-
1
-
-
27544479318
-
Role of tyrosine kinase inhibitors in cancer therapy
-
Arora A and Scholar EM: Role of tyrosine kinase inhibitors in cancer therapy. J Pharmacol Exp Ther 315: 971-979, 2005.
-
(2005)
J Pharmacol Exp Ther
, vol.315
, pp. 971-979
-
-
Arora, A.1
Scholar, E.M.2
-
2
-
-
0037087531
-
Inhibition of KIT tyrosine kinase activity: A novel molecular approach to the treatment of KIT-positive malignancies
-
Heinrich MC, Blanke CD, Druker BJ and Corless CL: Inhibition of KIT tyrosine kinase activity: a novel molecular approach to the treatment of KIT-positive malignancies. J Clin Oncol 20: 1692-1703, 2002.
-
(2002)
J Clin Oncol
, vol.20
, pp. 1692-1703
-
-
Heinrich, M.C.1
Blanke, C.D.2
Druker, B.J.3
Corless, C.L.4
-
3
-
-
0033816156
-
Abl protein-tyrosine kinase inhibitor STI571 inhibits in vitro signal transduction mediated by c-kit and platelet-derived growth factor receptors
-
Buchdunger E, Cioffi CL, Law N, et al: Abl protein-tyrosine kinase inhibitor STI571 inhibits in vitro signal transduction mediated by c-kit and platelet-derived growth factor receptors. J Pharmacol Exp Ther 295: 139-145, 2000.
-
(2000)
J Pharmacol Exp Ther
, vol.295
, pp. 139-145
-
-
Buchdunger, E.1
Cioffi, C.L.2
Law, N.3
-
4
-
-
0036715327
-
Flavopiridol potentiates STI571-induced mitochondrial damage and apoptosis in BCR-ABL-positive human leukemia cells
-
Yu C, Krystal G, Dent P and Grant S: Flavopiridol potentiates STI571-induced mitochondrial damage and apoptosis in BCR-ABL-positive human leukemia cells. Clin Cancer Res 8: 2976-2984, 2002.
-
(2002)
Clin Cancer Res
, vol.8
, pp. 2976-2984
-
-
Yu, C.1
Krystal, G.2
Dent, P.3
Grant, S.4
-
5
-
-
20344374146
-
Imatinib mesylate (Gleevec) downregulates telomerase activity and inhibits proliferation in telomerase-expressing cell lines
-
Uziel O, Fenig E, Nordenberg J, et al: Imatinib mesylate (Gleevec) downregulates telomerase activity and inhibits proliferation in telomerase-expressing cell lines. Br J Cancer 92: 1881-1891, 2005.
-
(2005)
Br J Cancer
, vol.92
, pp. 1881-1891
-
-
Uziel, O.1
Fenig, E.2
Nordenberg, J.3
-
6
-
-
15944404601
-
The development of imatinib as a therapeutic agent for chronic myeloid leukemia
-
Deininger M, Buchdunger E and Druker BJ: The development of imatinib as a therapeutic agent for chronic myeloid leukemia. Blood 105: 2640-2653, 2005.
-
(2005)
Blood
, vol.105
, pp. 2640-2653
-
-
Deininger, M.1
Buchdunger, E.2
Druker, B.J.3
-
7
-
-
33744903660
-
Therapeutic effect of imatinib in gastrointestinal stromal tumors: AKT signaling dependent and independent mechanisms
-
Tarn C, Skorobogatko YV, Taguchi T, Eisenberg B, von Mehren M and Godwin AK: Therapeutic effect of imatinib in gastrointestinal stromal tumors: AKT signaling dependent and independent mechanisms. Cancer Res 66: 5477-5486, 2006.
-
(2006)
Cancer Res
, vol.66
, pp. 5477-5486
-
-
Tarn, C.1
Skorobogatko, Y.V.2
Taguchi, T.3
Eisenberg, B.4
von Mehren, M.5
Godwin, A.K.6
-
8
-
-
0034665138
-
Intracranial inhibition of platelet-derived growth factor-mediated glioblastoma cell growth by an orally active kinase inhibitor of the 2-phenylaminopyrimidine class
-
Kilic T, Alberta JA, Zdunek PR, et al: Intracranial inhibition of platelet-derived growth factor-mediated glioblastoma cell growth by an orally active kinase inhibitor of the 2-phenylaminopyrimidine class. Cancer Res 60: 5143-5150, 2000.
-
(2000)
Cancer Res
, vol.60
, pp. 5143-5150
-
-
Kilic, T.1
Alberta, J.A.2
Zdunek, P.R.3
-
9
-
-
0033883653
-
The selective tyrosine kinase inhibitor STI571 inhibits small cell lung cancer growth
-
Krystal GW, Honsawek S, Litz J and Buchdunger E: The selective tyrosine kinase inhibitor STI571 inhibits small cell lung cancer growth. Clin Cancer Res 6: 3319-3326, 2000.
-
(2000)
Clin Cancer Res
, vol.6
, pp. 3319-3326
-
-
Krystal, G.W.1
Honsawek, S.2
Litz, J.3
Buchdunger, E.4
-
10
-
-
10744233548
-
Effect of imatinib mesylate (Gleevec) on anaplastic thyroid carcinoma cell lines
-
Mitsiades CS, Sykoutri D, McMullan C, Poulaki V and Mitsiades N: Effect of imatinib mesylate (Gleevec) on anaplastic thyroid carcinoma cell lines. J Clin Endocrinol Metab 88: 5043-5044, 2003.
-
(2003)
J Clin Endocrinol Metab
, vol.88
, pp. 5043-5044
-
-
Mitsiades, C.S.1
Sykoutri, D.2
McMullan, C.3
Poulaki, V.4
Mitsiades, N.5
-
11
-
-
33745271860
-
Targeting platelet-derived growth factor receptor on endothelial cells of multidrug-resistant prostate cancer
-
Kim SJ, Uehara H, Yazici S, et al: Targeting platelet-derived growth factor receptor on endothelial cells of multidrug-resistant prostate cancer. J Natl Cancer Inst 98: 783-793, 2006.
-
(2006)
J Natl Cancer Inst
, vol.98
, pp. 783-793
-
-
Kim, S.J.1
Uehara, H.2
Yazici, S.3
-
12
-
-
20144372598
-
Patupilone (epothilone B, EPO906) and imatinib (STI571, Glivec) in combination display enhanced antitumour activity in vivo against experimental rat C6 glioma
-
O'Reilly T, Wartmann M, Maira SM, et al: Patupilone (epothilone B, EPO906) and imatinib (STI571, Glivec) in combination display enhanced antitumour activity in vivo against experimental rat C6 glioma. Cancer Chemother Pharmacol 55: 307-317, 2005.
-
(2005)
Cancer Chemother Pharmacol
, vol.55
, pp. 307-317
-
-
O'Reilly, T.1
Wartmann, M.2
Maira, S.M.3
-
13
-
-
0036645057
-
Platelet-derived growth factor (PDGF) autocrine signaling regulates survival and mitogenic pathways in glioblastoma cells: Evidence that the novel PDGF-C and PDGF-D ligands may play a role in the development of brain tumors
-
Lokker NA, Sullivan CM, Hollenbach SJ, Israel MA and Giese NA: Platelet-derived growth factor (PDGF) autocrine signaling regulates survival and mitogenic pathways in glioblastoma cells: evidence that the novel PDGF-C and PDGF-D ligands may play a role in the development of brain tumors. Cancer Res 62: 3729-3735, 2002.
-
(2002)
Cancer Res
, vol.62
, pp. 3729-3735
-
-
Lokker, N.A.1
Sullivan, C.M.2
Hollenbach, S.J.3
Israel, M.A.4
Giese, N.A.5
-
14
-
-
16844384057
-
The effect of Bcrp1 (Abcg2) on the in vivo pharmacokinetics and brain penetration of imatinib mesylate (Gleevec): Implications for the use of breast cancer resistance protein and P-glycoprotein inhibitors to enable the brain penetration of imatinib in patients
-
Breedveld P, Pluim D, Cipriani G, et al: The effect of Bcrp1 (Abcg2) on the in vivo pharmacokinetics and brain penetration of imatinib mesylate (Gleevec): implications for the use of breast cancer resistance protein and P-glycoprotein inhibitors to enable the brain penetration of imatinib in patients. Cancer Res 65: 2577-2582, 2005.
-
(2005)
Cancer Res
, vol.65
, pp. 2577-2582
-
-
Breedveld, P.1
Pluim, D.2
Cipriani, G.3
-
15
-
-
33746919951
-
Characterization of an imatinib-sensitive subset of high-grade human glioma cultures
-
Hagerstrand D, Hesselager G, Achterberg S, et al: Characterization of an imatinib-sensitive subset of high-grade human glioma cultures. Oncogene 25: 4913-4922, 2006.
-
(2006)
Oncogene
, vol.25
, pp. 4913-4922
-
-
Hagerstrand, D.1
Hesselager, G.2
Achterberg, S.3
-
16
-
-
0024992311
-
Worldwide use of clomipramine
-
Trimble MR: Worldwide use of clomipramine. J Clin Psychiatry 51 (suppl): 51-58, 1990.
-
(1990)
J Clin Psychiatry
, vol.51
, Issue.SUPPL.
, pp. 51-58
-
-
Trimble, M.R.1
-
17
-
-
0028839614
-
Do antidepressants cause, promote, or inhibit cancers?
-
Steingart AB and Cotterchio M: Do antidepressants cause, promote, or inhibit cancers? J Clin Epidemiol 48: 1407-1412, 1995.
-
(1995)
J Clin Epidemiol
, vol.48
, pp. 1407-1412
-
-
Steingart, A.B.1
Cotterchio, M.2
-
18
-
-
0024556724
-
Cytostatic activity of commonly used tricyclic antidepressants
-
Sauter C: Cytostatic activity of commonly used tricyclic antidepressants. Oncology 46: 155-157, 1989.
-
(1989)
Oncology
, vol.46
, pp. 155-157
-
-
Sauter, C.1
-
19
-
-
0026026642
-
Circumvention of pleiotropic drug resistance in subcutaneous tumours in vivo with verapamil and clomipramine
-
Merry S, Hamilton TG, Flanigan P, Freshney RI and Kaye SB: Circumvention of pleiotropic drug resistance in subcutaneous tumours in vivo with verapamil and clomipramine. Eur J Cancer 27: 31-34, 1991.
-
(1991)
Eur J Cancer
, vol.27
, pp. 31-34
-
-
Merry, S.1
Hamilton, T.G.2
Flanigan, P.3
Freshney, R.I.4
Kaye, S.B.5
-
20
-
-
0041829262
-
The potential for strategies using micronutrients and heterocyclic drugs to treat invasive gliomas
-
Rooprai HK, Christidou M and Pilkington GJ: The potential for strategies using micronutrients and heterocyclic drugs to treat invasive gliomas. Acta Neurochir (Wien) 145: 683-690, 2003.
-
(2003)
Acta Neurochir (Wien)
, vol.145
, pp. 683-690
-
-
Rooprai, H.K.1
Christidou, M.2
Pilkington, G.J.3
-
21
-
-
0033562841
-
Changes in the generation of reactive oxygen species and in mitochondrial membrane potential during apoptosis induced by the antidepressants imipramine, clornipramine and citalopram and the effects on these changes by Bcl-2 and Bcl-X(L)
-
Xia Z, Lundgren B, Bergstrand A, De Pierre JW and Nassberger L: Changes in the generation of reactive oxygen species and in mitochondrial membrane potential during apoptosis induced by the antidepressants imipramine, clornipramine and citalopram and the effects on these changes by Bcl-2 and Bcl-X(L). Biochem Pharmacol 57: 1199-1208, 1999.
-
(1999)
Biochem Pharmacol
, vol.57
, pp. 1199-1208
-
-
Xia, Z.1
Lundgren, B.2
Bergstrand, A.3
De Pierre, J.W.4
Nassberger, L.5
-
22
-
-
13444293008
-
Chlorimipramine: A novel anticancer agent with a mitochondrial target
-
Daley E, Wilkie D, Loesch A, Hargreaves IP, Kendall DA, Pilkington GJ and Bates TE: Chlorimipramine: a novel anticancer agent with a mitochondrial target. Biochem Biophys Res Commun 328: 623-632, 2005.
-
(2005)
Biochem Biophys Res Commun
, vol.328
, pp. 623-632
-
-
Daley, E.1
Wilkie, D.2
Loesch, A.3
Hargreaves, I.P.4
Kendall, D.A.5
Pilkington, G.J.6
Bates, T.E.7
-
23
-
-
0034026078
-
Membrane permeation by multidrug-resistance-modulators and non-modulators: Effects of hydrophobicity and electric charge
-
Castaing M, Brouant P, Loiseau A, et al: Membrane permeation by multidrug-resistance-modulators and non-modulators: effects of hydrophobicity and electric charge. J Pharm Pharmacol 52: 289-296, 2000.
-
(2000)
J Pharm Pharmacol
, vol.52
, pp. 289-296
-
-
Castaing, M.1
Brouant, P.2
Loiseau, A.3
-
24
-
-
0028989153
-
Reversal of doxorubicin-resistance in solid tumors by clomipramine
-
Pommerenke EW and Volm M: Reversal of doxorubicin-resistance in solid tumors by clomipramine. In Vivo 9: 99-101, 1995.
-
(1995)
In Vivo
, vol.9
, pp. 99-101
-
-
Pommerenke, E.W.1
Volm, M.2
-
25
-
-
34250803209
-
Molecularly targeted therapy for malignant glioma
-
Sathornsumetee S, Reardon DA, Desjardins A, Quinn JA, Vredenburgh JJ and Rich JN: Molecularly targeted therapy for malignant glioma. Cancer 110: 13-24, 2007.
-
(2007)
Cancer
, vol.110
, pp. 13-24
-
-
Sathornsumetee, S.1
Reardon, D.A.2
Desjardins, A.3
Quinn, J.A.4
Vredenburgh, J.J.5
Rich, J.N.6
-
27
-
-
33646039750
-
Noscapine and diltiazem augment taxol and radiation-induced S-phase arrest and clonogenic death of C6 glioma in vitro
-
Altinoz MA, Bilir A, Del Maestro RF, Tuna S, Ozcan E and Gedikoglu G: Noscapine and diltiazem augment taxol and radiation-induced S-phase arrest and clonogenic death of C6 glioma in vitro. Surg Neurol 65: 478-485, 2006.
-
(2006)
Surg Neurol
, vol.65
, pp. 478-485
-
-
Altinoz, M.A.1
Bilir, A.2
Del Maestro, R.F.3
Tuna, S.4
Ozcan, E.5
Gedikoglu, G.6
-
28
-
-
34250712271
-
Erythropoietin changes contractility, cAMP and nitrite levels of isolated rat hearts
-
Kaygisiz Z, Erkasap N, Yazihan N, et al: Erythropoietin changes contractility, cAMP and nitrite levels of isolated rat hearts. J Physiol Sci 56: 247-251, 2006.
-
(2006)
J Physiol Sci
, vol.56
, pp. 247-251
-
-
Kaygisiz, Z.1
Erkasap, N.2
Yazihan, N.3
-
29
-
-
0016820947
-
Femtomole sensitive radioimmunoassay for cyclic AMP and cyclic GMP after 2′0 acetylation by acetic anhydride in aqueous solution
-
Harper JF, Brooker G, Harper JF, et al: Femtomole sensitive radioimmunoassay for cyclic AMP and cyclic GMP after 2′0 acetylation by acetic anhydride in aqueous solution. J Cyclic Nucleotide Res 1: 207-218, 1975.
-
(1975)
J Cyclic Nucleotide Res
, vol.1
, pp. 207-218
-
-
Harper, J.F.1
Brooker, G.2
Harper, J.F.3
-
30
-
-
0030999009
-
Allosteric equilibrium model explains steady-state coupling of β-adrenergic receptors to adenylate cyclase in turkey erythrocyte membranes
-
Ugur O and Onaran HO: Allosteric equilibrium model explains steady-state coupling of β-adrenergic receptors to adenylate cyclase in turkey erythrocyte membranes. Biochem J 323: 765-776, 1997.
-
(1997)
Biochem J
, vol.323
, pp. 765-776
-
-
Ugur, O.1
Onaran, H.O.2
-
31
-
-
0021118703
-
Quantitative analysis of dose-effect relationships: The combined effects of multiple drugs or enzyme inhibitors
-
Chou TC and Talalay P: Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors. Adv Enzyme Regul 22: 27-55, 1984.
-
(1984)
Adv Enzyme Regul
, vol.22
, pp. 27-55
-
-
Chou, T.C.1
Talalay, P.2
-
32
-
-
0000994406
-
Analysis of combined drug effects: A new look at a very old problem
-
Chou TC and Talalay P: Analysis of combined drug effects: a new look at a very old problem. Trends Pharmacol Sci 4: 450-454, 1983.
-
(1983)
Trends Pharmacol Sci
, vol.4
, pp. 450-454
-
-
Chou, T.C.1
Talalay, P.2
-
33
-
-
0028915592
-
Modulation of growth and proliferation in squamous cell carcinoma by retinoic acid: A rationale for combination therapy with chemotherapeutic agents
-
Sacks PG, Harris D and Chou TC: Modulation of growth and proliferation in squamous cell carcinoma by retinoic acid: a rationale for combination therapy with chemotherapeutic agents. Int J Cancer 61: 409-415, 1995.
-
(1995)
Int J Cancer
, vol.61
, pp. 409-415
-
-
Sacks, P.G.1
Harris, D.2
Chou, T.C.3
-
34
-
-
0344520475
-
Distribution of STI-571 to the brain is limited by P-glycoprotein-mediated efflux
-
Dai H, Marbach P, Lemaire M, Hayes M and Elmquist WF: Distribution of STI-571 to the brain is limited by P-glycoprotein-mediated efflux. J Pharmacol Exp Ther 304: 1085-1092, 2003.
-
(2003)
J Pharmacol Exp Ther
, vol.304
, pp. 1085-1092
-
-
Dai, H.1
Marbach, P.2
Lemaire, M.3
Hayes, M.4
Elmquist, W.F.5
-
35
-
-
33646201592
-
Constitutive activity of beta-adrenergic receptors in C6 glioma cells
-
Sokolowska P and Nowak JZ: Constitutive activity of beta-adrenergic receptors in C6 glioma cells. Pharmacol Rep 57: 659-663, 2005.
-
(2005)
Pharmacol Rep
, vol.57
, pp. 659-663
-
-
Sokolowska, P.1
Nowak, J.Z.2
-
36
-
-
1842867380
-
Rat C6 glioma as experimental model system for the study of glioblastoma growth and invasion
-
Grobben B, De Deyn PP and Slegers H: Rat C6 glioma as experimental model system for the study of glioblastoma growth and invasion. Cell Tissue Res 310: 257-270, 2002.
-
(2002)
Cell Tissue Res
, vol.310
, pp. 257-270
-
-
Grobben, B.1
De Deyn, P.P.2
Slegers, H.3
-
37
-
-
0141703301
-
Calcium regulation of the soluble adenylyl cyclase expressed in mammallian spermatozoa
-
Jaiswal BS and Conti M: Calcium regulation of the soluble adenylyl cyclase expressed in mammallian spermatozoa. Proc Natl Acad Sci USA 100: 10676-10681, 2003.
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 10676-10681
-
-
Jaiswal, B.S.1
Conti, M.2
-
38
-
-
15044353649
-
Arrestin times for compartmentalised cAMP signalling and phosphodiesterase-4 enzymes
-
Baillie GS and Houslay MD: Arrestin times for compartmentalised cAMP signalling and phosphodiesterase-4 enzymes. Curr Opin Cell Biol 17: 129-134, 2005.
-
(2005)
Curr Opin Cell Biol
, vol.17
, pp. 129-134
-
-
Baillie, G.S.1
Houslay, M.D.2
-
39
-
-
33847655190
-
Three-dimensional cellular spheroid formation provides human prostate tumor cells with tissue-like features
-
Takagi A, Watanabe M, Ishii Y, et al: Three-dimensional cellular spheroid formation provides human prostate tumor cells with tissue-like features. Anticancer Res 27: 45-53, 2007.
-
(2007)
Anticancer Res
, vol.27
, pp. 45-53
-
-
Takagi, A.1
Watanabe, M.2
Ishii, Y.3
-
41
-
-
34247646062
-
The anticancer drug imatinib induces cellular autophagy
-
Ertmer A, Huber V, Gilch S, et al: The anticancer drug imatinib induces cellular autophagy. Leukemia 21: 936-942, 2007.
-
(2007)
Leukemia
, vol.21
, pp. 936-942
-
-
Ertmer, A.1
Huber, V.2
Gilch, S.3
-
43
-
-
85117739353
-
Targeting autophagy augments the anticancer activity of the histone deacetylase inhibitor SAHA to overcome Bcr- Abl-mediated drug resistance
-
In press
-
Carew JS, Nawrocki ST, Kahue CN, et al: Targeting autophagy augments the anticancer activity of the histone deacetylase inhibitor SAHA to overcome Bcr- Abl-mediated drug resistance. Blood (In press).
-
Blood
-
-
Carew, J.S.1
Nawrocki, S.T.2
Kahue, C.N.3
-
44
-
-
33745591097
-
Pharmacokinetics of clomipramine and desmethyl-clomipramine after single-dose intravenous and oral administrations in cats
-
Lainesse C, Frank D, Meucci V, Intorre L, Soldani G and Doucet M: Pharmacokinetics of clomipramine and desmethyl-clomipramine after single-dose intravenous and oral administrations in cats. J Vet Pharmacol Ther 29: 271-278, 2006.
-
(2006)
J Vet Pharmacol Ther
, vol.29
, pp. 271-278
-
-
Lainesse, C.1
Frank, D.2
Meucci, V.3
Intorre, L.4
Soldani, G.5
Doucet, M.6
-
45
-
-
0032619135
-
The antidepressants imipramine, clomipramine, and citalopram induce apoptosis in human acute myeloid leukemia HL-60 cells via caspase-3 activation
-
Xia Z, Bergstrand A, De Pierre JW and Nassberger L: The antidepressants imipramine, clomipramine, and citalopram induce apoptosis in human acute myeloid leukemia HL-60 cells via caspase-3 activation. J Biochem Mol Toxicol 13: 338-347, 1999.
-
(1999)
J Biochem Mol Toxicol
, vol.13
, pp. 338-347
-
-
Xia, Z.1
Bergstrand, A.2
De Pierre, J.W.3
Nassberger, L.4
-
46
-
-
23444456915
-
Differential induction of apoptosis by antidepressants in glioma and neuroblastoma. cell lines: Evidence for p-c-Jun, cytochrome c, and caspase-3 involvement
-
Levkovitz Y, Gil-Ad I, Zeldich E, Dayag M and Weizman A: Differential induction of apoptosis by antidepressants in glioma and neuroblastoma. cell lines: evidence for p-c-Jun, cytochrome c, and caspase-3 involvement. J Mol Neurosci 27: 29-42, 2005.
-
(2005)
J Mol Neurosci
, vol.27
, pp. 29-42
-
-
Levkovitz, Y.1
Gil-Ad, I.2
Zeldich, E.3
Dayag, M.4
Weizman, A.5
-
47
-
-
13444293008
-
Chlorimipramine: A novel anticancer agent with a mitochondrial target
-
Daley E, Wilkie D, Loesch A, Hargreaves IP, Kendall DA, Pilkington GJ and Bates TE: Chlorimipramine: a novel anticancer agent with a mitochondrial target. Biochem Biophys Res Commun 328: 623-632, 2005.
-
(2005)
Biochem Biophys Res Commun
, vol.328
, pp. 623-632
-
-
Daley, E.1
Wilkie, D.2
Loesch, A.3
Hargreaves, I.P.4
Kendall, D.A.5
Pilkington, G.J.6
Bates, T.E.7
-
48
-
-
22844448146
-
The Role of P-glycoprotein in the Blood-Brain Barrier. Einstein Q
-
Ramakrishnan P: The Role of P-glycoprotein in the Blood-Brain Barrier. Einstein Q J Biol Med 19: 160-165, 2003.
-
(2003)
J Biol Med
, vol.19
, pp. 160-165
-
-
Ramakrishnan, P.1
|