Mortality from trauma haemorrhage and opportunities for improvement in transfusion practice

British Journal of Surgery

Volumn 103, Issue 4, 2016, Pages 357-365

  Stanworth, S J ^a   Davenport, R ^c   Curry, N ^b   Seeney, F ^d   Eaglestone, S ^c   Edwards, A ^e   Martin, K ^d   Allard, S ^f   Woodford, M ^e   Lecky, F E ^f   Brohi, K ^c  

^a JOHN RADCLIFFE HOSPITAL   (United Kingdom)

^b CHURCHILL HOSPITAL   (United Kingdom)

^c QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^d NHS BLOOD AND TRANSPLANT   (United Kingdom)

^e UNIVERSITY OF MANCHESTER   (United Kingdom)

^f UNIVERSITY OF SHEFFIELD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; BLOOD TRANSFUSION; CLINICAL TRIAL; COMPLICATION; CROSS-SECTIONAL STUDY; EMERGENCY HEALTH SERVICE; ENGLAND; EPIDEMIOLOGY; FEMALE; FOLLOW UP; HEMORRHAGE; HOSPITAL MORTALITY; HUMAN; INJURY SCALE; INTENSIVE CARE; MALE; MIDDLE AGED; MORTALITY; MULTICENTER STUDY; MULTIPLE TRAUMA; PROCEDURES; PROSPECTIVE STUDY; STANDARDS; TIME FACTOR; TREATMENT OUTCOME; TRENDS; YOUNG ADULT;

ADULT; BLOOD TRANSFUSION; CRITICAL CARE; CROSS-SECTIONAL STUDIES; ENGLAND; FEMALE; FOLLOW-UP STUDIES; HEMORRHAGE; HOSPITAL MORTALITY; HUMANS; INJURY SEVERITY SCORE; MALE; MIDDLE AGED; MULTIPLE TRAUMA; PROSPECTIVE STUDIES; TIME FACTORS; TRAUMA CENTERS; TREATMENT OUTCOME; YOUNG ADULT;

EID: 84959063040     PISSN: 00071323     EISSN: 13652168     Source Type: Journal    
DOI: 10.1002/bjs.10052     Document Type: Article

References (26)

1. Sauaia A, Moore FA, Moore EE, Moser KS, Brennan R, Read RA, et al,. Epidemiology of trauma deaths: a reassessment. J Trauma 1995; 38: 185-193.
2. World Health Organization. World Health Statistics. World Health Organization: Geneva, 2011.
3. Mock C., Strengthening care for the injured globally. J Trauma 2011; 70: 1307-1316.
4. Evans JA, van Wessem KJ, McDougall D, Lyons T, Balogh ZJ,. Epidemiology of traumatic deaths: comprehensive population-based assessment. World J Surg 2010; 34: 158-163.
5. Curry NS, Davenport RA, Hunt BJ, Stanworth SJ,. Transfusion strategies for traumatic coagulopathy. Blood Rev 2012; 26: 223-232.
6. NHS England. Urgent and Emergency Care Services in England. http://www.nhs.uk/NHSEngland/AboutNHSservices/Emergencyandurgentcareservices/Pages/Majortraumaservices.aspx [accessed 1 March 2015].
7. Davenport R, Curry N, Manson J, De'Ath H, Coates A, Rourke C, et al,. Hemostatic effects of fresh frozen plasma may be maximal at red cell ratios of 1: 2. J Trauma 2011; 70: 90-95.
8. Fuller G, Bouamra O, Woodford M, Jenks T, Stanworth S, Allard S, et al,. Recent massive blood transfusion practice in England and Wales: view from a trauma registry. Emerg Med J 2011; 29: 118-123.
9. Dzik WH, Blajchman MA, Fergusson D, Hameed M, Henry B, Kirkpatrick AW, et al,. Clinical review: Canadian National Advisory Committee on Blood and Blood Products-Massive Transfusion Consensus Conference 2011: report of the panel. Crit Care 2011; 15: 242.
10. Borgman MA, Spinella PC, Perkins JG, Grathwohl KW, Repine T, Beekley AC, et al,. The ratio of blood products transfused affects mortality in patients receiving massive transfusions at a combat support hospital. J Trauma 2007; 63: 805-813.
11. Holcomb JB, Wade CE, Michalek JE, Chisholm GB, Zarzabal LA, Schreiber MA, et al,. Increased plasma and platelet to red blood cell ratios improves outcome in 466 massively transfused civilian trauma patients. Ann Surg 2008; 248: 447-458.
12. Gunter OL Jr, Au BK, Isbell JM, Mowery NT, Young PP, Cotton BA,. Optimizing outcomes in damage control resuscitation: identifying blood product ratios associated with improved survival. J Trauma 2008; 65: 527-534.
13. Maegele M, Lefering R, Paffrath T, Tjardes T, Simanski C, Bouillon B,;, Working Group, on Polytrauma of the German Society of Trauma Surgery (DGU). Red-blood-cell to plasma ratios transfused during massive transfusion are associated with mortality in severe multiple injury: a retrospective analysis from the Trauma Registry of the Deutsche Gesellschaft für Unfallchirurgie. Vox Sang 2008; 95: 122-129.
14. Spinella PC, Holcomb JB,. Resuscitation and transfusion principles for traumatic hemorrhagic shock. Blood Rev 2009; 23: 231-240.
15. Phan HH, Wisner DH,. Should we increase the ratio of plasma/platelets to red blood cells in massive transfusion: what is the evidence? Vox Sang 2010; 98: 395-402.
16. Johansson PI, Stensballe J,. Hemostatic resuscitation for massive bleeding: the paradigm of plasma and platelets-a review of the current literature. Transfusion 2010; 50: 701-710.
17. Dente CJ, Shaz BH, Nicholas JM, Harris RS, Wyrzykowski AD, Patel S, et al,. Improvements in early mortality and coagulopathy are sustained better in patients with blunt trauma after institution of a massive transfusion protocol in a civilian level 1 trauma centre. J Trauma 2009; 66: 1616-1624.
18. Riskin DJ, Tsai TC, Riskin L, Hernandez-Boussard T, Purtill M, Maggio PM, et al,. Massive transfusion protocols: the role of aggressive resuscitation versus product ratio in mortality reduction. J Am Coll Surg 2009; 209: 198-205.
19. National Statistics,. Mortality Statistics: Review of the Registrar General on Deaths in England and Wales, 2005. Series DH1 no. 38. Office for National Statistics: London, 2007.
20. Bulger EM, Snyder D, Schoelles K, Gotschall C, Dawson D, Lang E, et al,. An evidence-based prehospital guideline for external haemorrhage control: American College of Surgeons Committee on Trauma. Prehosp Emerg Care 2014; 18: 163-173.
21. Morrison JJ, Ross JD, Rasmussen TE, Midwinter MJ, Jansen JO,. Resuscitative endovascular balloon occlusion of the aorta: a gap analysis of severely injured UK combat casualties. Shock 2014; 41: 388-393.
22. Khan S, Davenport R, Raza I, Glasgow S, De'Ath HD, Johansson PI, et al,. Damage control resuscitation using blood component therapy in standard doses has a limited effect on coagulopathy during trauma haemorrhage. Intensive Care Med 2015; 41: 239-247.
23. Holcomb J, Tilley B, Baraniuk S, Fox EE, Wade CE, Podbielski JM, et al,.; PROPPR Study Group. Transfusion of plasma, platelets, and red blood cells in a 1: 1: 1 vs a 1: 1: 2 ratio and mortality in patients with severe trauma. The PROPPR randomized clinical trial. JAMA 2015; 313: 471-482.
24. Holcomb JB, del Junco DJ, Fox EE, Wade CE, Cohen MJ, Schreiber MA, et al,.; PROMMPT Study Group. The prospective, observational, mulitcenter, major trauma transfusion (PROMMTT) study: comparative effectiveness of a time-varying treatment with competing risks. JAMA Surg 2013; 148: 127-136.
25. Rourke C, Curry N, Khan S, Taylor R, Raza I, Davenport R, et al,. Fibrinogen levels during trauma haemorrhage, response to replacement therapy and association with patient outcomes. J Thromb Haemost 2012; 10: 1342-1351.
26. Frolich M, Lefering R, Probst C, Paffrath T, Schneider MM, Maegele M, et al,.; Committee on Emergency Medicine, Intensive Care and Trauma Management of the German Trauma Society Sektion NIS. Epidemiology and risk factors of multiple-organ failure after multiple trauma: an analysis of 31 154 patients from the TraumaRegister DGU. J Trauma Acute Care Surg 2014; 76: 921-927.