Chloroquine inhibits autophagic flux by decreasing autophagosome-lysosome fusion

Autophagy

Volumn 14, Issue 8, 2018, Pages 1435-1455

  Mauthe, Mario ^a,b   Orhon, Idil ^a   Rocchi, Cecilia ^a   Zhou, Xingdong ^a,c   Luhr, Morten ^d   Hijlkema, Kerst Jan ^a   Coppes, Robert P ^a   Engedal, Nikolai ^d   Mari, Muriel ^a,b   Reggiori, Fulvio ^a,b  

^a UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^b UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^c NORTHEAST AGRICULTURAL UNIVERSITY   (China)

^d UNIVERSITY OF OSLO   (Norway)

Author keywords

Autophagy; bafilomycin A1; degradative compartments; fusion; Golgi; lysosomal degradation; lysosomal inhibitors

Indexed keywords

BAFILOMYCIN A1; CHLOROQUINE; EPIDERMAL GROWTH FACTOR RECEPTOR; HYDROXYCHLOROQUINE; MACROLIDE; SEQUESTOSOME 1; SQSTM1 PROTEIN, MOUSE;

ANIMAL CELL; ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; CELL ORGANELLE; ELECTRON MICROSCOPY; ENDOCYTOSIS; FLUORESCENCE MICROSCOPY; GOLGI COMPLEX; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; IMMUNOFLUORESCENCE MICROSCOPY; INTESTINE TISSUE; KIDNEY; LYSOSOME; MOUSE; NONHUMAN; ANIMAL; C57BL MOUSE; DRUG EFFECT; ENDOSOME; FEMALE; MEMBRANE FUSION; METABOLISM; PROTEIN DEGRADATION; TUMOR CELL LINE; ULTRASTRUCTURE;

ANIMALS; AUTOPHAGOSOMES; AUTOPHAGY; CELL LINE, TUMOR; CHLOROQUINE; ENDOCYTOSIS; ENDOSOMES; ERBB RECEPTORS; FEMALE; GOLGI APPARATUS; HUMANS; HYDROXYCHLOROQUINE; LYSOSOMES; MACROLIDES; MEMBRANE FUSION; MICE, INBRED C57BL; PROTEOLYSIS; SEQUESTOSOME-1 PROTEIN;

EID: 85050360458     PISSN: 15548627     EISSN: 15548635     Source Type: Journal    
DOI: 10.1080/15548627.2018.1474314     Document Type: Article

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