Juglone prevents metabolic endotoxemia-induced hepatitis and neuroinflammation via suppressing TLR4/NF-κB signaling pathway in high-fat diet rats

Biochemical and Biophysical Research Communications

Volumn 462, Issue 3, 2015, Pages 245-250

  Peng, Xiaohui ^a   Nie, Yao ^a   Wu, Jianjun ^a   Huang, Qiang ^a   Cheng, Yuqiang ^a  

^a NATIONAL UNIVERSITY OF DEFENSE TECHNOLOGY   (China)

Author keywords

Hepatitis; Hypothalamus inflammation; Juglone; NF kappa B; Toll like receptor 4

Indexed keywords

ANTIINFLAMMATORY AGENT; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; JUGLONE; MYELOID DIFFERENTIATION FACTOR 88; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA; CYTOKINE; LIPOPOLYSACCHARIDE; MESSENGER RNA; NAPHTHOQUINONE; TLR4 PROTEIN, RAT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; ASTROCYTE; CONTROLLED STUDY; CYTOKINE RELEASE; HEPATITIS; HYPOTHALAMUS; IN VITRO STUDY; MALE; NERVOUS SYSTEM INFLAMMATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; ADVERSE EFFECTS; ANIMAL; BIOSYNTHESIS; COMPLICATION; DRUG EFFECTS; ENDOTOXEMIA; GENETICS; HEPATITIS, ANIMAL; INFLAMMATION; LIPID DIET; METABOLISM; MOUSE; NERVOUS SYSTEM DISEASES; PATHOLOGY; SPRAGUE DAWLEY RAT;

JUGLANS; JUGLANS MANDSHURICA; MUS; RATTUS;

ANIMALS; ANTI-INFLAMMATORY AGENTS; ASTROCYTES; CYTOKINES; DIET, HIGH-FAT; ENDOTOXEMIA; HEPATITIS, ANIMAL; HYPOTHALAMUS; INFLAMMATION; LIPOPOLYSACCHARIDES; MALE; MICE; NAPHTHOQUINONES; NERVOUS SYSTEM DISEASES; NF-KAPPA B; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 4;

EID: 84930179419     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2015.04.124     Document Type: Article

References (29)

1. A.I. Vazquez, Y.C. Klimentidis, E.J. Dhurandhar, Y.C. Veturi, and P. Paerez-Rodriguez Assessment of whole-genome regression for type II diabetes PLoS One 10 2015 e0123818
2. G.T. Russo, G. Baggio, M.C. Rossi, and A. Kautzky-Willer Type 2 diabetes and cardiovascular risk in women Int. J. Endocrinol. 2015 2015 832484
3. J. Sargent Obesity: obesity turns the hepatic epigenetic clock forward Nat. Rev. Endocrinol. 11 2015 2
4. K.C. de Git, and R.A. Adan Leptin resistance in diet-induced obesity: the role of hypothalamic inflammation Obes. Rev. 16 2015 207 224
5. H. Pan, J. Guo, and Z. Su Advances in understanding the interrelations between leptin resistance and obesity Physiol. Behav. 130 2014 157 169
6. F. Mitchell Baleta Country in Focus: diabetes and obesity in South Africa Lancet Diabetes Endocrinol. 2 2014 687 688
7. K. Sohn Sufficiently good measures of obesity: the case of a developing country J. Biosoc. Sci. 46 2014 797 817
8. P.D. Cani, R. Bibiloni, and C. Knauf Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice Diabetes 57 2008 1470 1481
9. M.A. Hildebrandt, C. Hoffmann, and S.A. Sherrill-Mix High-fat diet determines the composition of the murine gut microbiome independently of obesity Gastroenterology 137 2009 1716-1724 e1711-1712
10. H. Daniel, A. Moghaddas Gholami, and D. Berry High-fat diet alters gut microbiota physiology in mice ISME J. 8 2014 295 308
11. T. Fujita Is endotoxemia a therapeutic target in liver injury? Hepatology 53 2011 1785
12. Y. Guo, Y. Zhang, K. Hong, F. Luo, Q. Gu, N. Lu, and A. Bai AMPK inhibition blocks ROS-NFkappaB signaling and attenuates endotoxemia-induced liver injury PLoS One 9 2014 e86881
13. S. Sharma, and P. Kesav Bilateral facial nerve palsy: a rare association with hepatitis A Ann. Indian Acad. Neurol. 16 2013 729 730
14. D.S. Grewal, and J.L. Zeid Isolated abducens nerve palsy following neonatal hepatitis B vaccination J. AAPOS 18 2014 75 76
15. J.R. Caso, J.M. Pradillo, O. Hurtado, P. Lorenzo, M.A. Moro, and I. Lizasoain Toll-like receptor 4 is involved in brain damage and inflammation after experimental stroke Circulation 115 2007 1599 1608
16. X. Zhang, H. Dong, S. Zhang, S. Lu, J. Sun, and Y. Qian Enhancement of LPS-induced microglial inflammation response via TLR4 under high glucose conditions Cell. Physiol. Biochem. 35 2015 1571 1581
17. L.A. Velloso, F. Folli, and M.J. Saad TLR4 at the crossroads of nutrients, gut microbiota and metabolic inflammation Endocr. Rev. 2015 er20141100
18. S.M. Wi, G. Moon, and J. Kim TAK1-ECSIT-TRAF6 complex plays a key role in the TLR4 signal to activate NF-kappaB J. Biol. Chem. 289 2014 35205 35214
19. S. Cosmulescu, I. Trandafir, and V. Nour Seasonal variation of the main individual phenolics and juglone in walnut (Juglans regia) leaves Pharm. Biol. 52 2014 575 580
20. H. Xu, X. Yu, S. Qu, and D. Sui Juglone, isolated from juglans mandshurica Maxim, induces apoptosis via down-regulation of AR expression in human prostate cancer LNCaP cells Bioorg Med. Chem. Lett. 23 2013 3631 3634
21. C. Lorenzo, S.M. Haffner, A. Stancakova, J. Kuusisto, and M. Laakso Fasting and OGTT-derived measures of insulin resistance as compared with the euglycemic-hyperinsulinemic clamp in nondiabetic Finnish offspring of type 2 diabetic individuals J. Clin. Endocrinol. Metab. 100 2015 544 550
22. M. Canki, M.J. Potash, and G. Bentsman Isolation and long-term culture of primary ocular human immunodeficiency virus type 1 isolates in primary astrocytes J. Neurovirol 3 1997 10 15
23. H. Zhu, M.F. Chen, and W.J. Yu Time-dependent changes in BDNF expression of pentylenetetrazole-induced hippocampal astrocytes in vitro Brain Res. 1439 2012 1 6
24. Y. Kim, C.K. Kim, S. Jung, B.W. Yoon, and S.H. Lee Obesity-stroke paradox and initial neurological severity J. Neurol. Neurosurg. Psychiatry 2014 http://dx.doi.org/10.1136/jnnp-2014-308664
25. J.B. Cohen, and D.L. Cohen Cardiovascular and renal effects of weight reduction in obesity and the metabolic syndrome Curr. Hypertens. Rep. 17 2015 544
26. J.P. Vucenik Stains, obesity and cancer risk: evidence, mechanisms, and recommendations Ann. N. Y. Acad. Sci. 1271 2012 37 43
27. L. Bird Gut microbiota influences liver disease Nat. Rev. Immunol. 12 2012 153
28. D. Spector, and S. Shikora Neuro-modulation and bariatric surgery for type 2 diabetes mellitus Int. J. Clin. Pract. Suppl. 2010 53 58
29. H. Xu, G.T. Barnes, and Q. Yang Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance J. Clin. Invest 112 2003 1821 1830