Suppression of lysosome function induces autophagy via a feedback down-regulation of MTOR complex 1 (MTORC1) activity

Journal of Biological Chemistry

Volumn 288, Issue 50, 2013, Pages 35769-35780

  Li, Min ^a,b   Khambu, Bilon ^a   Zhang, Hao ^a   Kang, Jeong Han ^c   Chen, Xiaoyun ^a   Chen, Daohong ^a   Vollmer, Laura ^d   Liu, Pei Qing ^b   Vogt, Andreas ^d   Yin, Xiao Ming ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b SUN YAT SEN UNIVERSITY   (China)

^c MAYO GRADUATE SCHOOL   (United States)

^d UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

, INHIBITOR; AUTOPHAGIC DEGRADATION; BAFILOMYCIN; CONCANAMYCIN; DOWN-REGULATION; DUAL EFFECT; INHIBITORY EFFECT; SIGNALING SYSTEMS;

BIOCHEMISTRY; BIOLOGY;

AMINO ACIDS;

ALOXISTATIN; BAFILOMYCIN A1; CELL PROTEIN; CHLOROQUINE; CONCANAMYCIN A; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; NICLOSAMIDE; PEPSTATIN; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATASE; RAG PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; AUTOPHAGY; CANCER CELL; CELL FUNCTION; CELL MEMBRANE PERMEABILITY; CELL METABOLISM; CONTROLLED STUDY; DOWN REGULATION; DRUG MECHANISM; EMBRYO; ENZYMATIC DEGRADATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME REPRESSION; HUMAN; HUMAN CELL; INTRACELLULAR SIGNALING; KIDNEY CELL; LYSOSOME; MOUSE; NEGATIVE FEEDBACK; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; PROTEIN TARGETING; REGULATORY MECHANISM;

AUTOPHAGY; CELL BIOLOGY; LYSOSOMES; MTOR; SIGNAL TRANSDUCTION;

AUTOPHAGY; CELL LINE; DOWN-REGULATION; FEEDBACK, PHYSIOLOGICAL; HUMANS; LYSOSOMES; MONOMERIC GTP-BINDING PROTEINS; MULTIPROTEIN COMPLEXES; NICLOSAMIDE; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES;

EID: 84890405966     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.511212     Document Type: Article

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