Protocol guided bleeding management improves cardiac surgery patient outcomes

Vox Sanguinis

Volumn 109, Issue 3, 2015, Pages 267-279

  Pearse, Bronwyn L ^a,b   Smith, I ^a   Faulke, D ^a   Wall, D ^a   Fraser, J F ^a   Ryan, E G ^c,d   Drake, L ^a   Rapchuk, I L ^a   Tesar, P ^a   Ziegenfuss, M ^a   Fung, Y L ^b,e  

^a THE PRINCE CHARLES HOSPITAL   (Australia)

^b GRIFFITH UNIVERSITY   (Australia)

^c QUEENSLAND UNIVERSITY OF TECHNOLOGY   (Australia)

^d KING'S COLLEGE LONDON   (United Kingdom)

^e UNIVERSITY OF THE SUNSHINE COAST   (Australia)

Author keywords

Bleeding management protocol; Haemostasis; Patient blood management; Transfusion surgery

Indexed keywords

FRESH FROZEN PLASMA; TRANEXAMIC ACID;

ADULT; ARTICLE; BLOOD TRANSFUSION; BLOOD VOLUME; CLINICAL PROTOCOL; CORONARY ARTERY BYPASS GRAFT; CRYOPRECIPITATE; ERYTHROCYTE TRANSFUSION; FEMALE; HEART SURGERY; HEART VALVE SURGERY; HUMAN; INCIDENCE; LENGTH OF STAY; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; OPERATIVE BLOOD LOSS; OUTCOME ASSESSMENT; POINT OF CARE TESTING; PRIORITY JOURNAL; RETROSPECTIVE STUDY; SURGICAL PATIENT; THORAX INJURY; THROMBOCYTE FUNCTION ANALYZER; THROMBOCYTE TRANSFUSION; THROMBOCYTOPHERESIS; THROMBOELASTOGRAPH; THROMBOELASTOGRAPHY; WOUND INFECTION; ADVERSE EFFECTS; AGED; BLOOD CLOTTING TEST; CARDIOPULMONARY BYPASS; HEART DISEASES; HEMORRHAGE; POINT OF CARE SYSTEM;

AGED; BLOOD COAGULATION TESTS; CARDIAC SURGICAL PROCEDURES; CARDIOPULMONARY BYPASS; ERYTHROCYTE TRANSFUSION; FEMALE; HEART DISEASES; HEMORRHAGE; HUMANS; MALE; MIDDLE AGED; PLATELET TRANSFUSION; POINT-OF-CARE SYSTEMS; RETROSPECTIVE STUDIES; TRANEXAMIC ACID;

EID: 84941601265     PISSN: 00429007     EISSN: 14230410     Source Type: Journal    
DOI: 10.1111/vox.12279     Document Type: Article

References (55)

1. Karthik S, Grayson AD, McCarron EE, et al.: Reexploration for bleeding after coronary artery bypass surgery: risk factors, outcomes, and the effect of time delay. Ann Thorac Surg 2004; 78:527-534; discussion 34
2. Karkouti K, Wijeysundera DN, Yau TM, et al.: The independent association of massive blood loss with mortality in cardiac surgery. Transfusion 2004; 44:1453-1462
3. Christensen MC, Dziewior F, Kempel A, et al.: Increased chest tube drainage is independently associated with adverse outcome after cardiac surgery. J Cardiothorac Vasc Anesth 2012; 26:46-51
4. Horvath KA, Acker MA, Chang H, et al.: Blood transfusion and infection after cardiac surgery. Ann Thorac Surg 2013; 95:2194-2201
5. Leal-Noval SR, Marquez-Vacaro JA, Garcia-Curiel A, et al.: Nosocomial pneumonia in patients undergoing heart surgery. Crit Care Med 2000; 28:935-940
6. Looney MR, Gilliss BM, Matthay MA: Pathophysiology of transfusion-related acute lung injury. Curr Opin Hematol 2010; 17:418-423
7. Fukushima S, Tesar PJ, Pearse B, et al.: Long-term clinical outcomes after aortic valve replacement using cryopreserved aortic allograft. J Thorac Cardiovasc Surg 2013; 148:65-72
8. Ranucci M, Baryshnikova E, Castelvecchio S, et al.: Major bleeding, transfusions, and anemia: the deadly triad of cardiac surgery. Ann Thorac Surg 2013; 96:478-485
9. Smith I, Rapchuk I, Macdonald C, et al.: Management of exsanguination during laser lead extraction. J Cardiothorac Vasc Anesth 2013; 28:1575-1579
10. Lang T, Bauters A, Braun SL, et al.: Multi-centre investigation on reference ranges for ROTEM thromboelastometry. Blood Coagul Fibrinolysis 2005; 16:301-310
11. Reed MJ, Nimmo AF, McGeeb D, et al.: Rotational thrombolelastometry produces potentially clinical useful results within 10 min in bleeding Emergency Department patients: the DEUCE study. Eur J Emerg Med 2013; 20:160-166
12. Gorlinger K, Dirkmann D, Hanke AA, et al.: First-line therapy with coagulation factor concentrates combined with point-of-care coagulation testing is associated with decreased allogeneic blood transfusion in cardiovascular surgery: a retrospective, single-center cohort study. Anesthesiology 2011; 115:1179-1191
13. Larsen OH, Fenger-Eriksen C, Christiansen K, et al.: Diagnostic performance and therapeutic consequence of thromboelastometry activated by kaolin versus a panel of specific reagents. Anesthesiology 2011; 115:294-302
14. Gronchi F, Perret A, Ferrari E, et al.: Validation of rotational thromboelastometry during cardiopulmonary bypass: a prospective, observational in-vivo study. Eur J Anaesthesiol 2014; 31:68-75
15. Gorlinger K, Dirkmann D, Solomon C, et al.: Fast interpretation of thromboelastometry in non-cardiac surgery: reliability in patients with hypo-, normo-, and hypercoagulability. Br J Anaesth 2013; 110:222-230
16. Dirkmann D, Gorlinger K, Dusse F, et al.: Early thromboelastometric variables reliably predict maximum clot firmness in patients undergoing cardiac surgery: a step towards earlier decision making. Acta Anaesthesiol Scand 2013; 57:594-603
17. Olde Engberink RH, Kuiper GJ, Wetzels RJ, et al.: Rapid and correct prediction of thrombocytopenia and hypofibrinogenemia with rotational thromboelastometry in cardiac surgery. J Cardiothorac Vasc Anesth 2014; 28:210-216
18. Gorlinger K, Jambor C, Dirkmann D, et al.: Perioperative coagulation management and control of platelet transfusion by point of care platelet function analysis. Transfus Med Hemother 2007; 34:369-411
19. Rahe-Meyer N, Winterhalter M, Boden A, et al.: Platelet concentrates transfusion in cardiac surgery and platelet function assessment by multiple electrode aggregometry. Acta Anaesthesiol Scand 2009; 53:168-175
20. Ranucci M, Baryshnikova E, Soro G, et al.: Multiple electrode whole-blood aggregometry and bleeding in cardiac surgery patients receiving thienopyridines. Ann Thorac Surg 2011; 91:123-129
21. Ranucci M, Colella D, Baryshnikova E, et al.: Effect of preoperative P2Y12 and thrombin platelet receptor inhibition on bleeding after cardiac surgery. Br J Anaesth 2014; 113:970-976
22. Authority ANB: What Blood Products are Supplied - National Product List. Australian Government (Commonwealth of Australia), 2012. http://www.blood.gov.au/national-product-list [Last accessed June 2012 2012]
23. Hofmann A, Farmer S, Shander A: Five drivers shifting the paradigm from product-focused transfusion practice to patient blood management. Oncologist 2011; 16(Suppl. 3):3-11
24. Shander A, Hofmann A, Isbister J, et al.: Patient blood management-the new frontier. Best Pract Res Clin Anaesthesiol 2013; 27:5-10
25. Isbister JP: The three-pillar matrix of patient blood management-an overview. Best Pract Res Clin Anaesthesiol 2013; 27:69-84
26. Kozek-Langenecker SA, Afshari A, Albaladejo P, et al.: Management of severe perioperative bleeding: guidelines from the European Society of Anaesthesiology. Eur J Anaesthesiol 2013; 30:270-382
27. Society of Thoracic Surgeons Blood Conservation Guideline Task Force, Ferraris VA, Brown JR, et al.: 2011 update to the Society of Thoracic Surgeons and the Society of Cardiovascular Anesthesiologists blood conservation clinical practice guidelines. Ann Thorac Surg. 2011;91: 944-982
28. Authority ANB: Patient Blood Management Guidelines; Module 2. Perioperative. Canberra, National Blood Authority, 2012
29. Scheme NH: NHS National Blood Transfusion Commitee's Patient Blood Management Recommendations. UK, NHS England, 2014. http://www.transfusionguidelines.org.uk/uk-transfusion-committees/national-blood-transfusion-committee/patient-blood-management [Last accessed 02/10/2014]
30. Ranucci M, Aronson S, Dietrich W, et al.: Patient blood management during cardiac surgery: do we have enough evidence for clinical practice? J Thorac Cardiovasc Surg 2011; 142:249 e1-249 e32
31. Likosky DS, FitzGerald DC, Groom RC, et al.: The effect of the perioperative blood transfusion and blood conservation in cardiac surgery Clinical Practice Guidelines of the Society of Thoracic Surgeons and the Society of Cardiovascular Anesthesiologists upon clinical practices. J Extra Corpor Technol 2010; 42:114-121
32. Ker K, Edwards P, Perel P, et al.: Effect of tranexamic acid on surgical bleeding: systematic review and cumulative meta-analysis. BMJ 2012; 344:e3054
33. Ngaage DL, Bland JM: Lessons from aprotinin: is the routine use and inconsistent dosing of tranexamic acid prudent? Meta-analysis of randomised and large matched observational studies. Eur J Cardiothorac Surg 2010; 37:1375-1383
34. McIlroy DR, Myles PS, Phillips LE, et al.: Antifibrinolytics in cardiac surgical patients receiving aspirin: a systematic review and meta-analysis. Br J Anaesth 2009; 102:168-178
35. Weber CF, Gorlinger K, Meininger D, et al.: Point-of-care testing: a prospective, randomized clinical trial of efficacy in coagulopathic cardiac surgery patients. Anesthesiology 2012; 117:531-547
36. Gorlinger K, Dirkmann D, Hanke AA: Potential value of transfusion protocols in cardiac surgery. Curr Opin Anaesthesiol 2013; 26:230-243
37. Hiippala ST, Myllyla GJ, Vahtera EM: Hemostatic factors and replacement of major blood loss with plasma-poor red cell concentrates. Anest Analg 1995; 81:360-365
38. Solomon C, Pichlmaier U, Schoechl H, et al.: Recovery of fibrinogen after administration of fibrinogen concentrate to patients with severe bleeding after cardiopulmonary bypass surgery. Br J Anaesth 2010; 104:555-562
39. Solomon C, Rahe-Meyer N, Sorensen B: Fibrin formation is more impaired than thrombin generation and platelets immediately following cardiac surgery. Thromb Res 2011; 128:277-282
40. Levy JH, Szlam F, Tanaka KA, et al.: Fibrinogen and hemostasis: a primary hemostatic target for the management of acquired bleeding. Anest Analg 2012; 114:261-274
41. Sørensen B, Tang M, Larsen OH, et al.: The role of fibrinogen: a new paradigm in the treatment of coagulopathic bleeding. Thromb Res 2011; 128:S13-S16
42. Karkouti K, Callum J, Crowther MA, et al.: The relationship between fibrinogen levels after cardiopulmonary bypass and large volume red cell transfusion in cardiac surgery: an observational study. Anest Analg 2013; 117:14-22
43. Reinhofer M, Brauer M, Franke U, et al.: The value of rotation thromboelastometry to monitor disturbed perioperative haemostasis and bleeding risk in patients with cardiopulmonary bypass. Blood Coagul Fibrinolysis 2008; 19:212-219
44. Michalopoulos A, Geroulanos S, Rosmarakis ES, et al.: Frequency, characteristics, and predictors of microbiologically documented nosocomial infections after cardiac surgery. Eur J Cardiothorac Surg 2006; 29:456-460
45. Sarani B, Dunkman WJ, Dean L, et al.: Transfusion of fresh frozen plasma in critically ill surgical patients is associated with an increased risk of infection. Crit Care Med 2008; 36:1114-1118
46. Schneider SO, Rensing H, Graber S, et al.: Impact of platelets and fresh frozen plasma in contrast to red cell concentrate on unstimulated and stimulated cytokine release in an in vitro model of transfusion. Scand J Immunol 2009; 70:101-105
47. Inaba K, Branco BC, Rhee P, et al.: Impact of plasma transfusion in trauma patients who do not require massive transfusion. J Am Coll Surg 2010; 210:957-965
48. Bjursten H, Dardashti A, Ederoth P, et al.: Increased long-term mortality with plasma transfusion after coronary artery bypass surgery. Intensive Care Med 2013; 39:437-444
49. Watson GA, Sperry JL, Rosengart MR, et al.: Fresh frozen plasma is independently associated with a higher risk of multiple organ failure and acute respiratory distress syndrome. J Trauma 2009; 67:221-227; discussion 8-30
50. Gajic O, Dzik WH, Toy P: Fresh frozen plasma and platelet transfusion for nonbleeding patients in the intensive care unit: benefit or harm? Crit Care Med 2006; 34:S170-S173
51. NICE: Detecting, managing, and monitoring haemostasis: viscoelastometric point of care testing (ROTEM, TEG and Sonoclot systems). 2014 http://www.nice.org.uk/guidance/dg13/documents/detecting-managing-and-monitoring-haemostasis-viscoelastometric-pointofcare-testing-rotem-teg-and-sonoclot-systems-diagnostics-consultation-document-pdf2 [last accessed 3 November 2014]
52. Christensen MC, Krapf S, Kempel A, et al.: Costs of excessive postoperative hemorrhage in cardiac surgery. J Thorac Cardiovasc Surg 2009; 138:687-693
53. Spalding GJ, Hartrumpf M, Sierig T, et al.: Cost reduction of perioperative coagulation management in cardiac surgery: value of "bedside" thrombelastography (ROTEM). Eur J Cardiothorac Surg 2007; 31:1052-1057
54. Parsons HM: What Happened at Hawthorne? New evidence suggests the Hawthorne effect resulted from operant reinforcement contingencies. Science 1974; 183:922-932
55. Isbister JP, Shander A, Spahn DR, et al.: Adverse blood transfusion outcomes: establishing causation. Transfus Med Rev 2011; 25:89-101