The use of viscoelastic haemostatic assays in goal-directing treatment with allogeneic blood products - A systematic review and meta-analysis

Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine

Volumn 25, Issue 1, 2017, Pages

  Fahrendorff, Mathilde ^a   Oliveri, Roberto S ^a   Johansson, Pär I ^a,b,c  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF ICELAND   (Iceland)

Author keywords

Bleeding; Mortality; ROTEM; TEG; Thrombelastography; Thrombelastometry

Indexed keywords

BLOOD; BLOOD CLOTTING TEST; BLOOD COAGULATION DISORDERS; BLOOD TRANSFUSION; ERYTHROCYTE TRANSFUSION; HEMORRHAGE; HEMOSTASIS; HUMAN; META ANALYSIS; PLASMA; PROCEDURES; RANDOMIZED CONTROLLED TRIAL (TOPIC); THROMBOCYTE TRANSFUSION; THROMBOELASTOGRAPHY;

BLOOD COAGULATION DISORDERS; BLOOD COAGULATION TESTS; BLOOD TRANSFUSION; ERYTHROCYTE TRANSFUSION; HEMORRHAGE; HEMOSTASIS; HUMANS; PLASMA; PLATELET TRANSFUSION; RANDOMIZED CONTROLLED TRIALS AS TOPIC; THROMBELASTOGRAPHY;

EID: 85018486562     PISSN: None     EISSN: 17577241     Source Type: Journal    
DOI: 10.1186/s13049-017-0378-9     Document Type: Review

References (76)

1. Armand R, Hess JR. Treating coagulopathy in trauma patients. Transfus Med Rev. 2003;17(3):223-31.
2. Cosgriff N, Moore EE, Sauaia A, Kenny-Moynihan M, Burch JM, Galloway B. Predicting life-threatening coagulopathy in the massively transfused trauma patient: hypothermia and acidoses revisited. J Trauma. 1997;42(5):857-61. discussion 61-2.
3. Hess JR, Brohi K, Dutton RP, Hauser CJ, Holcomb JB, Kluger Y, et al. The coagulopathy of trauma: a review of mechanisms. J Trauma. 2008;65(4):748-54.
4. Johansson PI, Ostrowski SR, Secher NH. Management of major blood loss: an update. Acta Anaesthesiol Scand. 2010;54(9):1039-49.
5. Johansson PI, Stensballe J, Rasmussen LS, Ostrowski SR. A high admission syndecan-1 level, a marker of endothelial glycocalyx degradation, is associated with inflammation, protein C depletion, fibrinolysis, and increased mortality in trauma patients. Ann Surg. 2011;254(2):194-200.
6. Kashuk JL, Moore EE, Sawyer M, Le T, Johnson J, Biffl WL, et al. Postinjury coagulopathy management: goal directed resuscitation via POC thrombelastography. Ann Surg. 2010;251(4):604-14.
7. Maegele M, Lefering R, Yucel N, Tjardes T, Rixen D, Paffrath T, et al. Early coagulopathy in multiple injury: an analysis from the German trauma registry on 8724 patients. Injury. 2007;38(3):298-304.
8. Ostrowski SR, Johansson PI. Endothelial glycocalyx degradation induces endogenous heparinization in patients with severe injury and early traumatic coagulopathy. J Trauma Acute Care Surg. 2012;73(1):60-6.
9. Simmons JW, Pittet JF, Pierce B. Trauma-induced coagulopathy. Curr Anesthesiol Rep. 2014;4(3):189-99.
10. Shander A, Moskowitz D, Rijhwani TS. The safety and efficacy of "bloodless" cardiac surgery. Semin Cardiothorac Vasc Anesth. 2005;9(1):53-63.
11. Despotis GJ, Avidan MS, Hogue Jr CW. Mechanisms and attenuation of hemostatic activation during extracorporeal circulation. Ann Thorac Surg. 2001;72(5):S1821-31.
12. Johansson PI, Solbeck S, Genet G, Stensballe J, Ostrowski SR. Coagulopathy and hemostatic monitoring in cardiac surgery: an update. Scand Cardiovasc J. 2012;46(4):194-202.
13. Lier H, Krep H, Schroeder S, Stuber F. Preconditions of hemostasis in trauma: a review. The influence of acidosis, hypocalcemia, anemia, and hypothermia on functional hemostasis in trauma. J Trauma. 2008;65(4):951-60.
14. Lamb CM, MacGoey P, Navarro AP, Brooks AJ. Damage control surgery in the era of damage control resuscitation. Br J Anaesth. 2014;113(2):242-9.
15. Undurraga Perl VJ, Leroux B, Cook MR, Watson J, Fair K, Martin DT, et al. Damage-control resuscitation and emergency laparotomy: findings from the PROPPR study. J Trauma Acute Care Surg. 2016;80(4):568-74. discussion 74-5.
16. Holcomb JB, Tilley BC, Baraniuk S, Fox EE, Wade CE, Podbielski JM, et al. Transfusion of plasma, platelets, and red blood cells in a 1:1:1 vs a 1:1:2 ratio and mortality in patients with severe trauma: the PROPPR randomized clinical trial. JAMA. 2015;313(5):471-82.
17. Duchesne JC, Islam TM, Stuke L, Timmer JR, Barbeau JM, Marr AB, et al. Hemostatic resuscitation during surgery improves survival in patients with traumatic-induced coagulopathy. J Trauma. 2009;67(1):33-7. discussion 7-9.
18. Johansson PI, Oliveri RS, Ostrowski SR. Hemostatic resuscitation with plasma and platelets in trauma. J Emerg Trauma Shock. 2012;5(2):120-5.
19. Johansson PI, Stensballe J. Effect of haemostatic control resuscitation on mortality in massively bleeding patients: a before and after study. Vox Sang. 2009;96(2):111-8.
20. Cotton BA, Gunter OL, Isbell J, Au BK, Robertson AM, Morris Jr JA, et al. Damage control hematology: the impact of a trauma exsanguination protocol on survival and blood product utilization. J Trauma. 2008;64(5):1177-82. discussion 82-3.
21. Johansson PI, Stensballe J, Rosenberg I, Hilslov TL, Jorgensen L, Secher NH. Proactive administration of platelets and plasma for patients with a ruptured abdominal aortic aneurysm: evaluating a change in transfusion practice. Transfusion. 2007;47(4):593-8.
22. Gonzalez E, Moore EE, Moore HB, Chapman MP, Chin TL, Ghasabyan A, et al. Goal-directed Hemostatic Resuscitation of Trauma-induced Coagulopathy: A Pragmatic Randomized Clinical Trial Comparing a Viscoelastic Assay to Conventional Coagulation Assays. Ann Surg. 2016;263(6):1051-9.
23. Levrat A, Gros A, Rugeri L, Inaba K, Floccard B, Negrier C, et al. Evaluation of rotation thrombelastography for the diagnosis of hyperfibrinolysis in trauma patients. Br J Anaesth. 2008;100(6):792-7.
24. Murray D, Pennell B, Olson J. Variability of prothrombin time and activated partial thromboplastin time in the diagnosis of increased surgical bleeding. Transfusion. 1999;39(1):56-62.
25. Park MS, Martini WZ, Dubick MA, Salinas J, Butenas S, Kheirabadi BS, et al. Thromboelastography as a better indicator of hypercoagulable state after injury than prothrombin time or activated partial thromboplastin time. J Trauma. 2009;67(2):266-75. discussion 75-6.
26. DerSimonian R, Laird N. Meta-analysis in clinical trials. Control Clin Trials. 1986;7(3):177-88.
27. Higgins JP, Thompson SG. Quantifying heterogeneity in a meta-analysis. Stat Med. 2002;21(11):1539-58.
28. Ak K, Isbir CS, Tetik S, Atalan N, Tekeli A, Aljodi M, et al. Thromboelastography-based transfusion algorithm reduces blood product use after elective CABG: a prospective randomized study. J Card Surg. 2009;24(4):404-10.
29. Avidan MS, Alcock EL, Da Fonseca J, Ponte J, Desai JB, Despotis GJ, et al. Comparison of structured use of routine laboratory tests or near-patient assessment with clinical judgement in the management of bleeding after cardiac surgery. Br J Anaesth. 2004;92(2):178-86.
30. Girdauskas E, Kempfert J, Kuntze T, Borger MA, Enders J, Fassl J, et al. Thromboelastometrically guided transfusion protocol during aortic surgery with circulatory arrest: a prospective, randomized trial. J Thorac Cardiovasc Surg. 2010;140(5):1117-24.e2.
31. Nuttall GA, Oliver WC, Santrach PJ, Bryant S, Dearani JA, Schaff HV, et al. Anesthesiology. 2001;94(5):773-81. discussion 5A-6A.
32. Royston D, von Kier S. Reduced haemostatic factor transfusion using heparinase-modified thrombelastography during cardiopulmonary bypass. Br J Anaesth. 2001;86(4):575-8.
33. Shore-Lesserson L, Manspeizer HE, DePerio M, Francis S, Vela-Cantos F, Ergin MA. Thromboelastography-guided transfusion algorithm reduces transfusions in complex cardiac surgery. Anesth Analg. 1999;88(2):312-9.
34. Weber CF, Gorlinger K, Meininger D, Herrmann E, Bingold T, Moritz A, et al. Point-of-care testing: a prospective, randomized clinical trial of efficacy in coagulopathic cardiac surgery patients. Anesthesiology. 2012;117(3):531-47.
35. Westbrook AJ, Olsen J, Bailey M, Bates J, Scully M, Salamonsen RF. Protocol based on thromboelastograph (TEG) out-performs physician preference using laboratory coagulation tests to guide blood replacement during and after cardiac surgery: a pilot study. Heart Lung Circ. 2009;18(4):277-88.
36. Paniagua P, Koller T, Requena T, Gil JM, Campos JM, Galan J. Randomized controled trial to evaluate postoperative coagulation management with bed-side trombelastometry (Rotem) compared with a transfusion protocol based on laboratory meausurments in bleeding patients after cardiac surgery: Preliminary data. Eur J Anaesthesiol. 2011;28:94.
37. Wang SC, Shieh JF, Chang KY, Chu YC, Liu CS, Loong CC, et al. Thromboelastography-guided transfusion decreases intraoperative blood transfusion during orthotopic liver transplantation: randomized clinical trial. Transplant Proc. 2010;42(7):2590-3.
38. Schaden E, Kimberger O, Kraincuk P, Baron DM, Metnitz PG, Kozek-Langenecker S. Perioperative treatment algorithm for bleeding burn patients reduces allogeneic blood product requirements. Br J Anaesth. 2012;109(3):376-81.
39. De Pietri L, Bianchini M, Montalti R, De Maria N, Di Maira T, Begliomini B, et al. Thrombelastography-guided blood product use before invasive procedures in cirrhosis with severe coagulopathy: A randomized, controlled trial. Hepatology. 2016;63(2):566-73.
40. Cao X, Zhang X, Li Q. Efficacy of thromboelastography to monitor the clinical massive transfusion in scoliosis: a randomized controlled trial. Zhonghua Wai Ke Za Zhi. 2016;54(2):137-41.
41. Barinov SV, Zhukovsky YG, Dolgikh VT, Medyannikova IV. Novel combined strategy of obstetric haemorrhage management during caesarean section using intrauterine balloon tamponade. J Matern Fetal Neonatal Med. 2015:1-21.
42. Shore-Lesserson L, Ammar T, DePerio M, Vela-Cantos F, Fisher C, Sarier K. Platelet-activated clotting time does not measure platelet reactivity during cardiac surgery. Anesthesiology. 1999;91(2):362-8.
43. Weber CF, Klages M, Zacharowski K. Perioperative coagulation management during cardiac surgery. Curr Opin Anaesthesiol. 2013;26(1):60-4.
44. Wikkelso A, Wetterslev J, Moller AM, Afshari A. Thromboelastography (TEG) or thromboelastometry (ROTEM) to monitor haemostatic treatment versus usual care in adults or children with bleeding. Cochrane Database Syst Rev. 2016;8:CD007871.
45. Whiting P, Al M, Westwood M, Ramos IC, Ryder S, Armstrong N, et al. Viscoelastic point-of-care testing to assist with the diagnosis, management and monitoring of haemostasis: A systematic review and cost-effectiveness analysis. Health Technol Assess. 2015;19(58):1-228.
46. Agarwal S, Johnson RI, Shaw M, Agarwal S, Johnson RI, Shaw M. Preoperative Point-of-Care Platelet Function Testing in Cardiac Surgery. J Cardiothorac Vasc Anesth. 2015;29(2):333-41.
47. Branco BC, Inaba K, Ives C, Okoye O, Shulman I, David JS, et al. Thromboelastogram evaluation of the impact of hypercoagulability in trauma patients. Shock. 2014;41(3):200-7.
48. Brilej D, Stropnik D, Lefering R, Komadina R. Algorithm for activation of coagulation support treatment in multiple injured patients--cohort study. Eur J Trauma Emerg Surg. 2016;22.
49. Capraro L, Kuitunen A, Salmenperä M, Kekomäki R, Capraro L, Kuitunen A, Salmenperä M, Kekomäki R. On-site coagulation monitoring does not affect hemostatic outcome after cardiac surgery. Acta Anaesthesiol Scand. 2001;45(2):200-6.
50. Despotis GJ, Grishaber JE, Goodnough LT, Despotis GJ, Grishaber JE, Goodnough LT. The effect of an intraoperative treatment algorithm on physicians' transfusion practice in cardiac surgery. Transfusion. 1994;34(4):290-6.
51. Despotis GJ, Santoro SA, Spitznagel E, Kater KM, Cox JL, Barnes P, et al. Prospective evaluation and clinical utility of on-site monitoring of coagulation in patients undergoing cardiac operation. Radiol Med. 1994;87(3):219-28.
52. Dietrich W, Spannagl M, Boehm J, Hauner K, Braun S, Schuster T, et al. Tranexamic acid and aprotinin in primary cardiac operations: an analysis of 220 cardiac surgical patients treated with tranexamic acid or aprotinin. Anesth Analg. 2008;107(5):1487-95.
53. Einersen PM, Moore EE, Chapman MP, Moore HB, Gonzalez E, Silliman CC, et al. Rapid-thrombelastography (r-TEG) thresholds for goal-directed resuscitation of patients at risk for massive transfusion. J Trauma Acute Care Surg. 2016;31.
54. Hajek R, Ruzickova J, Nemec P, Fluger I, Simek M. Thrombelastography in haemostasis monitoring during cardiac surgery. Anesthesia and Analgesia.Conference:2010 Annual Meeting of the International AnesthesiaResearch Society, IARS. Honolulu, HI United States. Conference Start: 20100320. Conference End: 3. Conference Publication: (var.pagings). 110 (3 SUPPL. 1) (pp S101)
55. Hanke AA, Herold U, Dirkmann D, Tsagakis K, Jakob H, Görlinger K, Hanke AA, Herold U, Dirkmann D, Tsagakis K, Jakob H, Görlinger K. Thromboelastometry Based Early Goal-Directed Coagulation Management Reduces Blood Transfusion Requirements, Adverse Events, and Costs in Acute Type A Aortic Dissection: A Pilot Study. Transfus Med Hemother. 2012;39(2):121-8.
56. Harding SA, Mallett SV, Peachey TD, Cox DJ, Harding SA, Mallett SV, Peachey TD, Cox DJ. Use of heparinase modified thrombelastography in liver transplantation. Br J Anaesth. 1997;78(2):175-9.
57. Helm RE, Rosengart TK, Gomez M, Klemperer JD, DeBois WJ, Velasco F, Gold JP, Altorki NK, Lang S, Thomas S, Isom OW, Krieger KH. Comprehensive Multimodality Blood Conservation: 100 Consecutive CABG Operations Without Transfusion. Ann Thorac Surg. 1998;65(1):125-36.
58. Hoenicka M, Rupp P, Müller-Eising K, Deininger S, Kunert A, Liebold A, Gorki H, Hoenicka M, Rupp P, Müller-Eising K, Deininger S, Kunert A, Liebold A, Gorki H. Anticoagulation management during multivessel coronary artery bypass grafting: a randomized trial comparing individualized heparin management and conventional hemostasis management. J Thromb Haemost. 2015;13(7):1196-206.
59. Hopkins JA, Shoemaker WC, Chang PC, Schluchter M, Greenfield S. Clinical trial of an emergency resuscitation algorithm. J Surg Res. 1983;35(3):227-33.
60. Israelian LA, Gromova VV, Lubnin AI. Reducing the frequency of fresh frozen donor plasma transfusion on the basis of the results of thromboelastographic study in neurosurgical patients with intraoperative blood loss. Anesteziologiia i reanimatologiia; 2009
61. Karkouti K, Callum J, Wijeysundera DN, Rao V, Crowther M, Grocott HP, Pinto R, Scales DC, Karkouti K, Callum J, Wijeysundera DN, Rao V, Crowther M, Grocott HP, Pinto R, Scales DC. Point-of-Care Hemostatic Testing in Cardiac SurgeryClinical Perspective. Circulation. 2016;134(16):1152-62.
62. Levin AI, Heine AM, Coetzee JF, Coetzee A, Levin AI, Heine AM, Coetzee JF, Coetzee A. Heparinase Thromboelastography Compared With Activated Coagulation Time for Protamine Titration After Cardiopulmonary Bypass. J Cardiothorac Vasc Anesth. 2014;28(2):224-9.
63. Lier H, Krep H, Schochl H. Coagulation management in the treatment of multiple trauma. Anaesthesist. 2009;58(10):1010-26.
64. McNamara H, Mallaiah S, Barclay P, Chevannes C, Bhalla A, McNamara H, Mallaiah S, Barclay P, Chevannes C, Bhalla A. Coagulopathy and placental abruption: changing management with ROTEM-guided fibrinogen concentrate therapy. Int J Obstet Anesth. 2015;24(2):174-9.
65. Manikappa S, Mehta Y, Juneja R, Trehan N. Changes in transfusion therapy guided by thromboelastograph in cardiac surgery. Clin Pharmacol Ther. 2008;83(3):460-70. Epub 2007 Sep 12.
66. Messenger BM, Craft RM, Carroll RC, Daley BJ, Enderson B, Snider CG. TEG-guided massive transfusion in trauma patients. Anesthesia and Analgesia.Conference:2011 Annual Meeting of the International Anesthesia Research Society, IARS. Vancouver, BC Canada. Conference Start: 20110521. Conference End: 4. Conference Publication: (var.pagings). 112 (5 SUPPL. 1) (no pagination).
67. Mishra PK, Thekkudan J, Sahajanandan R, Gravenor M, Lakshmanan S, Fayaz KM, Luckraz H, Mishra PK, Thekkudan J, Sahajanandan R, Gravenor M, Lakshmanan S, Fayaz KM, Luckraz H. The role of point-of-care assessment of platelet function in predicting postoperative bleeding and transfusion requirements after coronary artery bypass grafting. Ann Card Anaesth. 2015;18(1):45.
68. Naik BI, Pajewski TN, Bogdonoff DL, Zuo Z, Clark P, Terkawi AS, et al. Rotational thromboel astometry-guided blood product management in major spine surgery. Journal of Neurosurgery: Spine. 2015;23(2):239-49.
69. Petricevic M, Biocina B, Milicic D, Konosic S, Svetina L, Lekić A, Zdilar B, Burcar I, Milosevic M, Brahimaj R, Samardzic J, Gasparovic H, Petricevic M, Biocina B, Milicic D, Konosic S, Svetina L, Lekić A, Zdilar B, Burcar I, Milosevic M, Brahimaj R, Samardzic J, Gasparovic H. Bleeding risk assessment using whole blood impedance aggregometry and rotational thromboelastometry in patients following cardiac surgery. J Thromb Thrombolysis. 2013;36(4):514-26.
70. Rahe-Meyer N, Solomon C, Winterhalter M, Piepenbrock S, Tanaka K, Haverich A, Pichlmaier M, Rahe-Meyer N, Solomon C, Winterhalter M, Piepenbrock S, Tanaka K, Haverich A, Pichlmaier M. Thromboelastometry-guided administration of fibrinogen concentrate for the treatment of excessive intraoperative bleeding in thoracoabdominal aortic aneurysm surgery. J Thorac Cardiovasc Surg. 2009;138(3):694-702.
71. Roullet S, Freyburger G, Cruc M, Quinart A, Stecken L, Audy M, Chiche L, Sztark F, Roullet S, Freyburger G, Cruc M, Quinart A, Stecken L, Audy M, Chiche L, Sztark F. Management of bleeding and transfusion during liver transplantation before and after the introduction of a rotational thromboelastometry-based algorithm. Liver Transpl. 2015;21(2):169-79.
72. Smart L, Scharpf DT, Gray NO, Traetow D, Black S, Michaels A, et al. Rotational thromboelastometry (ROTEM) versus conventional coagulation tests during orthotopic liver transplantation: Comparison of intraoperative blood loss, transfusion requirements, and cost. Hepatology.Conference:66th Annual Meeting of the American Association for the Study of Liver Diseases: The Liver Meeting 2015. San Francisco, CA United States. Conference Start: 20151113. Conference End: 7. Conference Publication: (var.pagings). 62 (pp 832A).
73. Stancheva A, Spassov L, Tzatchev K. Correlation between rotation thrombelastometry ROTEM analysis and standard haemostatic parameters during liver transplantation. Clin Lab. 2011;57(5-6):407-13.
74. Tarabarin OA, Tkachenko AI, Salekh EN, Kushnir OS, Zarutskii IL, Tuchkov AV. [Diagnosis and correction of hemostasis disorder during surgeries for bile duct diseases]. Klinichna khirurhiia / Ministerstvo okhorony zdorov'ia Ukrainy, Naukove tovarystvo khirurhiv Ukrainy. 2013.
75. Weitzel NS, Weitzel LB, Epperson LE, Karimpour-Ford A, Tran ZV, Seres T, Weitzel NS, Weitzel LB, Epperson LE, Karimpour-Ford A, Tran ZV, Seres T. Platelet mapping as part of modified thromboelastography (TEG ) in patients undergoing cardiac surgery and cardiopulmonary bypass. Anaesthesia. 2012;67(10):1158-65.
76. Xu L, Wang LF, Yang XC, Li KB, Sun H, Zhang DP, et al. Platelet function monitoring guided antiplatelet therapy in patients receiving high-risk coronary interventions. Chin Med J (Engl). 2014;127(19):3364-70.