Combined PDK1 and CHK1 inhibition is required to kill glioblastoma stem-like cells in vitro and in vivo

Cell Death and Disease

Volumn 5, Issue 5, 2014, Pages

  Signore, M ^a   Pelacchi, F ^a   Di Martino, S ^b   Runci, D ^a   Biffoni, M ^a   Giannetti, S ^c   Morgante, L ^c   De Majo, M ^a   Petricoin, E F ^d   Stancato, L ^e   Larocca, L M ^c   De Maria, R ^b   Pallini, R ^c   Ricci Vitiani, L ^a  

^a ISTITUTO SUPERIORE DI SANITÀ   (Italy)

^b REGINA ELENA NATIONAL CANCER INSTITUTE   (Italy)

^c CATHOLIC UNIVERSITY   (Italy)

^d GEORGE MASON UNIVERSITY   (United States)

^e ELI LILLY AND COMPANY   (United States)

Author keywords

DNA damage; Glioblastoma stem like cells; Kinase inhibitors; PDK1; Phospho proteomics

Indexed keywords

7 HYDROXYSTAUROSPORINE; CHECKPOINT KINASE 1; CYCLIN B1; CYCLIN D1; PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE 1; TEMOZOLOMIDE;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; BLOOD BRAIN BARRIER; CANCER GROWTH; CANCER INHIBITION; CANCER RECURRENCE; CANCER SIZE; CANCER STEM CELL; CANCER SURVIVAL; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; DNA DAMAGE; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; GLIOBLASTOMA; GLIOBLASTOMA CELL LINE; GLIOBLASTOMA STEM LIKE CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LIMIT OF DETECTION; MALE; MITOSIS INDEX; MOUSE; NEURAL STEM CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN MICROARRAY; PROTEIN PHOSPHORYLATION; PROTEOMICS; SIGNAL TRANSDUCTION; TREATMENT DURATION; TUMOR XENOGRAFT;

ANIMALS; ANTINEOPLASTIC AGENTS; BRAIN NEOPLASMS; CELL DEATH; CELL LINE, TUMOR; DACARBAZINE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG RESISTANCE, NEOPLASM; GLIOBLASTOMA; HUMANS; MICE; MICE, INBRED NOD; MICE, SCID; MOLECULAR TARGETED THERAPY; NEOPLASTIC STEM CELLS; PROTEIN ARRAY ANALYSIS; PROTEIN KINASE INHIBITORS; PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES; PROTEOMICS; SIGNAL TRANSDUCTION; SMALL MOLECULE LIBRARIES; STAUROSPORINE; TIME FACTORS; TUMOR BURDEN; TUMOR CELLS, CULTURED; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84901001820     PISSN: None     EISSN: 20414889     Source Type: Journal    
DOI: 10.1038/cddis.2014.188     Document Type: Article

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