Pharmacological inhibition of ULK1 kinase blocks mammalian target of rapamycin (mTOR)-dependent autophagy

Journal of Biological Chemistry

Volumn 290, Issue 18, 2015, Pages 11376-11383

  Petherick, Katy J ^a   Conway, Owen J L ^a   Mpamhanga, Chido ^b   Osborne, Simon A ^b   Kamal, Ahmad ^b   Saxty, Barbara ^b   Ganley, Ian G ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

^b Centre for Therapeutics Discovery   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; ENZYMES; MAMMALS; MOBILE SECURITY;

AUTOPHAGOSOMES; CELLULAR COMPONENTS; DEGRADATIVE PROCESS; MAMMALIAN TARGET OF RAPAMYCIN (MTOR); PHARMACOLOGICAL INHIBITION; PROTEIN KINASE; SPECIFIC INHIBITORS; TUMORIGENESIS;

ANTIBIOTICS;

AMINO ACID; BAFILOMYCIN A1; ENZYME INHIBITOR; LIGHT CHAIN 3; MAMMALIAN TARGET OF RAPAMYCIN; MEMBRANE PROTEIN; MRT 67307; MRT 68921; PROTEIN SERINE THREONINE KINASE; ULK1 PROTEIN; ULK2 PROTEIN; UNCLASSIFIED DRUG; PROTEIN KINASE INHIBITOR; TARGET OF RAPAMYCIN KINASE; ULK1 PROTEIN, MOUSE;

ANIMAL CELL; ARTICLE; AUTOPHAGY; CONTROLLED STUDY; EMBRYO; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; ENZYME SPECIFICITY; IMMUNOFLUORESCENCE; IN VITRO STUDY; MOUSE; NONHUMAN; PHARMACOLOGICAL BLOCKING; PRIORITY JOURNAL; PROTEIN EXPRESSION; WESTERN BLOTTING; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL LINE; DRUG EFFECTS; METABOLISM; PRECLINICAL STUDY;

MAMMALIA;

ANIMALS; AUTOPHAGY; CELL LINE; DRUG EVALUATION, PRECLINICAL; MICE; PROTEIN KINASE INHIBITORS; PROTEIN-SERINE-THREONINE KINASES; TOR SERINE-THREONINE KINASES;

EID: 84928806944     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.C114.627778     Document Type: Article

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