Reduced transfusion during OLT by POC coagulation management and TEG functional fibrinogen: A retrospective observational study

Transplantation Direct

Volumn 2, Issue 9, 2016, Pages

  de Pietri, Lesley ^a   Ragusa, Francesca ^a   Deleuterio, Annalisa ^a   Begliomini, Bruno ^a   Serra, Valentina ^a  

^a UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 85018044487     PISSN: None     EISSN: 23738731     Source Type: Journal    
DOI: 10.1097/TXD.0000000000000     Document Type: Article

References (33)

1. Clevenger B, Mallett SV. Transfusion and coagulation management in liver transplantation. World J Gastroenterol. 2014;20:6146–6158.
2. Massicotte L, Denault AY, Beaulieu D, et al. Transfusion rate for 500 consecutive liver transplantations: experience of one liver transplantation center. Transplantation. 2012;93:1276–1281.
3. de Boer MT, Christensen MC, Asmussen M, et al. The impact of intraoperative transfusion of platelets and red blood cells on survival after liver transplantation. Anesth Analg. 2008;106:32–44.
4. McNicol PL, Liu G, Harley ID, et al. Blood loss and transfusion requirements in liver transplantation: experience with the first 75 cases. Anaesth Intensive Care. 1994;22:666–671.
5. Perry DJ, Fitzmaurice DA, Kitchen S, et al. Point-of-care testing in haemostasis. Br J Haematol. 2010;150:501–514.
6. Kang YG, Martin DJ, Marquez J, et al. Intraoperative changes in blood coagulation and thrombelastographic monitoring in liver transplantation. Anesth Analg. 1985;64:888–896.
7. Kozek-Langenecker SA, Afshari A, Albaladejo P, et al. Management of severe perioperative bleeding: guidelines from the European Society of Anaesthesiology. Eur J Anaesthesiol. 2013;30:270–382.
8. Yang Lu S, Tanaka KA, Abuelkasem E, et al. Clinical applicability of rapid thrombelastography and functional fibrinogen thrombelastography to adult liver transplantation. Liver Transpl. 2014;20:1097–1105.
9. Harr JN, Moore EE, Ghasabyan A, et al. Functional fibrinogen assay indicates that fibrinogen is critical in correcting abnormal clot strength following trauma. Shock. 2013;39:45–49.
10. Rahe-Meyer N, Pichlmaier M, Haverich A, et al. Bleeding management with fibrinogen concentrate targeting a high-normal plasma fibrinogen level: a pilot study. Br J Anaesth. 2009;102:785–792.
11. Rahe-Meyer N, Solomon C, Winterhalter M, et al. Thromboelastometryguided administration of fibrinogen concentrate for the treatment of excessive intraoperative bleeding in thoracoabdominal aortic aneurysm surgery. J Thorac Cardiovasc Surg. 2009;138:694–702.
12. Schöchl H, Nienaber U, Maegele M, et al. Transfusion in trauma: thromboelastometry-guided coagulation factor concentrate-based therapy versus standard fresh frozen plasma-based therapy. Crit Care. 2011;15:R83.
13. Weber CF, Görlinger K, Meininger D, et al. Point-of-care testing: a prospective, randomized clinical trial of efficacy in coagulopathic cardiac surgery patients. Anesthesiology. 2012;117:531–547.
14. Görlinger K, Dirkmann D, Hanke AA, et al. First-line therapy with coagulation factor concentrates combined with point-of-care coagulation testing is associated with decreased allogeneic blood transfusion in cardiovascular surgery: a retrospective, single-center cohort study. Anesthesiology. 2011;115:1179–1191.
15. Noval-Padillo JA, León-Justel A, Mellado-Miras P, et al. Introduction of fibrinogen in the treatment of hemostatic disorders during orthotopic liver transplantation: implications in the use of allogenic blood. Transplant Proc. 2010;42:2973–2974.
16. Kirchner C, Dirkmann D, Treckmann JW, et al. Coagulation management with factor concentrates in liver transplantation: a single-center experience. Transfusion. 2014;54:2760–2768.
17. Carroll RC, Craft RM, Chavez JJ, et al. Measurement of functional fibrinogen levels using the thrombelastograph. J Clin Anesth. 2008;20: 186–190.
18. R Core Team (2013). R: A language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria. URL http://www.R-project.org/.
19. Sabate A, Dalmau A, Koo M, et al. Coagulopathy management in liver transplantation. Transplant Proc. 2012;44:1523–1525.
20. Mangus RS, Kinsella SB, Nobari MM, et al. Predictors of blood product use in orthotopic liver transplantation using the piggyback hepatectomy technique. Transplant Proc. 2007;39:3207–3213.
21. Makroo RN, Walia RS, Aneja S, et al. Preoperative predictors of blood component transfusion in living donor liver transplantation. Asian J Transfus Sci. 2013;7:140–146.
22. Cywinski JB, Alster JM, Miller C, et al. Prediction of intraoperative transfusion requirements during orthotopic liver transplantation and the influence on postoperative patient survival. Anesth Analg. 2014;118:428–437.
23. Gurusamy KS, Pissanou T, Pikhart H, et al. Methods to decrease blood loss and transfusion requirements for liver transplantation. Cochrane Database Syst Rev. 2011;CD009052.
24. Görlinger K, Fries D, Dirkmann D, et al. Reduction of fresh frozen plasma requirements by perioperative point-of-care coagulation management with early calculated goal-directed therapy. Transfus Med Hemother. 2012;39:104–113.
25. Álamo JM, León A, Mellado P, et al. Is “intra-operating room” thromboelastometry useful in liver transplantation? A case-control study in 303 patients. Transplant Proc. 2013;45:3637–3639.
26. Wang SC, Shieh JF, Chang KY, et al. Thromboelastography-guided transfusion decreases intraoperative blood transfusion during orthotopic liver transplantation: randomized clinical trial. Transplant Proc. 2010;42: 2590–2593.
27. Shore-Lesserson L, Manspeizer HE, De Perio M, et al. Thromboelastography-guided transfusion algorithm reduces transfusions in complex cardiac surgery. Anesth Analg. 1999;88:312–319.
28. Zambruni A, Thalheimer U, Leandro G, et al. Thromboelastography with citrated blood: comparability with native blood, stability of citrate storage and effect of repeated sampling. Blood Coagul Fibrinolysis. 2004;15: 103–107.
29. Roche AM, James MF, Grocott MP, et al. Citrated blood does not reliably reflect fresh whole blood coagulability in trials of in vitro hemodilution. Anesth Analg. 2003;96:58–61.
30. Ågren A, Wikman AT, Ostlund A, et al. TEG® functional fibrinogen analysis may overestimate fibrinogen levels. Anesth Analg. 2014;118:933–935.
31. Steib A, Freys G, Lehmann C, et al. Intraoperative blood losses and transfusion requirements during adult liver transplantation remain difficult to predict. Can J Anaesth. 2001;48:1075–1079.
32. Araújo T, Cordeiro A, Proença P, et al. Predictive variables affecting transfusion requirements in orthotopic liver transplantation. Transplant Proc. 2010;42:1758–1759.
33. McCluskey SA, Karkouti K, Wijeysundera DN, et al. Derivation of a risk index for the prediction of massive blood transfusion in liver transplantation. Liver Transpl. 2006;12:1584–1593.