Transfusion in trauma: Thromboelastometry-guided coagulation factor concentrate-based therapy versus standard fresh frozen plasma-based therapy

Critical Care

Volumn 15, Issue 2, 2011, Pages

  Schöchl, Herbert ^a,b   Nienaber, Ulrike ^c   Maegele, Marc ^c   Hochleitner, Gerald ^d   Primavesi, Florian ^b   Steitz, Beatrice ^e   Arndt, Christian ^f   Hanke, Alexander ^g   Voelckel, Wolfgang ^b   Solomon, Cristina ^e  

^a LUDWIG BOLTZMANN INSTITUTE FOR LUNG VASCULAR RESEARCH   (Austria)

^b AUVA Trauma Centre   (Austria)

^c UNIVERSITY OF WITTEN HERDECKE   (Germany)

^d Cologne Merheim Medical Centre ^*  (United Kingdom)

^e Salzburger Landeskliniken   (Austria)

^f UNIVERSITY HOSPITAL MARBURG   (Germany)

^g HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

FIBRINOGEN; FRESH FROZEN PLASMA; PROTHROMBIN COMPLEX; THROMBOCYTE CONCENTRATE;

ADULT; AGED; ARTICLE; AUSTRIA; BLOOD COMPONENT THERAPY; EMERGENCY CARE; EMERGENCY WARD; FEMALE; HEMOSTASIS; HUMAN; INJURY; MAJOR CLINICAL STUDY; MALE; PLASMA TRANSFUSION; PRIORITY JOURNAL; RETROSPECTIVE STUDY; THROMBOCYTE TRANSFUSION;

EID: 79952197748     PISSN: 13648535     EISSN: 1466609X     Source Type: Journal    
DOI: 10.1186/cc10078     Document Type: Article

References (45)

1. Brohi K, Singh J, Heron M, Coats T. Acute traumatic coagulopathy. J Trauma 2003, 54:1127-1130. 10.1097/01.TA.0000069184.82147.06, 12813333.
2. Rossaint R, Bouillon B, Cerny V, Coats TJ, Duranteau J, Fernandez-Mondejar E, Hunt BJ, Komadina R, Nardi G, Neugebauer E, Ozier Y, Riddez L, Schultz A, Stahel PF, Vincent JL, Spahn DR. Management of bleeding following major trauma: an updated European guideline. Crit Care 2010, 14:R52. 10.1186/cc8943, 2887168, 20370902.
3. Holcomb JB, Jenkins D, Rhee P, Johannigman J, Mahoney P, Mehta S, Cox ED, Gehrke MJ, Beilman GJ, Schreiber M, Flaherty SF, Grathwohl KW, Spinella PC, Perkins JG, Beekley AC, McMullin NR, Park MS, Gonzalez EA, Wade CE, Dubick MA, Schwab CW, Moore FA, Champion HR, Hoyt DB, Hess JR. Damage control resuscitation: directly addressing the early coagulopathy of trauma. J Trauma 2007, 62:307-310. 10.1097/TA.0b013e3180324124, 17297317.
4. Ketchum L, Hess JR, Hiippala S. Indications for early fresh frozen plasma, cryoprecipitate, and platelet transfusion in trauma. J Trauma 2006, 60:S51-58. 10.1097/01.ta.0000199432.88847.0c, 16763482.
5. Borgman MA, Spinella PC, Perkins JG, Grathwohl KW, Repine T, Beekley AC, Sebesta J, Jenkins D, Wade CE, Holcomb JB. The ratio of blood products transfused affects mortality in patients receiving massive transfusions at a combat support hospital. J Trauma 2007, 63:805-813. 10.1097/TA.0b013e3181271ba3, 18090009.
6. Maegele M, Lefering R, Paffrath T, Tjardes T, Simanski C, Bouillon B. Red-blood-cell to plasma ratios transfused during massive transfusion are associated with mortality in severe multiple injury: a retrospective analysis from the Trauma Registry of the Deutsche Gesellschaft fur Unfallchirurgie. Vox Sang 2008, 95:112-119. 10.1111/j.1423-0410.2008.01074.x, 18557827.
7. Teixeira PG, Inaba K, Shulman I, Salim A, Demetriades D, Brown C, Browder T, Green D, Rhee P. Impact of plasma transfusion in massively transfused trauma patients. J Trauma 2009, 66:693-697. 10.1097/TA.0b013e31817e5c77, 19276739.
8. Snyder CW, Weinberg JA, McGwin G, Melton SM, George RL, Reiff DA, Cross JM, Hubbard-Brown J, Rue LW, Kerby JD. The relationship of blood product ratio to mortality: survival benefit or survival bias?. J Trauma 2009, 66:358-362. 10.1097/TA.0b013e318196c3ac, 19204508.
9. Riskin DJ, Tsai TC, Riskin L, Hernandez-Boussard T, Purtill M, Maggio PM, Spain DA, Brundage SI. Massive transfusion protocols: the role of aggressive resuscitation versus product ratio in mortality reduction. J Am Coll Surg 2009, 209:198-205. 10.1016/j.jamcollsurg.2009.04.016, 19632596.
10. Gonzalez EA, Moore FA, Holcomb JB, Miller CC, Kozar RA, Todd SR, Cocanour CS, Balldin BC, McKinley BA. Fresh frozen plasma should be given earlier to patients requiring massive transfusion. J Trauma 2007, 62:112-119. 10.1097/01.ta.0000250497.08101.8b, 17215741.
11. Schöchl H, Forster L, Woidke R, Solomon C, Voelckel W. Use of rotation thromboelastometry (ROTEM) to achieve successful treatment of polytrauma with fibrinogen concentrate and prothrombin complex concentrate. Anaesthesia 2010, 65:199-203.
12. Schöchl H, Nienaber U, Hofer G, Voelckel W, Jambor C, Scharbert G, Kozek-Langenecker S, Solomon C. Goal-directed coagulation management of major trauma patients using thromboelastometry (ROTEM(R))-guided administration of fibrinogen concentrate and prothrombin complex concentrate. Crit Care 2010, 14:R55. 2887173, 20374650.
13. Lang T, Johanning K, Metzler H, Piepenbrock S, Solomon C, Rahe-Meyer N, Tanaka KA. The effects of fibrinogen levels on thromboelastometric variables in the presence of thrombocytopenia. Anesth Analg 2009, 108:751-758. 10.1213/ane.0b013e3181966675, 19224779.
14. Velik-Salchner C, Haas T, Innerhofer P, Streif W, Nussbaumer W, Klingler A, Klima G, Martinowitz U, Fries D. The effect of fibrinogen concentrate on thrombocytopenia. J Thromb Haemost 2007, 5:1019-1025. 10.1111/j.1538-7836.2007.02481.x, 17461931.
15. Rivera J, Lozano ML, Navarro-Nunez L, Vicente V. Platelet receptors and signaling in the dynamics of thrombus formation. Haematologica 2009, 94:700-711. 10.3324/haematol.2008.003178, 2675683, 19286885.
16. Solomon C, Pichlmaier U, Schoechl H, Hagl C, Raymondos K, Scheinichen D, Koppert W, Rahe-Meyer N. Recovery of fibrinogen after administration of fibrinogen concentrate to patients with severe bleeding after cardiopulmonary bypass surgery. Br J Anaesth 2010, 104:555-562. 10.1093/bja/aeq058, 2855672, 20348140.
17. Dargaud Y, Desmurs-Clavel H, Marin S, Bordet JC, Poplavsky JL, Negrier C. Comparison of the capacities of two prothrombin complex concentrates to restore thrombin generation in plasma from orally anticoagulated patients: an in vitro study. J Thromb Haemost 2008, 6:962-968. 10.1111/j.1538-7836.2008.02964.x, 18373620.
18. Lefering R. Development and validation of the revised injury severity classification score for severely injured patients. Eur J Trauma Emerg Surg 2009, 35:437-447.
19. Davis EG, MacKenzie EJ, Sacco WJ, Bain LW, Buckman RF, Champion HR, Lees PS. A new "TRISS-like" probability of survival model for intubated trauma patients. J Trauma 2003, 55:53-61. 10.1097/01.TA.0000075340.22097.B5, 12855881.
20. Nouwairi NS. The risks of blood transfusions and the shortage of supply leads to the quest for blood substitutes. AANA J 2004, 72:359-364.
21. Spahn DR. Blood substitutes. Crit Care 1999, 3:R91-92. 10.1186/cc363, 137238, 11094487.
22. Dara SI, Rana R, Afessa B, Moore SB, Gajic O. Fresh frozen plasma transfusion in critically ill medical patients with coagulopathy. Crit Care Med 2005, 33:2667-2671. 10.1097/01.CCM.0000186745.53059.F0, 16276195.
23. Sarani B, Dunkman WJ, Dean L, Sonnad S, Rohrbach JI, Gracias VH. Transfusion of fresh frozen plasma in critically ill surgical patients is associated with an increased risk of infection. Crit Care Med 2008, 36:1114-1118. 10.1097/CCM.0b013e318168f89d, 18379235.
24. Serious Hazards Of Transfusion annual report 2007. , http://www.shotuk.org/wp-content/uploads/2010/03/SHOT-Report-2007.pdf
25. Armand R, Hess JR. Treating coagulopathy in trauma patients. Transfus Med Rev 2003, 17:223-231. 10.1016/S0887-7963(03)00022-1, 12881783.
26. Chowdhury P, Saayman AG, Paulus U, Findlay GP, Collins PW. Efficacy of standard dose and 30 ml/kg fresh frozen plasma in correcting laboratory parameters of haemostasis in critically ill patients. Br J Haematol 2004, 125:69-73. 10.1111/j.1365-2141.2004.04868.x, 15015971.
27. Rugeri L, Levrat A, David JS, Delecroix E, Floccard B, Gros A, Allaouchiche B, Negrier C. Diagnosis of early coagulation abnormalities in trauma patients by rotation thrombelastography. J Thromb Haemost 2007, 5:289-295. 10.1111/j.1538-7836.2007.02319.x, 17109736.
28. Schöchl H, Frietsch T, Pavelka M, Jambor C. Hyperfibrinolysis after major trauma: differential diagnosis of lysis patterns and prognostic value of thrombelastometry. J Trauma 2009, 67:125-131.
29. Plotkin AJ, Wade CE, Jenkins DH, Smith KA, Noe JC, Park MS, Perkins JG, Holcomb JB. A reduction in clot formation rate and strength assessed by thrombelastography is indicative of transfusion requirements in patients with penetrating injuries. J Trauma 2008, 64:S64-68. 10.1097/TA.0b013e318160772d, 18376174.
30. Spalding GJ, Hartrumpf M, Sierig T, Oesberg N, Kirschke CG, Albes JM. Cost reduction of perioperative coagulation management in cardiac surgery: value of "bedside" thrombelastography (ROTEM). Eur J Cardiothorac Surg 2007, 31:1052-1057. 10.1016/j.ejcts.2007.02.022, 17398108.
31. Theusinger OM, Spahn DR, Ganter MT. Transfusion in trauma: why and how should we change our current practice?. Curr Opin Anaesthesiol 2009, 22:305-312. 10.1097/ACO.0b013e3283212c7c, 19390257.
32. Girdauskas E, Kempfert J, Kuntze T, Borger MA, Enders J, Fassl J, Falk V, Mohr FV. Thromboelastometrically-guided transfusion protocol during aortic surgery with circulatory arrest: a prospective, randomized trial. J Thorac Cardiovasc Surg 2010, 140:1117-1124. 10.1016/j.jtcvs.2010.04.043, 20951260.
33. Nascimento B, Callum J, Rubenfeld G, Neto JB, Lin Y, Rizoli S. Clinical review: fresh frozen plasma in massive bleedings - more questions than answers. Crit Care 2010, 14:202. 10.1186/cc8205, 2875489, 20156316.
34. Johansson PI, Bochsen L, Stensballe J, Secher NH. Transfusion packages for massively bleeding patients: the effect on clot formation and stability as evaluated by Thrombelastograph (TEG). Transfus Apher Sci 2008, 39:3-8. 10.1016/j.transci.2008.05.012, 18583193.
35. Shander A, Hofmann A, Ozawa S, Theusinger OM, Gombotz H, Spahn DR. Activity-based costs of blood transfusions in surgical patients at four hospitals. Transfusion 2010, 50:753-765. 10.1111/j.1537-2995.2009.02518.x, 20003061.
36. Pabinger I, Tiede A, Kalina U, Knaub S, Germann R, Ostermann H, . Beriplex P/N Anticoagulation Reversal Study Group Impact of infusion speed on the safety and effectiveness of prothrombin complex concentrate: a prospective clinical trial of emergency anticoagulation reversal. Ann Hematol 2010, 89:309-316. 10.1007/s00277-009-0830-7, 19787352, Beriplex P/N Anticoagulation Reversal Study Group.
37. Hauser CJ, Boffard K, Dutton R, Bernard GR, Croce MA, Holcomb JB, Leppaniemi A, Parr M, Vincent JL, Tortella BJ, Dimsits J, Bouillon B, . CONTROL Study Group Results of the CONTROL trial: efficacy and safety of recombinant activated Factor VII in the management of refractory traumatic hemorrhage. J Trauma 2010, 69:489-500. 10.1097/TA.0b013e3181edf36e, 20838118, CONTROL Study Group.
38. Stinger HK, Spinella PC, Perkins JG, Grathwohl KW, Salinas J, Martini WZ, Hess JR, Dubick MA, Simon CD, Beekley AC, Wolf SE, Wade CE, Holcomb JB. The ratio of fibrinogen to red cells transfused affects survival in casualties receiving massive transfusions at an army combat support hospital. J Trauma 2008, 64:S79-85. 10.1097/TA.0b013e318160a57b, 18376176.
39. Fenger-Eriksen C, Jensen TM, Kristensen BS, Jensen KM, Tonnesen E, Ingerslev J, Sorensen B. Fibrinogen substitution improves whole blood clot firmness after dilution with hydroxyethyl starch in bleeding patients undergoing radical cystectomy: a randomized, placebo-controlled clinical trial. J Thromb Haemost 2009, 7:795-802. 10.1111/j.1538-7836.2009.03331.x, 19320829.
40. Rahe-Meyer N, Solomon C, Winterhalter M, Piepenbrock S, Tanaka K, Haverich A, Pichlmaier M. Thromboelastometry-guided administration of fibrinogen concentrate for the treatment of excessive intraoperative bleeding in thoracoabdominal aortic aneurysm surgery. J Thorac Cardiovasc Surg 2009, 138:694-702. 10.1016/j.jtcvs.2008.11.065, 19698858.
41. Rahe-Meyer N, Pichlmaier M, Haverich A, Solomon C, Winterhalter M, Piepenbrock S, Tanaka KA. Bleeding management with fibrinogen concentrate targeting a high-normal plasma fibrinogen level: a pilot study. Br J Anaesth 2009, 102:785-792. 10.1093/bja/aep089, 2683341, 19411671.
42. Bruce D, Nokes TJ. Prothrombin complex concentrate (Beriplex P/N) in severe bleeding: experience in a large tertiary hospital. Crit Care 2008, 12:R105. 10.1186/cc6987, 2575594, 18706082.
43. Schick KS, Fertmann JM, Jauch KW, Hoffmann JN. Prothrombin complex concentrate in surgical patients: retrospective evaluation of vitamin K antagonist reversal and treatment of severe bleeding. Crit Care 2009, 13:R191. 10.1186/cc8186, 2811941, 19948037.
44. Dickneite G, Pragst I. Prothrombin complex concentrate vs fresh frozen plasma for reversal of dilutional coagulopathy in a porcine trauma model. Br J Anaesth 2009, 102:345-354. 10.1093/bja/aen391, 2642652, 19168856.
45. Fries D, Innerhofer P, Perger P, Gütl M, Heil S, Hofmann N, Kneifl W, Neuner L, Pernerstorfer T, Pfanner G, Schöchl H, Ziegler B, Köblinger C, Kozek-Langenecker S. [Coagulation management in trauma-related massive bleeding. Recommendations of the Task Force for Coagulation (AGPG) of the Austrian Society of Anesthesiology, Resuscitation and Intensive Care Medicine (OGARI)]. Anasthesiol Intensivmed Notfallmed Schmerzther 2010, 45:552-561. 10.1055/s-0030-1265746, 20839143.