Balance between senescence and apoptosis is regulated by telomere damage–induced association between p16 and caspase-3

Journal of Biological Chemistry

Volumn 293, Issue 25, 2018, Pages 9784-9800

  Selvam, Shanmugam Panneer ^a,b   Roth, Braden M ^a,b   Nganga, Rose ^a,b   Kim, Jisun ^a,b   Cooley, Marion A ^a,d   Helke, Kristi ^a   Smith, Charles D ^c   Ogretmen, Besim ^a,b  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^b MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^c PENNSYLVANIA STATE UNIVERSITY   (United States)

^d AUGUSTA UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALKANOLAMINES; BIOLOGICAL ORGANS; CELL CULTURE; CHEMICAL ACTIVATION; DISEASES; DRUG PRODUCTS; MAMMALS; PROTEINS; SPHINGOSINES; TRANSCRIPTION; TUMORS;

CASPASE-3 ACTIVATION; ECTOPIC EXPRESSIONS; HUMAN TELOMERASE REVERSE TRANSCRIPTASE (HTERT); MOUSE EMBRYONIC FIBROBLASTS; SENESCENCE INDUCTION; SPHINGOSINE 1 PHOSPHATES; SPHINGOSINE KINASE 2; TUMOR SUPPRESSOR PROTEINS;

CELL DEATH;

CASPASE 3; OPAGANIB; PROTEIN P16; SHORT HAIRPIN RNA; SPHINGOSINE 1 PHOSPHATE; SPHINGOSINE KINASE 2; TELOMERASE; TELOMERASE REVERSE TRANSCRIPTASE; TRANSCRIPTION FACTOR 21; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG; CYCLIN DEPENDENT KINASE INHIBITOR 2A; LYSOPHOSPHOLIPID; PHOSPHOTRANSFERASE; SPHINGOSINE; SPHINGOSINE 1-PHOSPHATE; SPHINGOSINE KINASE 2, HUMAN; SPHINGOSINE KINASE 2, MOUSE;

A-549 CELL LINE; AGING; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL STRESS; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN TISSUE; LUNG TUMOR; MALE; MEF CELL LINE; MOUSE; NON SMALL CELL LUNG CANCER; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; SENESCENCE; SMALL CELL LUNG CANCER; TELOMERE; TESTIS TISSUE; TUMOR GROWTH; TUMOR XENOGRAFT; ANALOGS AND DERIVATIVES; ANIMAL; CELL AGING; CELL PROLIFERATION; DRUG SCREENING; GENETICS; KNOCKOUT MOUSE; METABOLISM; PATHOLOGY; PHYSIOLOGY; SCID MOUSE; TUMOR CELL CULTURE;

ANIMALS; APOPTOSIS; CASPASE 3; CELL PROLIFERATION; CELLULAR SENESCENCE; CYCLIN-DEPENDENT KINASE INHIBITOR P16; FEMALE; HUMANS; LUNG NEOPLASMS; LYSOPHOSPHOLIPIDS; MICE; MICE, KNOCKOUT; MICE, SCID; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); SPHINGOSINE; TELOMERE; TUMOR CELLS, CULTURED; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 85048974807     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.RA118.003506     Document Type: Article

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