Point-of-care testing: A prospective, randomized clinical trial of efficacy in coagulopathic cardiac surgery patients

Anesthesiology

Volumn 117, Issue 3, 2012, Pages 531-547

  Weber, Christian Friedrich ^a   Görlinger, Klaus ^b   Meininger, Dirk ^a   Herrmann, Eva ^c   Bingold, Tobias ^a   Moritz, Anton ^a   Cohn, Lawrence H ^d,e   Zacharowski, Kai ^a  

^a UNIVERSITY HOSPITAL FRANKFURT   (Germany)

^b UNIVERSITY HOSPITAL ESSEN   (Germany)

^c GOETHE UNIVERSITY   (Germany)

^d HARVARD MEDICAL SCHOOL   (United States)

^e BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CLORAZEPATE DIPOTASSIUM; DESMOPRESSIN; FIBRINOGEN CONCENTRATE; FRESH FROZEN PLASMA; HEMOCOMPLETTAN; HEMOSTATIC AGENT; HEPARIN; HETASTARCH; NORADRENALIN; PROPOFOL; ROCURONIUM; SEVOFLURANE; SEVORAN; SUFENTANIL; SUFENTANIL CITRATE; TRANEXAMIC ACID; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; ARTIFICIAL VENTILATION; BLEEDING; BLOOD TRANSFUSION; CONTROLLED STUDY; ERYTHROCYTE CONCENTRATE; ERYTHROCYTE TRANSFUSION; FEMALE; HEART SURGERY; HOSPITAL INFORMATION SYSTEM; HUMAN; INTENSIVE CARE UNIT; LENGTH OF STAY; MAJOR CLINICAL STUDY; MALE; POSTOPERATIVE HEMORRHAGE; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; THROMBOCYTE TRANSFUSION; THROMBOELASTOGRAPHY; TREATMENT OUTCOME;

AGED; CARDIAC SURGICAL PROCEDURES; CARDIOPULMONARY BYPASS; ERYTHROCYTE TRANSFUSION; FACTOR VIIA; FEMALE; FIBRINOGEN; HEMOSTATICS; HUMANS; MALE; MIDDLE AGED; POINT-OF-CARE SYSTEMS; PROSPECTIVE STUDIES;

EID: 84862889184     PISSN: 00033022     EISSN: 15281175     Source Type: Journal    
DOI: 10.1097/ALN.0b013e318264c644     Document Type: Article

References (47)

1. Murphy GJ, Reeves BC, Rogers CA, Rizvi SI, Culliford L, Angelini GD: Increased mortality, postoperative morbidity, and cost after red blood cell transfusion in patients having cardiac surgery. Circulation 2007; 116:2544-52
2. Moulton MJ, Creswell LL, Mackey ME, Cox JL, Rosenbloom M: Reexploration for bleeding is a risk factor for adverse outcomes after cardiac operations. J Thorac Cardiovasc Surg 1996; 111:1037-46
3. Goodnough LT: Risks of blood transfusion. Crit Care Med 2003; 31:678-86
4. Levy JH, Dutton RP, Hemphill JC 3rd, Shander A, Cooper D, Paidas MJ, Kessler CM, Holcomb JB, Lawson JH, Hemostasis Summit Participants: Multidisciplinary approach to the challenge of hemostasis. Anesth Analg 2010; 110:354-64
5. Avidan MS, Alcock EL, Da Fonseca J, Ponte J, Desai JB, Despotis GJ, Hunt BJ: Comparison of structured use of routine laboratory tests or near-patient assessment with clinical judgement in the management of bleeding after cardiac surgery. Br J Anaesth 2004; 92:178-86
6. Shore-Lesserson L, Manspeizer HE, DePerio M, Francis S, Vela-Cantos F, Ergin MA: Thromboelastography-guided transfusion algorithm reduces transfusions in complex cardiac surgery. Anesth Analg 1999; 88:312-9
7. Nuttall GA, Oliver WC, Santrach PJ, Bryant S, Dearani JA, Schaff HV, Ereth MH: Efficacy of a simple intraoperative transfusion algorithm for nonerythrocyte component utilization after cardiopulmonary bypass. ANESTHESIOLOGY 2001; 94: 773-81; discussion 5A-6A
8. Ak K, Isbir CS, Tetik S, Atalan N, Tekeli A, Aljodi M, Civelek A, Arsan S: Thromboelastography-based transfusion algorithm reduces blood product use after elective CABG: A prospective randomized study. J Card Surg 2009; 24:404-10
9. Westbrook AJ, Olsen J, Bailey M, Bates J, Scully M, Salamon-sen RF: Protocol based on thromboelastograph (TEG) outperforms physician preference using laboratory coagulation tests to guide blood replacement during and after cardiac surgery: A pilot study. Heart Lung Circ 2009; 18:277-88
10. Girdauskas E, Kempfert J, Kuntze T, Borger MA, Enders J, Fassl J, Falk V, Mohr FW: Thromboelastometrically guided transfusion protocol during aortic surgery with circulatory arrest: A prospective, randomized trial. J Thorac Cardiovasc Surg 2010; 140:1117-24.e2
11. Luddington RJ: Thrombelastography/thromboelastometry. Clin Lab Haematol 2005; 27:81-90
12. Rahe-Meyer N, Solomon C, Winterhalter M, Piepenbrock S, Tanaka K, Haverich A, Pichlmaier M: Thromboelastometry-guided administration of fibrinogen concentrate for the treatment of excessive intraoperative bleeding in thoracoabdomi-nal aortic aneurysm surgery. J Thorac Cardiovasc Surg 2009; 138:694-702
13. Tth O, Calatzis A, Penz S, Losonczy H, Siess W: Multiple electrode aggregometry: A new device to measure platelet aggregation in whole blood. Thromb Haemost 2006; 96: 781-8
14. Cardinal DC, Flower RJ: The electronic aggregometer: A novel device for assessing platelet behavior in blood. J Pharmacol Methods 1980; 3:135-58
15. The Board of the German Medical Association on the Recommendation of the Scientific Advisory Board: Cross-sectional guidelines for therapy with blood components and plasma derivatives(4th revised edition). Transfus Med He-mother 2009; 36:351-482
16. British Committee for Standards in Haematology, Stainsby D, MacLennan S, Thomas D, Isaac J, Hamilton PJ: Guidelines on the management of massive blood loss. Br J Haematol 2006; 135:634-41
17. Society of Thoracic Surgeons Blood Conservation Guideline Task Force, Ferraris VA, Ferraris SP, Saha SP, Hessel EA 2nd, Haan CK, Royston BD, Bridges CR, Higgins RS, Despotis G, Brown JR, Society of Cardiovascular Anesthesiologists Special Task Force on Blood Transfusion, Spiess BD, Shore-Lesserson L, Stafford-Smith M, Mazer CD, Bennett-Guerrero E, Hill SE, Body S: Perioperative blood transfusion and blood conservation in cardiac surgery: The Society of Thoracic Surgeons and The Society of Cardiovascular Anesthesiologists clinical practice guideline. Ann Thorac Surg 2007; 83: S27-86
18. Napolitano LM, Kurek S, Luchette FA, Corwin HL, Barie PS, Tisherman SA, Hebert PC, Anderson GL, Bard MR, Bromberg W, Chiu WC, Cipolle MD, Clancy KD, Diebel L, Hoff WS, Hughes KM, Munshi I, Nayduch D, Sandhu R, Yelon JA; American College of Critical Care Medicine of the Society of Critical Care Medicine; Eastern Association for the Surgery of Trauma Practice Management Workgroup: Clinical practice guideline: Red blood cell transfusion in adult trauma and critical care. Crit Care Med 2009;37: 3124-57
19. Görlinger K, Dirkmann D, Weber CF, Rahe-Meyer N, Hanke AA: Algorithms for transfusion and coagulation management in massive haemorrhage. Anästh Intensivmed 2011; 52: 145-59
20. Görlinger K, Dirkmann D, Hanke AA, Kamler M, Kottenberg E, Thielmann M, Jakob H, Peters J: First-line therapy with coagulation factor concentrates combined with point-of-care coagulation testing is associated with decreased allogeneic blood transfusion in cardiovascular surgery. A retrospective, single-center cohort study. ANESTHESIOLOGY 2011; 115: 1179-91
21. Christensen MC, Krapf S, Kempel A, von Heymann C: Costs of excessive postoperative hemorrhage in cardiac surgery. J Thorac Cardiovasc Surg 2009; 138:687-93
22. Christensen MC, Dziewior F, Kempel A, von Heymann C: Increased chest tube drainage is independently associated with adverse outcome after cardiac surgery. J Cardiothorac Vasc Anesth 2012; 26:46-51
23. Snyder CW, Weinberg JA, McGwin G Jr, Melton SM, George RL, Reiff DA, Cross JM, Hubbard-Brown J, Rue LW 3rd, Kerby JD: The relationship of blood product ratio to mortality: Survival benefit or survival bias? J Trauma 2009; 66:358-62; discussion 362-4
24. Ho AM, Dion PW, Yeung JH, Holcomb JB, Critchley LA, Ng CS, Karmakar MK, Cheung CW, Rainer TH: Prevalence of survivor bias in observational studies on fresh frozen plasma: Erythrocyte ratios in trauma requiring massive transfusion. ANESTHESIOLOGY 2012; 116:716-28
25. Hardy JF, Perrault J, Tremblay N, Robitaille D, Blain R, Carrier M: The stratification of cardiac surgical procedures according to use of blood products: A retrospective analysis of 1480 cases. Can J Anaesth 1991; 38:511-7
26. Goodnough LT, Soegiarso RW, Birkmeyer JD, Welch HG: Economic impact of inappropriate blood transfusions in coronary artery bypass graft surgery. Am J Med 1993; 94:509-14
27. Snyder-Ramos SA, Möhnle P, Weng YS, Böttiger BW, Kulier A, Levin J, Mangano DT; Investigators of the Multicenter Study of Perioperative Ischemia; MCSPI Research Group: The ongoing variability in blood transfusion practices in cardiac surgery. Transfusion 2008; 48:1284-99
28. Shander A, Fink A, Javidroozi M, Erhard J, Farmer SL, Corwin H, Goodnough LT, Hofmann A, Isbister J, Ozawa S, Spahn DR; International Consensus Conference on Transfusion Outcomes Group: Appropriateness of allogeneic red blood cell transfusion: The international consensus conference on transfusion outcomes. Transfus Med Rev 2011;25: 232-46.e53
29. Stanworth SJ, Grant-Casey J, Lowe D, Laffan M, New H, Murphy MF, Allard S: The use of fresh-frozen plasma in England: High levels of inappropriate use in adults and children. Transfusion 2011; 51:62-70
30. Kaushal R, Bates DW, Franz C, Soukup JR, Rothschild JM: Costs of adverse events in intensive care units. Crit Care Med 2007; 35:2479-83
31. Despotis G, Eby C, Lublin DM: A review of transfusion risks and optimal management of perioperative bleeding with cardiac surgery. Transfusion 2008; 48:2S-30S
32. Sniecinski RM, Levy JH: Bleeding and management of coagulopathy. J Thorac Cardiovasc Surg 2011; 142:662-7
33. Kozek-Langenecker SA: Perioperative coagulation monitoring. Best Pract Res Clin Anaesthesiol 2010; 24:27-40
34. Toulon P, Ozier Y, Ankri A, Fleron MH, Leroux G, Samama CM: Point-of-care versus central laboratory coagulation testing during haemorrhagic surgery. A multicenter study. Thromb Haemost 2009; 101:394-401
35. Haas T, Spielmann N, Mauch J, Madjdpour C, Speer O, Schmugge M, Weiss M: Comparison of thromboelastometry (ROTEM®) with standard plasmatic coagulation testing in paediatric surgery. Br J Anaesth 2012; 108:36-41
36. Dirkmann D, Görlinger K, Dusse F, Kottenberg E, Peters J: Early clot firmness accurately predicts maximum clot firmness in thromboelastometry during cardiac surgery. Eur J Anaesthesiol 2010; 27:105-6
37. Venema LF, Post WJ, Hendriks HG, Huet RC, de Wolf JT, de Vries AJ: An assessment of clinical interchangeability of TEG and RoTEM thromboelastographic variables in cardiac surgical patients. Anesth Analg 2010; 111:39-44
38. Görlinger K, Jambor C, Hanke AA, Dirkmann D, Adamzik M, Hartmann M, Rahe-Meyer N: Perioperative coagulation management and control of platelet transfusion by point-of-care platelet function analysis. Transfus Med Hemother 2007; 34:396-411
39. Zacharowski K, Sucker C, Zacharowski P, Hartmann M: Thrombelastography for the monitoring of lipopolysaccha-ride induced activation of coagulation. Thromb Haemost 2006; 95:557-61
40. Reinhöfer M, Brauer M, Franke U, Barz D, Marx G, Lösche W: The value of rotation thromboelastometry to monitor disturbed perioperative haemostasis and bleeding risk in patients with cardiopulmonary bypass. Blood Coagul Fibrino-lysis 2008; 19:212-9
41. Bolliger D, Görlinger K, Tanaka KA: Pathophysiology and treatment of coagulopathy in massive hemorrhage and he-modilution. ANESTHESIOLOGY 2010; 113:1205-19
42. Fenger-Eriksen C, Moore GW, Rangarajan S, Ingerslev J, Sø-rensen B: Fibrinogen estimates are influenced by methods of measurement and hemodilution with colloid plasma expanders. Transfusion 2010; 50:2571-6
43. Larsen OH, Fenger-Eriksen C, Christiansen K, Ingerslev J, Sørensen B: Diagnostic performance and therapeutic consequence of thromboelastometry activated by kaolin versus a panel of specific reagents. ANESTHESIOLOGY 2011; 115:294-302
44. Rahe-Meyer N, Winterhalter M, Boden A, Froemke C, Piepenbrock S, Calatzis A, Solomon C: Platelet concentrates transfusion in cardiac surgery and platelet function assessment by multiple electrode aggregometry. Acta Anaesthesiol Scand 2009; 53:168-75
45. Ferreiro JL, Sibbing D, Angiolillo DJ: Platelet function testing and risk of bleeding complications. Thromb Haemost 2010; 103:1128-35
46. Sibbing D, Steinhubl SR, Schulz S, Schömig A, Kastrati A: Platelet aggregation and its association with stent thrombosis and bleeding in clopidogrel-treated patients: Initial evidence of a therapeutic window. J Am Coll Cardiol 2010; 56:317-8
47. Despotis G, Avidan M, Eby C: Prediction and management of bleeding in cardiac surgery. J Thromb Haemost 2009; 7:111-7