The ability of walnut extract and fatty acids to protect against the deleterious effects of oxidative stress and inflammation in hippocampal cells

Nutritional Neuroscience

Volumn 16, Issue 1, 2013, Pages 13-20

  Carey, Amanda N ^a   Fisher, Derek R ^a   Joseph, James A ^a   Shukitt Hale, Barbara ^a  

^a TUFTS UNIVERSITY   (United States)

Author keywords

Hippocampal cells; Inflammation; Omega 3; Oxidative stress; Walnut

Indexed keywords

CALCIUM; DOCOSAHEXAENOIC ACID; DOPAMINE; ICOSAPENTAENOIC ACID; JUGLANS REGIA EXTRACT; LINOLEIC ACID; LIPOPOLYSACCHARIDE; PLANT EXTRACT; POLYUNSATURATED FATTY ACID; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CALCIUM CELL LEVEL; CALCIUM HOMEOSTASIS; CELL DEATH; CELL PROTECTION; CELL VIABILITY; CONTROLLED STUDY; DEPOLARIZATION; FLUORESCENCE IMAGING; HIPPOCAMPUS; INFLAMMATION; JUGLANS REGIA; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT;

ALPHA-LINOLENIC ACID; ANIMALS; CALCIUM; CELL SURVIVAL; CELLS, CULTURED; DIETARY FATS, UNSATURATED; DOCOSAHEXAENOIC ACIDS; EICOSAPENTAENOIC ACID; HIPPOCAMPUS; INFLAMMATION; JUGLANS; LINOLEIC ACID; LIPOPOLYSACCHARIDES; NEURONS; NEUROPROTECTIVE AGENTS; NUTS; OXIDATIVE STRESS; PLANT EXTRACTS; RATS;

EID: 84873108810     PISSN: 1028415X     EISSN: 14768305     Source Type: Journal    
DOI: 10.1179/1476830512Y.0000000023     Document Type: Article

References (40)

1. Yehuda S, Rabinovitz S, Mostofsky DI. Essential fatty acids and the brain: from infancy to aging. Neurobiol Aging 2005; 26(Suppl 1):98-102.
2. Cole GM, Ma QL, Frautschy SA. Dietary fatty acids and the aging brain. Nutr Rev 2010;68(Suppl 2):S102-11.
3. Willis LM, Bielinski DF, Fisher DR, Matthan NR, Joseph JA. Walnut extract inhibits LPS-induced activation of BV-2 microglia via internalization of TLR4: possible involvement of phospholipase D2. Inflammation 2010;33(5):325-33.
4. Bazan NG. The onset of brain injury and neurodegeneration triggers the synthesis of docosanoid neuroprotective signaling. Cell Mol Neurobiol 2006;26(4-6):901-13.
5. Willis LM, Shukitt-Hale B, Joseph JA. Dietary polyunsaturated fatty acids improve cholinergic transmission in the aged brain. Genes Nutr 2009;4(4):309-14.
6. Cole GM, Frautschy SA. DHA may prevent age-related dementia. J Nutr 2010;140(4):869-74.
7. Barberger-Gateau P, Letenneur L, Deschamps V, Peres K, Dartigues JF, Renaud S. Fish, meat, and risk of dementia: cohort study. BMJ 2002;325(7370):932-3.
8. Kaduce TL, Chen Y, Hell JW, Spector AA. Docosahexaenoic acid synthesis from n-3 fatty acid precursors in rat hippocampal neurons. J Neurochem 2008;105(4):1525-35.
9. Moore SA, Yoder E, Murphy S, Dutton GR, Spector AA. Astrocytes, not neurons, produce docosahexaenoic acid (22:6 omega-3) and arachidonic acid (20:4 omega-6). J Neurochem 1991;56(2):518-24.
10. Barcelo-Coblijn G, Murphy EJ. Alpha-linolenic acid and its conversion to longer chain n-3 fatty acids: benefits for human health and a role in maintaining tissue n-3 fatty acid levels. Prog Lipid Res 2009;48(6):355-74.
11. Innis SM. Plasma and red blood cell fatty acid values as indexes of essential fatty acids in the developing organs of infants fed with milk or formulas. J Pediatr 1992;120(4 Pt 2):S78-86.
12. Burdge GC, Wootton SA. Conversion of alpha-linolenic acid to eicosapentaenoic, docosapentaenoic and docosahexaenoic acids in young women. Br J Nutr 2002;88(4):411-20.
13. Glaser C, Heinrich J, Koletzko B. Role of FADS1 and FADS2 polymorphisms in polyunsaturated fatty acid metabolism. Metabolism 2010;59(7):993-9.
14. de Wilde MC, Hogyes E, Kiliaan AJ, Farkas T, Luiten PG, Farkas E. Dietary fatty acids alter blood pressure, behavior and brain membrane composition of hypertensive rats. Brain Res 2003;988(1-2):9-19.
15. Solfrizzi V, Colacicco AM, D'Introno A, Capurso C, Torres F, Rizzo C, et al. Dietary intake of unsaturated fatty acids and age-related cognitive decline: a 8.5-year follow-up of the Italian longitudinal study on aging. Neurobiol Aging 2006;27(11): 1694-704.
16. Perry VH. Contribution of systemic inflammation to chronic neurodegeneration. Acta Neuropathol 2010;120(3):277-86.
17. Romano AD, Serviddio G, de Matthaeis A, Bellanti F, Vendemiale G. Oxidative stress and aging. J Nephrol 2010; 23(Suppl 15):S29-36.
18. Mattson MP. Calcium as sculptor and destroyer of neural circuitry. Exp Gerontol 1992;27(1):29-49.
19. Gibson GE, Peterson C. Calcium and the aging nervous system. Neurobiol Aging 1987;8(4):329-43.
20. Thibault O, Gant JC, Landfield PW. Expansion of the calcium hypothesis of brain aging and Alzheimer's disease: minding the store. Aging Cell 2007;6(3):307-17.
21. Joseph JA, Carey A, Brewer GJ, Lau FC, Fisher DR. Dopamine and Abeta-induced stress signaling and decrements in Ca2+ buffering in primary neonatal hippocampal cells are antagonized by blueberry extract. J Alzheimers Dis 2007;11(4):433-46.
22. Joseph JA, Shukitt-Hale B, Brewer GJ, Weikel KA, Kalt W, Fisher DR. Differential protection among fractionated blueberry polyphenolic families against DA-, Abeta(42)- and LPS-induceddecrements in Ca(2+) buffering in primary hippocampal cells. J Agric Food Chem 2010;58(14):8196-204.
23. Dyall SC, Michael-Titus AT. Neurological benefits of omega-3 fatty acids. Neuromol Med 2008;10(4):219-35.
24. du Bois TM, Bell W, Deng C, Huang XF. A high n-6 polyunsaturated fatty acid diet reduces muscarinic M2/M4 receptor binding in the rat brain. J Chem Neuroanat 2005;29(4):282-8.
25. Chauhan N, Wang KC, Wegiel J, Malik MN. Walnut extract inhibits the fibrillization of amyloid beta-protein, and also defibrillizes its preformed fibrils. Curr Alzheimer Res 2004;1(3): 183-8.
26. Grynkiewicz G, Poenie M, Tsien RY. A new generation of Ca2+ indicators with greatly improved fluorescence properties. J Biol Chem 1985;260(6):3440-50.
27. Willis LM, Shukitt-Hale B, Cheng V, Joseph JA. Dose-dependent effects of walnuts on motor and cognitive function in aged rats. Br J Nutr 2009;101(8):1140-4.
28. Khachaturian ZS. Calcium hypothesis of Alzheimer's disease and brain aging. Ann N Y Acad Sci 1994;747:1-11.
29. Toescu EC, Verkhratsky A. The importance of being subtle: small changes in calcium homeostasis control cognitive decline in normal aging. Aging Cell 2007;6(3):267-73.
30. Esin MM. Ageing and the brain. J Pathol 2007;211:181-7.
31. Calder PC. n-3 Polyunsaturated fatty acids, inflammation, and inflammatory diseases. Am J Clin Nutr 2006;83(6 Suppl): 1505S-19S.
32. Calder PC. Polyunsaturated fatty acids and inflammation. Prostaglandins Leukot Essent Fatty Acids 2006;75(3):197-202.
33. Fornstedt B, Pileblad E, Carlsson A. In vivo autoxidation of dopamine in guinea pig striatum increases with age. J Neurochem 1990;55:655-8.
34. Nolan Y, Vereker E, Lynch AM, Lynch MA. Evidence that lipopolysaccharide-induced cell death is mediated by accumulation of reactive oxygen species and activation of p38 in rat cortex and hippocampus. Exp Neurol 2003;184(2):794-804.
35. Calabrese EJ, Baldwin LA. Hormesis: the dose-response revolution. Annu Rev Pharmacol Toxicol 2003;43:175-97.
36. Shamim U, Hanif S, Ullah MF, Azmi AS, Bhat SH, Hadi SM. Plant polyphenols mobilize nuclear copper in human peripheral lymphocytes leading to oxidatively generated DNA breakage: implications for an anticancer mechanism. Free Radic Res 2008;42(8):764-72.
37. Liu RH. Health benefits of fruit and vegetables are from additive and synergistic combinations of phytochemicals. Am J Clin Nutr 2003;78(3 Suppl):517S-20S.
38. Fukuda T, Ito H, Yoshida T. Antioxidative polyphenols from walnuts (Juglans regia L.). Phytochemistry 2003;63(7):795-801.
39. Smith CD, Carney JM, Starke-Reed PE, Oliver CN, Stadtman ER, Floyd RA, Markesbery WR. Excess brain protein oxidation and enzyme dysfunction in normal aging and in Alzheimer disease. Proc Natl Acad Sci 1991;88:10540-3.
40. Spencer JP, Jenner P, Daniel SE, Lees AJ, Marsden DC, Halliwell B. Conjugates of catecholamines with cysteine and GSH in Parkinson's disease: possible mechanisms of formation involving reactive oxygen species. J Neurochem 1998;71(5): 2112-22.