The hypoglycemic effect of Juglans regia leaves aqueous extract in diabetic patients: A first human trial

DARU, Journal of Pharmaceutical Sciences

Volumn 22, Issue 1, 2014, Pages

  Hosseini, Saeed ^a   Huseini, Hasan Fallah ^b   Larijani, Bagher ^a   Mohammad, Kazem ^c   Najmizadeh, Alireza ^d   Nourijelyani, Keramt ^c   Jamshidi, Leila ^c  

^a TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b Institute of Medicinal Plants   (Iran)

^c TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^d Karaj Diabetes Society   (Iran)

Author keywords

Diabetes mellitus; Glucose; Insulin; J. regia; Liver enzymes

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; GLIBENCLAMIDE; HEMOGLOBIN A1C; INSULIN; JUGLANS REGIA LEAF EXTRACT; LACTATE DEHYDROGENASE; METFORMIN; PLACEBO; PLANT EXTRACT; UNCLASSIFIED DRUG;

ADULT; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANTIDIABETIC ACTIVITY; AQUEOUS SOLUTION; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BLOOD SAMPLING; CLINICAL TRIAL; CONTROLLED STUDY; DIABETIC PATIENT; FEMALE; GLUCOSE BLOOD LEVEL; HEMOGLOBIN BLOOD LEVEL; HUMAN; INSULIN BLOOD LEVEL; IRAN; JUGLANS REGIA; LACTATE DEHYDROGENASE BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; NON INSULIN DEPENDENT DIABETES MELLITUS; PLANT LEAF; PROLIFERATIVE RETINOPATHY; RANDOMIZED CONTROLLED TRIAL;

EID: 84893842759     PISSN: 15608115     EISSN: 20082231     Source Type: Journal    
DOI: 10.1186/2008-2231-22-19     Document Type: Article

References (19)

1. Global estimates of the prevalence of diabetes for 2010 and 2030. Shaw JE, Sicree RA, Zimmet PZ, Diabetes Res Clin Pract 2010 87 1 4 14 PubMed,MedLine, PDF 10.1016/j.diabres.2009.10.007 19896746
2. Antidiabetic plants of Iran. Shojaii A, Dabaghian FH, Goushegir A, Fard MA, Acta Med Iran 2011 49 10 637 642 PubMed,MedLine, PDF 22071637
3. Meta-analysis of the effect of herbal supplement on glycemic control in type 2 diabetes. Suksomboon N, Poolsup N, Boonkaew S, Suthisisang CC, J Ethnopharmacol 2011 137 3 1328 1333 10.1016/j.jep.2011.07.059 21843614
4. Medicinal plant diversity in the flora of Saudi Arabia 1: a report on seven plant families. Rahman MA, Mossa JS, Al-Said MS, Al-Yahya MA, Fitoterapia 2004 75 2 149 161 10.1016/j.fitote.2003.12.012 15030919 (Pubitemid 38353078)
5. Mozafarian V, Walnut tree. Identification of medicinal and aromatic plants of Iran Tehran, Iran: Farhang Moaser press 2012 473 475
6. Studies on correlation of antimutagenic and antiproliferative activities of Juglans regia L. Kaumar S, Harkonen PL, Arora S, Kaur M, J Environ Pathol Toxicol Oncol 2003 22 59 67 PDF 12678406 (Pubitemid 36397494)
7. Phenolic profile in the quality control of walnut (Juglans regia L.) leaves. Amaral JS, Seabra RM, Andrade PB, Valent AOP, Pereira JA, Ferreres F, J Food Chem 2004 88 373 379 10.1016/j.foodchem.2004.01.055 (Pubitemid 38980417)
8. Walnut (Juglans regia L.) leaves: phenolic compounds, antibacterial activity and antioxidant potential of different cultivars. Pereira JA, Oliveira I, Sousa A, Valentãob P, Andrade PB, Ferreira I, et al. J Food Chem Tox 2007 45 2287 2295 Pubmed, Medline,Fulltext 10.1016/j.fct.2007.06.004 (Pubitemid 47454758)
9. Anti-diabetic effects of an alcoholic extract of Juglans regia in an animal model. Mohammadi J, Sadeqpour K, Delaviz H, Mohammadi B, Turk J Med Sci 2011 41 685 691 Pubmed, Medline,PDF
10. Effect of walnut leaf, coriander and pomegranate on blood glucose and histopathology of pancreas of alloxan induced diabetic rats. Jelodar G, Mohsen M, Shahram S, Afr J Trad CAM 2007 43 299 305 Pubmed, Medline,PDF (Pubitemid 46930363)
11. Effect of ethanolic extract of Juglans regia L. on blood sugar in diabetes-induced rats. Asgary S, Parkhideh S, Solhpour A, Madani H, Mahzouni P, Rahimi P, J Med Food 2008 11 533 538 Pubmed, Medline,PDF 10.1089/jmf.2007.0611 18800903
12. Screening for type 2 diabetes. American Diabetes Association, Diabetes Care 2003 26 21 24 Pubmed, Medline,PDF
13. Glucosidase inhibitory activity of the methanolic extract from Tournefortia hartwegiana: an antihyperglycemic agent. Ortiz-Andrade RR, Garcia-Jimenez S, Castillo-Espana P, Ramirez-A G, Villalobos-Molina R, Estrada-Soto S, J Ethnopharmacol 2007 109 48 53 CrossRef, PubMed, CAS, Web of Science® Times Cited: 28 10.1016/j.jep.2006.07.002 16920301 (Pubitemid 44889199)
14. Dietary (Poly) phenolics in human health: Structures, bioavailability, and evidence of protective effects against chronic diseases. Del Rio D, Rodriguez-Mateos A, Spencer JP, Tognolini M, Borges G, Crozier A, Antioxid Redox Signal 2013 18 14 1818 1892 10.1089/ars.2012.4581 22794138
15. Bioactive properties and chemical composition of six walnut (Juglans regia L.) cultivars. Pereira JA, Oliveira I, Sousa A, Ferreira I, Bento A, Estevinho L, Food ChemToxicol 2008 46 2103 2111 CrossRef, Web of Science® 10.1016/j.fct.2008.02.002
16. Chemical composition of walnuts (Juglans regia L.) grown in New Zealand. Savage GP, Plant Food Hum Nutr 2001 56 75 82 Pubmed, Medline,PDF 10.1023/A:1008175606698 (Pubitemid 32111370)
17. Antioxidative polyphenols from walnuts (Juglans regia L.). Fukuda T, Ito H, Yoshida T, Phytochemistry 2004 63 795 801 Pubmed, PDF (Pubitemid 36903593)
18. Liver fat, serum triglycerides and visceral adipose tissue in insulin sensitive and insulin-resistant black men with NIDDM. Banerji MA, Buckley MC, Chaiken RL, Gordon D, Lebovitz HE, Kral JG, Int J Obes Relat Metab Disord 1995 19 846 850 PubMed, MedLine 8963350 (Pubitemid 26003019)
19. Effects of hydroalcoholic extract of Juglans regia leaves on activity of AST and ALT enzymes in alloxan- induced diabetic rats. Madani H, Rahimi P, Mahzoni P, Pharmaceut Sci 2009 15 2 213 218 PubMed,MedLine, PDF