Viscoelastometry guided fresh frozen plasma infusion for postpartum haemorrhage: OBS2, an observational study

British Journal of Anaesthesia

Volumn 119, Issue 3, 2017, Pages 422-434

  Collins, P W ^a   Cannings John, R ^a   Bruynseels, D ^b   Mallaiah, S ^c   Dick, J ^d   Elton, C ^e   Weeks, A ^f   Sanders, J ^a   Aawar, N ^a   Townson, J ^a   Hood, K ^a   Hall, J ^a   Harding, K ^g   Gauntlett, R ^h   Collis, R ^b  

^a CARDIFF UNIVERSITY   (United Kingdom)

^b CARDIFF AND VALE UNIVERSITY HEALTH BOARD   (United Kingdom)

^c LIVERPOOL WOMEN S HOSPITAL   (United Kingdom)

^d UNIVERSITY COLLEGE HOSPITAL   (United Kingdom)

^e LEICESTER ROYAL INFIRMARY   (United Kingdom)

^f UNIVERSITY OF LIVERPOOL   (United Kingdom)

^g GUY'S AND ST THOMAS' NHS FOUNDATION TRUST   (United Kingdom)

^h ROYAL VICTORIA INFIRMARY   (United Kingdom)

Author keywords

fresh frozen plasma; postpartum haemorrhage; viscoelastometric test

Indexed keywords

FIBRINOGEN; FRESH FROZEN PLASMA;

ADULT; CLINICAL ASSESSMENT; COHORT ANALYSIS; CONFERENCE PAPER; CONTROLLED STUDY; ERYTHROCYTE TRANSFUSION; FEMALE; FIBRINOGEN BLOOD LEVEL; HUMAN; INTERVENTION STUDY; LABORATORY TEST; MAJOR CLINICAL STUDY; MEASUREMENT; OBSERVATIONAL STUDY; OUTCOME ASSESSMENT; PARTIAL THROMBOPLASTIN TIME; PLASMA TRANSFUSION; POINT OF CARE TESTING; POSTPARTUM HEMORRHAGE; PRIORITY JOURNAL; PROTHROMBIN TIME; RANDOMIZED CONTROLLED TRIAL; THROMBOELASTOGRAPHY; VISCOELASTOMETRY; ADOLESCENT; BLOOD TRANSFUSION; DOUBLE BLIND PROCEDURE; MIDDLE AGED; PLASMA; PROCEDURES; TREATMENT OUTCOME; YOUNG ADULT;

ADOLESCENT; ADULT; BLOOD TRANSFUSION; COHORT STUDIES; DOUBLE-BLIND METHOD; FEMALE; HUMANS; MIDDLE AGED; PLASMA; POSTPARTUM HEMORRHAGE; THROMBELASTOGRAPHY; TREATMENT OUTCOME; YOUNG ADULT;

EID: 85029805178     PISSN: 00070912     EISSN: 14716771     Source Type: Journal    
DOI: 10.1093/bja/aex245     Document Type: Conference Paper

References (32)

1. Allard S, Green L, Hunt BJ. How we manage the haematologi-cal aspects of major obstetric haemorrhage. Br J Haematol 2014; 164: 177-88
2. Collins PW, Kadir R, Thachil J. Management of coagulopathy associated with postpartum haemorrhage: guidance from the SSC of ISTH. J Thromb Haemost 2016; 14: 205-10
3. Collis RE, Collins PW. Haemostatic management of obstetric haemorrhage. Anaesthesia 2015; 70: 78-86
4. Mavrides E, Allard S, Chandraharan E, et al. Prevention and management of postpartum haemorrhage. Br J Obstet Gynaecol 2016; 124: e106-e149
5. Solomon C, Collis RE, Collins PW. Haemostatic monitoring during postpartum haemorrhage and implications for management. Br J Anaesth 2012; 109: 851-63
6. Shields LE, Smalarz K, Reffigee L, et al. Comprehensive maternal hemorrhage protocols improve patient safety and reduce utilization of blood products. Am J Obstet Gynecol 2011; 205: 368
7. Shields LE, Wiesner S, Fulton J, Pelletreau B. Comprehensive maternal hemorrhage protocols reduce the use of blood products and improve patient safety. Am J Obstet Gynecol 2015; 212: 272-80
8. Klein AA, Arnold P, Bingham RM, et al. AAGBI guidelines: the use of blood components and their alternatives 2016. Anaesthesia 2016; 71: 829-42
9. Pacheco LD, Saade GR, Costantine MM, Clark SL, Hankins GDV. The role of massive transfusion protocols in obstetrics. Am J Perinatol 2013; 30: 1-4
10. Pasquier P, Gayat E, Rackelboom T, et al. An observational study of the fresh frozen plasma: red blood cell ratio in post-partum hemorrhage. Anesth Analg 2013; 116: 155-61
11. Saule I, Hawkins N. Transfusion practice in major obstetric haemorrhage: lessons from trauma. Int J Obstet Anesth 2012; 21: 79-83
12. Frith D, Brohi K. The pathophysiology of trauma-induced coagulopathy. Curr Opin Crit Care 2012; 18: 631-6
13. Davenport R, Brohi K. Causes of trauma-induced coagulop-athy. Curr Opin Anesthesiol 2016; 29: 212-9
14. Mallaiah S, Chevannes C, McNamara H, Barclay P. A reply. Anaesthesia 2015; 70: 760-1
15. Mallaiah S, Barclay P, Harrod I, Chevannes C, Bhalla A. Introduction of an algorithm for ROTEM-guided fibrinogen concentrate administration in major obstetric haemorrhage. Anaesthesia 2015; 70: 166-75
16. Teofili L, Bianchi M, Zanfini BA, et al. Acute lung injury complicating blood transfusion in post-partum hemorrhage: Incidence and risk factors. Mediterr J Hematol Infect Dis 2014; 6: e2014069
17. De Lloyd L, Bovington R, Kaye A, et al. Standard haemostatic tests following major obstetric haemorrhage. Int J Obstet Anesth 2011; 20: 135-41
18. Huissoud C, Carrabin N, Audibert F, et al. Bedside assessment of fibrinogen level in postpartum haemorrhage by thrombe-lastometry. BJOG 2009; 116: 1097-102
19. Collins PW, Lilley G, Bruynseels D, et al. Fibrin-based clot formation as an early and rapid biomarker for progression of postpartum hemorrhage: a prospective study. Blood 2014; 124: 1727-36
20. Collins PW, Cannings-John R, Bruynseels D, et al. Viscoelastometric-guided early fibrinogen concentrate replacement during postpartum haemorrhage: a double blind randomised controlled trial: OBS2. Br J Anaesth 2017; 119: 411-21
21. Aawar N, Alikhan R, Bruynseels D, et al. Fibrinogen concentrate versus placebo for treatment of postpartum haemorrhage: study protocol for a randomised controlled trial. Trials 2015; 16
22. Lilley G, Burkitt St Laurent D, Precious E, et al. Measurement of blood loss during postpartum haemorrhage. Int J Obstet Anesth 2015; 24: 8-14
23. Levi M. Pathogenesis and management of peripartum coagulopathic calamities (disseminated intravascular coag-ulation and amniotic fluid embolism). Thromb Res 2013; 131: S32-4
24. McNamara H, Mallaiah S, Barclay P, Chevannes C, Bhalla A. Coagulopathy and placental abruption: changing management with ROTEM-guided fibrinogen concentrate therapy. Int J Obstet Anesth 2015; 24: 174-90
25. Thachil J, Toh CH. Disseminated intravascular coagulation in obstetric disorders and its acute haematological management. Blood Rev 2009; 23: 167-76
26. Jones R, Hamlyn V, Collis RE, et al. Platelets in postpartum haemorrhage. Int J Obstet Anesth 2015; 24: S10
27. Charbit B, Mandelbrot L, Samain E, et al. The decrease of fibri-nogen is an early predictor of the severity of postpartum hemorrhage. J Thromb Haemost 2007; 5: 266-73
28. Cortet M, Deneux-Tharaux C, Dupont C, et al. Association between fibrinogen level and severity of postpartum haemorrhage: Secondary analysis of a prospective trial. Br J Anaesth 2012; 108: 984-9
29. Gayat E, Resche-Rigon M, Morel O, et al. Predictive factors of advanced interventional procedures in a multicentre severe postpartum haemorrhage study. Intensive Care Med 2011; 37: 1816-25
30. Wikkelsø AJ, Edwards HM, Afshari A, et al. Pre-emptive treat-ment with fibrinogen concentrate for postpartum haemorrhage: randomized controlled trial. Br J Anaesth 2015; 114: 623-33
31. Ickx B, Samama CM. Fibrinogen concentrates for post-partum haemorrhage? Do not miss the most relevant population! Br J Anaesth 2015; 114: 548-50
32. Sentilhes L, Lasocki S, Ducloy-Bouthors AS, et al. Tranexamic acid for the prevention and treatment of postpartum hae-morrhage. Br J Anaesth 2015; 114: 576-87