Phytochemical profile and biological activity of Juglans regia

Journal of Integrative Medicine

Volumn 14, Issue 5, 2016, Pages 359-373

  Panth, Nisha ^a   Paudel, Keshav Raj ^a   Karki, Rajendra ^a  

^a Mokpo National University   (South Korea)

Author keywords

Juglans regia; ; medicine; pharmacology; phytochemicals; plant extracts; traditional

Indexed keywords

ANTINEOPLASTIC AGENT; CARDIOVASCULAR AGENT; ESSENTIAL OIL; FLAVONE DERIVATIVE; FLAVONOID GLYCOSIDE; JUGLANS REGIA EXTRACT; LIVER PROTECTIVE AGENT; NEUROPROTECTIVE AGENT; PLANT EXTRACT; PLANT MEDICINAL PRODUCT; STEROID; TANNIN DERIVATIVE; UNCLASSIFIED DRUG; ANTIOXIDANT; PHYTOCHEMICAL;

ANTIBACTERIAL ACTIVITY; ANTIINFLAMMATORY ACTIVITY; ANTINEOPLASTIC ACTIVITY; ANTIOXIDANT ACTIVITY; BIOLOGICAL ACTIVITY; COGNITION; DIABETES MELLITUS; DRUG INFORMATION; ETHNOBOTANY; HUMAN; JUGLANS REGIA; NONHUMAN; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; CHEMISTRY; DRUG EFFECT; PHYTOTHERAPY; WALNUT;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; ANTIOXIDANTS; COGNITION; ETHNOBOTANY; HUMANS; JUGLANS; NEUROPROTECTIVE AGENTS; PHYTOCHEMICALS; PHYTOTHERAPY; PLANT EXTRACTS;

EID: 85050579475     PISSN: 20954964     EISSN: None     Source Type: Journal    
DOI: 10.1016/S2095-4964(16)60274-1     Document Type: Review

References (108)

1. Paudel, KR, Panth, N, Phytochemical profile and biological activity of Nelumbo nucifera. Evid Based Complement Alternat Med, 2015, 2015, 789124.
2. Paudel, KR, Lee, UW, Kim, DW, Chungtaejeon, a Korean fermented tea, prevents the risk of atherosclerosis in rats fed a high-fat atherogenic diet. J Integr Med 14:2 (2016), 134–142.
3. Devkota, SR, Paudel, KR, Sharma, K, Baral, A, Chhetri, SBB, Thapa, PPU, Baral, KP, Investigation of antioxidant and anti-inflammatory activity of roots of Rumex nepalensis. World J Pharm Pharm Sci 4:3 (2015), 582–594.
4. Jun, MY, Karki, R, Paudel, KR, Sharma, BR, Adhikari, D, Kim, DW, Alkaloid rich fraction from Nelumbo nucifera targets VSMC proliferation and migration to suppress restenosis in balloon-injured rat carotid artery. Atherosclerosis 248 (2016), 179–189.
5. Gîrzu, M, Carnat, A, Privat, AM, Fialip, J, Carnat, AP, Lamaison, JL, Sedative effect of walnut leaf extract and juglone, an isolated constituent. Pharm Biol 36:4 (1998), 280–286.
6. Mouhajir, F, Hudson, JB, Rejdali, M, Towers, GHN, Multiple antiviral activities of endemic medicinal plants used by Berber people of Morocco. Pharm Biol 39:5 (2001), 364–374.
7. Warrier, PK, Nambiar, VPK, Ramankutty, C, Indian medicinal plants: a compendium of 500 species, 3rd ed., 1994, Orient Black Swan, Telangana, 59–64.
8. Fujita, T, Sezik, E, Tabata, M, Yesilada, E, Honda, G, Takeda, Y, Tanaka, T, Takaishi, Y, Traditional medicine in Turkey VII. Folk medicine in Middle and West Black Sea regions. Econ Bot 49:4 (1995), 406–422.
9. Sener, B, Biodiversity: Biomolecular aspects of biodiversity and innovative utilization, 2002, Kluwer Academic/Plenum Publishers, London, 119–135.
10. Rahimi, R, Shams-Ardekani, MR, Abdollahi, M, A review of the efficacy of traditional Iranian medicine for inflammatory bowel disease. World J Gastroenterol 16:36 (2010), 4504–4514.
11. Jaradat, NA, Medical plants utilized in Palestinian folk medicine for treatment of diabetes mellitus and cardiac diseases. J Al-Aqsa Unv 19 (2005), 1–28.
12. Kaileh, MB, Berghea, WV, Boonec, E, Essawib, T, Haegemana, G, Screening of indigenous Palestinian medicinal plants for potential anti-inflammatory and cytotoxic activity. J Ethnopharmacol 113:3 (2007), 510–516.
13. Spaccarotella, KJI, Kris-Etherton, PM, Stone, WL, Bagshaw, DM, Fishell, VK, West, SG, Lawrence, FR, Hartman, TJ, The effect of walnut intake on factors related to prostate and vascular health in older men. Nutr J 7:13 (2008), 1–10.
14. Liu, L, Li, W, Koike, K, Zhang, S, Nikaido, T, New alpha tetralonyl glucosides from the fruit of Juglans mandshurica. Chem Pharm Bull (Tokyo) 52:5 (2004), 566–569.
15. Nael, AT, Mohammed, AA-W, Utility and importance of walnut, Juglans regia Linn: a review. Afr J Microbiol Res 5:32 (2011), 5796–5805.
16. 4-induced damage on the Huh7 human hepatoma cell line. Ann Hematol 10:1 (2011), 73–79.
17. Kunwar, RM, Adhikari, N, Ethnomedicine of Dolpa district, Nepal: the plants, their vernacular names and uses. J Ecol App 8:1 (2005), 43–49.
18. Tagarelli, G, Tagarelli, A, Piro A. Folk medicine used to heal malaria in Calabria (southern Italy). J Ethnobiol Ethnomed, 6, 2010, 27.
19. Salimi, M, Ardestaniyan, MH, Mostafapour Kandelous, H, Saeidnia, S, Gohari, AR, Amanzadeh, A, Sanati, H, Sepahdar, Z, Ghorbani, S, Salimi, M, Anti-proliferative and apoptotic activities of constituents of chloroform extract of Juglans regia leaves. Cell Prolif 47:2 (2014), 172–179.
20. Parle, M, Khanna, D, Walnut: not a hard nut to crack. Int J Pharm Pharm 2:5 (2011), 8–17.
21. Pereira, JA, Oliveira, I, Sousa, A, Valentão, P, Andrade, PB, Ferreira, IC, Ferreres, F, Bento, A, Seabra, R, Estevinho, L, Walnut (Juglans regia L.) leaves: phenolic compounds, antibacterial activity and antioxidant potential of different cultivars. Food Chem Toxicol 45:11 (2007), 2287–2295.
22. Jia, Z, Zhan, PF, Tao, BQ, Li, C, Study on flavones of the flower of Juglans regia. Chin Pharm J 44:7 (2009), 496–497 Chinese with abstract in English.
23. Rather, MA, Dar, BA, Dar, MY, Wani, BA, Shah, WA, Bhat, BA, Ganai, BA, Bhat, KA, Anand, R, Qurishi, MA, Chemical composition, antioxidant and antibacterial activities of the leaf essential oil of Juglans regia L. and its constituents. Phytomedicine 19:13 (2012), 1185–1190.
24. Talapatra, SK, Bimala, K, Shambhu, CD, Bani, T, (–)-Regiolone, an α-tetralone from Juglans regia: structure, stereochemistry and conformation. Phytochemistry 27:12 (1988), 3929–3932.
25. Li, CY, Du, HJ, Su, XH, Zhong, YJ, Yuan, ZP, Li, YF, Liang, B, Juglanones A and B: two novel tetralone dimers from walnut pericarp (Juglans regia). Helvetica Chimica Acta 96:6 (2013), 1031–1035.
26. Fukuda, T, Ito, H, Yoshida, T, Antioxidative polyphenols from walnuts (Juglans regia L.). Phytochemistry 63:7 (2003), 795–801.
27. Amaral, JS, Casal, S, Pereira, JA, Seabra, RM, Oliveira, BP, Determination of sterol and fatty acid compositions, oxidative stability, and nutritional value of six walnut (Juglans regia L.) cultivars grown in Portugal. J Agric Food Chem 51:26 (2003), 7698–7702.
28. Colaric, M, Robert, V, Anita, S, Metka, H, Franci, S, Phenolic acids, syringaldehyde, and juglone in fruits of different cultivars of Juglans regia L. J Agric Food Chem 53:16 (2005), 6390–6396.
29. Zhang, Z, Liao, L, Moore, J, Wu, T, Wang, Z, Antioxidant phenolic compounds from walnut kernels (Juglans regia L.). Food Chem 113:1 (2009), 160–165.
30. Luo, JJ, Yang, B, Zeng, Y, Li, C, Chemical constituents from the flower of Juglans regia. Zhong Yao Cai 35:10 (2013), 1614–1616 Chinese with abstract in English.
31. Du, HJ, Li, CY, Wen, YY, Tu, YB, Zhong, YJ, Yuan, ZP, Li, YF, Liang, B, Secondary metabolites from pericarp of Juglans regia. Biochem Syst Ecol 54 (2014), 88–91.
32. Liu, J, Meng, M, Li, C, Huang, X, Di, D, Simultaneous determination of three diarylheptanoids and an α-tetralone derivative in the green walnut husks (Juglans regia L.) by high-performance liquid chromatography with photodiode array detector. J Chromatogr A 1190:1–2 (2008), 80–85.
33. 4-induced oxidative damage in rats. Pharm Biol 51:5 (2013), 558–565.
34. Zhao, MH, Jiang, ZT, Liu, T, Li, R, Flavonoids in Juglans regia L. leaves and evaluation of in vitro antioxidant activity via intracellular and chemical methods. Sci World J, 2014, 2014, 303878.
35. Haddad, EH, Gaban-Chong, N, Oda, K, Sabaté, J, Effect of a walnut meal on postprandial oxidative stress and antioxidants in healthy individuals. Nutr J 13:4 (2014), 1–9.
36. Cosmulescu, S, Trandafir, I, Anti-oxidant activities and total phenolics contents of leaf extracts from 14 cultivars of walnut (Juglans regia L.). J Hortic Sci Biotech 87:5 (2012), 504–508.
37. Grace, MH, Neff, SA, Warlick, C, Ayoub, E, Esposito, D, Wilson, M, Komarnytsky, S, Lila, MA, HSCCC isolation and characterization of walnut polyphenols with antioxidative and lipolytic activity. FASEB J, 27(Suppl 1), 2013, 1065 1017.
38. Carey, AN, Fisher, DR, Joseph, JA, Shukitt-Hale, B, The ability of walnut extract and fatty acids to protect against the deleterious effects of oxidative stress and inflammation in hippocampal cells. Nutr Neurosci 16:1 (2013), 13–20.
39. Willis, LM, Shukitt-Hale, B, Cheng, V, Joseph, JA, Dose-dependent effects of walnuts on motor and cognitive function in aged rats. Br J Nutr 101:8 (2009), 1140–1144.
40. Poulose, SM, Miller, MG, Shukitt-Hale, B, Role of walnuts in maintaining brain health with age. J Nutr 144:4 (2014), 561S–566S.
41. Haider, S, Zehra, B, Saiqa, T, Tahira, P, Sadia, S, Fizza, N, Huma, J, Darakhshan, JH, Effects of walnuts (Juglans regia) on learning and memory functions. Plant Foods Hum Nutr 66:4 (2011), 335–340.
42. Ros, E, Mataix, J, Fatty acid composition of nuts—implications for cardiovascular health. Br J Nutr 96:Suppl 2 (2006), S29–S35.
43. Willis, LM, Shukitt-Hale, B, Joseph, JA, Modulation of cognition and behavior in aged animals: role for antioxidant- and essential fatty acid-rich plant foods. Am J Clin Nutr 89:5 (2009), 1602S–1606S.
44. Willis, LM, Shukitt-Hale, B, Joseph, JA, Dietary polyunsaturated fatty acids improve cholinergic transmission in the aged brain. Genes Nutr 4:4 (2009), 309–314.
45. Asadi-Shekaari, M, Karimi, A, Shabani, M, Sheibani, V, Esmaeilpour, K, Maternal feeding with walnuts (Juglans regia) improves learning and memory in their adult pups. Avicenna J Phytomed 3:4 (2013), 341–346.
46. Fisher DR, Poulose SM, Bielinski DF, Shukitt-Hale B. Serum metabolites from walnut-fed aged rats attenuate stress-induced neurotoxicity in BV-2 microglial cells. Nutr Neurosci. 2014. Epub ahead of print.
47. Shabani, M, Nazeri, M, Parsania, S, Razavinasab, M, Zangiabadi, N, Esmaeilpour, K, Abareghi, F, Walnut consumption protects rats against cisplatin-induced neurotoxicity. Neurotoxicology 33:5 (2012), 1314–1321.
48. Essa, MM, Subash, S, Dhanalakshmi, C, Manivasagam, T, Al-Adawi, S, Guillemin, GJ, Justin Thenmozhi, A, Dietary supplementation of walnut partially reverses 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine induced neurodegeneration in a mouse model of Parkinson's disease. Neurochem Res 40:6 (2015), 1283–1293.
49. Orhan, IE, Suntar, IP, Akkol, EK, In vitro neuroprotective effects of the leaf and fruit extracts of Juglans regia L. (walnut) through enzymes linked to Alzheimer's disease and antioxidant activity. Int J Food Sci Nutr 62:8 (2011), 781–786.
50. Asgary, S, Sahar, P, Amirreza, S, Hossein, M, Parvin, M, Parivash, R, Effect of ethanolic extract of Juglans regia L. on blood sugar in diabetes-induced rats. J Med Food 11:3 (2008), 533–538.
51. Mohammadi, J, Delaviz, H, Malekzadeh, JM, Roozbehi, A, The effect of hydro alcoholic extract of Juglans regia leaves in streptozotocin-nicotinamide induced diabetic rats. Pak J Pharm Sci 25:2 (2012), 407–411.
52. Hosseini, S, Jamshidi, L, Mehrzadi, S, Mohammad, K, Najmizadeh, AR, Alimoradi, H, Huseini, HF, Effects of Juglans regia L. leaf extract on hyperglycemia and lipid profiles in type two diabetic patients: a randomized double-blind, placebo-controlled clinical trial. J Ethnopharmacol 152:3 (2014), 451–456.
53. Hosseini, S, Huseini, HF, Larijani, B, Mohammad, K, Najmizadeh, A, Nourijelyani, K, Jamshidi, L, The hypoglycemic effect of Juglans regia leaves aqueous extract in diabetic patients: a first human trial. Daru, 22(1), 2014, 19.
54. Pitschmann, A, Zehl, M, Atanasov, AG, Dirsch, VM, Heiss, E, Glasl, S, Walnut leaf extract inhibits PTP1B and enhances glucose-uptake in vitro. J Ethnopharmacol 152:3 (2014), 599–602.
55. Lozano, A, Perez-Martinez, P, Marin, C, Tinahones, FJ, Delgado-Lista, J, Cruz-Teno, C, Gomez-Luna, P, Rodriguez-Cantalejo, F, Perez-Jimenez, F, Lopez-Miranda, J, An acute intake of a walnut-enriched meal improves postprandial adiponectin response in healthy young adults. Nutr Res 33:12 (2013), 1012–1018.
56. Zhang, XB, Zou, CL, Duan, YX, Wu, F, Li, G, Activity guided isolation and modification of juglone from Juglans regia as potent cytotoxic agent against lung cancer cell lines. BMC Complement Altern Med, 15, 2015, 396.
57. Hasan, TN, B, LG, Shafi, G, Al-Hazzani, AA, Alshatwi, AA, Anti-proliferative effects of organic extracts from root bark of Juglans Regia L. (RBJR) on MDA-MB-231 human breast cancer cells: role of Bcl-2/Bax, caspases and Tp53. Asian Pac J Cancer Prev 12:2 (2011), 525–530.
58. Alshatwi, AA, Hasan, TN, Shafi, G, Syed, NA, Al-Assaf, AH, Alamri, MS, Al-Khalifa, AS, Validation of the antiproliferative effects of organic extracts from the green husk of Juglans regia L. on PC-3 human prostate cancer cells by assessment of apoptosis-related genes. Evid Based Complement Alternat Med, 2012, 2012, 103026.
59. Nagel, JM, Brinkoetter, M, Magkos, F, Liu, X, Chamberland, JP, Shah, S, Zhou, J, Blackburn, G, Mantzoros, CS, Dietary walnuts inhibit colorectal cancer growth in mice by suppressing angiogenesis. Nutrition 28:1 (2012), 67–75.
60. Hardman, WE, Ion, G, Suppression of implanted MDA-MB 231 human breast cancer growth in nude mice by dietary walnut. Nutr Cancer 60:5 (2008), 666–674.
61. Liao, W, Lai, T, Chen, L, Fu, J, Sreenivasan, ST, Yu, Z, Ren, J, Synthesis and characterization of a walnut peptides–zinc complex and its antiproliferative activity against human breast carcinoma cells through the induction of apoptosis. J Agric Food Chem 64:7 (2016), 1509–1519.
62. Ma, S, Huang, D, Zhai, M, Yang, L, Peng, S, Chen, C, Feng, X, Weng, Q, Zhang, B, Xu, M, Isolation of a novel biopeptide from walnut residual protein inducing apoptosis and autophagy on cancer cells. BMC Complement Altern Med, 15, 2015, 413.
63. Oguzhan, D, Zeynep, BD, Evaluation of the selective anticancer potential and the genetic mechanisms of the induction of apoptosis by walnut milk in human breast and prostate cancer cells. Biomed Res 27:1 (2016), 268–278.
64. Sánchez-González, C, Ciudad, CJ, Noé, V, Izquierdo-Pulido, M, Walnut polyphenol metabolites, urolithins A and B, inhibit the expression of the prostate-specific antigen and the androgen receptor in prostate cancer cells. Food Funct 5:11 (2014), 2922–2930.
65. Salimi, M, Majd, A, Sepahdar, Z, Azadmanesh, K, Irian, S, Ardestaniyan, MH, Hedayati, MH, Rastkari, N, Cytotoxicity effects of various Juglans regia (walnut) leaf extracts in human cancer cell lines. Pharm Biol 50:11 (2012), 1416–1422.
66. Lee, HH, Paudel, KR, Jeong, J, Wi, AJ, Park, WS, Kim, DW, Oak, MH, Antiatherogenic effect of Camellia japonica fruit extract in high fat diet-fed rats. Evid Based Complement Alternat Med, 2016, 2016, 9679867.
67. Paudel, KR, Karki, R, Kim, DW, Cepharanthine inhibits in vitro VSMC proliferation and migration and vascular inflammatory responses mediated by RAW264.7. Toxicol In Vitro 34 (2016), 16–25.
68. Paudel, KR, Panth, N, Kim, DW, Circulating endothelial microparticles: a key hallmark of atherosclerosis progression. Scientifica (Cairo), 2016, 2016, 8514056.
69. Karki, R, Kim, SB, Kim, DW, Magnolol inhibits migration of vascular smooth muscle cells via cytoskeletal remodeling pathway to attenuate neointima formation. Exp Cell Res 319:20 (2013), 3238–3250.
70. Karki, R, Jeon, ER, Kim, DW, Nelumbo nucifera leaf extract inhibits neointimal hyperplasia through modulation of smooth muscle cell proliferation and migration. Nutrition 29:1 (2013), 268–275.
71. Karki, R, Jeon, ER, Kim, DW, Magnoliae cortex inhibits intimal thickening of carotid artery through modulation of proliferation and migration of vascular smooth muscle cells. Food Chem Toxicol 50:3–4 (2012), 634–640.
72. Hayes, D, Angove, MJ, Tucci, J, Dennis, C, Walnuts (Juglans regia) chemical composition and research in human health. Crit Rev Food Sci Nutr 56:8 (2016), 1231–1241.
73. Feldman, EB, The scientific evidence for a beneficial health relationship between walnuts and coronary heart disease. J Nutr 132:5 (2002), 1062S–1101S.
74. Davis, P, Valacchi, G, Pagnin, E, Shao, Q, Gross, HB, Calo, L, Yokoyama, W, Walnuts reduce aortic ET-1 mRNA levels in hamsters fed a high-fat atherogenic diet. J Nutr 136:2 (2006), 428–432.
75. Gu, X, Hou, YK, Li, D, Wang, JZ, Wang, FJ, Separation, purification, and identification of angiotensin I-converting enzyme inhibitory peptides from Walnut (Juglans regia L.) hydrolyzate. Int J Food Prop 18:2 (2015), 266–276.
76. Wang, X, Chen, H, Li, S, Zhou, J, Xu, J, Physico-chemical properties, antioxidant activities and antihypertensive effects of walnut protein and its hydrolysate. J Sci Food Agric 96:7 (2016), 2579–2587.
77. Nergiz-Ünal, R, Kuijpers, MJ, de Witt, SM, Heeneman, S, Feijge, MA, Garcia Caraballo, SC, Biessen, EA, Haenen, GR, Cosemans, JM, Heemskerk, JW, Atheroprotective effect of dietary walnut intake in ApoE-deficient mice: involvement of lipids and coagulation factors. Thromb Res 131:5 (2013), 411–417.
78. Shimoda, H, Tanaka, J, Kikuchi, M, Fukuda, T, Ito, H, Hatano, T, Yoshida, T, Walnut polyphenols prevent liver damage induced by carbon tetrachloride and D-galactosamine: hepatoprotective hydrolyzable tannins in the kernel pellicles of walnut. J Agric Food Chem 56:12 (2008), 4444–4449.
79. Peng, X, Nie, Y, Wu, J, Huang, Q, Cheng, Y, Juglone prevents metabolic endotoxemia-induced hepatitis and neuroinflammation via suppressing TLR4/NF-κB signaling pathway in high-fat diet rats. Biochem Biophys Res Commun 462:3 (2015), 245–250.
80. Bati, B, Celik, I, Dogan, A, Determination of hepatoprotective and antioxidant role of walnuts against ethanol-induced oxidative stress in rats. Cell Biochem Biophys 71:2 (2015), 1191–1198.
81. Shimoda, H, Tanaka, J, Kikuchi, M, Fukuda, T, Ito, H, Hatano, T, Yoshida, T, Effect of polyphenol-rich extract from walnut on diet-induced hypertriglyceridemia in mice via enhancement of fatty acid oxidation in the liver. J Agric Food Chem 57:5 (2009), 1786–1792.
82. Erdemoglu, N, Kupeli, E, Yesilada, E, Anti-inflammatory and antinociceptive activity assessment of plants used as remedy in Turkish folk medicine. J Ethnopharmacol 89:1 (2003), 123–129.
83. Willis, LM, Bielinski, DF, Fisher, DR, Matthan, NR, Joseph, JA, Walnut extract inhibits LPS-induced activation of BV-2 microglia via internalization of TLR4: possible involvement of phospholipase D2. Inflammation 33:5 (2010), 325–333.
84. Hosseinzadeh, H, Zarei, H, Taghiabadi, E, Antinociceptive, anti-inflammatory and acute toxicity effects of Juglans regia L. leaves in mice. Iran Red Crescent Med J 13:1 (2011), 27–33.
85. Qamar, W, Sarwat, S, Polyphenols from Juglans regia L.(walnut) kernel modulate cigarette smoke extract induced acute inflammation, oxidative stress and lung injury in Wistar rats. Hum Exp Toxicol 30:6 (2011), 499–506.
86. Papoutsi, Z, Kassi, E, Chinou, I, Halabalaki, M, Skaltsounis, LA, Moutsatsou, P, Walnut extract (Juglans regia L.) and its component ellagic acid exhibit anti-inflammatory activity in human aorta endothelial cells and osteoblastic activity in the cell line KS483. Br J Nutr 99:4 (2008), 715–722.
87. Wang, X, Zhao, MM, Su, GW, Cai, MS, Sun-Waterhouse, DX, Zhou, CM, Lin, LZ, Antihyperuricemic activities of an ethanolic and aqueous extract of walnut (Juglans regia L.) shell and a new aldehyde xanthine oxidase inhibitor. Int J Food Sci Technol 51:2 (2016), 453–460.
88. Oliveira, I, Sousa, A, Ferreira, IC, Bento, A, Estevinho, L, Pereira, JA, Total phenols, antioxidant potential and antimicrobial activity of walnut (Juglans regia L.) green husks. Food Chem Toxicol 46:7 (2008), 2326–2331.
89. Kong, YH, Zhang, L, Yang, ZY, Han, C, Hu, LH, Jiang, HL, Shen, X, Natural product juglone targets three key enzymes from Helicobacter pylori: inhibition assay with crystal structure characterization. Acta Pharmacol Sin 29:7 (2008), 870–876.
90. Cruz-Vega, DE, Verde-Star, MJ, Salinas-González, N, Rosales-Hernández, B, Estrada-García, I, Mendez-Aragón, P, Carranza-Rosales, P, González-Garza, MT, Castro-Garza, J, Antimycobacterial activity of Juglans regia, Juglans mollis, Carya illinoensis and Bocconia frutescens. Phytother Res 22:4 (2008), 557–559.
91. Qadan, F, Thewaini, AJ, Ali, DA, Afifi, R, Elkhawad, A, Matalka, KZ, The antimicrobial activities of psidium guajava and Juglans regia leaf extracts to acne-developing organisms. Am J Chin Med 33:2 (2005), 197–204.
92. Sharafati, R, Sharafati, F, Rafieian-kopaei, M, Biological characterization of Iranian walnut (Juglans regia) leaves. Turk J Biol 35:5 (2011), 635–639.
93. Sharafati-Chaleshtori, R, Sharafati-Chaleshtori, F, Rafieian-kopaei, M, Drees, F, Ashrafi, K, Comparison of the antibacterial effect of ethanolic walnut (Juglans regia) leaf extract with chlorhexidine mouth rinse on Streptococcus mutans and sanguinis. J Islam Dent Assoc Iran 22:4 (2010), 211–217.
94. Zhang, WX, He, KZ, Pu, Q, Antimicrobial and antioxidant activities of extracts from walnut green husks. Ying Yong Yu Huan Jing Sheng Wu Xue Bao 20:1 (2014), 87–92 Chinese with abstract in English.
95. Zibaeenezhad, MJ, Rezaiezadeh, M, Mowla, A, Ayatollahi, SMT, Panjehshahin, MR, Antihypertriglyceridemic effect of walnut oil. Angiology 54:4 (2003), 411–414.
96. Ros, E, Núñez, I, Pérez-Heras, A, Serra, M, Gilabert, R, Casals, E, Deulofeu, R, A walnut diet improves endothelial function in hypercholesterolemic subjects: a randomized crossover trial. Circulation 109:13 (2004), 1609–1614.
97. Iwamoto, M, Imaizumi, K, Sato, M, Hirooka, Y, Sakai, K, Takeshita, A, Kono, M, Serum lipid profiles in Japanese women and men during consumption of walnuts. Eur J Clin Nutr 56:7 (2002), 629–637.
98. Wu, L, Piotrowski, K, Rau, T, Waldmann, E, Broedl, UC, Demmelmair, H, Koletzko, B, Stark, RG, Nagel, JM, Mantzoros, CS, Parhofer, KG, Walnut-enriched diet reduces fasting non-HDL-cholesterol and apolipoprotein B in healthy Caucasian subjects: a randomized controlled cross-over clinical trial. Metabolism 63:3 (2014), 382–391.
99. Sharma, BR, Kim, MS, Rhyu, DY, Nelumbo nucifera leaf extract attenuated pancreatic β-cells toxicity induced by interleukin-1β and interferon-γ, and increased insulin secrection of pancreatic β-cells in streptozotocin-induced diabetic rats. J Tradit Chin Med 36:1 (2016), 71–77.
100. Karki, R, Park, CH, Kim, DW, Extract of buckwheat sprouts scavenges oxidation and inhibits pro-inflammatory mediators in lipopolysaccharide-stimulated macrophages (RAW264.7). J Integr Med 11:4 (2013), 246–252.
101. Lee, HH, Paudel, KR, Kim, DW, Terminalia chebula fructus inhibits migration and proliferation of vascular smooth muscle cells and production of inflammatory mediators in RAW 264.7. Evid Based Complement Alternat Med, 2015, 2015, 502182.
102. Woods, B, Calnan, CD, Toxic woods. Br J Dermatol, 94(Suppl 13), 1976, 1.
103. Hausen, BM, Woods injurious to human health: a manual, 1981, Walter de Gruyter, Berlin, 119–121.
104. Bonamonte, D, Foti, C, Angelini, G, Hyperpigmentation and contact dermatitis due to Juglans regia. Contact Dermatitis 44:2 (2001), 102–103.
105. Haque, R, Bin-Hafeez, B, Parvez, S, Pandey, S, Sayeed, I, Ali, M, Raisuddin, S, Aqueous extract of walnut (Juglans regia L.) protects mice against cyclophosphamide-induced biochemical toxicity. Hum Exp Toxicol 22:9 (2003), 473–480.
106. Calabrò, S, Alzoubi, K, Bissinger, R, Jilani, K, Faggio, C, Lang, F, Enhanced eryptosis following juglone exposure. Basic Clin Pharmacol Toxicol 116:6 (2015), 460–467.
107. Belknap, JK, Black walnut extract: an inflammatory model. Vet Clin North Am Equine Pract 26:1 (2010), 95–101.
108. Chiavaccini, L, Hassel, DM, Shoemaker, ML, Charles, JB, Belknap, JK, Ehrhart, EJ, Detection of calprotectin and apoptotic activity within the equine colon from horses with black walnut extract-induced laminitis. Vet Immunol Immunopathol 144:3–4 (2011), 366–373.