Acidic extracellular pH neutralizes the autophagy-inhibiting activity of chloroquine: Implications for cancer therapies

Autophagy

Volumn 10, Issue 4, 2014, Pages 562-571

  Pellegrini, Paola ^a   Strambi, Angela ^a   Zipoli, Chiara ^a   Hägg Olofsson, Maria ^a   Buoncervello, Maria ^a   Linder, Stig ^a   De Milito, Angelo ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Autophagy; Cancer therapy; Chloroquine; pH; Tumor acidosis

Indexed keywords

BAFILOMYCIN A1; CHLOROQUINE; ACID;

ACIDIFICATION; ACIDITY; ACIDOSIS; ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; CANCER CELL CULTURE; CANCER RESISTANCE; CANCER THERAPY; CELL STRESS; CELL VIABILITY; COLON CARCINOMA; DRUG CYTOTOXICITY; EXTRACELLULAR SPACE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; LYSOSOME; MELANOMA CELL; OSTEOSARCOMA CELL; OXYGEN TENSION; PH; TUMOR MICROENVIRONMENT; TUMOR XENOGRAFT; APOPTOSIS; DRUG EFFECTS; NEOPLASMS; PHYSIOLOGY; TUMOR CELL LINE;

ACIDS; APOPTOSIS; AUTOPHAGY; CELL LINE, TUMOR; CHLOROQUINE; EXTRACELLULAR SPACE; HUMANS; HYDROGEN-ION CONCENTRATION; NEOPLASMS; TUMOR MICROENVIRONMENT;

EID: 84898641223     PISSN: 15548627     EISSN: 15548635     Source Type: Journal    
DOI: 10.4161/auto.27901     Document Type: Article

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