Brain tumour stem cells: Possibilities of new therapeutic strategies

Expert Opinion on Biological Therapy

Volumn 7, Issue 8, 2007, Pages 1129-1135

  Piccirillo, Sara G M ^a   Vescovi, Angelo L ^a  

^a UNIVERSITY OF MILANO BICOCCA   (Italy)

Author keywords

Bone morphogenetic proteins; Cancer stem cells; Differentiation; Glioblastoma multiforme; Neural stem cells; Tumorigenicity

Indexed keywords

BRAIN TUMOR; CANCER STEM CELL; CELL DIFFERENTIATION; CELL POPULATION; GLIOBLASTOMA; HUMAN; IMMOBILIZED CELL; NERVE CELL; NONHUMAN; REVIEW; STEM CELL TRANSPLANTATION;

ANIMALS; BRAIN NEOPLASMS; CELL TRANSFORMATION, NEOPLASTIC; HUMANS; NEOPLASM TRANSPLANTATION; TUMOR STEM CELLS;

MUS;

EID: 34548156768     PISSN: 14712598     EISSN: None     Source Type: Journal    
DOI: 10.1517/14712598.7.8.1129     Document Type: Review

References (42)

1. HANAHAN D, WEINBERG RA: The hallmarks of cancer. Cell (2000) 100(1):57-70.
2. REYA T, MORRISON SJ, CLARKE MF, WEISSMAN IL: Stem cells, cancer, and CSCs. Nature (2001) 414(6859):105-111.
3. VESCOVI AL, GALLI R, REYNOLDS BA: Brain tumour stem cells. Nat. Rev. Cancer (2006) 6(6):425-436.
4. FRANK SA, NOWAK MA: Cell biology: developmental predisposition to cancer. Nature (2003) 422(6931):494.
5. SANAI N, ALVAREZ-BUYLLA A, BERGER MS: Neural stem cells and the origin ofgliomas. N. Engl. J. Med. (2005) 353(8):811-822.
6. BONNET D, DICK JE: Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nat. Med. (1997) 3(7):730-737.
7. HOPE KJ, JIN L, DICK JE: Acute myeloid leukemia originates from a hierarchy of leukemic stem cell classes that differ in self-renewal capacity. Nat. Immunol. (2004) 5(7):738-743.
8. AL-HAJJ M, WICHA MS, BENITO-HERNANDEZ A, MORRISON SJ, CLARKE MF: Prospective identification of tumorigenic breast cancer cells. Proc. Natl. Acad. Sci. USA (2003) 100(7):3983-3988.
9. LOOIJENGA LH, STOOP H, DE LEEUW HP et al.: POU5F1 (OCT3/4) identifies cells with pluripotent potential in human germ cell tumors. Cancer Res. (2003) 63(9):2244-2250.
10. IGNATOVA TN, KUKEKOV VG, LAYWELL ED et al.: Human cortical glial tumors contain neural stem-like cells expressing astroglial and neuronal markers in vitro. Glia (2002) 39(3): 193-206.
11. SINGH SK, CLARKE ID, TERASAKI M et al.: Identification of a cancer stem cell in human brain tumors. Cancer Res. (2003) 63(18):5821- 5828.
12. HEMMATI HD, NAKANO I, LAZAREFF JA et al.: Cancerous stem cells can arise from pediatric brain tumors. Proc. Natl. Acad. Sci. USA (2003) 100(25):15178-15183.
13. GALLIR, BINDA E, ORFANELLI U et al.: Isolation and characterization of tumorigenic, stem-like neural precursors from human glioblastoma. Cancer Res. (2004) 64(19):7011-7021.
14. SINGH SK, HAWKINS C, CLARKE ID et al.: Identification of human brain tumour initiating cells. Nature (2004) 432(7015):396-401.
15. TAYLOR MD, POPPLETON H, FULLER C et al.: Radial glia cells are candidate stem cells of ependymoma. Cancer Cell (2005) 8(4):323-335.
16. COLLINS AT, BERRY PA, HYDE C, STOWER MJ, MAITLAND NJ: Prospective identification of tumorigenic prostate CSCs. Cancer Res. (2005) 65(23):10946-10951.
17. SZOTEK PP, PIERETTI-VANMARCKE R, MASIAKOS PT et al.: Ovarian cancer side population defines cells with stem cell-like characteristics and Mullerian inhibiting Substance responsiveness. Proc. Natl. Acad. Sci. USA (2006) 103(30):11154-11159.
18. O'BRIEN CA, POLLETT A, GALLINGER S, DICK JE: A human colon cancer cell capable of initiating tumour growth in immunodeficient mice. Nature (2007) 445(7123):106-110.
19. RICCI-VITIANI L, LOMBARDI DG, PILOZZI E et al.: Identification and expansion of human colon-cancer-initiating cells. Nature (2007) 445(7123):111-115.
20. BEHIN A, HOANG-XUAN K, CARPENTIER AF, DELATTRE JY: Primary brain tumours in adults. Lancet (2003) 361(9354):323-331.
21. HOLLAND EC: Glioblastoma multiforme: the terminator. Proc. Natl. Acad. Sci. USA (2000) 97(12):6242-6244.
22. REYNOLDS BA, WEISS S: Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system. Science (1992) 255(5052):1707-1710.
23. GRITTI A, PARATI EA, COVA L et al.: Multipotential stem cells from the adult mouse brain proliferate and self-renew in response to basic fibroblast growth factor. J. Neuro. Sci. (1996) 16(3):1091-1100.
24. SANAI N, TRAMONTIN AD, QUINONES-HINOJOSA A et al.: Unique astrocyte ribbon in adult human brain contains neural stem cells but lacks chain migration. Nature (2004) 427(6976):740-744.
25. DOETSCH F, CAILLE I, LIM DA, GARCIA-VERDUGO JM, ALVAREZ-BUYLLA A: Subventricular zone astrocytes are neural stem cells in the adult mammalian brain. Cell (1999) 97:703-716.
26. HOLLAND EC, HIVELY WP, GALLO V, VARMUS HE: Modeling mutations in the G1 arrest pathway in human gliomas: overexpression of CDK4 but not loss of INK4a-ARF induces hyperploidy in cultured mouse astrocytes. Genes Dev. (1998) 12(23):3644-3649.
27. HOLLAND EC, CELESTINO J, DAI C et al.: Combined activation of Ras and Akt in neural progenitors induces glioblastoma formation in mice. Nat. Genet. (2000) 25:55-57.
28. ZHU Y, GUIGNARD F, ZHAO D et al.: Early inactivation of p53 tumor suppressor gene cooperating with NF1 loss induces malignant astrocytoma. Cancer Cell (2005) 8(2):119-130.
29. UCHIDA N, BUCK DW, HE D et al.: Direct isolation of human central nervous system stem cells. Proc. Natl. Acad. Sci. USA (2000) 97(26):14720-14725.
30. RIETZE RL, VALCANIS H, BROOKER GF etal.: Purification of a pluripotent neural stem cell from the adult mouse brain. Nature (2001) 412(6848):736-739.
31. CAPELA A, TEMPLE S: LeX/ssea-1 is expressed by adult mouse CNS stem cells, identifying them as nonependymal. Neuron (2002) 35(5):865-875.
32. REYNOLDS BA, RIETZE RL: Neural stem cells and neurospheres-re-evaluating the relationship. Nat. Methods (2005) 2(5):333-336.
33. REYNOLDS BA, WEISS S: Clonal and population analyses demonstrate that an EGF-responsive mammalian embryonic CNS precursor is a stem cell. Dev. Biol. (1996) 175(1):1-13.
34. KUMMERMEHR J: Tumour stem cells. In: Stem cells. Potten C (Ed.), Academic Press, London, UK (1997):363-399.
35. LEE J, KOTLIAROVA S, KOTLIAROV Y et al.: Tumor stem cells derived from glioblastomas cultured in bFGF and EGF more closely mirror the phenotype and genotype of primary tumors than do serum-cultured cell lines. Cancer Cell (2006) 9(5):391-403.
36. BAO S, WU Q, SATHORNSUMETEE S et al.: Stem cell-like glioma cells promote tumor angiogenesis through vascular endothelial growth factor. Cancer Res. (2006) 66(16):7843-7848.
37. BAO S, WU Q, MCLENDON RE et al.: Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Nature (2006) 444(7120):756-760.
38. JACKSON EL, GARCIA-VERDUGO JM, GIL-PEROTIN S et al.: PDGFRa-positive B cells are neural stem cells in the adult SVZ that form glioma-like growths in response to increased PDGF signaling. Neuron (2006) 51:187-199.
39. PICCIRILLO SGM, REYNOLDS BA, ZANETTI N et al.: Bone morphogenetic proteins inhibit the tumorigenic potential of human brain tumour-initiating cells. Nature (2006) 444(7120):761-765.
40. LIGON KL, HUILLARD E, MEHTA S et al.: Olig2-regulated lineage-restricted pathway controls replication competence in neural stem cells and malignant glioma. Neuron (2007) 53:503-517.
41. LIM DA, TRAMONTIN AD, TREVEJO JM et al.: Noggin antagonizes BMP signaling to create a niche for adult neurogenesis. Neuron (2000) 28(3):713-726.
42. PANCHISION DM, MCKAY RD: The control of neural stem cells by morphogenic signals. Curr. Opin. Genet. Dev. (2002) 12(4):478-487.