Clot formation is associated with fibrinogen and platelet forces in a cohort of severely injured emergency department trauma patients

Shock

Volumn 44, Issue , 2015, Pages 39-44

  White, Nathan J ^a   Newton, Jason C ^b   Martin, Erika J ^b   Mohammed, Bassem M ^b,c   Contaifer, Daniel ^b   Bostic, Jessica L ^b   Brophy, Gretchen M ^d   Spiess, Bruce D ^d   Pusateri, Anthony E ^e   Ward, Kevin R ^f   Brophy, Donald F ^b  

^a UNIVERSITY OF WASHINGTON   (United States)

^b VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^c CAIRO UNIVERSITY   (Egypt)

^d VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e U S ARMY MEDICAL RESEARCH AND MATERIEL COMMAND   (United States)

^f UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

Author keywords

Bleeding; Coagulopathy; Injury; Trauma

Indexed keywords

D DIMER; FIBRINOGEN; KAOLIN; PROTHROMBIN; FIBRIN DEGRADATION PRODUCT; FIBRIN FRAGMENT D;

ACCIDENTAL INJURY; ADULT; ARTICLE; BLOOD CLOTTING; BLOOD CLOTTING DISORDER; BLOOD CLOTTING PARAMETERS; BLOOD SAMPLING; BLUNT TRAUMA; COHORT ANALYSIS; COMPARATIVE STUDY; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; EMERGENCY HEALTH SERVICE; EMERGENCY WARD; FALLING; FIBRIN POLYMERIZATION; GUNSHOT INJURY; HUMAN; INJURY SEVERITY; MAJOR CLINICAL STUDY; PENETRATING TRAUMA; PLATELET CONTRACTILE FORCE; PROSPECTIVE STUDY; PROTHROMBIN TIME; SHOCK; SURGICAL INJURY; THROMBOCYTE FUNCTION; THROMBOELASTOGRAPHY; TRAUMATIC BRAIN INJURY; BLOOD; BLOOD CLOTTING TEST; CHEMISTRY; CYTOLOGY; DISCRIMINANT ANALYSIS; EMERGENCY MEDICINE; HOSPITAL EMERGENCY SERVICE; MIDDLE AGED; REGRESSION ANALYSIS; THROMBOCYTE; TIME FACTOR; WOUNDS AND INJURIES; YOUNG ADULT;

ADULT; BLOOD COAGULATION; BLOOD COAGULATION TESTS; BLOOD PLATELETS; CROSS-SECTIONAL STUDIES; DISCRIMINANT ANALYSIS; EMERGENCY MEDICINE; EMERGENCY SERVICE, HOSPITAL; FIBRIN FIBRINOGEN DEGRADATION PRODUCTS; FIBRINOGEN; HUMANS; KAOLIN; MIDDLE AGED; PROSPECTIVE STUDIES; PROTHROMBIN TIME; REGRESSION ANALYSIS; THROMBELASTOGRAPHY; TIME FACTORS; WOUNDS AND INJURIES; YOUNG ADULT;

EID: 84922247459     PISSN: 10732322     EISSN: 15400514     Source Type: Journal    
DOI: 10.1097/SHK.0000000000000342     Document Type: Article

References (24)

1. Eastridge BJ, Mabry RL, Seguin P, Cantrell J, Tops T, Uribe P, Mallett O, Zubko T, Oetjen-Gerdes L, Rasmussen TE, et al.: Death on the battlefield (2001Y2011): implications for the future of combat casualty care. J Trauma Acute Care Surg 73(6 Suppl 5):S431-S437, 2012.
2. Kelly JF, Ritenour AE, McLaughlin DF: Injury severity and causes of death from operation Iraqi freedom and operation enduring freedom: 2003Y2004 versus 2006. J Trauma Acute Care Surg 64(2):S21-S26, 2008.
3. Evans JA, van Wessem KJP, McDougall D, Lee KA, Lyons T, Balogh ZJ: Epidemiology of traumatic deaths: comprehensive population-based assessment. World J Surg 34(1):158-163, 2010.
4. Jenkins DH, Rappold JF, Badloe JF, Berséus O, Blackbourne L, Brohi KH, Butler FK, Cap AP, Cohen MJ, Davenport R, et al.: Trauma hemostasis and oxygenation research position paper on remote damage control resuscitation: definitions, current practice, and knowledge gaps. Shock 41(Suppl 1): 3-12, 2014.
5. Hess JR, Brohi K, Dutton RP: The coagulopathy of trauma: A review of mechanisms. J Trauma Acute Care Surg 65(4):748-754, 2008.
6. Niles SE, McLaughlin DF, Perkins JG: Increased mortality associated with the early coagulopathy of trauma in combat casualties. J Trauma Acute Care Surg 64(6):1459-1463, 2008.
7. Maegele M, Lefering R, Yucel N: Early coagulopathy in multiple injury: An analysis from the German Trauma Registry on 8724 patients. Injury 38(3): 298-304, 2007.
8. Brohi K, Cohen MJ, Davenport RA: Acute coagulopathy of trauma: mechanism, identification and effect. Curr Opin Crit Care 13(6):680-685, 2007.
9. Brohi K, Cohen MJ, Ganter MT, Matthay MA, Mackersie RC, Pittet J: Acute traumatic coagulopathy: initiated by hypoperfusion: modulated through the protein C pathway? Ann Surg 245(5):812-818, 2007.
10. Davenport R, Manson J, De'Ath H, Platton S, Coates A, Allard S, Hart D, Pearse R, Pasi KJ, MacCallum P, et al.: Functional definition and characterization of acute traumatic coagulopathy. Crit Care Med 39(12):2652-2658, 2011.
11. Nystrup KB, Windelov NA, Thomsen AB, Johansson PI: Reduced clot strength upon admission, evaluated by thrombelastography (TEG), in trauma patients is independently associated with increased 30-day mortality. Scand J Trauma Resusc Emerg Med 19:52, 2011.
12. Schöchl H, Frietsch T, Pavelka M, Jámbor C: Hyperfibrinolysis after major trauma: differential diagnosis of lysis patterns and prognostic value of thromboelastometry. J Trauma Acute Care Surg 67(1):125-131, 2007.
13. Carr ME: Development of platelet contractile force as a research and clinical measure of platelet function. Cell Biochem Biophys 38(1):55-78, 2003.
14. Hiippala ST, Myllyki GJ, Vahtera EM: Hemostatic factors and replacement of major blood loss with plasma-poor red cell concentrates. Anesth Analg 81:360-365, 1995.
15. Kutcher ME, Redick BJ, McCreery RC, Crane IM, Greenberg MD, Cachola LM, Nelson MF, Cohen MJ: Characterization of platelet dysfunction after trauma. J Trauma Acute Care Surg 73(1):13-19, 2012.
16. Raza I, Davenport R, Rourke C, Platton S, Manson J, Spoors C, Khan S, De'Ath HD, Allard S, Hart DP, et al.: The incidence and magnitude of fibrinolytic activation in trauma patients. J Thromb Haemost 11(2):307-314, 2013.
17. Rourke C, Curry N, Khan S, Taylor R, Raza I, Davenport R, Stanworth S, Brohi K: Fibrinogen levels during trauma hemorrhage, response to replacement therapy, and association with patient outcomes. J Thromb Haemost 10(7): 1342-1351, 2012.
18. Yanagida Y1, Gando S, Sawamura A, Hayakawa M, Uegaki S, Kubota N, Homma T, Ono Y, Honma Y, Wada T, et al.: Normal prothrombinase activity, increased systemic thrombin activity, and lower antithrombin levels in patients with disseminated intravascular coagulation at an early phase of trauma: comparison with acute coagulopathy of trauma-shock. Surgery 154(1):48-57, 2013.
19. Kornblith LZ, Kutcher ME, Redick BJ, Calfee CS, Vilardi RF, Cohen MJ: Fibrinogen and platelet contributions to clot formation: implications for trauma resuscitation and thromboprophylaxis. J Trauma Acute Care Surg 76(2): 255-256, 2014.
20. Shenkman B, Einav Y, Livnat T, Budnik I, Martinowitz U: In vitro evaluation of clot quality and stability in a model of severe thrombocytopenia: Effect of fibrinogen, factor XIII and thrombin-Activatable fibrinolysis inhibitor. Blood Transfus 12(1):78-84, 2014.
21. Shenkman B, Livnat T, Misgav M, Budnik I, Einav Y, Martinowitz U: The in vivo effect of fibrinogen and factor XIII on clot formation and fibrinolysis in Glanzmann's thrombasthenia. Platelets 23(8):604-610, 2012.
22. Velik-Salchner C, Haas T, Innerhofer P, Streif W, Nussbaumer W, Klingler A, Klima G, Martinowitz U, Fries D: The effect of fibrinogen concentrate on thrombocytopenia. J Thromb Haemost 5(5):1019-1025, 2007.
23. Kutcher ME, Ferguson AR, Cohen MJ: A principal component analysis of coagulation after trauma. J Trauma Acute Care Surg 74(5):1223-1229, 2013.
24. Cohen MJ, Grossman AD, Morabito D, Knudson MM, Butte AJ, Manley GT: Identification of complex metabolic states in critically injured patients using bioinformatic cluster analysis. Crit Care 14(1):R10, 2010.