Thromboelastometry (ROTEM®) in children: Age-related reference ranges and correlations with standard coagulation tests

British Journal of Anaesthesia

Volumn 105, Issue 6, 2010, Pages 827-835

  Oswald, E ^a   Stalzer, B ^a   Heitz, E ^b   Weiss, M ^b   Schmugge, M ^b   Strasak, A ^a   Innerhofer, P ^a   Haas, T ^a  

^a INNSBRUCK MEDICAL UNIVERSITY   (Austria)

^b UNIVERSITY CHILDREN S HOSPITAL   (Switzerland)

Author keywords

blood, coagulation; gender; measurement techniques, thromboelastograph; paediatrics; thromboelastometry

Indexed keywords

ALFENTANIL; ANTITHROMBIN; ATRACURIUM; BLOOD CLOTTING FACTOR 13; FENTANYL; FIBRINOGEN; MIDAZOLAM; PROPOFOL; REMIFENTANIL; ROCURONIUM; SEVOFLURANE; FIBRIN;

ADOLESCENT; ARTICLE; BLEEDING TENDENCY; BLOOD CLOT LYSIS; BLOOD CLOTTING TEST; CHILD; ELECTIVE SURGERY; FIBRIN POLYMERIZATION; FIBRINOGEN BLOOD LEVEL; GROUPS BY AGE; HUMAN; INFANT; LABORATORY TEST; LYSIS; OBSERVATIONAL STUDY; PARTIAL THROMBOPLASTIN TIME; PRESCHOOL CHILD; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROTHROMBIN TIME; SCHOOL CHILD; THROMBOCYTE COUNT; THROMBOELASTOMETRY; AGING; BLOOD; BLOOD SAMPLING; CLINICAL TRIAL; FEMALE; MALE; METABOLISM; METHODOLOGY; MULTICENTER STUDY; NEWBORN; REFERENCE VALUE; REPRODUCIBILITY; SEXUAL DEVELOPMENT; THROMBOELASTOGRAPHY;

ADOLESCENT; AGING; BLOOD COAGULATION TESTS; BLOOD SPECIMEN COLLECTION; CHILD; CHILD, PRESCHOOL; FACTOR XIII; FEMALE; FIBRIN; FIBRINOGEN; HUMANS; INFANT; INFANT, NEWBORN; MALE; REFERENCE VALUES; REPRODUCIBILITY OF RESULTS; SEX CHARACTERISTICS; THROMBELASTOGRAPHY;

EID: 78649484910     PISSN: 00070912     EISSN: 14716771     Source Type: Journal    
DOI: 10.1093/bja/aeq258     Document Type: Article

References (35)

1. Luddington RJ. Thromboelastography/thromboelastometry. Clin Lab Haematol 2005; 27: 81-90
2. Kozek-Langenecker S. Management of massive operative blood loss. Minerva Anestesiol 2007; 73: 401-15
3. Haas T, Fries D, Velik-Salchner C, Oswald E, Innerhofer P. Fibrino-gen in craniosynostosis surgery. Anesth Analg 2008; 106: 725-31
4. Mittermayr M, Streif W, Haas T, et al. Hemostatic changes following crystalloid or colloid fluid administration during major orthopedic surgery: role of fibrinogen administration. Anesth Analg 2007; 105: 905-17
5. Lang T, Bauters A, Braun SL, et al. Multi-centre investigation on reference ranges for ROTEM thromboelastometry. Blood Coagul Fibrinolysis 2005; 16: 301-10
6. Strauss T, Levy-Shraga Y, Ravid B, et al. Clot formation of neonates tested by thromboelastography correlates with gestational age. Thromb Haemost 2010; 103: 344-50
7. Haizinger B, Gombotz H, Rehak P, Geiselseder G, Mair R. Activated thrombelastogram in neonates and infants with complex congenital heart disease in comparison with healthy children. Br J Anaesth 2006; 97: 545-52
8. Osthaus WA, Boethig D, Johanning K, et al. Whole blood coagulation measured by modified thrombelastography (ROTEM) is impaired in infants with congenital heart diseases. Blood Coagul Fibrinolysis 2008; 19: 220-5
9. Edwards RM, Naik-Mathuria BJ, Gay AN, Olutoye OO, Teruya J. Parameters of thromboelastography in healthy newborns. Am J Clin Pathol 2008; 130: 99-102
10. Cvirn G, Kutschera J, Wagner T, et al. Collagen/endogenous thrombin-induced platelet aggregation in cord versus adult whole blood. Neonatology 2009; 95: 187-92
11. Chan KL, Summerhayes RG, Ignjatovic V, Horton SB, Monagle PT. Reference values for kaolin-activated thromboelastography in healthy children. Anesth Analg 2007; 105: 1610-3
12. Andrew M, Vegh P, Johnston M, Bowker J, Ofosu F, Mitchell L. Maturation of the hemostatic system during childhood. Blood 1992; 80: 1998-2005
13. NCCLS. How to Define and Determine Reference Intervals in the Clinical Laboratory; Approved Guideline, 2nd Edn. Wayne, PA: NCCLS, 2000. NCCLS document C28-A2
14. Monagle P, Ignjatovic V, Savoia H. Hemostasis in neonates and children: pitfalls and dilemmas. Blood Rev 2010; 24: 63-8
15. Andrew M, Paes B, Johnston M. Development of the hemostatic system in the neonate and young infant. Am J Pediatr Hematol Oncol 1990; 12: 95-104
16. Reganon E, Vila V, Laiz B, Gilabert J, Aznar J. Decreased high-molecular weight fibrinogen and impaired alpha-chain polymerization in full-term newborns. Haemostasis 1993; 23: 149-58
17. Witt I, Muller H, Kunzer W. Evidence for the existence of foetal fibrinogen. Thromb Diath Haemorrh 1969; 22: 101-9
18. Hamulyak K, Nieuwenhuizen W, Devilee PP, Hemker HC. Reevalua-tion of some properties of fibrinogen, purified from cord blood of normal newborns. Thromb Res 1983; 32: 301-10
19. Cvirn G, Gallistl S, Rehak T, Jurgens G, Muntean W. Elevated thrombin-forming capacity of tissue factor-activated cord compared with adult plasma. J Thromb Haemost 2003; 1: 1785-90
20. Bischof D, Dalbert D, Zollinger A, Gantner MT, Hofer CK. Thromb-elastography in the surgical patient. Minerva Anestesiol 2009; 76: 131-7
21. Miller BE, Bailey JM, Mancuso TJ, et al. Functional maturity of the coagulation system in children: an evaluation using thrombelas-tography. Anesth Analg 1997; 84: 745-8
22. Herbstreit F, Winter EM, Peters J, Hartmann M. Monitoring of hae-mostasis in liver transplantation: comparison of laboratory based and point of care tests. Anaesthesia 2010; 65: 44-9
23. Oshita K, Az-ma T, Osawa Y, Yuge O. Quantitative measurement of thromboelastography as a function of platelet count. Anesth Analg 1999; 89: 296-9
24. Kalina U, Stohr HA, Bickhard H, et al. Rotational thromboelasto-graphy for monitoring of fibrinogen concentrate therapy in fibri-nogen deficiency. Blood Coagul Fibrinolysis 2008; 19: 777-83
25. Miller BE, Tosone SR, Guzzetta NA, Miller JL, Brosius KK. Fibrinogen in children undergoing cardiac surgery: is it effective? Anesth Analg 2004; 99: 1341-6
26. Rugeri L, Levrat A, David JS, et al. Diagnosis of early coagulation abnormalities in trauma patients by rotation thrombelastogra-phy. J Thromb Haemost 2007; 5: 289-95
27. Jambor C, Reul V, Schnider TW, Degiacomi P, Metzner H, Korte WC. In vitro inhibition of factor XIII retards clot formation, reduces clot firmness, and increases fibrinolytic effects in whole blood. Anesth Analg 2009; 109: 1023-8
28. Spiel AO, Mayr FB, Firbas C, Quehenberger P, Jilma B. Validation of rotation thrombelastography in a model of systemic activation of fibrinolysis and coagulation in humans. J Thromb Haemost 2006; 4: 411-6
29. Van Der Salm P, Ubachs HM, van Wersch JW. Fibrinogen and factor VII in male neonates. Thromb Res 1994; 73: 239-45
30. Adam S, Karger R, Kretschmer V. Photo-optical methods can lead to clinically relevant overestimation of fibrinogen concentration in plasma diluted with hydroxyethyl starch. Clin Appl Thromb Hemost 2009; 16: 461-71
31. Okude M, Yamanaka A, Akihama S. The effects of pH on the generation of turbidity and elasticity associated with fibrinogen-fibrin conversion by thrombin are remarkably influenced by sialic acid in fibrinogen. Biol Pharm Bull 1995; 18: 203-7
32. Lipinski B, Lipinska I. Effect of magnesium on fibrin formation from lower molecular weight (LMW) fibrinogen. Magnes Res 2000; 13: 233-7
33. Vindigni A, Di Cera E. Release of fibrinopeptides by the slow and fast forms of thrombin. Biochemistry 1996; 35: 4417-26
34. Azizova OA, Piryazev AP, Aseychev AV, Shvachko AG. Oxidative modification of fibrinogen inhibits its transformation into fibrin under the effect of thrombin. Bull Exp Biol Med 2009; 147: 201-3
35. Dordoni PL, Frassanito L, Bruno MF, et al. In vivo and in vitro effects of different anaesthetics on platelet function. Br J Haema-tol 2004; 125: 79-82