, 293–298
9. Avidan, M.S., Alcock, E.L., Da Fonseca, J., Ponte, J., Desai, J.B., Despotis, G.J. & Hunt, B.J. (2004) Comparison of structured use of routine laboratory tests or near patient assessment with clinical judgement in the management of bleeding after cardiac surgery. British Journal of Anaesthesia, 92, 178–186
10. Barinov, S.V., Zhukovsky, Y.G., Dolgikh, T.V. & Medyannikova, I.V. (2017) Novel combined strategy of obstetric haemorrhage management during caesarean section using intrauterine balloon tamponade. The Journal of Maternal-Fetal and Neonatal Medicine, 30, 29–33
11. Bedreli, S., Sowa, J.-P., Malek, S., Blomeyer, S., Katsounas, A., Gerken, G., Saner, F.H. & Canbay, A. (2017) Rotational thromboelastometry can detect factor XIII deficiency and bleeding diathesis in patients with cirrhosis. Liver International: Official Journal of the International Association for the Study of the Liver, 37, 562–568
12. Blasi, A., Beltran, J., Pereira, A., Martinez-Palli, G., Torrents, A., Balust, J., Zavala, E., Taura, P. & Garcia-Valdecasas, J.-C. (2012) An assessment of thromboelastometry to monitor blood coagulation and guide transfusion support in liver transplantation. Transfusion, 52, 1989–1998
13. Bliden, K.P., Chaudary, R., Mohammed, N., Muresan, A.A., Lopez-Espina, C.G., Cohen, E., Raviv, G., Doubleday, M., Zaman, F., Mathew, B., Tantry, U.S. & Gurbel, P.A. (2017) Determination of non-vitamin K oral anticoagulant (NOAC) effects using a new-generation thromboelastography TEG 6s system. Journal of Thrombosis and Thrombolysis, 43, 437–445
14. de Boer, M.T., Christensen, M.C., Asmussen, M., van der Hilst, C.S., Hendriks, H.G., Slooff, M.J. & Porte, R.J. (2008) The impact of intraoperative transfusion of platelets and red blood cells on survival after liver transplantation. Anesthesia and Analgesia, 106, 32–44
15. Chan, K.L., Summerhayes, R.G., Ignjatovic, V., Horton, S.B. & Monagle, P.T. (2007) Reference values for kaolin-activated thromboelastography in healthy children. Anesthesia and Analgesia, 105, 16190–1613
16. Chau, T.N., Chan, Y.W., Patch, D., Tokunaga, S., Greenslade, L. & Burroughs, A.K. (1998) Thrombelastographic changes and early rebleeding in cirrhotic patients with variceal bleeding. Gut, 43, 267–271
17. Cherng, Y.-G., Chao, A., Shih, R.-L., Lin, C.-S., Chan, W.-H., Huang, C.-H. & Tsai, S.-K. (1998) Preoperative evaluation and postoperative prediction of hemostatic function with thromboelastography in patients undergoing redo cardiac surgery. Acta Anaesthesiologica Sinica, 36, 179–186
18. Coakley, M., Reddy, K., Mackie, I. & Mallett, S. (2006) Transfusion triggers in orthotopic liver transplantation: a comparison of the thromboelastometry analyzer, the thromboelastogram, and conventional coagulation tests. Journal of Cardiothoracic and Vascular Anesthesia, 20, 548–553
19. Collins, P.W., Lilley, G., Sanders, J., Alikhan, R., Rayment, R., Rees, A., Kaye, A., Hall, J.E., Paranjothy, S., Weeks, A. & Collis, R.E. (2014) Fibrin-based clot formation as an early and rapid biomarker for progression of postpartum hemorrhage: a prospective study. Blood, 124, 1727–1736
20. Collins, P.W., Cannings-John, R., Bruynseels, D., Mallaiah, S., Dick, J., Elton, C., Weeks, A.D., Sanders, J., Aawar, N., Townson, J., Hood, K., Hall, J.E. & Collis, R.E.; The OBS2 Study Team. (2017a) Viscoelastometric-guided early fibrinogen concentrate replacement during postpartum haemorrhage: a double blind randomised controlled trial: OBS2. British Journal of Anaesthesia, 119, 411–421
21. Collins, P.W., Cannings-John, R., Bruynseels, D., Mallaiah, S., Dick, J., Elton, C., Weeks, A.D., Sanders, J., Aawar, N., Townson, J., Hood, K., Hall, J.E. & Collis, R.E.; The OBS2 Study Team. (2017b) Viscoelastometry guided fresh frozen plasma infusion for postpartum haemorrhage: an observational study: OBS2. British Journal of Anaesthesia, 119, 422–434
22. Cotton, B.A., Faz, G., Hatch, Q.M., Radwan, Z.A., Podbielski, J., Wade, C., Kozar, R.A. & Holcomb, J.B. (2011) Rapid thrombelastography delivers real-time results that predict transfusion within 1 hour of admission. Journal of Trauma, 71, 407–417
23. Crighton, S.P., Bell, S.F., Collis, R.E., de Lloyd, L., Jenkins, V. & Collins, P.W. (2017) ROTEM Sigma versus Delta: a comparison of results obtained in non-pregnant participants. www document. URL: http://epostersonline.com/oaa2017/node/392?view=true
24. ®) on diagnosis of coagulopathy, transfusion guidance and mortality in trauma: descriptive systematic review. Critical Care, 18, 518
25. Davenport, R., Manson, J., De'Ath, H., Platton, S., Coates, A., Allard, S., Hart, D., Pearse, R., Pasi, K.J., MacCallum, P., Stanworth, S. & Brohi, K. (2011) Functional definition and characterization of acute traumatic coagulopathy. Critical Care Medicine, 39, 2652–1658
26. Davidson, S.J., McGrowder, D., Roughton, M. & Kelleher, A.A. (2008) Can ROTEM thromboelastometry predict postoperative bleeding after cardiac surgery? Journal of Cardiothoracic and Vascular Anesthesia, 22, 655–661
27. De Pietri, L., Ragusa, F., Deleuterio, A., Begliomini, B. & Serra, V. (2016) Reduced transfusion during OLT by POC coagulation management and TEG functional fibrinogen: a retrospective observational study. Transplantation Direct, 2, e49
28. Della Rocca, G., Dogareschi, T., Cecconet, T., Buttera, S., Spasiano, A., Nadbath, P., Angelini, M., Galluzzo, C. & Marchesoni, D. (2012) Coagulation assessment in normal pregnancy: thrombelastography with citrated non activated samples. Minerva Anestesiologica, 78, 1357–1364
29. Doran, C.M., Wooley, T. & Midwinter, M.J. (2010) Feasibility of using rotational thromboelastometry to assess coagulation status of combat casualties in a deployed setting. Journal of Trauma, 69, S40–S48
30. Dotsch, T.M., Dirkmann, D., Bezinover, D., Hartmann, M., Treckmann, J.W., Paul, A. & Saner, F.H. (2017) Assessment of standard laboratory tests and rotational thromboelastometry for the prediction of postoperative bleeding in liver transplantation. BJA: British Journal of Anaesthesia, 119, 402–410
31. Espinosa, A., Stenseth, R., Videm, V. & PLeym, H. (2014) Comparison of three point-of-care testing devices to detect hemostatic changes in adult elective cardiac surgery: a prospective observational study. BMC Anesthesiology, 14, 80
32. Fahrendorff, M., Oliveri, R. & Johansson, P.I. (2017) The use of viscoelastic haemostatic assays in goal-directing treatment with allogeneic blood products – A systematic review and meta-analysis. Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine, 25, 39
33. Faraoni, D., Willems, A., Romlin, B.S., Belisle, S. & Van der Linden, P. (2015) Development of a specific algorithm to guide haemostatic therapy in children undergoing cardiac surgery. European Journal of Anaesthesiology, 32, 320–329
34. Fassl, J., Matt, P., Eckstein, F., Filipovic, M., Gregor, M., Zenklusen, U., Seeberger, M.D. & Bolliger, D. (2013) Transfusion of allogeneic blood products in proximal aortic surgery with hypothermic circulatory arrest: effect of thromboelastometry-guided transfusion management. J Cardiothorac Vasc Anesthesia, 27, 1181–1188
35. Fayed, N., Mourad, W., Yassen, K. & Gorlinger, K. (2015) Preoperative thromboelastometry as a predictor of transfusion requirements during adult living donor liver transplantation. Transfusion Medicine and Hemotherapy, 42, 99–108
36. Gill, M. (2017) The TEG6s on shaky ground? A novel assessment of the TEG6s performance under a challenging condition. Journal of Extra-Corporeal Technology, 49, 26–29
37. Girdauskas, E., Kempfert, J., Kuntze, T., Borger, M.A., Enders, J., Fassl, J., Falk, V. & Mohr, F.-M. (2010) Thromboelasometrically guided transfusion protocol during aortic surgery with circulatory arrest: a prospective, randomized trial. The Journal of Thoracic and Cardiovascular Surgery, 140, 1117–1124
38. Gonzalez, E., Moore, E.E., Moore, H.B., Chapman, M.P., Chin, T.L., Ghasabyan, A., Wohlauer, M.V., Barnett, C.C., Bensard, D.D., Biffl, W.L., Burlew, C.C., Johnson, J.L., Pieracci, F.M., Jurkovich, G.J., Banerjee, A., Silliman, C.C. & Sauaia, A. (2016) Goal-directed hemostatic resuscitation of trauma-induced coagulopathy a pragmatic randomized clinical trial comparing a viscoelastic assay to conventional coagulation assays. Annals of Surgery, 263, 1051–1059
39. Gurbel, P.A., Bliden, K.P., Tantry, U.S., Monroe, A.L., Muresan, A.A., Brunner, N.E., Lopez-Espina, C.G., Delmenico, P.R., Cohen, E., Raviv, G., Haugen, D.L. & Ereth, M.H. (2016) First report of the point-of-care TEG: a validation study of the TEG-6S system. Platelets, 27, 642–649
40. Gurusamy, K.S., Pissanou, T., Pikhart, H., Vaughan, J., Burroughs, A.K. & Davidson, B.R. (2011) Methods to decrease blood loss and transfusion requirements for liver transplantation. Cochrane Database of Systematic Reviews, Issue 12. Art No.: CD009052
41. Haas, T., Gorlinger, K., Grassetto, A., Agostini, V., Simioni, P., Nardi, G. & Ranucci, M. (2014) Thromboelastometry for guiding bleeding management of the critically ill patient: a systematic review of the literature. Minerva Anesthesiologica, 80, 1320–1625
42. Hagemo, J.S., Christiaans, S.C., Stanworth, S.J., Brohi, K., Johansson, P.I., Goslings, J.C., Naess, P.A. & Gaarder, C. (2015) Detection of acute traumatic coagulopathy and massive transfusion requirements by means of rotational thromboelastometry: an international prospective validation study. Critical Care, 19, 97
43. ®-guided transfusion algorithm. Anaesthesia and Intensive Care, 40, 1007–1015
44. Huissoud, C., Carrabin, N., Audibert, F., Levrat, A., Massignon, D., Berland, M. & Rudigoz, R.-C. (2009) Bedside assessment of fibrinogen level in postpartum haemorrhage by thrombelastometry. BJOG, 116, 1097–1102
45. Hunt, B.J., Allard, S., Keeling, D., Norfolk, D., Stanworth, S.J. & Pendry, K.; on behalf of the BCSH. (2015a) A practical guideline for the haematological management of major haemorrhage. British Journal of Haematology, 170, 788–803
46. Hunt, H., Stanworth, S., Curry, N., Wooley, T., Cooper, C., Ukoumunne, O., Zhelev, Z. & Hyde, C. (2015b) Thromboelastography (TEG) and rotational thromboelastometry (ROTEM) for trauma induced coagulopathy in adult trauma patients with bleeding. Cochrane Database of Systematic Reviews, Issue 2. Art. No.:CD010438
47. Ichikawa, J., Marubuchi, T., Nishiyama, K., Kodaka, M., Gorlinger, K., Ozaki, M. & Komori, M. (2017) Introduction of thromboelastometry-guided administration of fresh-frozen plasma is associated with decreased allogeneic blood transfusions and post-operative blood loss in cardiopulmonary-bypass surgery. Blood Transfusion, 16, 1–9
48. Innerhofer, P., Fries, D., Mittermayr, M., Innerhofer, N., von Langen, D., Hell, T., Gruber, G., Schmid, S., Friesenecker, B., Lorenz, I.H., Strohle, M., Rastner, V., Trubsbach, S., Raab, H., Treml, B., Wally, D., Treichl, B., Mayr, A., Kranewitter, C. & Oswald, E. (2017) Reversal of trauma-induced coagulopathy using first-line coagulation factor concentrates or fresh frozen plasma (RETIC): a single-centre, parallel-group, open-label, randomised trial. The Lancet Haematology, 4, e258–e271
49. Jeger, V., Willi, S., Liu, T., Yeh, D.D., DeMoya, M., Zimmermann, H. & Exadaktylos, A.K. (2012) The rapid TEG α-angle may be a sensitive predictor of transfusion in moderately injured blunt trauma patients. The Scientific World Journal, 2012, Article ID 821794
50. Johansson, P.I. (2012) Coagulation monitoring of the bleeding traumatized patient. Current Opinion in Anesthesiology, 25, 235–241
51. Johansson, P.I. & Stensballe, J. (2009) Effect of haemostatic control resuscitation on mortality in massively bleeding patients: a before and after study. Vox Sanguinis, 96, 111–118
52. Johansson, P.I., Stensballe, J., Oliveri, R., Wade, C.E., Ostrowski, S.R. & Holcomb, J.B. (2014) How I treat patients with massive hemorrhage. Blood, 124, 3052–3058
53. Kang, Y.G., Martin, D.J., Marquez, J., Lewis, J.H., Bontempo, F.A., Shaw, B.W. Jr, Starzl, P.E. & Winter, P.M. (1985) Intraoperative changes in blood coagulation and thrombelastographic monitoring in liver transplantation. Anesthesia and Analgesia, 64, 888–896
54. Karkouti, K., McMluskey, S.A., Callum, J., Freedman, J., Selby, R., Timoumi, T., Roy, D. & Rao, V. (2015) Evaluation of a novel transfusion algorithm employing point-of-care coagulation assays in cardiac surgery. A retrospective cohort study with interrupted time–series analysis. Anesthesiology, 122, 560–570
55. Kashuk, J.L., Moore, E.E., Wohlauer, M., Johnson, J.L., Pezold, M., Lawrence, J., Biffl, W.L., Burlew, C.C.C., Barnett, C., Sawyer, M. & Sauaia, A. (2012) Initial experiences with point-of-care rapid thromboelastography for management of life-threatening postinjury coagulopathy. Transfusion, 52, 23–33
56. Kaufner, L., Henkelmann, A., von Heymann, C., Feldheiser, A., Mickley, L., Niepraschk-von, Dollen K., Grittner, U., Henrich, W. & Bamberg, C. (2017) Can prepartum thromboelastometry-derived parameters and fibrinogen levels really predict postpartum haemorrhage? Journal of Perinatal Medicine, 45, 427–435
57. Kirchner, C., Dirkmann, D., Trecckmann, J.W., Paul, A., Hartmann, M., Saner, F.H. & Gorlinger, K. (2014) Coagulation management with factor concentrates in liver transplantation: a single-center experience. Transfusion, 54, 2760–2768
58. Kitchen, D.P., Kitchen, S., Jennings, I., Woods, T. & Walker, I. (2010) Quality assurance and quality control of thromboelastography and rotational thromboelastometry: the UK NEQAS for blood coagulation experience. Seminars in Thrombosis Hemostasis, 36, 757–763
59. Kozek-Langenecker, S.A., Ahmed, A.B., Afshari, A., Albaladejo, P., Aldecoa, C., Barauskas, G., De Robertis, E., Faraoni, D., Filipescu, D.C., Fries, D., Haas, T., Joacob, M., Lance, M.D., Pitarch, J.V.L., Mallett, S., Meier, J., Molnar, Z.L., Rahe-Meyer, N., Samama, C.M., Stensballe, J., Van der Linden, P.J.F., Wikkelso, A.J., Wouters, P., Wyffels, P. & Zacharowski, K. (2017) Management of severe perioperative bleeding: guidelines from the European Society of Anaesthesiology. European Journal of Anaesthesiology, 34, 332–395
60. Krzanicki, D., Sugavanam, A. & Mallett, S. (2013) Intraoperative hypercoagulability during liver transplantation as demonstrated by thromboelastography. Liver Transplantation: Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, 19, 852–861
61. de Lange, N.M., van Rheenen-Flach, L.E., Lance, M.D., Mooyman, L., Woiski, M., van Pampus, E.C., Porath, M., Bolte, A.C., Smits, L., Henskens, Y.M. & Scheepers, H.C. (2014) Peri-partum reference ranges for ROTEM thromboelastometry. British Journal of Anaesthesia, 112, 852–859
62. Larsen, O.H., Fenger-Eriksen, C., Christiansen, K., Ingerslev, J. & Sorensen, B. (2011) Diagnostic performance and therapeutic consequence of thromboelastometry activated by kaolin versus a panel of specific reagents. Anesthesiology, 115, 294–302
63. Lee, G.C., Kicza, A.M., Liu, K.-Y., Nyman, C.B., Kaufman, R.M. & Body, S.C. (2012) Does rotational thromboelastometry (ROTEM) improve prediction of bleeding after cardiac surgery? Anesthesia and Analgesia, 115, 499–506
64. Leon-Justel, A., Noval-Padillo, J.A., Alvarez-Rios, A.I., Mellado, P., Gomez-Bravo, M.A., Alamo, J.M., Porras, M., Barrero, L., Hinojosa, R., Carmona, M., Vilches-Arenas, A. & Guerrero, J.M. (2015) Point-of-care haemostasis monitoring during liver transplantation reduces transfusion requirements and improves patient outcomes. Clinica Chimica Acta, 446, 277–283
65. Mace, H., Lightfoot, N., McCluskey, S., Selby, R., Roy, D., Timoumi, T. & Karkouti, K. (2016) Validity of thromboelastometry for rapid assessment of fibrinogen levels in heparinized samples during cardiac surgery: a retrospective, single-center, observational study. Journal of Cardiothoracic and Vascular Anesthesia, 30, 90–95
66. Mallaiah, S., Barclay, P., Harrod, I., Chevannes, C. & Bhalla, A. (2015a) Introduction of an algorithm for ROTEM-guided fibrinogen concentrate administration in major obstetric haemorrhage. Anaesthesia, 70, 166–175
67. Mallaiah, S., Chevannes, C., McNamara, H. & Barclay, P. (2015b) A reply. Anaesthesia, 70, 760–761
68. Mamczak, C.N., Maloney, M., Fritz, B., Boyer, B., Thomas, C., Evans, E., Ploplis, V.A., Castellino, F.J., McCollester, J. & Walsh, M. (2016) Thromboelastography in orthopaedic trauma acute pelvic fracture resuscitation: a descriptive pilot study. Journal of Orthopaedic Trauma, 30, 299–305
69. Massicotte, L., Denault, A.Y., Thibeault, L., Hevesi, Z., Nozza, A. & Roy, A. (2014) Relationship between conventional coagulation tests and bleeding for 600 consecutive liver transplantations. Transplantation, 98, e13–e15
70. Mavrides, E., Allard, S., Chandraharan, E., Collins, P., Green, L., Hunt, B.J., Riris, S. & Thomson, A.J.; on behalf of the Royal College of Obstetricians and Gynaecologists. (2016) Prevention and management of postpartum haemorrhage. BJOG, 124, e106–e149
71. Mehaffey, J.H., Schubert, S.A., Gelvin, M.G., Charles, E.J., Hawkins, R.B., Johnston, L.E., Ailwadi, G., Kron, I.L. & Yarboro, L.T. (2017) A new intraoperative protocol for reducing perioperative transfusions in cardiac surgery. Annals of Thoracic Surgery, 104, 176–181
72. Meyer, A.S., Meyer, M.A.S., Sorensen, A.M., Rasmussen, L.S., Hansen, M.B., Holcomb, J.B., Cotton, B.A.C., Wade, C.E., Ostrowski, S.R. & Johansson, P.I. (2014) Thrombelastography and rotational thromboelastometry early amplitudes in 182 trauma patients with clinical suspicion of severe injury. Journal of Trauma and Acute Care Surgery, 76, 682–690
73. Moore, H.B., Moore, E.E., Chapman, M.P., Huebner, B.R., Einersen, P.M., Oushy, S., Silliman, C.C., Banerjee, A. & Sauaia, A. (2017) Viscoelastic tissue plasminogen activator challenge predicts massive transfusion in 15 minutes. Journal of the American College of Surgeons, 225, 138–147
74. Nakayama, Y., Nakajima, Y., Tanaka, K.A., Sessler, D.I., Maeda, S., Iida, J., Ogawa, S. & Mizob, T. (2015) Thromboelastometry-guided intraoperative haemostatic management reduces bleeding and red cell transfusion after paediatric cardiac surgery. British Journal of Anaesthesia, 114, 91–102
75. Niebler, R.A., Gill, J.C., Brabant, C.P., Mitchell, M.E., Nugent, M., Simpson, P., Tweddell, J.S. & Ghanayem, N.S. (2012) Thromboelastography in the assessment of bleeding following surgery for congenital heart disease. World Journal for Pediatric and Congenital Heart Surgery, 3, 433–438
76. Noval-Padillo, J.A., Leon-Justel, A., Mellado-Miras, P., Porras-Lopez, F., Villegas-Duque, D., Gomez-Bravo, M.A. & Guerrero, J.M. (2010) Introduction of fibrinogen in the treatment of hemostatic disorders during orthotopic liver transplantation: implications in the use of allogenic blood. Transplantation Proceedings, 42, 2973–2974
77. Ogawa, S., Szlam, F., Chen, E.P., Nishimura, T., Kim, H., Roback, J.D., Levy, J.H. & Tanaka, K.A. (2012a) A comparative evaluation of rotation thromboelastometry and standard coagulation tests in hemodilution-induced coagulation changes after cardiac surgery. Transfusion, 52, 14–22
78. Ogawa, S., Szlam, F., Bolliger, D., Nishimura, T., Chen, E.P. & Tanaka, K.A. (2012b) The impact of haematocrit on fibrin clot formation assessed by rotational thromboelastometry. Anesthesia and Analgesia, 115, 16–21
79. Ortmann, E., Rubino, A., Altemimi, B., Collier, T., Besser, M.W. & Klein, A. (2015) Validation of viscoelastic coagulation tests during cardiopulmonary bypass. Journal of Thrombosis and Haemostasis, 13, 1207–1216
80. Oswald, E., Stalzer, B., Heitz, E., Weiss, M., Schmugge, M., Strasak, A., Innerhofer, P. & Haas, T. (2010) Thromboelastometry (ROTEM) in children: age-related reference ranges and correlations with standard coagulation tests. BJA: British Journal of Anaesthesia, 105, 827–835
81. ®) parameters following nonhaemorrhagic deliveries. Correlations with standard haemostasis parameters. Thrombosis and Haemostasis, 106, 176–178
82. Pearse, B.L., Smith, I., Faulke, D., Wall, D., Fraser, J.F., Ryan, E.G., Drake, L., Rapchuk, I.L., Tesar, P., Ziegenfuss, M. & Fung, Y.L. (2015) Protocol guided bleeding management improves cardiac surgery patient outcomes. Vox Sanguinis, 109, 267–279
83. Pekelharan, J., Furck, A., Banya, W., Macrae, D. & Davidson, S.J. (2014) Comparison between thromboelastography and conventional coagulation tests after cardiopulmonary bypass surgery in the paediatric intensive care unit. International Journal of Laboratory Hematology, 36, 465–471
84. Pivalizza, E.G., Abramson, D.C. & King, F.S. (1998) Thromboelastography with heparinase in orthotopic liver transplantation. Journal of Cardiothoracic and Vascular Anesthesia, 112, 305–308
85. Polak, F., Kolnikova, I., Lips, M., Parizek, A., Blaha, J. & Stritesky, M. (2011) New recommendations for thromboelastography reference ranges for pregnant women. Thrombosis Research, 128, e14–e17
86. Pommerening, M.J., Goodman, M.D., Farley, D.L., Cardenas, J.C., Podbielski, J., Matijevic, N., Wade, C.E., Holcomb, J.B. & Cotton, B.A. (2014) Early diagnosis of clinically significant hyperfibrinolysis using thrombelastography velocity curves. Journal of the American College of Surgeons, 219, 1157–1166
87. Prat, N.J., Meyer, A.D., Ingalls, N.K., Trichereau, J., DuBose, J.J. & Cap, A.P. (2017) Rotational thromboelastometry significantly optimizes transfusion practices for damage control resuscitation in combat casualties. Journal of Trauma and Acute Care Surgery, 83, 373–380
88. Pustavoitau, A., Lesley, M., Ariyo, P., Latif, A., Villamayor, A.J., Frank, S.M., Rizkalla, N., Merritt, W., Cameron, A., Dagher, N., Philosophe, B., Gurakar, A. & Gottschalk, A. (2017) Predictive modelling of massive transfusion requirements during liver transplantation and its potential to reduce utilization of blood bank resources. Anesthesia and Analgesia, 124, 1644–1652
89. Rahe-Meyer, N., Solomon, C., Winterhalter, M., Piepenbrock, S., Tanaka, K., Haverich, A. & Pichlmaier, M. (2009) Thromboelastometry-guided administration of fibrinogen concentrate for the treatment of excessive intraoperative bleeding in thoracoabdominal aortic aneurysm surgery. The Thoracic and Cardiovascular Surgeon, 13, 694–702
90. Ranucci, M., Baryshnikova, E., Pistuddi, V., Menicanti, L. & Frigiola, A.; for the Surgical and Clinical Outcome Research (SCORE) Group. (2017) The effectiveness of 10 years of interventions to control postoperative bleeding in adult cardiac surgery. Interactive Cardiovascular and Thoracic Surgery, 24, 196–202
91. Raza, I., Davenport, R., Rourke, C., Platton, S., Manson, J., Spoors, C., Khan, S., De'ath, H.D., Allard, S., Hart, D.P., Pasi, K.J., Hunt, B.J., Stanworth, S., MacCallum, P.K. & Brohi, K. (2013) The incidence and magnitude of fibrinolytic activation in trauma patients. Journal of Thrombosis and Haemostasis, 11, 307–314
92. van Rheenen-Flach, L.E., Zweegman, S., Boersma, F., Lenglet, J.E., Twisk, J.W.R. & Bolte, A.C. (2013) A prospective longitudinal study on rotation thromboelastometry in women with uncomplicated pregnancies and postpartum. Australian and New Zealand Journal of Obstetrics and Gynaecology, 53, 32–36
93. Rizoli, S., Min, A., Perez Sanchez, A., Shek, P., Grodecki, R., Veigas, P. & Peng, H.T. (2016) In trauma, conventional ROTEM and TEG results are not interchangeable but are similar in clinical applicability. Military Medicine, 181, 117
94. Romlin, B.S., Wahlander, H., Berggren, H., Synnergren, M., Baghaei, F. & Jeppson, A. (2013) Earlier detection of coagulopathy with thromboelastometry during pediatric cardiac surgery: a prospective observational study. Pediatric Anesthesia, 23, 222–227
95. Roullet, S., Pillot, J., Freyburger, G., Biais, M., Quinart, A., Rault, A., Revel, P. & Sztark, F. (2010) Rotation thromboelastometry detects thrombocytopenia and hypofibrinogenaemia during orthotopic liver transplantation. BJA: British Journal of Anaesthesia, 104, 422–428
96. Royston, D. & von Kier, S. (2001) Reduced haemostatic factor transfusion using heparinise-modified thromboelastography during cardiopulmonary bypass. BJA: British Journal of Anaesthesia, 86, 575–578
97. Sartorius, D., Waeber, J.-L., Pavlovic, G., Frei, A., Diaper, J., Myers, P., Cassina, T. & Licker, M. (2014) Goal-directed haemostatic therapy using the rotational thromboelastometry in patients requiring emergent cardiovascular surgery. Annals of Cardiac Anaesthesia, 17, 100–108
98. Say, L., Chou, D., Gemmill, A., Tunçalp, Ö., Moller, A.B., Daniels, J., Gülmezoglu, A.M., Temmerman, M. & Alkema, L. (2014) Global causes of maternal death: a WHO systematic analysis. The Lancet Global Health, 2, e323–3
99. Schochl, H., Nienaber, U., Hoferi, G., Voelckel, W., Jambor, C., Scharbert, G., Kozek-Langenecker, S. & Solomon, C. (2010) Goal-directed coagulation management of major trauma patients using thromboelastometry (ROTEM)-guided administration of fibrinogen concentrate and prothrombin complex concentrate. Critical Care, 14, R55
100. Schochl, H., Nienaber, U., Maegele, M., Hochleitner, G., Primavesi, F., Steitz, B., Arndt, C., Hanke, A., Voelckel, W. & Solomon, C. (2011) Transfusion in trauma: thromboelastometry-guided coagulation factor concentrate-based therapy versus standard fresh frozen plasma-based therapy. Critical Care, 15, R83
101. Segal, J.B. & Dzik, W.H. (2005) Paucity of studies to support that abnormal coagulation test results predict bleeding in the setting of invasive procedures: an evidence-based review. Transfusion, 45, 1413–1425
102. Serraino, G.F. & Murphy, G.J. (2017) Routine use of viscoelastic blood tests for diagnossi and treatment of coagulopathic bleeding in cardiac surgery: updated systematic review and meta-analysis. BJA: British Journal of Anaesthesia, 118, 823–833
103. Seyve, L., Richarme, C., Polack, B. & Marlu, R. (2018) Impact of four direct oral anticoagulants on rotational thromboelastometry (ROTEM). International Journal of Laboratory Hematology, 40, 84–93
104. Sharma, A., Al-Achib, A., Seccombe, J.F., Hummela, R., Prestona, M. & Behrenda, D. (2014) Does incorporation of thromboelastography improve bleeding prediction following adult cardiac surgery? Blood Coagulation & Fibrinolysis, 25, 561–570
105. Song, J.-G., Jeong, S.-M., Jun, I.-G., Lee, H.-M. & Hwang, G.-S. (2014) Five-minute parameter of thromboelastometry is sufficient to detect thrombocytopenia and hypofibrinogenaemia in patients undergoing liver transplantation. British Journal of Anaesthesia, 112, 290–297
106. Speiss, B.D., Gdhes, B.S.A., Chandler, W. & Vetoer, E. (1995) Changes in transfusion therapy and reexploratoin rate after institution of a blood management program in cardiac surgical patients. Journal of Cardiothoracic and Vascular Anesthesia, 9, 168–173
107. Stanworth, S.J., Davenport, R., Curry, N., Seeney, F., Eaglestone, S., Edwards, A., Martin, K., Allard, S., Woodford, M., Lecky, F.E. & Brohi, K. (2016) Mortality from trauma haemorrhage and opportunities for improvement in transfusion practice. British Journal of Surgery, 103, 357–365
108. Stravitz, R.T. (2012) Potential applications of thromboelastography in patients with acute and chronic liver disease. Gastroenterology & Hepatology, 8, 513–520
109. Tafur, L.A., Taura, P., Blasi, A., Beltran, J., Martinez-Palli, G., Balust, J. & Garcia-Valdecasas, J.C. (2016) Rotation thromboelastometry velocity curve predicts blood loss during liver transplantation. British Journal of Anaesthesia, 117, 741–748
110. Tapia, N.M., Chang, A., Norman, M., Welsh, F., Scott, B., Wall, M.J., Mattox, K.L. & Suliburk, J. (2013) TEG-guided resuscitation is superior to standardized MTP resuscitation in massively transfused penetrating trauma patients. Journal of Trauma and Acute Care Surgery, 74, 378–386
111. Tauber, H., Innerhofer, P., Breitkopf, R., Westermann, I., Beer, R., El Attal, R., Strasak, A. & Mittermayr, M. (2011) Prevalence and impact of abnormal ROTEM assays in severe blunt trauma: results of the ‘Diagnosis and Treatment of Trauma-Induced Coagulopathy (DIA-TRE-TIC) study’. British Journal of Anaesthesia, 107, 378–387
112. Theusinger, O.M., Nurnberg, J., Asmis, L.M., Seifert, B. & Spahn, D.R. (2010) Rotation thromboelastometry (ROTEM) stability and reproducibility over time. European Journal of Cardio-Thoracic Surgery, 37, 677–683
113. Trevisan, D., Zavatti, L., Gabbieri, D., Pedulli, M., Giordano, G. & Meli, M. (2016) Point-of-care-based protocol with first-line therapy with coagulation factor concentrates is associated with decrease allogenic blood transfusion and costs in cardiovascular surgery: an Italian single-center experience. Minerva Anestesiologica, 82, 1077–1088
114. Trzebicki, J., Flakiewicz, E., Kosieradzki, M., Blaszczyk, B., Kolacz, M., Jureczko, L., Pacholczyk, M., Chmura, A., Lagiewska, B., Lisik, W., Wasiak, D., Kosson, D., Kwiatkowski, A. & Lazowski, T. (2010) The use of thromboelastometry in the assessment of hemostasis during orthotopic liver transplantation reduces the demand for blood products. Annals of Transplantation, 15, 24
115. Tynngård, N., Lindahl, T.L. & Ramström, S. (2015) Assays of different aspects of haemostasis – what do they measure? Thrombosis Journal, 13, 8
116. ® thromboelastographic variables in cardiac surgical patients. Anesthesia and Analgesia, 111, 339–344
117. Wang, S.C., Shieh, J.F., Chang, K.Y., Chu, Y.C., Liu, C.S., Loong, C.C., Chan, K.H., Mandell, S. & Tsou, M.Y. (2010) Thromboelastography-guided transfusion decreases intraoperative blood transfusion during orthotopic liver transplantation: randomized clinical trial. Transplantation Proceedings, 42, 2590–2593
118. Wang, S.C., Lin, H.T., Chang, K.Y., Mandell, S., Ting, C.K., Chu, Y.C., Loong, C.C., Chan, K.H. & Tsou, M.Y. (2012) Use of higher thromboelastogram transfusion values is not associated with greater blood loss in liver transplant surgery. Liver Transplantation, 18, 1254–1258
119. Wasowicz, M., McCluskey, S.A., Wijeysundera, D.N., Yau, T.M., Meinri, M., Beattie, S. & Karkouti, K. (2010) The incremental value of thrombelastography for prediction of excessive blood loss after cardiac surgery: an observational study. Anesthesia and Analgesia, 111, 331–338
120. Weber, C.F., Gorlinger, K., Meininger, D., Herrmann, E., Bingold, T., Moritz, A., Cohn, L.H. & Zacharowski, K. (2012) A prospective, randomized clinical trial of efficacy in coagulopathic cardiac surgery patients. Anesthesiology, 117, 531–547
121. Welsh, K.J., Padilla, A., Dasgupta, A., Nguyen, A.N.D. & Wahed, A. (2014) Thromboelastography is a suboptimal test for determination of the underlying cause of bleeding associated with cardiopulmonary bypass and may not predict a hypercoagulable state. American Journal of Clinical Pathology, 142, 492–497
122. Westbrook, A.J., Olsen, J., Bailey, M., Bates, J., Scully, M. & Salamonsen, R.F. (2009) Protocol based on thromboelastograph (TEG) out-performs physician preference using laboratory coagulation tests to guide blood replacement during and after cardiac surgery: a pilot study. Heart, Lung and Circulation, 18, 277–288
123. White, N.J., Newton, J.C., Martin, E.J., Mohammed, B.M., Contaifer, D., Bostic, J., Brophy, G.M. & Speiss, B.D. (2015) Clot formation is associated with fibrinogen and platelet forces in a cohort of severely injured emergency department trauma patients. Shock, 44(Suppl 1), 39–44
124. Whiting, P., Al, M., Westwood, M., Corro Ramos, I., Ryder, S., Armstrong, N., Misso, K., Ross, J., Severens, J. & Kleijnen, J. (2015) Viscoelastic point-of-care testing to assist with the diagnosis, management and monitoring of haemostasis: a systematic review and cost-effectiveness analysis. Health Technology Assessment, 19, 1–228. Issue 58, ISSN 1366-5278. https://doi.org/10.3310/hta19580
125. WOMAN Trial Collaborators. (2017) Effect of early tranexamic acid administration on mortality, hysterectomy, and other morbidities in women with post-partum haemorrhage (WOMAN): an international, randomised, double-blind, placebo-controlled trial. Lancet, 389, 2105–2116
126. Wooley, T., Midwinter, M., Spencer, P., Watts, S., Doran, C. & Kirkman, E. (2013) Utility of interim ROTEM1 values of clot strength, A5 and A10, in predicting final assessment of coagulation status in severely injured battle patients. Injury, 44, 593–599
127. Yang Lu, S, Tanaka, K.A., Abuelkasem, E., Planinsic, R.M. & Sakai, T. (2014) Clinical applicability of rapid thrombelastography and functional fibrinogen thrombelastography to adult liver transplantation. Liver Transplantation, 20, 1097–1105
128. Yin, J., Zhao, Z., Li, Y., Wang, J., Yao, D., Zhang, S., Yu, W., Li, N. & Li, J. (2014) Goal-directed transfusion protocol via thrombelastography in patients with abdominal trauma: a retrospective study. World Journal of Emergency Surgery, 9, 28