Walnut polyphenols prevent liver damage induced by carbon tetrachloride and D-galactosamine: Hepatoprotective hydrolyzable tannins in the kernel pellicles of walnut

Journal of Agricultural and Food Chemistry

Volumn 56, Issue 12, 2008, Pages 4444-4449

  Shimoda, Hiroshi ^a   Tanaka, Junji ^a   Kikuchi, Mitsunori ^a   Fukuda, Toshiyuji ^b   Ito, Hideyuki ^c   Hatano, Tsutomu ^c   Yoshida, Takashi ^d  

^a 1 Numata Kitagata cho   (Japan)

^b POLA CHEMICAL INDUSTRIES INC   (Japan)

^c OKAYAMA UNIVERSITY   (Japan)

^d MATSUYAMA UNIVERSITY   (Japan)

Author keywords

Carbon tetrachloride; D galactosamine; Hydrolyzable tannin; Liver injury; Polyphenol; Tellimagrandin I; Walnut

Indexed keywords

CARBON TETRACHLORIDE; DRUG DERIVATIVE; FLAVONOID; GALACTOSAMINE; GALLIC ACID; GLUCOSIDE; PHENOL DERIVATIVE; POLYPHENOLS; TANNIN DERIVATIVE; TELLIMAGRANDIN I;

ANIMAL; ARTICLE; CELL CULTURE; CHEMICALLY INDUCED DISORDER; CHEMISTRY; HYDROLYSIS; ISOLATION AND PURIFICATION; LIVER DISEASE; METABOLISM; PLANT SEED; RAT; WALNUT;

ANIMALS; CARBON TETRACHLORIDE; CELLS, CULTURED; FLAVONOIDS; GALACTOSAMINE; GALLIC ACID; GLUCOSIDES; HYDROLYSIS; JUGLANS; LIVER DISEASES; PHENOLS; RATS; SEEDS; TANNINS;

JUGLANS; MUS; RATTUS;

EID: 47349134055     PISSN: 00218561     EISSN: None     Source Type: Journal    
DOI: 10.1021/jf8002174     Document Type: Article

References (30)

1. Mukuddem-Petersen, J.; Oosthuizen, W.; Jerling, J. C. A systematic review of the effects of nuts on blood lipid profiles in humans. J. Nutr. 2005, 135, 2082-2089.
2. Maguire, L. S.; O'Sullivan, S. M.; Galvin, K.; O'Connor, T. P.; O'Brien, N. M. Fatty acid profile, tocopherol, squalene and phytosterol content of walnuts, almonds, peanuts, hazelnuts and the macadamia nut. Int. J. Food Sci. Nutr. 2004, 55, 171-178.
3. Amaral, J. S.; Alves, M. R.; Seabra, R. M.; Oliveira, B. P. Vitamin E composition of walnuts (Juglans regia L.): a 3-year comparative study of different cultivars. J. Agric. Food Chem. 2005, 53, 5467-5472.
4. Fukuda, T.; Ito, H.; Yoshida, T. Antioxidative polyphenols from walnuts (Juglans regia L.). Phytochemistry 2003, 63, 795-801.
5. Ito, H.; Okuda, T.; Fukuda, T.; Hatano, T.; Yoshida, T. Two novel dicarboxylic acid derivatives and a new dimeric hydrolyzable tannin from walnuts. J. Agric. Food Chem. 2007, 55, 672-679.
6. Colaric, M.; Veberic, R.; Solar, A.; Hudina, M.; Stampar, F. Phenolic acids, syringaldehyde, and juglone in fruits of different cultivars of Juglans regia L. J. Agric. Food Chem. 2005, 53, 6390-6396.
7. Ros, E.; Núñez, I.; Pérez-Heras, A.; Serra, M.; Gilabert, R.; Casals, E.; Deulofeu, R. A walnut diet improves endothelial function in hypercholesterolemic subjects. Circulation 2004, 109, 1609-1614.
8. Tapsell, L. C.; Owen, A.; Gillen, L. J.; Baré, M.; Pach, C. S.; Kennedy, M.; Batterham, M. Including walnuts in a low-fat/ modified-fat diet improves HDL cholesterol-to-total cholesterol ratios in patients with type 2 diabetes. Diabetes Care 2004, 27, 2777-2783.
9. Iwamoto, M.; Sato, M.; Kono, M.; Hirooka, Y.; Sakai, K.; Takeshita, A.; Imaizumi, K. Walnuts lower serum cholesterol in Japanese men and women. J. Nutr. 2000, 130, 171-176.
10. Feldman, E. B. The scientific evidence for a beneficial health relationship between walnuts and coronary heart disease. J. Nutr. 2002, 132, 1062S-1101S..
11. Morgan, J. M.; Horton, K.; Reese, D.; Carey, C.; Walker, K.; Capuzzi, D. M. Effects of walnut consumption as part of a low-fat, low-cholesterol diet on serum cardiovascular risk factors. Int. J. Vitam. Nutr. Res. 2002, 72, 341-347.
12. Zibaeenezhad, M. J.; Rezaiezadeh, M.; Mowla, A.; Ayatollahi, S. M. T.; Panjehshahin, M. R. Antihypertriglyceridemic effect of walnut oil. Angiology 2003, 54, 411-414.
13. Zibaeenezhad, M. J.; Shamsnia, S. J.; Khorasani, M. Walnut consumption in hyperlipidemic patients. Angiology 2005, 56, 581-583.
14. Gillen, L. J.; Tapsell, L. C.; Pach, C. S.; Owen, A.; Batterham, M. Structured dietary advice incorporating walnuts achieves optimal fat and energy balance in patients with type 2 diabetes mellitus. J. Am. Diet. Assoc. 2005, 105, 1087-1096.
15. Fukuda, T.; Ito, H.; Yoshida, T. Effect of the walnut polyphenol fraction on oxidative stress in type 2 diabetes mice. BioFactors 2004, 21, 251-253.
16. Li, L.; Tsao, R.; Yang, R.; Liu, C.; Zhu, H.; Young, J. C. Polyphenols profiles and antioxidant activities of heartnut (Juglans ailanthifolia var. cordiformis) and Persian walnut (Juglans regia L.). J. Agric. Food Chem. 2006, 54, 8033-8040.
17. Anderson, K. J.; Teuber, S. S.; Gobeille, A.; Cremin, P.; Waterhouse, A. L.; Steinberg, F. M. Walnut polyphenolics inhibit in vitro human plasma and LDL oxidation. J. Nutr. 2001, 131, 2837-2842.
18. 4-induced liver injury in mice. Biol. Pharm. Bull. 2002, 25, 72-76.
19. Matsuda, H.; Ninomiya, K.; Shimoda, H.; Yoshikawa, M. Hepatoprotective principles from the flowers of Tilia argentea (Linden): structure requirements of tiliroside and mechanisms of action. Bioorg. Med. Chem. 2002, 10, 707-712.
20. Reyes-Gordillo, K.; Segovia, J.; Shibayama, M.; Vergara, P.; Moreno, M. G.; Muriel, P. Curcumin protects against acute liver damage in the rat by inhibiting NF-κB, proinflammatory cytokines production and oxidative stress. Biochim. Biophys. Acta 2007, 1770, 989-996.
21. Liu, Y. G.; Chen, H. C.; Jiang, Y. P. Protective effect of curcumin on experimental liver injury in mice. Zhongguo Zhong Yao Za Zhi 2003, 28, 756-758.
22. Marzouk, M. S.; El-Toumy, S. A.; Moharram, F. A.; Shalaby, N. M.; Ahmed, A. A. Pharmacologically active ellagitannins from Terminalia myriocarpa. Planta Med. 2002, 68, 523-527.
23. Lin, C. C.; Hsu, Y. F.; Lin, T. C.; Hsu, F. L.; Hsu, H. Y. Antioxidant and hepatoprotective activity of punicalagin and punicalin on carbon tetrachloride-induced liver damage in rats. J. Pharm. Pharmacol. 1998, 50, 789-794.
24. Lehmann, V.; Freudenberg, M. A.; Galanos, C. Lethal toxicity of lipopolysaccharide and tumor necrosis factor in normal and D- galactosamine-treated mice. J. Exp. Med. 1987, 165, 657-663.
25. Freudenberg, M. A.; Keppler, D.; Galanos, C. Requirement for lipopolysaccharide-responsive macrophages in galactosamine-induced sensitization to endotoxin. Infect. Immun. 1986, 51, 891-895.
26. Nakagiri, R.; Oda, H.; Kamiya, T. Small scale rat hepatocyte primary culture with applications for screening hepatoprotective substances. Biosci. Biotechnol. Biochem. 2003, 67, 1629-1635.
27. Morikawa, T.; Matsuda, H.; Ninomiya, K.; Yoshikawa, M. Medicinal food stuffs. XXIX. Potent protective effects of sesquiterpenes and curcumin from Zedoariae Rhizoma on liver injury induced by D-galactosamine/ lipopolysaccharide or tumor necrosis factor-α. Biol. Pharm. Bull. 2002, 25, 627-631.
28. Chen, A.; Zheng, S. Curcumin inhibits connective tissue growth factor gene expression in activated hepatic stellate cells in vitro by blocking NF-κB and ERK signaling. Br. J. Pharmacol. 2008, 153, 557-567.
29. Kaur, G.; Tirkey, N.; Bharrhan, S.; Chanana, V.; Rishi, P.; Chopra, K. Inhibition of oxidative stress and cytokine activity by curcumin in amelioration of endotoxin-induced experimental hepatotoxicity in rodents. Clin. Exp. Immunol. 2006, 145, 313-321.
30. Hikino, H.; Kiso, Y.; Hatano, T.; Yoshida, T.; Okuda, T. Antihepatotoxic actions of tannins. J. Ethnopharmacol. 1985, 14, 19-29.